Published in J Lipid Res on January 09, 2006
Melanosomes--dark organelles enlighten endosomal membrane transport. Nat Rev Mol Cell Biol (2007) 3.19
Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds. Nat Prod Rep (2009) 2.32
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu Rev Biochem (2009) 1.61
Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol (2014) 1.48
A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes. PLoS One (2014) 1.39
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.26
Splice variants of SmgGDS control small GTPase prenylation and membrane localization. J Biol Chem (2010) 1.25
Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic (2009) 1.25
Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds. J Biol Chem (2008) 1.23
Species-independent translational leaders facilitate cell-free expression. Nat Biotechnol (2009) 1.22
Lipidation by the host prenyltransferase machinery facilitates membrane localization of Legionella pneumophila effector proteins. J Biol Chem (2010) 1.18
Identification and validation of eukaryotic aspartate and glutamate methylation in proteins. J Proteome Res (2008) 1.16
Exploring protein lipidation with chemical biology. Chem Rev (2011) 1.15
Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev (2012) 1.13
In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I. Mol Cancer Ther (2009) 1.11
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis. J Biol Chem (2009) 1.06
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest (2011) 1.05
The physiology of protein S-acylation. Physiol Rev (2015) 1.03
A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome. Mol Genet Metab (2008) 0.99
Isoprenoids, small GTPases and Alzheimer's disease. Biochim Biophys Acta (2010) 0.98
A novel approach to tag and identify geranylgeranylated proteins. Electrophoresis (2009) 0.98
Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J (2008) 0.97
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
A novel geranylgeranyl transferase inhibitor in combination with lovastatin inhibits proliferation and induces autophagy in STS-26T MPNST cells. J Pharmacol Exp Ther (2010) 0.96
Multiple domain insertions and losses in the evolution of the Rab prenylation complex. BMC Evol Biol (2007) 0.92
Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons. Am J Physiol Cell Physiol (2008) 0.90
Reconstruct modular phenotype-specific gene networks by knowledge-driven matrix factorization. Bioinformatics (2009) 0.87
Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding. Traffic (2011) 0.86
Protein prenylation: unique fats make their mark on biology. Nat Rev Mol Cell Biol (2016) 0.85
Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease. Mol Neurobiol (2012) 0.85
Cdc42 GTPases facilitate TNF-α-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells. J Peripher Nerv Syst (2013) 0.85
A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases. Biochem Biophys Res Commun (2010) 0.84
Recent advances in chemical proteomics: exploring the post-translational proteome. J Chem Biol (2008) 0.84
Protein farnesylation and disease. J Inherit Metab Dis (2012) 0.83
Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem (2013) 0.82
The C. elegans rab family: identification, classification and toolkit construction. PLoS One (2012) 0.82
Regulation of β2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor. J Biol Chem (2011) 0.81
Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferase. J Lipid Res (2010) 0.80
Rab proteins and the secretory pathway: the case of rab18 in neuroendocrine cells. Front Endocrinol (Lausanne) (2011) 0.80
The puzzle of chloroplast vesicle transport - involvement of GTPases. Front Plant Sci (2014) 0.80
Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein. J Biol Chem (2011) 0.78
Intermittent neutropenia as an early feature of mild mevalonate kinase deficiency. J Clin Immunol (2013) 0.78
Protein geranylgeranyltransferase-I of Trypanosoma cruzi. Mol Biochem Parasitol (2007) 0.78
Mapping the interactions between a RUN domain from DENND5/Rab6IP1 and sorting nexin 1. PLoS One (2012) 0.78
Isoprenoid biosynthesis in Plasmodium falciparum. Eukaryot Cell (2014) 0.77
Chemical and functional aspects of posttranslational modification of proteins. Acta Naturae (2009) 0.77
On the Archaeal Origins of Eukaryotes and the Challenges of Inferring Phenotype from Genotype. Trends Cell Biol (2016) 0.77
Protein prenylation and synaptic plasticity: implications for Alzheimer's disease. Mol Neurobiol (2014) 0.77
Are There Rab GTPases in Archaea? Mol Biol Evol (2016) 0.76
New insights in the regulation of Rab GTPases by G protein-coupled receptors. Small GTPases (2014) 0.76
Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro. J Biol Chem (2015) 0.75
Simvastatin inhibits protein isoprenylation in the brain. Neuroscience (2016) 0.75
The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding. FEBS Lett (2011) 0.75
Characterization of taurine as anti-obesity agent in C. elegans. J Biomed Sci (2010) 0.75
GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet (2017) 0.75
Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol (2009) 5.44
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell (2006) 5.35
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol (2006) 2.79
A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J Biol Chem (2002) 2.69
Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol (2007) 2.69
Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria. J Immunol (2006) 2.65
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res (2012) 2.55
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J Clin Invest (2002) 1.81
A general role for Rab27a in secretory cells. Mol Biol Cell (2003) 1.76
Rab27b regulates number and secretion of platelet dense granules. Proc Natl Acad Sci U S A (2007) 1.66
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. J Natl Cancer Inst (2010) 1.65
Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus. Vision Res (2003) 1.63
The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes. Traffic (2002) 1.59
Membrane targeting of Rab GTPases is influenced by the prenylation motif. Mol Biol Cell (2003) 1.57
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis. Mol Biol Cell (2007) 1.50
Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol (2005) 1.50
Thousands of rab GTPases for the cell biologist. PLoS Comput Biol (2011) 1.44
Melanosomes at a glance. J Cell Sci (2008) 1.36
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms. Traffic (2009) 1.35
The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Mol Biol Cell (2004) 1.30
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium. Traffic (2007) 1.27
Multiple regions contribute to membrane targeting of Rab GTPases. J Cell Sci (2004) 1.26
Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia. Invest Ophthalmol Vis Sci (2010) 1.23
Rab27b regulates mast cell granule dynamics and secretion. Traffic (2007) 1.22
Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation. J Biol Chem (2006) 1.20
Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type. J Cell Sci (2003) 1.19
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes. Mol Biol Cell (2006) 1.18
A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood (2003) 1.11
Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells. Blood (2009) 1.11
The melanosome as a model to study organelle motility in mammals. Pigment Cell Res (2004) 1.09
Functional expression of Rab escort protein 1 following AAV2-mediated gene delivery in the retina of choroideremia mice and human cells ex vivo. J Mol Med (Berl) (2013) 1.09
Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Res (2004) 1.08
Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem (2003) 1.07
Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes. J Biol Chem (2008) 1.07
Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes. J Cell Sci (2007) 1.04
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol (2010) 1.03
Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum Mol Genet (2008) 0.98
Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion. FEBS J (2013) 0.97
ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome. Hum Mol Genet (2005) 0.97
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
Melanosomes on the move: a model to understand organelle dynamics. Biochem Soc Trans (2011) 0.95
The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. Biochem J (2005) 0.95
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium. PLoS One (2013) 0.94
Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol (2011) 0.94
CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice. J Gene Med (2012) 0.94
Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells. Traffic (2011) 0.93
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry. Chembiochem (2010) 0.93
PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. Blood (2010) 0.91
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate. J Med Chem (2007) 0.90
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models. BMC Cell Biol (2002) 0.90
Are prenyl groups on proteins sticky fingers or greasy handles? Biochem J (2003) 0.89
The host endocytic pathway is essential for Plasmodium berghei late liver stage development. Traffic (2012) 0.87
Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux. Hum Mol Genet (2008) 0.87
Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport. Pigment Cell Melanoma Res (2009) 0.87
Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding. Traffic (2011) 0.86
Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment. J Cell Sci (2012) 0.86
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. Invest Ophthalmol Vis Sci (2008) 0.86
Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochem J (2008) 0.85
Loss of Rab27 function results in abnormal lung epithelium structure in mice. Am J Physiol Cell Physiol (2010) 0.85
Rab and Arf proteins in genetic diseases. Traffic (2013) 0.85
A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases. Biochem Biophys Res Commun (2010) 0.84
An essential role for Rab27a GTPase in eosinophil exocytosis. J Leukoc Biol (2013) 0.82
Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes. J Cell Sci (2013) 0.82
Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function. Traffic (2011) 0.81
Bacteria and protozoa differentially modulate the expression of Rab proteins. PLoS One (2012) 0.81
Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs. Biochem Soc Trans (2012) 0.80
A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biol (2014) 0.79
Structural determinants of Rab and Rab Escort Protein interaction: Rab family motifs define a conserved binding surface. Biochem Biophys Res Commun (2003) 0.79
An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue. Int J Dev Biol (2012) 0.78
Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection. Traffic (2014) 0.78
Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function. Small GTPases (2011) 0.78
Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy. Mol Membr Biol (2013) 0.77
Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors. Eur J Med Chem (2011) 0.76
Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes. PLoS One (2016) 0.75
Quantitative structure-activity relationship (QSAR) of indoloacetamides as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett (2006) 0.75
Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise. Pigment Cell Melanoma Res (2014) 0.75
The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates. Bone (2011) 0.75
MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells. Immunity (2014) 0.75
Syntheses of functionalized biotin N-1' derivatives: new tools for the control of gene expression with small molecules. Bioconjug Chem (2006) 0.75
Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase. Methods Mol Biol (2002) 0.75