PubRank

Teodoro Bottiglieri

Author PubWeight™ 82.75‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA 2008 7.35
2 L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. Am J Psychiatry 2012 3.73
3 GABA, gamma-hydroxybutyric acid, and neurological disease. Ann Neurol 2003 1.91
4 Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Arch Gen Psychiatry 2007 1.72
5 Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. Am J Med 2012 1.71
6 Folate, homocysteine, and negative symptoms in schizophrenia. Am J Psychiatry 2004 1.65
7 The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem 2004 1.55
8 The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Crit Care Med 2011 1.54
9 High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proc Natl Acad Sci U S A 2006 1.47
10 Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Ann Neurol 2005 1.46
11 Effect of hyperhomocysteinemia on protein C activation and activity. Blood 2002 1.45
12 Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis. Alcohol Clin Exp Res 2004 1.37
13 Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke 2004 1.37
14 S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology 2009 1.32
15 Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Mol Genet Metab 2007 1.24
16 Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J Neurosci 2007 1.22
17 Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood 2006 1.20
18 Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circ Res 2002 1.20
19 Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. J Biol Chem 2007 1.18
20 Decreased C-reactive protein levels in Alzheimer disease. J Geriatr Psychiatry Neurol 2009 1.15
21 Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. J Clin Invest 2010 1.14
22 S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol 2004 1.11
23 Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arterioscler Thromb Vasc Biol 2002 1.11
24 Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J Biol Chem 2005 1.09
25 Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood 2003 1.09
26 Failed studies should not be used to malign good treatments. J Clin Psychiatry 2014 1.08
27 Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol Gastrointest Liver Physiol 2010 1.08
28 Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke 2007 1.07
29 Elevated plasma homocysteine level in patients with Parkinson disease: motor, affective, and cognitive associations. Arch Neurol 2004 1.05
30 Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. Arch Neurol 2008 1.04
31 Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia. Biol Psychiatry 2007 1.04
32 Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry 2004 1.03
33 Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency. J Autism Dev Disord 2007 1.03
34 Cerebral vascular dysfunction in methionine synthase-deficient mice. Circulation 2005 1.01
35 Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2006 0.99
36 Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice. J Inherit Metab Dis 2012 0.98
37 Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype. Neurobiol Dis 2012 0.97
38 Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol 2008 0.97
39 One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore. Int J Mol Epidemiol Genet 2012 0.96
40 Effects of exercise on emerging and traditional cardiovascular risk factors. Prev Med 2004 0.94
41 Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochim Biophys Acta 2009 0.94
42 Role of S-adenosylmethionine in two experimental models of pancreatitis. FASEB J 2002 0.93
43 Homocysteine and lipoprotein levels following resistance training in older adults. Prev Cardiol 2003 0.92
44 Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation. J Neurosci 2008 0.92
45 Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circ Res 2009 0.91
46 Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways. Mol Genet Metab 2010 0.91
47 Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy. J Clin Psychiatry 2004 0.90
48 Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. Neurobiol Dis 2006 0.90
49 Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice. Mol Genet Metab 2013 0.88
50 Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonate. J Perinatol 2003 0.88
51 Anger attacks in major depressive disorder and serum levels of homocysteine. Biol Psychiatry 2005 0.87
52 The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol 2005 0.86
53 Characterization of 2-(methylamino)alkanoic acid capacity to restrict blood-brain phenylalanine transport in Pah enu2 mice: preliminary findings. Mol Genet Metab 2013 0.86
54 Clinical course in Parkinson's disease with elevated homocysteine. Parkinsonism Relat Disord 2005 0.84
55 Brain-blood amino acid correlates following protein restriction in murine maple syrup urine disease. Orphanet J Rare Dis 2014 0.84
56 Maternal Phenylketonuria International Collaborative Study revisited: evaluation of maternal nutritional risk factors besides phenylalanine for fetal congenital heart defects. J Inherit Metab Dis 2013 0.83
57 Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore. BMC Cancer 2013 0.83
58 Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. J Pediatr Hematol Oncol 2004 0.83
59 Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial. J Clin Psychiatry 2014 0.82
60 Modest increase in plasma homocysteine follows levodopa initiation in Parkinson's disease. Mov Disord 2004 0.82
61 Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. J Clin Psychiatry 2012 0.82
62 The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr. Mol Genet Metab 2002 0.79
63 Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia. J Nutr 2009 0.79
64 Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU). J Inherit Metab Dis 2014 0.79
65 Hyperhomocysteinemia and cognitive function: more than just a casual link? Am J Clin Nutr 2005 0.78
66 Hyperhomocyst(e)inemia: a risk factor for cerebrovascular disease. Clin Exp Hypertens 2002 0.78
67 Homocysteine levels in preterm infants: is there an association with intraventricular hemorrhage? A prospective cohort study. BMC Pediatr 2007 0.78
68 Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma. Cancer Epidemiol Biomarkers Prev 2013 0.77
69 Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. Am J Physiol Endocrinol Metab 2009 0.77
70 Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia. Epigenetics 2012 0.77
71 The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. FASEB J 2013 0.76
72 Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice. Sci Rep 2017 0.75
73 Metabolic evaluation of infantile epilepsy: summary recommendations of the Amalfi Group. J Child Neurol 2002 0.75
74 Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease. Coron Artery Dis 2017 0.75