Published in N Engl J Med on June 27, 2012
Scandinavian Starch for Severe Sepsis/Septic Shock Trial (6S) | NCT00962156
Normal Saline Versus Balance Salt Solution Resuscitation on Kidney Function | NCT02520804
Glycocalyx Levels in Patients Undergoing Pancreatectomy | NCT04058236
Fluid challenges in intensive care: the FENICE study: A global inception cohort study. Intensive Care Med (2015) 3.27
Effect of hydroxyethyl starch on postoperative kidney function in patients having noncardiac surgery. Anesthesiology (2014) 2.85
Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: a retrospective cohort study. Chest (2014) 2.39
Septic Shock: Advances in Diagnosis and Treatment. JAMA (2015) 2.37
Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis. Crit Care (2014) 1.88
Fluid replacement with hydroxyethyl starch in critical care--a reassessment. Dtsch Arztebl Int (2013) 1.87
The growth of acute kidney injury: a rising tide or just closer attention to detail? Kidney Int (2014) 1.80
Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study. Crit Care (2012) 1.55
Hydroxyethyl starch (HES 130/0.4) impairs intestinal barrier integrity and metabolic function: findings from a mouse model of the isolated perfused small intestine. PLoS One (2015) 1.42
Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med (2016) 1.42
Enhanced Recovery After Surgery (ERAS) for gastrointestinal surgery, part 2: consensus statement for anaesthesia practice. Acta Anaesthesiol Scand (2015) 1.37
Outcomes and statistical power in adult critical care randomized trials. Am J Respir Crit Care Med (2014) 1.35
Resuscitative strategies in traumatic hemorrhagic shock. Ann Intensive Care (2013) 1.30
Perioperative organ injury. Anesthesiology (2013) 1.27
Hydroxyethyl starch and acute kidney injury in orthotopic liver transplantation: a single-center retrospective review. Anesth Analg (2015) 1.27
Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care (2014) 1.27
Derivation and validation of cutoffs for clinical use of cell cycle arrest biomarkers. Nephrol Dial Transplant (2014) 1.26
Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement. Crit Care (2013) 1.24
Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the "Seville Document". Blood Transfus (2013) 1.23
The impact of hydroxyethyl starches in cardiac surgery: a meta-analysis. Crit Care (2014) 1.12
Sources of Heterogeneity in Trials Reporting Hydroxyethyl Starch 130/0.4 or 0.42 Associated Excess Mortality in Septic Patients: A Systematic Review and Meta-regression. Chin Med J (Engl) (2015) 1.11
Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study. Crit Care (2013) 1.10
Reading between the (guide)lines--the KDIGO practice guideline on acute kidney injury in the individual patient. Kidney Int (2013) 1.10
AKI associated with cardiac surgery. Clin J Am Soc Nephrol (2014) 1.08
Hydroxyethyl starch versus other fluids for non-septic patients in the intensive care unit: a meta-analysis of randomized controlled trials. Crit Care (2015) 1.07
Acute kidney injury in cardiac surgery patients receiving hydroxyethyl starch solutions. Crit Care (2015) 1.07
Pathophysiology and management of septic acute kidney injury. Pediatr Nephrol (2013) 1.05
Hydroxyethyl starch - the importance of being earnest. Scand J Trauma Resusc Emerg Med (2013) 1.03
Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx. Crit Care (2014) 1.02
Concerns over use of hydroxyethyl starch solutions. BMJ (2014) 1.01
Quality of life and pruritus in patients with severe sepsis resuscitated with hydroxyethyl starch long-term follow-up of a randomised trial. Crit Care (2013) 0.98
Clinical review: Circulatory shock--an update: a tribute to Professor Max Harry Weil. Crit Care (2012) 0.97
The thresholds for statistical and clinical significance - a five-step procedure for evaluation of intervention effects in randomised clinical trials. BMC Med Res Methodol (2014) 0.96
Interactions between the volume effects of hydroxyethyl starch 130/0.4 and Ringer´s acetate. Crit Care (2013) 0.95
The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study. Crit Care (2013) 0.95
Prevention and treatment of sepsis-induced acute kidney injury: an update. Ann Intensive Care (2015) 0.95
Severe sepsis and septic shock: management and performance improvement. Virulence (2013) 0.94
Choices in fluid type and volume during resuscitation: impact on patient outcomes. Ann Intensive Care (2014) 0.94
Perioperative fluid therapy: a statement from the international Fluid Optimization Group. Perioper Med (Lond) (2015) 0.94
Dengue therapeutics, chemoprophylaxis, and allied tools: state of the art and future directions. PLoS Negl Trop Dis (2014) 0.94
Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study. Crit Care (2015) 0.93
Albumin administration in the acutely ill: what is new and where next? Crit Care (2014) 0.92
Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92
Albumin Kinetics in Patients Undergoing Major Abdominal Surgery. PLoS One (2015) 0.92
Current management of massive hemorrhage in trauma. Scand J Trauma Resusc Emerg Med (2012) 0.91
Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital. BMC Infect Dis (2014) 0.91
Translating resuscitation guidelines into practice: health care provider attitudes, preferences and beliefs regarding pediatric fluid resuscitation performance. PLoS One (2013) 0.90
Acute respiratory distress syndrome and risk of AKI among critically ill patients. Clin J Am Soc Nephrol (2014) 0.89
Causes of death after fluid bolus resuscitation: new insights from FEAST. BMC Med (2013) 0.88
Hydroxyethyl starch in severe sepsis: end of starch era? Crit Care (2013) 0.88
Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial. Trials (2015) 0.87
Controversies in fluid therapy: Type, dose and toxicity. World J Crit Care Med (2014) 0.87
Effect of 6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride (Voluven®) on complications after subarachnoid hemorrhage: a retrospective analysis. Springerplus (2013) 0.87
Debate on HES safety is important, but must be based on facts. Scand J Trauma Resusc Emerg Med (2013) 0.87
Acute kidney injury: short-term and long-term effects. Crit Care (2016) 0.86
Reporting bias in trials of volume resuscitation with hydroxyethyl starch. Wien Klin Wochenschr (2014) 0.86
Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort. Scand J Trauma Resusc Emerg Med (2014) 0.86
Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents. BMC Gastroenterol (2012) 0.85
The maintenance and monitoring of perioperative blood volume. Perioper Med (Lond) (2013) 0.84
Management of severe sepsis: advances, challenges, and current status. Drug Des Devel Ther (2015) 0.84
Methodological issues of the studies cited. Dtsch Arztebl Int (2013) 0.84
Management of sepsis in neutropenic patients: 2014 updated guidelines from the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO). Ann Hematol (2014) 0.84
Cardiac surgery-associated acute kidney injury. Ann Card Anaesth (2016) 0.83
The metabolic phenotype of rodent sepsis: cause for concern? Intensive Care Med Exp (2013) 0.83
American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery. Perioper Med (Lond) (2016) 0.83
Study on acute recent stage pancreatitis. World J Gastroenterol (2014) 0.82
Dose and type of crystalloid fluid therapy in adult hospitalized patients. Perioper Med (Lond) (2013) 0.82
Fluid therapy in the perioperative setting-a clinical review. J Intensive Care (2016) 0.82
Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice. PLoS Pathog (2016) 0.82
Sepsis: frontiers in diagnosis, resuscitation and antibiotic therapy. Intensive Care Med (2016) 0.82
Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials (2016) 0.81
Algorithm-guided goal-directed haemodynamic therapy does not improve renal function after major abdominal surgery compared to good standard clinical care: a prospective randomised trial. Crit Care (2016) 0.81
Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int (2014) 0.81
Strategies for Intravenous Fluid Resuscitation in Trauma Patients. World J Surg (2017) 0.81
Rational fluid management in today's ICU practice. Crit Care (2013) 0.81
Do larger periprocedural fluid volumes reduce the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis? Pancreas (2014) 0.81
Crystalloids vs. colloids: KO at the twelfth round? Crit Care (2013) 0.81
Liberal or restricted fluid administration: are we ready for a proposal of a restricted intraoperative approach? BMC Anesthesiol (2014) 0.81
Protocols, physiology, and trials of hydroxyethyl starch. N Engl J Med (2012) 0.81
Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med (2017) 0.81
[State of the art in fluid and volume therapy : A user-friendly staged concept]. Anaesthesist (2017) 0.81
Is the literature inconclusive about the harm from HES? No. Intensive Care Med (2016) 0.80
Hydroxyeyhyl starch: Controversies revisited. J Anaesthesiol Clin Pharmacol (2014) 0.80
Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial. Crit Care (2013) 0.80
Clinical controversies in the management of critically ill patients with severe sepsis: resuscitation fluids and glucose control. Virulence (2013) 0.80
Albumin versus other fluids for fluid resuscitation in patients with sepsis: a meta-analysis. PLoS One (2014) 0.80
Intraoperative Goal-directed Fluid Therapy in Elective Major Abdominal Surgery: A Meta-analysis of Randomized Controlled Trials. Ann Surg (2016) 0.80
Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial. Intensive Care Med (2017) 0.80
Mortality prediction in patients with severe septic shock: a pilot study using a target metabolomics approach. Sci Rep (2016) 0.79
Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation. PLoS One (2015) 0.79
Is the literature inconclusive about the harm from HES? Yes. Intensive Care Med (2016) 0.79
Anaesthesia in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: retrospective analysis of a single centre three-year experience. World J Surg Oncol (2014) 0.79
The intensive care medicine agenda on acute kidney injury. Intensive Care Med (2017) 0.79
Fluid resuscitation practice patterns in intensive care units of the USA: a cross-sectional survey of critical care physicians. Perioper Med (Lond) (2016) 0.78
Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies). Ann Intensive Care (2016) 0.78
Adverse effects of hydroxyethyl starch (HES 130/0.4) on intestinal barrier integrity and metabolic function are abrogated by supplementation with Albumin. J Transl Med (2016) 0.78
Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med (2013) 20.70
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med (2014) 6.93
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med (2011) 5.28
Perioperative beta blockers in patients having non-cardiac surgery: a meta-analysis. Lancet (2008) 5.05
Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis. JAMA Intern Med (2013) 5.02
Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma. Cochrane Database Syst Rev (2011) 3.73
Carotid artery stenting vs carotid endarterectomy: meta-analysis and diversity-adjusted trial sequential analysis of randomized trials. Arch Neurol (2010) 2.83
A practice survey on vasopressor and inotropic drug therapy in Scandinavian intensive care units. Acta Anaesthesiol Scand (2003) 2.81
Antihypertensive drugs and risk of cancer: network meta-analyses and trial sequential analyses of 324,168 participants from randomised trials. Lancet Oncol (2010) 2.77
Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev (2011) 2.72
Apparently conclusive meta-analyses may be inconclusive--Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol (2008) 2.66
Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime. Crit Care Med (2015) 2.62
Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol (2008) 2.61
Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol (2008) 2.31
Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med (2015) 2.25
Treatment in a specialised out-patient mood disorder clinic v. standard out-patient treatment in the early course of bipolar disorder: randomised clinical trial. Br J Psychiatry (2013) 2.22
No major differences in 30-day outcomes in high-risk patients randomized to off-pump versus on-pump coronary bypass surgery: the best bypass surgery trial. Circulation (2010) 2.21
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev (2013) 2.18
Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study. Intensive Care Med (2009) 2.14
High body mass index is a weak predictor for difficult and failed tracheal intubation: a cohort study of 91,332 consecutive patients scheduled for direct laryngoscopy registered in the Danish Anesthesia Database. Anesthesiology (2009) 2.06
The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis--a simulation study. PLoS One (2011) 2.02
Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev (2014) 2.01
Scandinavian glutamine trial: a pragmatic multi-centre randomised clinical trial of intensive care unit patients. Acta Anaesthesiol Scand (2011) 1.81
Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study. Intensive Care Med (2013) 1.80
Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study. Intensive Care Med (2013) 1.77
Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis (2003) 1.77
Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med (2013) 1.75
Deeper chest compression - more complications for cardiac arrest patients? Resuscitation (2013) 1.66
Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev (2011) 1.63
Pregnancy associated plasma protein-A as a marker for myocardial infarction and death in patients with stable coronary artery disease: a prognostic study within the CLARICOR Trial. Atherosclerosis (2010) 1.60
Restricting volumes of resuscitation fluid in adults with septic shock after initial management: the CLASSIC randomised, parallel-group, multicentre feasibility trial. Intensive Care Med (2016) 1.55
Prognosis of Allogeneic Haematopoietic Stem Cell Recipients Admitted to the Intensive Care Unit: A Retrospective, Single-Centre Study. Acta Haematol (2015) 1.54
Medical emergency team activation: performance of conventional dichotomised criteria versus national early warning score. Acta Anaesthesiol Scand (2014) 1.54
Long-term outcomes in patients with severe sepsis randomised to resuscitation with hydroxyethyl starch 130/0.42 or Ringer's acetate. Intensive Care Med (2014) 1.49
Effects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis. Intensive Care Med (2014) 1.48
Survey of routines for sedation of patients on controlled ventilation in Nordic intensive care units. Acta Anaesthesiol Scand (2004) 1.47
Selective recruitment maneuvers for lobar atelectasis: effects on lung function and central hemodynamics: an experimental study in pigs. Anesth Analg (2006) 1.47
Systematic Reviews of Anesthesiologic Interventions Reported as Statistically Significant: Problems with Power, Precision, and Type 1 Error Protection. Anesth Analg (2015) 1.45
Skin care education and individual counselling versus treatment as usual in healthcare workers with hand eczema: randomised clinical trial. BMJ (2012) 1.45
Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev (2011) 1.42
Off-pump versus on-pump coronary artery bypass grafting for ischaemic heart disease. Cochrane Database Syst Rev (2012) 1.39
Blood pressure during resuscitation in man--the effect of pause during rhythm analysis revisited. Resuscitation (2011) 1.38
Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses. PLoS One (2012) 1.33
Hypothermia after cardiac arrest should be further evaluated--a systematic review of randomised trials with meta-analysis and trial sequential analysis. Int J Cardiol (2010) 1.31
Provision of protein and energy in relation to measured requirements in intensive care patients. Clin Nutr (2011) 1.22
Trials on stress ulcer prophylaxis: finding the balance between benefit and harm. Intensive Care Med (2015) 1.22
Target Temperature Management after out-of-hospital cardiac arrest--a randomized, parallel-group, assessor-blinded clinical trial--rationale and design. Am Heart J (2012) 1.22
Instructor feedback versus no instructor feedback on performance in a laparoscopic virtual reality simulator: a randomized trial. Ann Surg (2013) 1.20
Evidence at a glance: error matrix approach for overviewing available evidence. BMC Med Res Methodol (2010) 1.16
HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med (2008) 1.15
Clinical outcomes in randomized trials of off- vs. on-pump coronary artery bypass surgery: systematic review with meta-analyses and trial sequential analyses. Eur Heart J (2008) 1.14
Antithrombin III in critically ill patients: systematic review with meta-analysis and trial sequential analysis. BMJ (2007) 1.14
High serum YKL-40 concentration is associated with cardiovascular and all-cause mortality in patients with stable coronary artery disease. Eur Heart J (2009) 1.12
Fibrinogen concentrate in bleeding patients. Cochrane Database Syst Rev (2013) 1.11
Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults. Cochrane Database Syst Rev (2010) 1.10