Published in Cancer Res on January 15, 2009
The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma. Oncogene (2011) 1.32
Downregulation of Rap1GAP through epigenetic silencing and loss of heterozygosity promotes invasion and progression of thyroid tumors. Cancer Res (2010) 1.21
EZH2: not EZHY (easy) to deal. Mol Cancer Res (2014) 1.20
Downregulation of Rap1GAP in human tumor cells alters cell/matrix and cell/cell adhesion. Mol Cell Biol (2010) 1.03
The primacy of β1 integrin activation in the metastatic cascade. PLoS One (2012) 1.03
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol (2012) 0.99
Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. J Clin Invest (2012) 0.98
RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Oncogene (2011) 0.98
Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway. J Biol Chem (2011) 0.95
Rap1GAP regulates renal cell carcinoma invasion. Cancer Lett (2012) 0.94
Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation. Oncotarget (2012) 0.94
Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion. Cell Adh Migr (2011) 0.92
Rap1 mediates galanin receptor 2-induced proliferation and survival in squamous cell carcinoma. Cell Signal (2011) 0.89
Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest (2014) 0.87
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. J Biol Chem (2012) 0.86
PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. Biochim Biophys Acta (2009) 0.86
Epigenetic biomarkers in skin cancer. Cancer Lett (2012) 0.84
In-vivo transfection of pcDNA3.1-IGFBP7 inhibits melanoma growth in mice through apoptosis induction and VEGF downexpression. J Exp Clin Cancer Res (2010) 0.83
Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells. Endocr Relat Cancer (2011) 0.81
Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP). J Biol Chem (2013) 0.80
Epigenetic cancer prevention mechanisms in skin cancer. AAPS J (2013) 0.79
PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS One (2014) 0.77
Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer. Int J Mol Sci (2016) 0.77
Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines. Invest New Drugs (2011) 0.76
RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells. Endocr Relat Cancer (2012) 0.76
Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med (2017) 0.75
EZH2 as a mediator of treatment resistance in melanoma. Pigment Cell Melanoma Res (2016) 0.75
Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer. Oncotarget (2017) 0.75
The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA. Nature (2003) 10.76
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation. Stroke (2007) 2.58
The role of chemokines in melanoma tumor growth and metastasis. J Invest Dermatol (2002) 2.27
Sentinel lymph node biopsy in patients with thin melanoma. Arch Dermatol (2003) 2.11
Response to Idelalisib in a Patient with Stage IV Merkel-Cell Carcinoma. N Engl J Med (2015) 2.03
Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study. Acta Diabetol (2010) 2.01
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol (2005) 2.00
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J Virol (2006) 1.84
Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem (2013) 1.80
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol (2010) 1.79
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. J Biol Chem (2009) 1.73
Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. Curr Biol (2010) 1.73
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest (2010) 1.71
Ocular melanoma: a review and the relationship to cutaneous melanoma. Arch Dermatol (2003) 1.67
The regulation of tendon stem cell differentiation by the alignment of nanofibers. Biomaterials (2009) 1.59
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol (2005) 1.52
Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Dev Cell (2008) 1.51
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases. Cancer Res (2006) 1.41
The photosensitiser xanthurenic acid is not present in normal human lenses. Exp Eye Res (2003) 1.40
IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity. J Clin Invest (2013) 1.36
Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res (2006) 1.35
Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. J Nutr (2007) 1.35
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
luxS and arcB control aerobic growth of Actinobacillus actinomycetemcomitans under iron limitation. Infect Immun (2003) 1.32
{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A (2008) 1.31
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. J Immunol (2012) 1.30
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Sci Rep (2012) 1.29
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med (2008) 1.24
In vivo photoacoustic microscopy of human cutaneous microvasculature and a nevus. J Biomed Opt (2011) 1.20
In vivo assessment of rapid cerebrovascular morphological adaptation following acute blood flow increase. J Neurosurg (2008) 1.19
Handheld photoacoustic microscopy to detect melanoma depth in vivo. Opt Lett (2014) 1.19
What is new in management of pediatric ranula? Curr Opin Otolaryngol Head Neck Surg (2014) 1.18
Potent suppression of viral infectivity by the peptides that inhibit multimerization of human immunodeficiency virus type 1 (HIV-1) Vif proteins. J Biol Chem (2002) 1.17
High-fat diet feeding impairs both the expression and activity of AMPKa in rats' skeletal muscle. Biochem Biophys Res Commun (2005) 1.16
Arteriogenesis: noninvasive quantification with multi-detector row CT angiography and three-dimensional volume rendering in rodents. Radiology (2006) 1.16
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake. Traffic (2003) 1.14
MicroRNA-155 prevents necrotic cell death in human cardiomyocyte progenitor cells via targeting RIP1. J Cell Mol Med (2010) 1.13
Chronic itch development in sensory neurons requires BRAF signaling pathways. J Clin Invest (2013) 1.13
Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Mol Cell Endocrinol (2008) 1.13
Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia. Sheng Li Xue Bao (2007) 1.11
Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription. J Cell Mol Med (2009) 1.11
HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition. Blood (2005) 1.09
Urinary prostaglandin F2alpha is generated from the isoprostane pathway and not the cyclooxygenase in humans. J Biol Chem (2006) 1.09
Actin stress fiber pre-extension in human aortic endothelial cells. Cell Motil Cytoskeleton (2008) 1.08
Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain. Ann Biomed Eng (2009) 1.08
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. J Biol Chem (2006) 1.07
Progressive aneurysm development following hemodynamic insult. J Neurosurg (2010) 1.07
Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity. Lipids Health Dis (2012) 1.06
Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J Biol Chem (2005) 1.05
Metastatic melanoma - a review of current and future treatment options. Acta Derm Venereol (2015) 1.05
Exonic mutations of TSC2/TSC1 are common but not seen in all sporadic pulmonary lymphangioleiomyomatosis. Am J Respir Crit Care Med (2013) 1.04
Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice. Endocrinology (2011) 1.03
Slit proteins, potential endogenous modulators of inflammation. J Neurovirol (2002) 1.02
Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem (2013) 1.02
Regiochemistry of neuroprostanes generated from the peroxidation of docosahexaenoic acid in vitro and in vivo. J Biol Chem (2005) 1.01
Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model. J Vasc Res (2011) 1.01
Organ preservation. Methods Mol Biol (2006) 1.00
Mechanisms of hepatoprotection of Terminalia catappa L. extract on D-Galactosamine-induced liver damage. Am J Chin Med (2004) 1.00
Proteomic analysis of neural differentiation of mouse embryonic stem cells. Proteomics (2005) 1.00
Presentations and management of thyroglossal duct cyst in children versus adults: a review of 106 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2011) 1.00
Proteomics, pathway array and signaling network-based medicine in cancer. Cell Div (2009) 0.99
Formation of highly reactive A-ring and J-ring isoprostane-like compounds (A4/J4-neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem (2002) 0.99
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol (2012) 0.99
Mechanisms for the formation of isoprostane endoperoxides from arachidonic acid. "Dioxetane" intermediate versus beta-fragmentation of peroxyl radicals. J Biol Chem (2003) 0.98
In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin. J Biomed Opt (2011) 0.98
Management of temporomandibular joint ankylosis: 11 years' clinical experience. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2009) 0.97
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling. Proc Natl Acad Sci U S A (2010) 0.96
Practices of unregulated tanning facilities in Missouri: implications for statewide legislation. Pediatrics (2013) 0.96
Molecular alterations associated with aneurysmal remodeling are localized in the high hemodynamic stress region of a created carotid bifurcation. Neurosurgery (2009) 0.96
Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. Hum Mol Genet (2009) 0.96
Tumor necrosis factor receptor-associated factor 6 is an intranuclear transcriptional coactivator in osteoclasts. J Biol Chem (2008) 0.95
Ghrelin-containing neuron in cerebral cortex and hypothalamus linked with the DVC of brainstem in rat. Regul Pept (2006) 0.95
Comparison of safety and efficacy of insulin glargine and neutral protamine hagedorn insulin in older adults with type 2 diabetes mellitus: results from a pooled analysis. J Am Geriatr Soc (2012) 0.95
Identification of photoreceptor genes affected by PRPF31 mutations associated with autosomal dominant retinitis pigmentosa. Neurobiol Dis (2007) 0.95
Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. J Mol Cell Cardiol (2006) 0.95
Thyroid stimulating hormone, independent of thyroid hormone, can elevate the serum total cholesterol level in patients with coronary heart disease: a cross-sectional design. Nutr Metab (Lond) (2012) 0.94
Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis. Traffic (2011) 0.94
Curcumin inhibits gene expression of receptor for advanced glycation end-products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress. Br J Pharmacol (2012) 0.94
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model. Blood (2009) 0.94
Captopril inhibits glucose accumulation in retinal cells in diabetes. Invest Ophthalmol Vis Sci (2003) 0.94
The effect of elevated serum soluble CD40 ligand on the prognostic value in patients with acute coronary syndromes. Clin Chim Acta (2004) 0.94
Primary graft failure after heart transplantation. J Transplant (2011) 0.93
MiR-21 modulates chemosensitivity of tongue squamous cell carcinoma cells to cisplatin by targeting PDCD4. Mol Cell Biochem (2014) 0.93
ELE restrains empty glumes from developing into lemmas. J Genet Genomics (2010) 0.93
V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption. J Bone Miner Res (2012) 0.93
LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1. PLoS One (2011) 0.92
The cyclopentenone product of lipid peroxidation, 15-A(2t)-isoprostane (8-isoprostaglandin A(2)), is efficiently conjugated with glutathione by human and rat glutathione transferase A4-4. Chem Res Toxicol (2002) 0.92
Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In Vitro Cell Dev Biol Anim (2003) 0.91
Ethanol feeding impairs insulin-stimulated glucose uptake in isolated rat skeletal muscle: role of Gs alpha and cAMP. Alcohol Clin Exp Res (2005) 0.91
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. J Clin Invest (2015) 0.90
A phase II, open-label study of ramucirumab in combination with paclitaxel and carboplatin as first-line therapy in patients with stage IIIB/IV non-small-cell lung cancer. J Thorac Oncol (2014) 0.90