Published in Structure on September 26, 2013
Degradation of AMPK by a cancer-specific ubiquitin ligase. Cell (2015) 1.91
Nitric oxide-induced conformational changes in soluble guanylate cyclase. Structure (2014) 1.55
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
HDX-MS guided drug discovery: small molecules and biopharmaceuticals. Curr Opin Struct Biol (2014) 0.89
Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry. Structure (2014) 0.82
Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14). J Biol Chem (2015) 0.79
Whole-protein alanine-scanning mutagenesis of allostery: a large percentage of a protein can contribute to mechanism. Hum Mutat (2017) 0.78
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Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase (AMPK) activator. Oncoimmunology (2016) 0.75
Differential isotopic enrichment to facilitate characterization of asymmetric multimeric proteins using hydrogen/deuterium exchange mass spectrometry. Anal Chem (2015) 0.75
β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase. Sci Rep (2016) 0.75
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding. J Biol Chem (2017) 0.75
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol (2007) 15.30
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab (2005) 13.91
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab (2005) 8.30
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
AMPK in Health and Disease. Physiol Rev (2009) 6.38
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem (2002) 6.36
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab (2006) 4.64
Structure of mammalian AMPK and its regulation by ADP. Nature (2011) 4.27
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Cloning and genetic mapping of SNF1, a gene required for expression of glucose-repressible genes in Saccharomyces cerevisiae. Mol Cell Biol (1984) 3.81
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature (2007) 3.26
The glycogen-binding domain on the AMPK beta subunit allows the kinase to act as a glycogen sensor. Cell Metab (2009) 2.92
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem (2006) 2.89
Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J Biol Chem (2006) 2.69
Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (2007) 2.57
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem (2007) 2.12
Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature (2007) 1.94
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol (2008) 1.93
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Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr Purif (2003) 1.62
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nat Struct Mol Biol (2011) 1.59
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J Biol Chem (2008) 1.41
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A (2008) 1.38
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol (2012) 1.30
AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N Biotechnol (2009) 1.24
Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases. FASEB J (2010) 1.17
Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding. J Biol Chem (2008) 1.16
Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PLoS One (2010) 1.15
Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes (2003) 1.14
AMPK structure and regulation from three angles. Structure (2007) 1.13
AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation. Autophagy (2011) 1.13
Conserved regulatory elements in AMPK. Nature (2013) 1.11
Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol (2011) 1.08
AMP-activated protein kinase: Role in metabolism and therapeutic implications. Diabetes Obes Metab (2006) 1.07
Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure (2011) 0.99
Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med (2011) 0.97
Caloric restriction mimetic 2-deoxyglucose antagonizes doxorubicin-induced cardiomyocyte death by multiple mechanisms. J Biol Chem (2011) 0.92
Direct AMP-activated protein kinase activators: a review of evidence from the patent literature. Expert Opin Ther Pat (2012) 0.91
AMPK beta subunits display isoform specific affinities for carbohydrates. FEBS Lett (2010) 0.90
Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase. Protein Expr Purif (2010) 0.85
An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.82
AMP-activated protein kinase β-subunit requires internal motion for optimal carbohydrate binding. Biophys J (2012) 0.79
Does tailoring matter? Meta-analytic review of tailored print health behavior change interventions. Psychol Bull (2007) 8.89
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature (2011) 4.19
Chemical derivatization of histones for facilitated analysis by mass spectrometry. Nat Protoc (2007) 3.78
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem (2006) 2.89
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell (2009) 2.84
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol (2007) 2.76
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol (2007) 2.62
Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (2007) 2.57
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science (2011) 2.52
The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Mol Pharmacol (2009) 2.30
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem (2009) 2.02
Genomic and functional evolution of the Drosophila melanogaster sperm proteome. Nat Genet (2006) 1.97
Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer. Structure (2010) 1.96
Structural regulation of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2011) 1.89
Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology (2010) 1.88
Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry. J Biomol Tech (2003) 1.85
HD desktop: an integrated platform for the analysis and visualization of H/D exchange data. J Am Soc Mass Spectrom (2008) 1.82
HDX workbench: software for the analysis of H/D exchange MS data. J Am Soc Mass Spectrom (2012) 1.80
Combined electron capture and infrared multiphoton dissociation for multistage MS/MS in a Fourier transform ion cyclotron resonance mass spectrometer. Anal Chem (2003) 1.75
A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J Biol Chem (2003) 1.69
A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions. J Biomol Tech (2007) 1.65
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem (2007) 1.61
DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nat Struct Mol Biol (2011) 1.59
Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators. Protein Sci (2006) 1.59
Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (2011) 1.54
A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nat Chem (2011) 1.49
Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci U S A (2010) 1.49
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther (2009) 1.46
Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Expert Rev Proteomics (2011) 1.45
Resetting the epigenetic histone code in the MRL-lpr/lpr mouse model of lupus by histone deacetylase inhibition. J Proteome Res (2005) 1.41
Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing. J Biol Chem (2003) 1.38
Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Anal Chem (2010) 1.38
Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A (2008) 1.38
Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy. Anal Bioanal Chem (2007) 1.37
Protein-induced photophysical changes to the amyloid indicator dye thioflavin T. Proc Natl Acad Sci U S A (2010) 1.35
Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. J Proteome Res (2004) 1.33
Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity. J Biol Chem (2009) 1.30
Modifications of human histone H3 variants during mitosis. Biochemistry (2005) 1.29
Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem Biol (2012) 1.29
A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochim Biophys Acta (2010) 1.28
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Mol Cell Proteomics (2006) 1.26
Kinetic analysis of estrogen receptor/ligand interactions. Proc Natl Acad Sci U S A (2002) 1.26
Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases. Proc Natl Acad Sci U S A (2011) 1.24
Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. ACS Chem Biol (2010) 1.22
Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. Structure (2012) 1.21
Extracting kinetic rate constants from surface plasmon resonance array systems. Anal Biochem (2007) 1.21
Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange. Biochemistry (2009) 1.18
Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity. Chem Biol (2012) 1.16
Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol (2010) 1.14
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. Bioorg Med Chem Lett (2010) 1.13
Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor. Mol Cell Biol (2005) 1.13
Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening. Mol Pharmacol (2008) 1.12
The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38). J Biol Chem (2003) 1.12
Identification of Mycobacterium tuberculosis H37Rv integral membrane proteins by one-dimensional gel electrophoresis and liquid chromatography electrospray ionization tandem mass spectrometry. J Proteome Res (2005) 1.11
Protein model discrimination using mutational sensitivity derived from deep sequencing. Structure (2012) 1.10
Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Curr Opin Lipidol (2010) 1.09
Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Hepatology (2009) 1.08
Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data. Int J Mass Spectrom (2011) 1.04
Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells. ACS Chem Biol (2012) 1.04