CD4(+)CD25 (+)CD127 (low/-) T cells: a more specific Treg population in human peripheral blood.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMID 22752562)

Published in Inflammation on December 01, 2012

Authors

Ning Yu1, Xiaomei Li, Weiya Song, Dongmei Li, Daliang Yu, Xiaofeng Zeng, Mengtao Li, Xiaomei Leng, Xiangpei Li

Author Affiliations

1: Department of Rheumatology and Immunology, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, China.

Articles citing this

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect. Blood (2015) 1.70

Treating atherosclerosis with regulatory T cells. Arterioscler Thromb Vasc Biol (2014) 0.95

Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease. Inflamm Bowel Dis (2016) 0.87

Phenotypical characterization of regulatory T cells in humans and rodents. Clin Exp Immunol (2016) 0.86

Immune phenotypes predict survival in patients with glioblastoma multiforme. J Hematol Oncol (2016) 0.83

Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood. Cytotherapy (2015) 0.81

Circulating T cell subsets are altered in individuals with chronic spinal cord injury. Immunol Res (2015) 0.77

Molecular Signatures of Human Regulatory T Cells in Colorectal Cancer and Polyps. Front Immunol (2017) 0.76

Adoptive T Regulatory Cell Therapy for Tolerance Induction. Curr Transplant Rep (2015) 0.76

MHC class II tetramer analyses in AE37-vaccinated prostate cancer patients reveal vaccine-specific polyfunctional and long-lasting CD4(+) T-cells. Oncoimmunology (2016) 0.76

Negative Correlation Between miR-326 and Ets-1 in Regulatory T Cells from new-Onset SLE Patients. Inflammation (2016) 0.75

Increased Th17/Treg Ratio in Poststroke Fatigue. Mediators Inflamm (2015) 0.75

Cellular immunity profile in children with congenital heart disease and bronchopneumonia: evaluation of lymphocyte subsets and regulatory T cells. Cent Eur J Immunol (2014) 0.75

The association between neovascular age-related macular degeneration and regulatory T cells in peripheral blood. Clin Ophthalmol (2015) 0.75

Expression and significance of CD4(+)CD25(+)CD127(-) regulatory T cells in peripheral blood of patients with different phenotypes of Guillain-Barré syndrome. Int J Clin Exp Med (2015) 0.75

Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses. PLoS One (2016) 0.75

T-helper and T-regulatory cells modulation in head and neck squamous cell carcinoma. Oncoimmunology (2017) 0.75

Cytokine-induced killer cell therapy for modulating regulatory T cells in patients with non-small cell lung cancer. Exp Ther Med (2017) 0.75

Tumor specific regulatory T cells in the bone marrow of breast cancer patients selectively upregulate the emigration receptor S1P1. Cancer Immunol Immunother (2017) 0.75

Articles cited by this

Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26

CD4+CD25high regulatory cells in human peripheral blood. J Immunol (2001) 11.25

Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol (2002) 9.18

Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med (2006) 8.41

Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood (2007) 6.03

Foxp3 in control of the regulatory T cell lineage. Nat Immunol (2007) 5.94

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol (2001) 4.99

T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol (2006) 3.40

Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol (2007) 3.22

CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med (2002) 3.18

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. Eur J Immunol (2004) 3.18

Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood (1997) 2.67

GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur J Immunol (2004) 2.47

The 'danger' sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol (2005) 2.43

Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods (2006) 2.14

Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol (2005) 2.00

Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression. J Immunol Methods (2009) 1.69

CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4. Int Immunol (2005) 1.50

Gene dose effect reveals no Gs-coupled A2A adenosine receptor reserve in murine T-lymphocytes: studies of cells from A2A-receptor-gene-deficient mice. Biochem J (2001) 1.49

CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice. J Infect Dis (2009) 1.25

Regulatory T cells in health and disease. J Intern Med (2007) 1.12

CD127(low/-) and FoxP3(+) expression levels characterize different regulatory T-cell populations in human peripheral blood. J Invest Dermatol (2009) 0.97

A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties. Eur J Immunol (2010) 0.89

The severity of systemic lupus erythematosus negatively correlates with the increasing number of CD4+CD25(high)FoxP3+ regulatory T cells during repeated plasmapheresis treatments of patients. Autoimmunity (2007) 0.87

Articles by these authors

Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53

Macitentan and morbidity and mortality in pulmonary arterial hypertension. N Engl J Med (2013) 4.98

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med (2012) 3.21

Safety and effectiveness of a 2009 H1N1 vaccine in Beijing. N Engl J Med (2010) 2.98

Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study. Ann Rheum Dis (2010) 2.64

Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members. J Lipid Res (2005) 2.56

Testosterone lab testing and initiation in the United Kingdom and the United States, 2000 to 2011. J Clin Endocrinol Metab (2014) 2.18

Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus. Arthritis Rheum (2010) 1.98

Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proc Natl Acad Sci U S A (2006) 1.82

Partitioning to uncover conditions for permutation tests to control multiple testing error rates. Biom J (2008) 1.68

Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med (2015) 1.62

The management of gout at an academic healthcare center in Beijing: a physician survey. J Rheumatol (2006) 1.56

Candida albicans response regulator gene SSK1 regulates a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Eukaryot Cell (2003) 1.53

Clinical parameter and Th17 related to lymphocytes infiltrating degree of labial salivary gland in primary Sjögren's syndrome. Clin Rheumatol (2014) 1.47

Major vascular involvement in Behçet's disease: a retrospective study of 796 patients. Clin Rheumatol (2013) 1.44

Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants. Arthritis Rheum (2011) 1.42

A recA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureus. J Biol Chem (2003) 1.41

Lesser trochanteric osteotomy in total hip arthroplasty for treating CROWE type IV developmental dysplasia of hip. Int Orthop (2013) 1.35

1-[(6-Chloro-3-pyrid-yl)meth-yl]-5-eth-oxy-8-nitro-1,2,3,5,6,7-hexa-hydro-imidazo[1,2-a]pyridine. Acta Crystallogr Sect E Struct Rep Online (2009) 1.30

Comparative efficacy of daptomycin and vancomycin in the therapy of experimental foreign body infection due to Staphylococcus aureus. J Antimicrob Chemother (2003) 1.21

Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. J Biol Chem (2006) 1.20

Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr (2009) 1.19

A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat Genet (2013) 1.19

Integration of tomato reproductive developmental landmarks and expression profiles, and the effect of SUN on fruit shape. BMC Plant Biol (2009) 1.19

Modulation of fibronectin adhesins and other virulence factors in a teicoplanin-resistant derivative of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2004) 1.16

Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. J Biol Chem (2008) 1.16

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. J Lipid Res (2010) 1.14

Performance of two rapid diagnostic tests for malaria diagnosis at the China-Myanmar border area. Malar J (2013) 1.13

Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem (2012) 1.11

By homing to the kidney, activated macrophages potently exacerbate renal injury. Am J Pathol (2008) 1.11

Incidence of malignancy in primary Sjogren's syndrome in a Chinese cohort. Rheumatology (Oxford) (2009) 1.10

Randomized controlled trial of icodextrin versus glucose containing peritoneal dialysis fluid. Clin J Am Soc Nephrol (2009) 1.10

Regulation of cell proliferation in the stomatal lineage by the Arabidopsis MYB FOUR LIPS via direct targeting of core cell cycle genes. Plant Cell (2010) 1.10

Primary Sjögren's syndrome as a systemic disease: a study of participants enrolled in an international Sjögren's syndrome registry. Arthritis Care Res (Hoboken) (2012) 1.10

Plasmodium falciparum populations from northeastern Myanmar display high levels of genetic diversity at multiple antigenic loci. Acta Trop (2012) 1.10

1-[(1,3-Dithio-lan-2-yl)meth-yl]-6-methyl-8-nitro-1,2,3,5,6,7-hexa-hydro-imidazo[1,2-c]pyrimidine. Acta Crystallogr Sect E Struct Rep Online (2010) 1.09

Clinical features and prognosis in adult-onset Still's disease: a study of 104 cases. Clin Rheumatol (2010) 1.08

T regulatory cells are markedly diminished in diseased salivary glands of patients with primary Sjögren's syndrome. J Rheumatol (2007) 1.08

Goa1p of Candida albicans localizes to the mitochondria during stress and is required for mitochondrial function and virulence. Eukaryot Cell (2009) 1.07

Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant (2006) 1.07

Effect of iodine addition on solid-state electrolyte LiI/3-hydroxypropionitrile (1:4) for dye-sensitized solar cells. J Phys Chem B (2006) 1.06

Tubulointerstitial nephritis with uveitis in Chinese adults. Clin J Am Soc Nephrol (2013) 1.05

Pregnancy in women with systemic lupus erythematosus: a retrospective study of 111 pregnancies in Chinese women. J Matern Fetal Neonatal Med (2011) 1.04

Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-Seam Gas Formation Water. Genome Announc (2013) 1.03

Coinfection with four genera of bacteria (Borrelia, Bartonella, Anaplasma, and Ehrlichia) in Haemaphysalis longicornis and Ixodes sinensis ticks from China. Vector Borne Zoonotic Dis (2008) 1.03

Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer. J Exp Clin Cancer Res (2013) 1.01

Development and validation of a web-based survey on the use of personal communication devices by hospital registered nurses: pilot study. JMIR Res Protoc (2013) 1.01

Loci and candidate gene identification for resistance to Sclerotinia sclerotiorum in soybean (Glycine max L. Merr.) via association and linkage maps. Plant J (2015) 1.00

ERK-dependent signaling pathway and transcriptional factor Ets-1 regulate matrix metalloproteinase-9 production in transforming growth factor-beta1 stimulated glomerular podocytes. Cell Physiol Biochem (2005) 1.00

The role of the Candida albicans histidine kinase [CHK1) gene in the regulation of cell wall mannan and glucan biosynthesis. FEMS Yeast Res (2003) 0.99

The correlation of genetic instability of PINX1 gene to clinico-pathological features of gastric cancer in the Chinese population. J Cancer Res Clin Oncol (2008) 0.99

A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vascul Pharmacol (2007) 0.99

Draft genome sequence of Clostridium sporogenes PA 3679, the common nontoxigenic surrogate for proteolytic Clostridium botulinum. J Bacteriol (2012) 0.98

Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis Rheumatol (2014) 0.98

Death causes and pathogens analysis of systemic lupus erythematosus during the past 26 years. Clin Rheumatol (2013) 0.98

Use of lateral upper arm free flaps for soft-tissue reconstruction of the contracted eye socket. Plast Reconstr Surg (2014) 0.97

Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor. J Virol (2007) 0.97

Highly efficient CdS/CdSe-sensitized solar cells controlled by the structural properties of compact porous TiO2 photoelectrodes. Phys Chem Chem Phys (2011) 0.96

Characterization of H5N1 influenza A viruses isolated from domestic green-winged teal. Virus Genes (2008) 0.96

Draft Genome Sequence of Methanobacterium sp. Maddingley, Reconstructed from Metagenomic Sequencing of a Methanogenic Microbial Consortium Enriched from Coal-Seam Gas Formation Water. Genome Announc (2013) 0.96

Facile synthesis of tin oxide nanoflowers: a potential high-capacity lithium-ion-storage material. Langmuir (2009) 0.95

Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J Biol Chem (2012) 0.95

Deletion of the SSK1 response regulator gene in Candida albicans contributes to enhanced killing by human polymorphonuclear neutrophils. Infect Immun (2005) 0.95

Fibrous CdS/CdSe quantum dot co-sensitized solar cells based on ordered TiO2 nanotube arrays. Nanotechnology (2010) 0.95

Novel indole C-glycosides from Isatis indigotica and their potential cytotoxic activity. Fitoterapia (2010) 0.94

Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14. Melanoma Res (2009) 0.94

Identification of QTL underlying isoflavone contents in soybean seeds among multiple environments. Theor Appl Genet (2009) 0.94

Bartonella quintana infections in captive monkeys, China. Emerg Infect Dis (2011) 0.94

Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses. Plant J (2010) 0.94

Adsorptive removal of phosphate from aqueous solutions using iron oxide tailings. Water Res (2004) 0.94

The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans. FEMS Yeast Res (2009) 0.93

Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants. Mol Microbiol (2006) 0.93

Intensive therapy with ceftobiprole medocaril of experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (2005) 0.92

Afyap1, encoding a bZip transcriptional factor of Aspergillus fumigatus, contributes to oxidative stress response but is not essential to the virulence of this pathogen in mice immunosuppressed by cyclophosphamide and triamcinolone. Med Mycol (2008) 0.92

Protection against multiple influenza A virus subtypes by intranasal administration of recombinant nucleoprotein. Arch Virol (2010) 0.92

Bartonella and Bartonella infections in China: from the clinic to the laboratory. Comp Immunol Microbiol Infect Dis (2012) 0.92

Female disclosure of HIV-positive serostatus to sex partners: a two-city study. Women Health (2010) 0.92

Simultaneous determination of five aristolochic acids and two aristololactams in Aristolochia plants by high-performance liquid chromatography. Biomed Chromatogr (2006) 0.92

Effect of nickel and iron co-exposure on human lung cells. Toxicol Appl Pharmacol (2004) 0.91

miR-139 regulates the proliferation and invasion of hepatocellular carcinoma through the WNT/TCF-4 pathway. Oncol Rep (2013) 0.91

Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation. Am J Physiol Renal Physiol (2014) 0.91

Draft Genome Sequence of Thermotoga maritima A7A Reconstructed from Metagenomic Sequencing Analysis of a Hydrocarbon Reservoir in the Bass Strait, Australia. Genome Announc (2013) 0.91

Colonization by Candida species of the oral and vaginal mucosa in HIV-infected and noninfected women. AIDS Res Hum Retroviruses (2012) 0.91

Genome analysis and characterization of zinc efflux systems of a highly zinc-resistant bacterium, Comamonas testosteroni S44. Res Microbiol (2011) 0.90

HIV-1 reactivation induced by the periodontal pathogens Fusobacterium nucleatum and Porphyromonas gingivalis involves Toll-like receptor 2 [corrected] and 9 activation in monocytes/macrophages. Clin Vaccine Immunol (2010) 0.90

Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction. PLoS One (2013) 0.90

Digital evaluation of orbital development in chinese children with congenital microphthalmia. Am J Ophthalmol (2012) 0.90

Low-dose rituximab therapy for refractory thrombocytopenia in patients with systemic lupus erythematosus--a prospective pilot study. Rheumatology (Oxford) (2011) 0.89

Early life events influence whole-of-life metabolic health via gut microflora and gut permeability. Crit Rev Microbiol (2014) 0.89

Serum IgG subclasses in autoimmune diseases. Medicine (Baltimore) (2015) 0.89