Host responses in tissue repair and fibrosis.

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Published in Annu Rev Pathol on October 22, 2012

Authors

Jeremy S Duffield1, Mark Lupher, Victor J Thannickal, Thomas A Wynn

Author Affiliations

1: Division of Nephrology, Center for Lung Biology, and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98019, USA.

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Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells. Antioxid Redox Signal (2009) 1.64

Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology. Adv Parasitol (2002) 1.61

Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol (2008) 1.58

IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. J Immunol (2002) 1.58

Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med (2011) 1.56

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Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53

Peroxisome proliferator-activated receptor-gamma activation inhibits tumor progression in non-small-cell lung cancer. Oncogene (2004) 1.50

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Altered DNA methylation profile in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2012) 1.47

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Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol (2010) 1.40

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NOX enzymes and pulmonary disease. Antioxid Redox Signal (2009) 1.29

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Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol (2011) 1.26

Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci U S A (2012) 1.24

T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A (2007) 1.23

Constitutive activation of prosurvival signaling in alveolar mesenchymal cells isolated from patients with nonresolving acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2005) 1.23

Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology (2010) 1.22

Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway. J Biol Chem (2008) 1.20

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Plasminogen activation induced pericellular fibronectin proteolysis promotes fibroblast apoptosis. Am J Respir Cell Mol Biol (2007) 1.20

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Lung cells from neonates show a mesenchymal stem cell phenotype. Am J Respir Crit Care Med (2007) 1.18

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol (2013) 1.17

IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. J Immunol (2008) 1.16

miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J (2013) 1.15

Fibrosis: ultimate and proximate causes. J Clin Invest (2014) 1.15

Exploiting worm and allergy models to understand Th2 cytokine biology. Curr Opin Allergy Clin Immunol (2005) 1.14

Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides. Eur J Immunol (2003) 1.14

IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol (2009) 1.13