Published in Biochem J on July 01, 2012
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
AMPK: a contextual oncogene or tumor suppressor? Cancer Res (2013) 1.82
AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling. J Leukoc Biol (2013) 1.65
Structural basis of AMPK regulation by small molecule activators. Nat Commun (2013) 1.58
AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation. Cell Metab (2013) 1.40
Dysregulation of RNA polymerase I transcription during disease. Biochim Biophys Acta (2012) 1.16
ABI1 and PP2CA phosphatases are negative regulators of Snf1-related protein kinase1 signaling in Arabidopsis. Plant Cell (2013) 1.15
AMPK: regulating energy balance at the cellular and whole body levels. Physiology (Bethesda) (2014) 1.06
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol Cancer Ther (2013) 1.05
Folliculin regulates ampk-dependent autophagy and metabolic stress survival. PLoS Genet (2014) 1.00
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Front Plant Sci (2014) 0.98
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends Pharmacol Sci (2015) 0.96
Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem J (2014) 0.96
Polarized activities of AMPK and BRSK in primary hippocampal neurons. Mol Biol Cell (2015) 0.95
AMPK: An emerging target for modification of injury-induced pain plasticity. Neurosci Lett (2013) 0.91
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (2013) 0.91
Signaling pathway cross talk in Alzheimer's disease. Cell Commun Signal (2014) 0.89
Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke. J Neurosci Res (2013) 0.88
AMPK-NF-κB axis in the photoreceptor disorder during retinal inflammation. PLoS One (2014) 0.87
Glutathione S-transferases interact with AMP-activated protein kinase: evidence for S-glutathionylation and activation in vitro. PLoS One (2013) 0.87
Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain. Prog Mol Biol Transl Sci (2015) 0.87
Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells. Oncol Lett (2013) 0.86
Phytochemistry and biological properties of glabridin. Fitoterapia (2013) 0.86
Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes. BMC Cancer (2014) 0.86
Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health. PLoS One (2012) 0.85
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Carcinogenesis (2015) 0.85
miR-135b expression downregulates Ppm1e to activate AMPK signaling and protect osteoblastic cells from dexamethasone. Oncotarget (2016) 0.84
Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function. Acta Neuropathol Commun (2013) 0.83
Antiaging Gene Klotho Deficiency Promoted High-Fat Diet-Induced Arterial Stiffening via Inactivation of AMP-Activated Protein Kinase. Hypertension (2016) 0.82
Regulation of metformin response by breast cancer associated gene 2. Neoplasia (2013) 0.82
Complement protein C1q and adiponectin stimulate Mer tyrosine kinase-dependent engulfment of apoptotic cells through a shared pathway. J Innate Immun (2014) 0.82
Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity. Mol Biol Cell (2013) 0.82
Targeted activation of AMPK by GSK621 ameliorates H2O2-induced damages in osteoblasts. Oncotarget (2017) 0.82
Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer. Mol Cancer Res (2014) 0.81
Novel small-molecule AMP-activated protein kinase allosteric activator with beneficial effects in db/db mice. PLoS One (2013) 0.81
The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase. J Biol Chem (2013) 0.81
β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages. J Clin Biochem Nutr (2012) 0.81
Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet. Cell Rep (2017) 0.81
Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels. J Biol Chem (2014) 0.80
PI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicity. Toxins (Basel) (2012) 0.79
Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats. Respir Res (2014) 0.79
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease. Hum Mol Genet (2015) 0.79
AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue. Mol Cell Biol (2016) 0.78
Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes. Biomol Ther (Seoul) (2016) 0.78
The pharmacology of nociceptor priming. Handb Exp Pharmacol (2015) 0.78
Enhanced expression of WD repeat-containing protein 35 via CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells. PLoS One (2014) 0.78
Identification of signalling cascades involved in red blood cell shrinkage and vesiculation. Biosci Rep (2015) 0.77
Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise. Nutr Metab (Lond) (2015) 0.77
A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. J Neurochem (2015) 0.77
Subtle Regulation of Potato Acid Invertase Activity by a Protein Complex of Invertase, Invertase Inhibitor, and SUCROSE NONFERMENTING1-RELATED PROTEIN KINASE. Plant Physiol (2015) 0.77
Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway. Int J Obes (Lond) (2015) 0.77
Constitutive activation of AMPK α1 in vascular endothelium promotes high-fat diet-induced fatty liver injury: role of COX-2 induction. Br J Pharmacol (2014) 0.76
Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. Biochem J (2014) 0.76
Involvement of 'stress-response' kinase pathways in Alzheimer's disease progression. Curr Opin Neurobiol (2014) 0.76
The AMPKα1 Pathway Positively Regulates the Developmental Transition from Proliferation to Quiescence in Trypanosoma brucei. Cell Rep (2016) 0.76
Hypothalamic AMPK as a Regulator of Energy Homeostasis. Neural Plast (2016) 0.76
Past strategies and future directions for identifying AMP-activated protein kinase (AMPK) modulators. Pharmacol Ther (2014) 0.76
Proteomic analysis of the inhibitory effect of epigallocatechin gallate on lipid accumulation in human HepG2 cells. Proteome Sci (2013) 0.76
AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms. Transl Oncol (2016) 0.75
Betulin exhibits anti-inflammatory activity in LPS-stimulated macrophages and endotoxin-shocked mice through an AMPK/AKT/Nrf2-dependent mechanism. Cell Death Dis (2017) 0.75
Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep (2016) 0.75
A High Throughput Assay for Discovery of Small Molecules that Bind AMP-activated Protein Kinase (AMPK). Curr Chem Genom Transl Med (2013) 0.75
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat Commun (2016) 0.75
The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development. PLoS One (2017) 0.75
Procyanidin Promotes Translocation of Glucose Transporter 4 in Muscle of Mice through Activation of Insulin and AMPK Signaling Pathways. PLoS One (2016) 0.75
2-Aminobutyric acid modulates glutathione homeostasis in the myocardium. Sci Rep (2016) 0.75
AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy. EMBO Mol Med (2014) 0.75
Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis. Redox Biol (2017) 0.75
AMPK modulatory activity of olive-tree leaves phenolic compounds: Bioassay-guided isolation on adipocyte model and in silico approach. PLoS One (2017) 0.75
Multi-regulatory network of ROS: the interconnection of ROS, PGC-1 alpha, and AMPK-SIRT1 during exercise. J Physiol Biochem (2017) 0.75
FDA-approved immunosuppressants targeting staphylococcal superantigens: mechanisms and insights. Immunotargets Ther (2017) 0.75
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases. Proc Natl Acad Sci U S A (2003) 4.87
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem (2004) 3.84
Context fear learning in the absence of the hippocampus. J Neurosci (2006) 2.36
Insulin antagonizes ischemia-induced Thr172 phosphorylation of AMP-activated protein kinase alpha-subunits in heart via hierarchical phosphorylation of Ser485/491. J Biol Chem (2005) 2.24
Thrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase beta. Mol Cell Biol (2006) 1.88
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J (2002) 1.87
AMP-activated protein kinase: nature's energy sensor. Nat Chem Biol (2011) 1.85
Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr Purif (2003) 1.62
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1. Proc Natl Acad Sci U S A (2002) 1.59
ADP regulates SNF1, the Saccharomyces cerevisiae homolog of AMP-activated protein kinase. Cell Metab (2011) 1.37
Mature and immature extracranial teratomas in children: the UK Children's Cancer Study Group Experience. J Clin Oncol (2008) 1.36
Trace fear conditioning is enhanced in mice lacking the delta subunit of the GABAA receptor. Learn Mem (2005) 1.27
The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor. Mol Endocrinol (2007) 1.15
Rethinking "Patient Testimony" in the Medical Humanities: The Case of Schizophrenia Bulletin's First Person Accounts. J Lit Sci (2012) 1.10
Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem (2007) 1.09
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes (2011) 1.02
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling and cell death in the immature central nervous system after hypoxia-ischemia and inflammation. J Biol Chem (2014) 1.02
Characterization of an alternative splice variant of LKB1. J Biol Chem (2008) 1.00
Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem (2010) 0.98
Report on the 2nd International Consortium on Hallucination Research: evolving directions and top-10 "hot spots" in hallucination research. Schizophr Bull (2013) 0.97
Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol (2006) 0.96
'The medical' and 'health' in a critical medical humanities. J Med Humanit (2015) 0.96
Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. J Biol Chem (2008) 0.95
The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet (2012) 0.90
LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis. PLoS One (2011) 0.84
Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury. FASEB J (2013) 0.83
Lasting neuroendocrine-immune effects of traumatic brain injury in rats. J Neurotrauma (2006) 0.82
Mitochondria and perinatal brain injury. J Matern Fetal Neonatal Med (2012) 0.80
Death associated protein kinases: molecular structure and brain injury. Int J Mol Sci (2013) 0.79
Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders. Genetica (2004) 0.79
The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia. Dev Neurosci (2015) 0.78
Cellular mechanisms of toll-like receptor-3 activation in the thalamus are associated with white matter injury in the developing brain. J Neuropathol Exp Neurol (2015) 0.77
A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. J Neurochem (2015) 0.77
Does Caspase-6 Have a Role in Perinatal Brain Injury? Dev Neurosci (2015) 0.77
Post-Narrative - An Appeal. Narrat Inq (2015) 0.75
Common arterial trunk with thanatophoric dysplasia: a unique case. Fetal Pediatr Pathol (2008) 0.75
On shame and voice-hearing. Med Humanit (2017) 0.75
Implicating Receptor Activator of NF-κB (RANK)/RANK Ligand Signalling in Microglial Responses to Toll-Like Receptor Stimuli. Dev Neurosci (2017) 0.75
Voices, identity, and meaning-making. Lancet (2015) 0.75