PubRank

Raghu Kalluri

Author PubWeight™ 265.12‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006 11.16
2 Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 2007 9.51
3 BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003 7.91
4 Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008 5.83
5 TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 2005 5.53
6 Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007 5.37
7 Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 2010 4.88
8 Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 2004 4.65
9 Origin and function of myofibroblasts in kidney fibrosis. Nat Med 2013 4.55
10 Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol Ther 2006 4.20
11 Modification of kidney barrier function by the urokinase receptor. Nat Med 2007 4.01
12 Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res 2007 3.86
13 Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell 2003 3.68
14 eRNAs are required for p53-dependent enhancer activity and gene transcription. Mol Cell 2012 3.63
15 Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med 2010 3.60
16 Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria. J Biol Chem 2003 3.36
17 The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med (Berl) 2004 3.32
18 Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 2012 3.19
19 Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 2002 3.16
20 Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci U S A 2006 3.03
21 Endogenous inhibitors of angiogenesis. Cancer Res 2005 2.88
22 Loss of β1-integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather than structural phenotype. FASEB J 2013 2.86
23 Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 2007 2.67
24 Cancer without disease. Nature 2004 2.65
25 Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nat Med 2013 2.55
26 Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science 2009 2.48
27 Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 2012 2.44
28 Structure and function of basement membranes. Exp Biol Med (Maywood) 2007 2.29
29 Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A 2003 2.28
30 Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science 2002 2.28
31 TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. J Am Soc Nephrol 2012 2.24
32 Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A 2011 2.21
33 Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Renal Physiol 2003 2.20
34 The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol 2010 2.18
35 Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell 2011 2.17
36 Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J Biol Chem 2004 2.13
37 Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med (Berl) 2013 2.12
38 Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 2008 2.09
39 The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol 2010 2.03
40 BMP-7 functions as a novel hormone to facilitate liver regeneration. FASEB J 2006 2.02
41 Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 2003 1.97
42 Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 2007 1.94
43 Determinants of vascular permeability in the kidney glomerulus. J Biol Chem 2002 1.93
44 Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J Biol Chem 2014 1.92
45 Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol 2009 1.83
46 NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. J Clin Invest 2002 1.81
47 Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol 2007 1.79
48 Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem 2005 1.79
49 Origins of cardiac fibroblasts. Circ Res 2010 1.76
50 Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol 2012 1.70
51 Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest 2003 1.69
52 Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin. J Clin Invest 2005 1.66
53 Transforming growth factor-β2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochem J 2011 1.65
54 Mechanistic connection between inflammation and fibrosis. Kidney Int Suppl 2010 1.64
55 Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells. Am J Pathol 2002 1.63
56 VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A 2011 1.60
57 Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol 2007 1.60
58 Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010 1.58
59 Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem 2006 1.58
60 Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med 2006 1.54
61 Type IV collagen-derived angiogenesis inhibitors. Microvasc Res 2007 1.51
62 Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. Proc Natl Acad Sci U S A 2005 1.51
63 Human antiglomerular basement membrane autoantibody disease in XenoMouse II. Kidney Int 2002 1.50
64 Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis. Front Biosci 2008 1.44
65 Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res 2004 1.42
66 Tumor microenvironment and angiogenesis. Front Biosci 2008 1.38
67 Epithelial-mesenchymal transition. Cancer Res 2008 1.37
68 Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant 2007 1.37
69 Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype. Semin Cancer Biol 2012 1.35
70 VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res 2009 1.32
71 Tumor stroma derived biomarkers in cancer. Cancer Metastasis Rev 2009 1.32
72 Endothelial-mesenchymal transition as a novel mechanism for generating myofibroblasts during diabetic nephropathy. Am J Pathol 2009 1.29
73 Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironment. Cancer Res 2003 1.29
74 A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion. Proc Natl Acad Sci U S A 2009 1.26
75 Selective impairment of gene expression and assembly of nephrin in human diabetic nephropathy. Kidney Int 2004 1.26
76 The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J 2003 1.25
77 Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes. Kidney Int 2002 1.24
78 Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn 2008 1.24
79 Tumstatin, the NC1 domain of alpha3 chain of type IV collagen, is an endogenous inhibitor of pathological angiogenesis and suppresses tumor growth. Biochem Biophys Res Commun 2005 1.22
80 The VEGF pathway in cancer and disease: responses, resistance, and the path forward. Cold Spring Harb Perspect Med 2012 1.21
81 Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease. Lab Invest 2008 1.19
82 Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation 2010 1.18
83 Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res 2006 1.17
84 Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis. Curr Mol Med 2005 1.17
85 The biology of preeclampsia. Kidney Int 2009 1.16
86 Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease. Kidney Int 2003 1.15
87 Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma. J Biol Chem 2011 1.14
88 The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer 2011 1.14
89 Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 2011 1.13
90 Animal models of renal fibrosis. Methods Mol Med 2005 1.11
91 The role of type IV collagen and basement membranes in cancer progression and metastasis. Am J Pathol 2006 1.11
92 Pre-eclampsia: connecting angiogenic and metabolic pathways. Trends Endocrinol Metab 2010 1.10
93 Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease. Pediatr Nephrol 2008 1.08
94 Experimental strategies to reverse chronic renal disease. Blood Purif 2004 1.08
95 A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol 2002 1.06
96 Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc Natl Acad Sci U S A 2008 1.05
97 Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Exp Biol Med (Maywood) 2008 1.04
98 The biology and function of exosomes in cancer. J Clin Invest 2016 1.04
99 Transcriptional regulation of epithelial-mesenchymal transition. J Clin Invest 2007 1.03
100 Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. Am J Pathol 2010 1.03
101 Interstitial fluid: the overlooked component of the tumor microenvironment? Fibrogenesis Tissue Repair 2010 1.02
102 Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor. Exp Cell Res 2008 1.02
103 Molecular pathways: microRNAs as cancer therapeutics. Clin Cancer Res 2012 1.01
104 Distribution of type IV collagen in the cochlea in Alport syndrome. Arch Otolaryngol Head Neck Surg 2005 1.00
105 Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proc Natl Acad Sci U S A 2013 0.99
106 A domain-specific usherin/collagen IV interaction may be required for stable integration into the basement membrane superstructure. J Cell Sci 2004 0.98
107 De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membrane. Mol Cell Biochem 2006 0.97
108 The contribution of vascular basement membranes and extracellular matrix to the mechanics of tumor angiogenesis. APMIS 2004 0.97
109 Possible mechanisms of kidney repair. Fibrogenesis Tissue Repair 2009 0.95
110 Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol 2009 0.95
111 miR-29b moulds the tumour microenvironment to repress metastasis. Nat Cell Biol 2013 0.94
112 Type IV collagen alpha6 chain-derived noncollagenous domain 1 (alpha6(IV)NC1) inhibits angiogenesis and tumor growth. Int J Cancer 2008 0.93
113 Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. J Am Soc Nephrol 2005 0.93
114 Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Cancer Res 2002 0.91
115 Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo. Am J Physiol Renal Physiol 2003 0.90
116 miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. PLoS One 2013 0.90
117 Lack of collagen XVIII/endostatin exacerbates immune-mediated glomerulonephritis. J Am Soc Nephrol 2010 0.90
118 Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis. Kidney Int 2011 0.88
119 Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticles. Theranostics 2012 0.88
120 Reduced DNA gap repair in aging rat neuronal extracts and its restoration by DNA polymerase beta and DNA-ligase. J Neurochem 2005 0.88
121 Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch. J Clin Invest 2014 0.88
122 Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. Blood 2005 0.88
123 Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical application. Gastroenterology 2005 0.87
124 Controlling angiogenesis in heart valves. Nat Med 2006 0.86
125 Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem 2010 0.86
126 Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. Cell Rep 2012 0.86
127 Stem cell-based therapy for glomerular diseases: an evolving concept. J Am Soc Nephrol 2008 0.86
128 Bifunctional promoter of type IV collagen COL4A5 and COL4A6 genes regulates the expression of alpha5 and alpha6 chains in a distinct cell-specific fashion. Biochem J 2005 0.86
129 Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells. Biochem Biophys Res Commun 2002 0.85
130 Chapter 1. Molecular mechanism of type IV collagen-derived endogenous inhibitors of angiogenesis. Methods Enzymol 2008 0.84
131 Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function. Matrix Biol 2010 0.84
132 Renal studies provide an insight into cardiac extracellular matrix remodeling during health and disease. J Mol Cell Cardiol 2009 0.84
133 Deletion of Smad4 in fibroblasts leads to defective chondrocyte maturation and cartilage production in a TGFβ type II receptor independent manner. Biochem Biophys Res Commun 2011 0.83
134 Idiopathic pulmonary fibrosis is associated with endothelial to mesenchymal transition. Am J Respir Cell Mol Biol 2010 0.83
135 Are there endogenous molecules that protect kidneys from injury? The case for bone morphogenic protein-7 (BMP-7). Nephrol Dial Transplant 2004 0.83
136 Dinosaur peptides suggest mechanisms of protein survival. PLoS One 2011 0.83
137 Intrathymic kidney cells delay the onset of lupus nephritis in MRL-lpr/lpr mice. Int Immunol 2002 0.82
138 Circulating TGF-beta1 as a reliable biomarker for chronic kidney disease progression in the African-American population. Kidney Int 2009 0.82
139 Targeted downregulation of extracellular nephrin in human IgA nephropathy. Am J Nephrol 2003 0.81
140 RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice. Am J Pathol 2010 0.79
141 Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech 2013 0.79
142 Angiogenesis is controlled by miR-27b associated with endothelial tip cells. Blood 2012 0.78
143 RNA interference: generic block on angiogenesis. Nature 2008 0.78
144 NF-kappaB-induced chromatin remodeling regulates angiogenesis. Blood 2010 0.78
145 An unusual case of pulmonary-renal syndrome associated with defects in type IV collagen composition and anti-glomerular basement membrane autoantibodies. Am J Kidney Dis 2005 0.77
146 Parstatin, a novel protease-activated receptor 1-derived inhibitor of angiogenesis. Mol Interv 2009 0.77
147 Waking up dormant tumors. Breast Cancer Res 2011 0.77
148 Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell 2015 0.76
149 Allograft rejection and glomerular basement membrane antibodies in Alport's syndrome. J Nephrol 2004 0.76
150 Recapitulation of kidney development paradigms by BMP-7 reverses chronic renal injury. Clin Exp Nephrol 2005 0.76
151 The Kielin/chordin-like protein checkpoint constitutes a system of checks and balances in CKD. J Am Soc Nephrol 2013 0.75
152 Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med 2013 0.75
153 Circulating endoglin concentration is not elevated in chronic kidney disease. PLoS One 2011 0.75
154 Antiglomerular basement membrane autoantibodies are nonpathogenic in Wegener's granulomatosis. Am J Med 2003 0.75