Exercise offers anxiolytic potential: a role for stress and brain noradrenergic-galaninergic mechanisms.

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Published in Neurosci Biobehav Rev on July 05, 2012

Authors

Natale R Sciolino1, Philip V Holmes

Author Affiliations

1: Neuroscience Program, Biomedical and Health Sciences Institute, Department of Psychology, University of Georgia, Athens, GA 30602, United States.

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Quality of life in individuals with anxiety disorders. Am J Psychiatry (2000) 2.53

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Can social interaction be used to measure anxiety? Br J Pharmacol (1978) 2.50

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Use of the elevated plus maze in the search for novel anxiolytic agents. Trends Pharmacol Sci (1995) 2.35

Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety. Psychopharmacology (Berl) (1994) 2.33

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs. J Neurosci Methods (1980) 2.26

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Exercise and the brain: something to chew on. Trends Neurosci (2009) 2.20

The psychophysiology of posttraumatic stress disorder: a meta-analysis. Psychol Bull (2007) 2.19

A meta-analysis on the anxiety-reducing effects of acute and chronic exercise. Outcomes and mechanisms. Sports Med (1991) 2.18

The relation between fear induced by novel stimulation and exploratory behavior. J Comp Physiol Psychol (1955) 2.13

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