Published in Endocr Relat Cancer on July 22, 2012
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Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab (2008) 5.94
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Regulating Rap small G-proteins in time and space. Trends Cell Biol (2011) 1.42
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors. Mol Cell Endocrinol (2009) 1.40
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Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Res (2008) 1.35
Identification of a putative tumor suppressor gene Rap1GAP in pancreatic cancer. Cancer Res (2006) 1.34
The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene (2011) 1.32
Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol (2000) 1.32
Rap1GAP inhibits tumor growth in oropharyngeal squamous cell carcinoma. Am J Pathol (2006) 1.26
Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. Cancer Res (2010) 1.21
Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res (2009) 1.19
Downregulation of Rap1GAP contributes to Ras transformation. Mol Cell Biol (2007) 1.16
Gene expression profiling of differentiated thyroid neoplasms: diagnostic and clinical implications. Clin Cancer Res (2004) 1.13
Inhibition of Src with AZD0530 reveals the Src-Focal Adhesion kinase complex as a novel therapeutic target in papillary and anaplastic thyroid cancer. J Clin Endocrinol Metab (2009) 1.11
Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma. Endocrinology (2010) 1.11
A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene (2005) 1.07
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol (2010) 1.03
Loss of Rap1GAP in papillary thyroid cancer. J Clin Endocrinol Metab (2008) 1.02
Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. J Biol Chem (2003) 1.02
Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation. J Biol Chem (2003) 1.01
Dasatinib reduces FAK phosphorylation increasing the effects of RPI-1 inhibition in a RET/PTC1-expressing cell line. Mol Cancer (2010) 0.97
RapGAPs in brain: multipurpose players in neuronal Rap signalling. Eur J Neurosci (2010) 0.97
Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Res (2010) 0.95
Fibrosis in undifferentiated (anaplastic) thyroid carcinomas: evidence for a dual action of tumour cells in collagen type I synthesis. J Pathol (2000) 0.91
Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin. Mol Pharmacol (2009) 0.89
The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas. Oncogene (2009) 0.85
Phosphorylation of Rap1GAP during the cell cycle. Biochem Biophys Res Commun (1994) 0.83
Contribution of PKB/AKT signaling to thyroid cancer. Front Biosci (Landmark Ed) (2011) 0.82
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer. J Thyroid Res (2011) 0.82
Thyroid cancer in 2010: a roadmap for targeted therapies. Nat Rev Endocrinol (2011) 0.81
Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. Endocr Relat Cancer (2011) 0.81
Role of Epac and protein kinase A in thyrotropin-induced gene expression in primary thyrocytes. Exp Cell Res (2012) 0.79
Loss of tyrosine phosphatase-dependent inhibition promotes activation of tyrosine kinase c-Src in detached pancreatic cells. Mol Carcinog (2010) 0.78
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet (2009) 7.48
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab (2008) 5.94
Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol (2008) 5.31
Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med (2015) 5.07
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res (2003) 4.03
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Molecular characterization of human prostate carcinoma cell lines. Prostate (2003) 3.81
Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol (2013) 3.37
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis (2003) 2.68
In utero gene therapy rescues vision in a murine model of congenital blindness. Mol Ther (2004) 2.56
Clinical cancer advances 2012: annual report on progress against cancer from the american society of clinical oncology. J Clin Oncol (2012) 2.48
Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res (2004) 2.17
Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem (2002) 2.06
TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. J Neurosci (2010) 2.05
A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clin Cancer Res (2008) 1.99
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development. Clin Cancer Res (2010) 1.96
Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas. Neuro Oncol (2010) 1.93
Application of a BRAF pyrosequencing assay for mutation detection and copy number analysis in malignant melanoma. J Mol Diagn (2007) 1.85
Novel AAV serotypes for improved ocular gene transfer. J Gene Med (2008) 1.80
Global Decrease of Histone H3K27 Acetylation in ZEB1-Induced Epithelial to Mesenchymal Transition in Lung Cancer Cells. Cancers (Basel) (2013) 1.65
Beware imposters: MA-1, a novel MALT lymphoma cell line, is misidentified and corresponds to Pfeiffer, a diffuse large B-cell lymphoma cell line. Genes Chromosomes Cancer (2013) 1.42
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice. J Clin Invest (2012) 1.31
Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway. Emerg Infect Dis (2002) 1.30
Herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins. J Virol (2005) 1.29
Systemic rapamycin inhibits retinal and choroidal neovascularization in mice. Mol Vis (2004) 1.27
Diverse cutaneous side effects associated with BRAF inhibitor therapy: a clinicopathologic study. J Am Acad Dermatol (2012) 1.27
Population-based estimate of the contribution of TP53 mutations to subgroups of early-onset breast cancer: Australian Breast Cancer Family Study. Cancer Res (2010) 1.26
Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell Proteomics (2005) 1.21
Downregulation of Rap1GAP contributes to Ras transformation. Mol Cell Biol (2007) 1.16
Clinical Cancer Advances 2013: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology. J Clin Oncol (2013) 1.15
In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. Mol Ther (2006) 1.15
Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Biol Reprod (2005) 1.14
Characterization CSMD1 in a large set of primary lung, head and neck, breast and skin cancer tissues. Cancer Biol Ther (2009) 1.14
Inhibition of Wee1 sensitizes cancer cells to antimetabolite chemotherapeutics in vitro and in vivo, independent of p53 functionality. Mol Cancer Ther (2013) 1.13
A 10-gene classifier for distinguishing head and neck squamous cell carcinoma and lung squamous cell carcinoma. Clin Cancer Res (2007) 1.10
Genome-wide profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization. Laryngoscope (2006) 1.08
Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates. Hum Gene Ther (2005) 1.07
Accelerated mortality from hydrocephalus and pneumonia in mice with a combined deficiency of SPAG6 and SPAG16L reveals a functional interrelationship between the two central apparatus proteins. Cell Motil Cytoskeleton (2007) 1.07
A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. Genes Chromosomes Cancer (2007) 1.06
Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling. J Biol Chem (2006) 1.05
Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. Diabetes (2005) 1.04
Targeting vascular endothelial growth factor receptor in thyroid cancer: the intracellular and extracellular implications. Clin Cancer Res (2010) 1.04
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol (2010) 1.03
Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. J Virol (2003) 1.02
Thyroid-stimulating hormone/cAMP and glycogen synthase kinase 3beta elicit opposing effects on Rap1GAP stability. J Biol Chem (2003) 1.02
Loss of Rap1GAP in papillary thyroid cancer. J Clin Endocrinol Metab (2008) 1.02
The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin. Cancer Chemother Pharmacol (2010) 0.99
Ras induces chromosome instability and abrogation of the DNA damage response. Cancer Res (2006) 0.99
Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J Biol Chem (2003) 0.98
Cooperative interaction of MUC1 with the HGF/c-Met pathway during hepatocarcinogenesis. Mol Cancer (2012) 0.94
Protein kinase C delta stimulates apoptosis by initiating G1 phase cell cycle progression and S phase arrest. J Biol Chem (2005) 0.93
Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Cell Adh Migr (2011) 0.92
Neuropilin-2 Is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition. Cancer Res (2013) 0.90
Protein kinase A and B-Raf mediate extracellular signal-regulated kinase activation by thyrotropin. Mol Pharmacol (2009) 0.89
Distribution of dendritic cell subtypes in primary oral squamous cell carcinoma is inconsistent with a functional response. Cancer Lett (2007) 0.89
Sorafenib-Related Hand-Foot Skin Reaction Improves, Not Worsens, with Continued Treatment. Clin Cancer Res (2009) 0.87
1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer. J Steroid Biochem Mol Biol (2010) 0.86
A phase I study of cabozantinib (XL184) in patients with differentiated thyroid cancer. Thyroid (2014) 0.84
TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology (2007) 0.84
TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. PLoS One (2011) 0.82
Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. Endocr Relat Cancer (2011) 0.81
Role of cAMP, PKA and Rap1A in thyroid follicular cell survival. Oncogene (2002) 0.80
Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP). J Biol Chem (2013) 0.80
Transcription factor Ets1 cooperates with estrogen receptor α to stimulate estradiol-dependent growth in breast cancer cells and tumors. PLoS One (2013) 0.79
Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Mol Vis (2004) 0.79
Spatial and temporal expression patterns of the choroideremia gene in the mouse retina. Mol Vis (2005) 0.78
Gene expression of vitamin D metabolic enzymes at baseline and in response to vitamin D treatment in thyroid cancer cell lines. Oncology (2012) 0.78
Interference with 3',5'-cyclic adenosine monophosphate response element binding protein stimulates apoptosis through aberrant cell cycle progression and checkpoint activation. Mol Endocrinol (2006) 0.78
Ras stimulates aberrant cell cycle progression and apoptosis in rat thyroid cells. Mol Endocrinol (2002) 0.78
Physician and stakeholder perceptions of conflict of interest policies in oncology. J Clin Oncol (2013) 0.77
Her-2 targeted therapy: beyond breast cancer and trastuzumab. Curr Oncol Rep (2006) 0.77
Thyrotropin and serum regulate thyroid cell proliferation through differential effects on p27 expression and localization. Mol Endocrinol (2004) 0.76
Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons. J Neuropathol Exp Neurol (2003) 0.75
Second-line treatment for advanced thyroid cancer: an indication in need of randomized clinical trials. J Clin Endocrinol Metab (2014) 0.75
Diagnosis and management of TRK fusion cancer. Am J Manag Care (2022) 0.75
Comparative effectiveness of larotrectinib and entrectinib for TRK fusion cancer. Am J Manag Care (2022) 0.75
Thyrotropin-stimulated DNA synthesis and thyroglobulin expression in normal and hyperthyroid feline thyrocytes in monolayer culture. Thyroid (2005) 0.75