Published in Traffic on August 03, 2012
Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med (2013) 2.06
Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies. Nat Rev Microbiol (2013) 0.98
Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms. Autophagy (2015) 0.96
A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. Nat Commun (2016) 0.86
Isoprenoid metabolism in apicomplexan parasites. Curr Clin Microbiol Rep (2014) 0.83
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection. Traffic (2014) 0.78
Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes. Curr Opin Microbiol (2015) 0.76
Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development. Mol Biol Cell (2017) 0.75
Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proc Natl Acad Sci U S A (2017) 0.75
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell (2006) 5.35
Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol (2006) 2.79
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem (2002) 2.69
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol (2007) 2.69
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol (2006) 2.65
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res (2012) 2.55
EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation. EMBO J (2005) 2.37
Membrane contacts between endosomes and ER provide sites for PTP1B-epidermal growth factor receptor interaction. Nat Cell Biol (2010) 2.07
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Res (2003) 1.63
Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases. J Lipid Res (2006) 1.60
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell (2007) 1.50
Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol (2005) 1.50
Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family. Proc Natl Acad Sci U S A (2005) 1.46
Multivesicular bodies: co-ordinated progression to maturity. Curr Opin Cell Biol (2008) 1.45
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
Hepatocyte growth factor and its receptor are required for malaria infection. Nat Med (2003) 1.37
Melanosomes at a glance. J Cell Sci (2008) 1.36
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
Rab11-FIP3 links the Rab11 GTPase and cytoplasmic dynein to mediate transport to the endosomal-recycling compartment. J Cell Sci (2009) 1.34
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic (2007) 1.27
Multiple regions contribute to membrane targeting of Rab GTPases. J Cell Sci (2004) 1.26
Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b. Immunity (2011) 1.24
The role of EGF receptor ubiquitination in regulating its intracellular traffic. Traffic (2011) 1.23
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. Invest Ophthalmol Vis Sci (2010) 1.23
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals. J Cell Sci (2012) 1.21
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. J Biol Chem (2006) 1.20
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci (2003) 1.19
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell (2006) 1.18
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med (2009) 1.17
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. PLoS Pathog (2008) 1.16
Down-regulation of epidermal growth factor receptor signalling within multivesicular bodies. Biochem Soc Trans (2009) 1.15
Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment. Traffic (2007) 1.14
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy (2013) 1.13
Hrs- and CD63-dependent competing mechanisms make different sized endosomal intraluminal vesicles. Traffic (2014) 1.11
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
The melanosome as a model to study organelle motility in mammals. Pigment Cell Res (2004) 1.09
The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity. Blood (2010) 1.09
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. J Mol Med (Berl) (2013) 1.09
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res (2004) 1.08
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem (2003) 1.07
Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest (2010) 1.06
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes. J Cell Sci (2007) 1.04
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol (2010) 1.03
Annexin A2 regulates phagocytosis of photoreceptor outer segments in the mouse retina. Mol Biol Cell (2009) 0.99
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum Mol Genet (2008) 0.98
Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J (2013) 0.97
Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex. Biochem Biophys Res Commun (2010) 0.97
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. Hum Mol Genet (2005) 0.97
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. Biochem J (2005) 0.95
Melanosomes on the move: a model to understand organelle dynamics. Biochem Soc Trans (2011) 0.95
Arl13b regulates endocytic recycling traffic. Proc Natl Acad Sci U S A (2012) 0.95
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium. PLoS One (2013) 0.94
CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice. J Gene Med (2012) 0.94
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2011) 0.94
Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal. Biochem J (2011) 0.94
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry. Chembiochem (2010) 0.93
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. Traffic (2011) 0.93
Autosomal dominant spastic paraplegias: a review of 89 families resulting from a portuguese survey. JAMA Neurol (2013) 0.92
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models. BMC Cell Biol (2002) 0.90
Methamphetamine-induced nitric oxide promotes vesicular transport in blood-brain barrier endothelial cells. Neuropharmacology (2012) 0.89
Are prenyl groups on proteins sticky fingers or greasy handles? Biochem J (2003) 0.89
Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux. Hum Mol Genet (2008) 0.87
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport. Pigment Cell Melanoma Res (2009) 0.87
Exophilin8 transiently clusters insulin granules at the actin-rich cell cortex prior to exocytosis. Mol Biol Cell (2011) 0.86
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. Invest Ophthalmol Vis Sci (2008) 0.86