Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

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Published in J Immunol on August 01, 1995

Authors

S Sakaguchi1, N Sakaguchi, M Asano, M Itoh, M Toda

Author Affiliations

1: Precursory Research for Embryonic Science and Technology (PRESTO), Research and Development Corporation of Japan (JRDC), Tsukuba Life Science Center.

Associated clinical trials:

CD4^LVFOXP3 in Participants With IPEX | NCT05241444

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