Intestinal microbiota in functional bowel disorders: a Rome foundation report.

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Published in Gut on June 22, 2012

Authors

Magnus Simrén1, Giovanni Barbara, Harry J Flint, Brennan M R Spiegel, Robin C Spiller, Stephen Vanner, Elena F Verdu, Peter J Whorwell, Erwin G Zoetendal, Rome Foundation Committee

Author Affiliations

1: Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-41345, Sweden. magnus.simren@medicine.gu.se

Associated clinical trials:

Effect of Lactobacillus Casei DG (Enterolactis Plus®) in Patient With Irritable Bowel Syndrome: a Pilot Study | NCT02371499

L. Casei DG® in Patients With Irritable Bowel Syndrome. (PROBE2) | NCT03449628

Allogeneic Microbiota-reconstitution (AMR) in Diarrhea-predominant Irritable Bowel Syndrome (IBS-D) (AMIRA) | NCT04095988

The Role of Irritable Bowel Syndrome in Lactose Intolerance (LION) (LION) | NCT05100719

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Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome. Gastroenterology (2009) 1.97

Combined oro-caecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-caecal transit, not small intestinal bacterial overgrowth in patients with IBS. Gut (2010) 1.93

Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol (2005) 1.93

Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol (2003) 1.92

The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes. PLoS One (2011) 1.90

Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol (2009) 1.89

The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol (2009) 1.87

Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans. Am J Clin Nutr (2013) 1.87

Hybrid tet genes and tet gene nomenclature: request for opinion. Antimicrob Agents Chemother (2005) 1.86

Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology (2010) 1.85

Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Gastroenterology (2006) 1.85

Oligonucleotide probes that detect quantitatively significant groups of butyrate-producing bacteria in human feces. Appl Environ Microbiol (2003) 1.77

Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples. Appl Environ Microbiol (2011) 1.76

Isolation of bifidobacteria from breast milk and assessment of the bifidobacterial population by PCR-denaturing gradient gel electrophoresis and quantitative real-time PCR. Appl Environ Microbiol (2008) 1.75

Esomeprazole versus other proton pump inhibitors in erosive esophagitis: a meta-analysis of randomized clinical trials. Clin Gastroenterol Hepatol (2006) 1.75

The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology (2006) 1.75

Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system. Appl Environ Microbiol (2003) 1.74

The influence of diet on the gut microbiota. Pharmacol Res (2012) 1.74

Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation. Gastroenterology (2011) 1.70

Contribution of acetate to butyrate formation by human faecal bacteria. Br J Nutr (2004) 1.70

Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit. Gastroenterology (2006) 1.69

Small intestinal bacterial overgrowth in irritable bowel syndrome: systematic review and meta-analysis. Clin Gastroenterol Hepatol (2009) 1.67

Selective colonization of insoluble substrates by human faecal bacteria. Environ Microbiol (2007) 1.63

Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces. Int J Syst Evol Microbiol (2006) 1.62

Cultivation-independent assessment of the bacterial diversity of breast milk among healthy women. Res Microbiol (2006) 1.61

Cultured representatives of two major phylogroups of human colonic Faecalibacterium prausnitzii can utilize pectin, uronic acids, and host-derived substrates for growth. Appl Environ Microbiol (2011) 1.60

The intestinal LABs. Antonie Van Leeuwenhoek (2002) 1.60

High temporal and inter-individual variation detected in the human ileal microbiota. Environ Microbiol (2010) 1.59

Predictors of treatment in patients with chronic hepatitis C infection - role of patient versus nonpatient factors. Hepatology (2007) 1.55

Enteric neuroplasticity evoked by inflammation. Auton Neurosci (2006) 1.55

Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis. Am J Gastroenterol (2012) 1.54

Yield of diagnostic tests for celiac disease in individuals with symptoms suggestive of irritable bowel syndrome: systematic review and meta-analysis. Arch Intern Med (2009) 1.53

Intestinal permeability--a new target for disease prevention and therapy. BMC Gastroenterol (2014) 1.52

Gender and irritable bowel syndrome: the male connection. J Clin Gastroenterol (2004) 1.50

Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection. Gastroenterology (2002) 1.50

Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology (2009) 1.50

Commonly used preparations for colonoscopy: efficacy, tolerability, and safety--a Canadian Association of Gastroenterology position paper. Can J Gastroenterol (2006) 1.49

Development of a semiquantitative degenerate real-time pcr-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples. Appl Environ Microbiol (2007) 1.45

Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study. Clin Gastroenterol Hepatol (2005) 1.42

Health-related quality of life predicts mortality in patients with advanced chronic liver disease. Clin Gastroenterol Hepatol (2009) 1.42

Comparative analysis of sequences flanking tet(W) resistance genes in multiple species of gut bacteria. Antimicrob Agents Chemother (2006) 1.42

Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol (2011) 1.41

Suicidal ideation in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol (2004) 1.41

Diverticular disease as a chronic illness: evolving epidemiologic and clinical insights. Am J Gastroenterol (2012) 1.40

Fewer polyps detected by colonoscopy as the day progresses at a Veteran's Administration teaching hospital. Clin Gastroenterol Hepatol (2009) 1.39

Hypnotherapy in irritable bowel syndrome: a large-scale audit of a clinical service with examination of factors influencing responsiveness. Am J Gastroenterol (2002) 1.39

The Butyrivibrio fibrisolvens tet(W) gene is carried on the novel conjugative transposon TnB1230, which contains duplicated nitroreductase coding sequences. J Bacteriol (2004) 1.38

Molecular diversity, cultivation, and improved detection by fluorescent in situ hybridization of a dominant group of human gut bacteria related to Roseburia spp. or Eubacterium rectale. Appl Environ Microbiol (2006) 1.38

Diversity and strain specificity of plant cell wall degrading enzymes revealed by the draft genome of Ruminococcus flavefaciens FD-1. PLoS One (2009) 1.37

Is irritable bowel syndrome a low-grade inflammatory bowel disease? Gastroenterol Clin North Am (2005) 1.35

Microbiota conservation and BMI signatures in adult monozygotic twins. ISME J (2012) 1.34

Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice. PLoS One (2009) 1.32

Novel organization and divergent dockerin specificities in the cellulosome system of Ruminococcus flavefaciens. J Bacteriol (2003) 1.32

Human intestinal microbiota composition is associated with local and systemic inflammation in obesity. Obesity (Silver Spring) (2013) 1.31

Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats. Environ Microbiol (2011) 1.31

Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut (2012) 1.30

The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environ Microbiol (2008) 1.28

Ileitis modulates potassium and sodium currents in guinea pig dorsal root ganglia sensory neurons. J Physiol (2003) 1.28

In vivo imaging of intragastric gelation and its effect on satiety in humans. J Nutr (2004) 1.28