Victor J Thannickal

Author PubWeight™ 134.39‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The myofibroblast: one function, multiple origins. Am J Pathol 2007 8.64
2 miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 2010 4.71
3 Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 2012 4.13
4 NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 2009 4.05
5 CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 2005 4.02
6 Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med 2014 3.23
7 miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol 2010 2.87
8 Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial-mesenchymal transition reveals a migratory/invasive phenotype. J Proteome Res 2006 2.43
9 Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease. Am J Respir Crit Care Med 2003 2.35
10 Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cell Signal 2006 2.22
11 Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis. Am J Respir Crit Care Med 2009 2.15
12 Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E. prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol 2003 2.14
13 Activation of the pro-survival phosphatidylinositol 3-kinase/AKT pathway by transforming growth factor-beta1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biol Chem 2003 2.12
14 Host responses in tissue repair and fibrosis. Annu Rev Pathol 2012 2.10
15 Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J 2005 2.09
16 Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches. Drugs 2004 2.05
17 Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis? Am J Respir Crit Care Med 2007 1.94
18 Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury. Am J Pathol 2005 1.93
19 A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med 2012 1.92
20 Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest 2007 1.87
21 Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. J Clin Invest 2013 1.81
22 Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10. Am J Respir Crit Care Med 2003 1.75
23 PPAR-gamma agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2007 1.74
24 Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis. J Pathol 2003 1.71
25 Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction. Am J Respir Cell Mol Biol 2012 1.67
26 Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid Redox Signal 2009 1.64
27 Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med 2011 1.56
28 Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med 2014 1.54
29 Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer. Oncogene 2004 1.50
30 Altered DNA methylation profile in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012 1.47
31 Participation of miR-200 in pulmonary fibrosis. Am J Pathol 2011 1.43
32 Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J 2009 1.41
33 Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem 2010 1.36
34 NOX enzymes and pulmonary disease. Antioxid Redox Signal 2009 1.29
35 Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2005 1.23
36 Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation. Am J Respir Cell Mol Biol 2009 1.20
37 Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway. J Biol Chem 2008 1.20
38 Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis. Am J Respir Cell Mol Biol 2007 1.20
39 PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling. Am J Physiol Lung Cell Mol Physiol 2007 1.19
40 Lung cells from neonates show a mesenchymal stem cell phenotype. Am J Respir Crit Care Med 2007 1.18
41 HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol 2013 1.17
42 miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J 2013 1.15
43 Fibrosis: ultimate and proximate causes. J Clin Invest 2014 1.15
44 Azithromycin blocks neutrophil recruitment in Pseudomonas endobronchial infection. Am J Respir Crit Care Med 2004 1.12
45 Extracorporeal membrane oxygenation for acute respiratory failure in adults: the need for pulmonary INTERMACS. Am J Respir Crit Care Med 2014 1.07
46 STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection. J Immunol 2004 1.06
47 Oxygen in the evolution of complex life and the price we pay. Am J Respir Cell Mol Biol 2008 1.05
48 Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury. Am J Respir Crit Care Med 2008 1.05
49 New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis. Drugs 2011 1.03
50 Platelet-derived growth factor-induced p42/44 mitogen-activated protein kinase activation and cellular growth is mediated by reactive oxygen species in the absence of TSC2/tuberin. Cancer Res 2005 1.03
51 Idiopathic pulmonary fibrosis: a disorder of lung regeneration? Am J Respir Crit Care Med 2008 1.02
52 Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res 2011 1.02
53 Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med 2012 1.01
54 Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol 2012 1.00
55 Effects of the protein kinase inhibitor, imatinib mesylate, on epithelial/mesenchymal phenotypes: implications for treatment of fibrotic diseases. J Pharmacol Exp Ther 2007 1.00
56 Deactivation of murine alveolar macrophages by peroxisome proliferator-activated receptor-gamma ligands. Am J Physiol Lung Cell Mol Physiol 2003 0.99
57 Epithelial-mesenchymal interactions in pulmonary fibrosis. Semin Respir Crit Care Med 2006 0.99
58 Retracted miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. FASEB J 2012 0.99
59 Histone modifications in senescence-associated resistance to apoptosis by oxidative stress. Redox Biol 2013 0.98
60 Histone deacetylase inhibition promotes fibroblast apoptosis and ameliorates pulmonary fibrosis in mice. Eur Respir J 2014 0.97
61 Enhancement of antitumor immunity in lung cancer by targeting myeloid-derived suppressor cell pathways. Cancer Res 2013 0.96
62 Microbicidal activity of vascular peroxidase 1 in human plasma via generation of hypochlorous acid. Infect Immun 2012 0.95
63 Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. FASEB J 2013 0.93
64 Relaxin regulates myofibroblast contractility and protects against lung fibrosis. Am J Pathol 2011 0.93
65 Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol 2012 0.92
66 Targeting NOX enzymes in pulmonary fibrosis. Cell Mol Life Sci 2012 0.92
67 Development and maintenance of a biospecimen repository for clinical samples derived from pulmonary patients. Clin Transl Sci 2014 0.91
68 Challenges in translating preclinical studies to effective drug therapies in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2010 0.91
69 Idiopathic pulmonary fibrosis : new concepts in pathogenesis and implications for drug therapy. Treat Respir Med 2006 0.90
70 Innovative approaches to the therapy of fibrosis. Curr Opin Rheumatol 2009 0.88
71 Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury. Am J Pathol 2013 0.87
72 Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish. Dev Biol 2010 0.86
73 Vascular peroxidase-1 is rapidly secreted, circulates in plasma, and supports dityrosine cross-linking reactions. Free Radic Biol Med 2011 0.86
74 Vascular peroxidase 1 catalyzes the formation of hypohalous acids: characterization of its substrate specificity and enzymatic properties. Free Radic Biol Med 2012 0.85
75 Heritability of pulmonary function estimated from pedigree and whole-genome markers. Front Genet 2013 0.85
76 Protein kinase inhibitors in the treatment of pulmonary fibrosis. Curr Med Chem 2008 0.85
77 Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc 2011 0.83
78 Elevated levels of NO are localized to distal airways in asthma. Free Radic Biol Med 2011 0.82
79 Histone deacetylase inhibition downregulates collagen 3A1 in fibrotic lung fibroblasts. Int J Mol Sci 2013 0.82
80 Update in diffuse parenchymal lung disease 2008. Am J Respir Crit Care Med 2009 0.81
81 Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages. J Immunol 2013 0.81
82 Current and emerging drugs for idiopathic pulmonary fibrosis. Expert Opin Emerg Drugs 2007 0.81
83 NADPH oxidases in lung health and disease. Antioxid Redox Signal 2014 0.81
84 Nonresolving fibrotic disorders: idiopathic pulmonary fibrosis as a paradigm of impaired tissue regeneration. Am J Med Sci 2011 0.81
85 The code of non-coding RNAs in lung fibrosis. Cell Mol Life Sci 2015 0.80
86 The paradox of reactive oxygen species: injury, signaling, or both? Am J Physiol Lung Cell Mol Physiol 2003 0.80
87 Classification of interstitial pneumonias: what do gene expression profiles tell us? Am J Respir Crit Care Med 2006 0.79
88 Wnt/β-catenin and transforming growth factor-β signaling in pulmonary fibrosis. A case for antagonistic pleiotropy? Am J Respir Crit Care Med 2014 0.78
89 Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema. COPD 2009 0.78
90 An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol 2017 0.77
91 Systemic sclerosis-associated fibrosis: an accelerated aging phenotype? Curr Opin Rheumatol 2015 0.77
92 Use of ECMO in the Management of Severe Acute Respiratory Distress Syndrome: A Survey of Academic Medical Centers in the United States. ASAIO J 2015 0.76
93 Update in diffuse parenchymal lung disease 2011. Am J Respir Crit Care Med 2012 0.76
94 Lactate, a novel trigger of transforming growth factor-β activation in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2012 0.76
95 Biological insights from clinical trials and networks. Am J Respir Crit Care Med 2012 0.75
96 3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. JCI Insight 2017 0.75