Published in Gastroenterology on January 01, 2007
Mesalazine Therapy in Patients With Irritable Bowel Syndrome (IBS-02/07) | NCT00626288
Gut feelings: the emerging biology of gut-brain communication. Nat Rev Neurosci (2011) 3.15
Interactions between the immune and nervous systems in pain. Nat Med (2010) 2.91
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut (2008) 2.77
Intestinal microbiota in functional bowel disorders: a Rome foundation report. Gut (2012) 2.60
Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions. Nat Rev Gastroenterol Hepatol (2010) 2.23
Increase of colonic mast cells in obstructed defecation and their relationship with enteric glia. Dig Dis Sci (2011) 2.02
Prospective study of motor, sensory, psychologic, and autonomic functions in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol (2008) 1.93
Serum and colonic mucosal immune markers in irritable bowel syndrome. Am J Gastroenterol (2011) 1.89
5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes (2013) 1.79
Mast cell degranulation activates a pain pathway underlying migraine headache. Pain (2007) 1.74
The brain-gut axis in abdominal pain syndromes. Annu Rev Med (2011) 1.68
Randomised controlled trial of mesalazine in IBS. Gut (2014) 1.58
A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D). Gut (2015) 1.55
Functional GI disorders: from animal models to drug development. Gut (2007) 1.55
Mycobacterium avium subspecies paratuberculosis infection in cases of irritable bowel syndrome and comparison with Crohn's disease and Johne's disease: common neural and immune pathogenicities. J Clin Microbiol (2007) 1.54
Intestinal permeability--a new target for disease prevention and therapy. BMC Gastroenterol (2014) 1.52
Early weaning stress impairs development of mucosal barrier function in the porcine intestine. Am J Physiol Gastrointest Liver Physiol (2009) 1.49
Colonic mucosal immune activity in irritable bowel syndrome: comparison with healthy controls and patients with ulcerative colitis. Dig Dis Sci (2013) 1.48
Mast cell-derived histamine mediates cystitis pain. PLoS One (2008) 1.40
Association of TNFSF15 polymorphism with irritable bowel syndrome. Gut (2011) 1.31
Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome? Gend Med (2009) 1.28
The role of stress on physiologic responses and clinical symptoms in irritable bowel syndrome. Gastroenterology (2011) 1.27
Stress and visceral pain: from animal models to clinical therapies. Exp Neurol (2011) 1.25
Biopsychosocial model of irritable bowel syndrome. J Neurogastroenterol Motil (2011) 1.25
Plasticity of enteric nerve functions in the inflamed and postinflamed gut. Neurogastroenterol Motil (2009) 1.21
Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol (2013) 1.20
Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice. Am J Physiol Gastrointest Liver Physiol (2009) 1.16
The immune system in irritable bowel syndrome. J Neurogastroenterol Motil (2011) 1.16
Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review. J Gastroenterol (2011) 1.15
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol (2012) 1.14
Irritable bowel syndrome. Nat Rev Dis Prim (2016) 1.14
Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms? Neurogastroenterol Motil (2012) 1.14
Corticotropin releasing factor signaling in colon and ileum: regulation by stress and pathophysiological implications. J Physiol Pharmacol (2009) 1.13
Irritable bowel syndrome - An inflammatory disease involving mast cells. Asia Pac Allergy (2011) 1.09
Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun (2011) 1.08
An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome. J Neurogastroenterol Motil (2012) 1.07
Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. World J Gastrointest Pathophysiol (2010) 1.05
Evidence for neuronal and structural changes in submucous ganglia of patients with functional dyspepsia. Am J Gastroenterol (2015) 1.04
Gut microbiota as potential orchestrators of irritable bowel syndrome. Gut Liver (2015) 1.03
Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study. J Neurogastroenterol Motil (2011) 1.00
Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. J Immunol (2009) 1.00
Duodenal implications in the pathophysiology of functional dyspepsia. J Neurogastroenterol Motil (2010) 0.99
Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity. Am J Physiol Gastrointest Liver Physiol (2012) 0.98
A survey about irritable bowel syndrome in South Korea: prevalence and observable organic abnormalities in IBS patients. Dig Dis Sci (2007) 0.96
Effect of red pepper on symptoms of irritable bowel syndrome: preliminary study. Dig Dis Sci (2011) 0.95
TRPV1: a new target for treatment of visceral pain in IBS? Gut (2008) 0.93
Chemo-nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels. Br J Pharmacol (2010) 0.92
Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit. Gut (2013) 0.92
Mast cells. Curr Gastroenterol Rep (2010) 0.92
Microflora modulation of motility. J Neurogastroenterol Motil (2011) 0.91
Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain (2011) 0.91
Cellular and molecular basis of intestinal barrier dysfunction in the irritable bowel syndrome. Gut Liver (2012) 0.89
IBS and the role of otilonium bromide. Int J Colorectal Dis (2012) 0.89
The association of mast cells and serotonin in children with chronic abdominal pain of unknown etiology. BMC Res Notes (2010) 0.89
The mast cell degranulator compound 48/80 directly activates neurons. PLoS One (2012) 0.88
Gastrointestinal roles for proteinase-activated receptors in health and disease. Br J Pharmacol (2007) 0.88
Drug development for the irritable bowel syndrome: current challenges and future perspectives. Front Pharmacol (2013) 0.88
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One (2011) 0.88
Post-infectious irritable bowel syndrome: mechanistic insights into chronic disturbances following enteric infection. World J Gastroenterol (2014) 0.87
TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis. J Immunol (2013) 0.87
Role of enteric nerves in immune-mediated changes in protease-activated receptor 2 effects on gut function. Neurogastroenterol Motil (2010) 0.86
Activity of protease-activated receptors in primary cultured human myenteric neurons. Front Neurosci (2012) 0.86
Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome. World J Gastroenterol (2009) 0.86
IBS-like symptoms in patients with ulcerative colitis. Clin Exp Gastroenterol (2015) 0.86
Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome. World J Gastroenterol (2014) 0.85
What does irritable bowel syndrome share with non-alcoholic fatty liver disease? World J Gastroenterol (2013) 0.85
From cytokines to toll-like receptors and beyond - current knowledge and future research needs in irritable bowel syndrome. J Neurogastroenterol Motil (2010) 0.85
Neuroanatomy of lower gastrointestinal pain disorders. World J Gastroenterol (2014) 0.85
Elevated expression of c-fos in central nervous system correlates with visceral hypersensitivity in irritable bowel syndrome (IBS): a new target for IBS treatment. Int J Colorectal Dis (2011) 0.84
Social stress induces changes in urinary bladder function, bladder NGF content, and generalized bladder inflammation in mice. Am J Physiol Regul Integr Comp Physiol (2014) 0.84
Food allergy in irritable bowel syndrome: The case of non-celiac wheat sensitivity. World J Gastroenterol (2015) 0.83
Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome. Pain (2014) 0.83
Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility. Drug Target Insights (2012) 0.83
Citrobacter rodentium colitis evokes post-infectious hyperexcitability of mouse nociceptive colonic dorsal root ganglion neurons. J Physiol (2009) 0.83
Mast Cells and Irritable Bowel Syndrome: From the Bench to the Bedside. J Neurogastroenterol Motil (2016) 0.83
Protease-activated receptors as therapeutic targets in visceral pain. Curr Neuropharmacol (2013) 0.82
Histamine H₄ receptors in the gastrointestinal tract. Br J Pharmacol (2015) 0.82
Lessons Learnt from Post-Infectious IBS. Front Physiol (2011) 0.82
Infiltration of mast cells in rat colon is a consequence of ischemia/reperfusion. Dig Dis Sci (2008) 0.82
Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications. Am J Physiol Gastrointest Liver Physiol (2015) 0.81
Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome. J Gastroenterol (2015) 0.81
Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain. PLoS One (2013) 0.81
The role of colonic mast cells and myenteric plexitis in patients with diverticular disease. Int J Colorectal Dis (2012) 0.80
Mast Cell-Mediated Mechanisms of Nociception. Int J Mol Sci (2015) 0.80
Vaginal hypersensitivity and hypothalamic-pituitary-adrenal axis dysfunction as a result of neonatal maternal separation in female mice. Neuroscience (2014) 0.80
Change in functional bowel symptoms after prostatectomy: a case-control study. J Res Med Sci (2011) 0.80
Mast cells drive mesenteric afferent signalling during acute intestinal ischaemia. J Physiol (2011) 0.80
Chronic pain treatment: the influence of tricyclic antidepressants on serotonin release and uptake in mast cells. Mediators Inflamm (2013) 0.80
Condition-specific role of colonic inflammatory molecules in persistent functional colorectal hypersensitivity in the mouse. Neurogastroenterol Motil (2014) 0.80
Increased production of BDNF in colonic epithelial cells induced by fecal supernatants from diarrheic IBS patients. Sci Rep (2015) 0.79
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists. PLoS One (2013) 0.79
The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments. J Neurogastroenterol Motil (2016) 0.79
Roads Less Traveled: Sexual Dimorphism and Mast Cell Contributions to Migraine Pathology. Front Immunol (2016) 0.79
Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evid Based Complement Alternat Med (2012) 0.79
Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS). Neurogastroenterol Motil (2014) 0.79
Inflammation in irritable bowel syndrome: Myth or new treatment target? World J Gastroenterol (2016) 0.79
Gut pain & visceral hypersensitivity. Br J Pain (2013) 0.78
Intestinal secretory mechanisms in irritable bowel syndrome-diarrhea. Clin Gastroenterol Hepatol (2014) 0.78
Role of psychiatric disorders and irritable bowel syndrome in asthma patients. Clinics (Sao Paulo) (2011) 0.78
Immunomodulation of enteric neural function in irritable bowel syndrome. World J Gastroenterol (2015) 0.78
Functional gastroduodenal disorders. Gastroenterology (2006) 8.51
Protease-activated receptors: contribution to physiology and disease. Physiol Rev (2004) 4.49
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology (2004) 4.05
Effect of β-blockers and other antihypertensive drugs on the risk of melanoma recurrence and death. Mayo Clin Proc (2013) 3.59
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci U S A (2002) 3.16
Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study. Clin Gastroenterol Hepatol (2005) 2.68
Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol (2009) 2.57
Treatment with β-blockers and reduced disease progression in patients with thick melanoma. Arch Intern Med (2011) 2.53
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci (2004) 2.42
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol (2006) 2.34
Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A (2009) 2.33
Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev (2006) 2.30
Chronic intestinal pseudo-obstruction. World J Gastroenterol (2008) 2.29
A 5-year experience of benign pancreatic hyperenzymemia. Pancreas (2014) 2.27
Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2. Am J Gastroenterol (2013) 2.23
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest (2008) 2.20
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol (2002) 2.16
Prostate growth and prevalence of prostate diseases in early onset spinal cord injuries. Eur Urol (2008) 2.15
Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest (2007) 2.09
Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J Physiol (2006) 2.07
Inflammatory neuropathies of the enteric nervous system. Gastroenterology (2004) 2.02
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol (2002) 1.99
Chronic asymptomatic pancreatic hyperenzymemia is a benign condition in only half of the cases: a prospective study. Scand J Gastroenterol (2009) 1.99
Gastroparesis Cardinal Symptom Index (GCSI): development and validation of a patient reported assessment of severity of gastroparesis symptoms. Qual Life Res (2004) 1.88
Mast cell tryptase controls paracellular permeability of the intestine. Role of protease-activated receptor 2 and beta-arrestins. J Biol Chem (2005) 1.87
Characterization of myenteric sensory neurons in the mouse small intestine. J Neurophysiol (2006) 1.79
Warm water or oil-assisted colonoscopy: toward simpler examinations? Am J Gastroenterol (2007) 1.77
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system. Brain (2011) 1.70
Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon. Gastroenterology (2006) 1.66
Proteinase-activated receptors, targets for kallikrein signaling. J Biol Chem (2006) 1.63
Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol (2004) 1.63
OnabotulinumtoxinA significantly attenuates bladder afferent nerve firing and inhibits ATP release from the urothelium. BJU Int (2013) 1.61
Gastrointestinal dysmotility in patients with acute pancreatitis. J Gastroenterol Hepatol (2003) 1.60
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology (2007) 1.60
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2008) 1.59
Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine. Gastroenterology (2011) 1.59
Enteric neuroplasticity evoked by inflammation. Auton Neurosci (2006) 1.55
Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction. Anesthesiology (2010) 1.54
Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor. Am J Physiol Cell Physiol (2011) 1.51
The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology (2009) 1.50
Small intestine contrast ultrasonography in pediatric Crohn's disease. J Pediatr (2013) 1.49
Neutral endopeptidase determines the severity of pancreatitis-associated lung injury. J Surg Res (2005) 1.49
Chromogranin A: is it a useful marker of neuroendocrine tumors? J Clin Oncol (2007) 1.49
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J (2005) 1.48
The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity. Eur Urol (2010) 1.46
Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma. Mod Pathol (2006) 1.46
A child with aphthae and diarrhoea. Lancet (2002) 1.45
Trypsin IV, a novel agonist of protease-activated receptors 2 and 4. J Biol Chem (2004) 1.45
Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J Cell Mol Med (2009) 1.44
Natural history of chronic idiopathic intestinal pseudo-obstruction in adults: a single center study. Clin Gastroenterol Hepatol (2005) 1.42
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2. J Biol Chem (2005) 1.41
Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol (2011) 1.41
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease. Physiol Rev (2014) 1.40
Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages. Am J Respir Cell Mol Biol (2007) 1.40
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J Immunol (2003) 1.38
Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am J Gastroenterol (2005) 1.35
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation. Pain (2011) 1.35
Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol (2003) 1.34
TRPV1: a therapeutic target for novel analgesic drugs? Trends Mol Med (2006) 1.34
Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol (2005) 1.34
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology (2012) 1.33
Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol (2004) 1.30
The TRPA1 channel in inflammatory and neuropathic pain and migraine. Rev Physiol Biochem Pharmacol (2014) 1.29
VSL#3 improves symptoms in children with irritable bowel syndrome: a multicenter, randomized, placebo-controlled, double-blind, crossover study. J Pediatr Gastroenterol Nutr (2010) 1.29