Published in Neuroscience on July 13, 2012
Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest (2013) 1.02
Role of nociceptor αCaMKII in transition from acute to chronic pain (hyperalgesic priming) in male and female rats. J Neurosci (2013) 0.98
Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain. Prog Mol Biol Transl Sci (2015) 0.87
Accounting for the delay in the transition from acute to chronic pain: axonal and nuclear mechanisms. J Neurosci (2015) 0.87
Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci (2015) 0.85
Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeutics. Gene (2015) 0.85
Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II). Med Sci Monit (2014) 0.85
Second messengers mediating the expression of neuroplasticity in a model of chronic pain in the rat. J Pain (2014) 0.84
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A (2016) 0.82
Distinct terminal and cell body mechanisms in the nociceptor mediate hyperalgesic priming. J Neurosci (2015) 0.82
Adenosine-A1 receptor agonist induced hyperalgesic priming type II. Pain (2016) 0.80
G-protein-coupled receptor kinases in inflammation and disease. Genes Immun (2015) 0.80
Contribution of Piezo2 to endothelium-dependent pain. Mol Pain (2015) 0.79
The pharmacology of nociceptor priming. Handb Exp Pharmacol (2015) 0.78
Paroxetine alleviates rat limb post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia. Int J Clin Exp Med (2015) 0.77
The fundamental unit of pain is the cell. Pain (2013) 0.76
GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity. Cell Rep (2016) 0.76
Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med (2015) 0.75
A method for measurement of analgesic activity on inflamed tissue. Arch Int Pharmacodyn Ther (1957) 6.07
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu Rev Immunol (2001) 5.59
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci (2002) 5.04
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron (1999) 2.82
Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci (2005) 2.47
Hypotonicity induces TRPV4-mediated nociception in rat. Neuron (2003) 2.43
Comprehensive review of epidemiology, scope, and impact of spinal pain. Pain Physician (2009) 2.29
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta (2006) 2.24
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci (2000) 2.20
Dissociation of bradykinin-induced prostaglandin formation from phosphatidylinositol turnover in Swiss 3T3 fibroblasts: evidence for G protein regulation of phospholipase A2. Proc Natl Acad Sci U S A (1987) 2.17
Critical role of nociceptor plasticity in chronic pain. Trends Neurosci (2009) 2.07
Stress induces a switch of intracellular signaling in sensory neurons in a model of generalized pain. J Neurosci (2008) 1.70
Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience (1989) 1.62
Measurement of intracellular free calcium in monkey kidney cells with aequorin. Science (1982) 1.57
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience (1991) 1.54
Tumor necrosis factor receptor type-1 in sensory neurons contributes to induction of chronic enhancement of inflammatory hyperalgesia in rat. Eur J Neurosci (2003) 1.51
Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia. Eur J Neurosci (2005) 1.44
Transient attenuation of protein kinase Cepsilon can terminate a chronic hyperalgesic state in the rat. Neuroscience (2003) 1.42
Repetitive strain injury. Lancet (2007) 1.40
Computer use increases the risk of musculoskeletal disorders among newspaper office workers. Arch Med Res (2003) 1.36
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways. Pain (2005) 1.34
Repeated sound stress enhances inflammatory pain in the rat. Pain (2005) 1.25
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican. Eur J Neurosci (2008) 1.23
The contribution of training to sensitivity in the nociceptive paw-withdrawal test. Brain Res (1989) 1.21
Risk factors for persistent elbow, forearm and hand pain among computer workers. Scand J Work Environ Health (2005) 1.20
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Receptors Channels (1997) 1.20
PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia. Pain (2007) 1.18
Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain (2010) 1.17
GRK2: a novel cell-specific regulator of severity and duration of inflammatory pain. J Neurosci (2010) 1.15
Generation of a pain memory in the primary afferent nociceptor triggered by PKCε activation of CPEB. J Neurosci (2012) 1.15
Behavioural effects of receptor-specific substance P agonists. Pain (1987) 1.14
Sound stress-induced long-term enhancement of mechanical hyperalgesia in rats is maintained by sympathoadrenal catecholamines. J Pain (2009) 1.10
Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol (1994) 1.09
Protein kinase C in pain: involvement of multiple isoforms. Pharmacol Res (2007) 1.09
Hyperalgesic priming in the rat demonstrates marked sexual dimorphism. Pain (2003) 1.08
Treatment of myofascial trigger points in patients with chronic shoulder pain: a randomized, controlled trial. BMC Med (2011) 1.08
Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK. J Neurosci (2010) 1.06
Upper extremity pain and computer use among engineering graduate students. Am J Ind Med (2004) 1.05
Muscle inflammation induces a protein kinase Cepsilon-dependent chronic-latent muscle pain. J Pain (2008) 1.04
Activation of Gi induces mechanical hyperalgesia poststress or inflammation. Neuroscience (2009) 1.02
Mechanisms mediating vibration-induced chronic musculoskeletal pain analyzed in the rat. J Pain (2009) 1.01
Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stress. Eur J Pain (2011) 1.00
Shared mechanisms for opioid tolerance and a transition to chronic pain. J Neurosci (2010) 1.00
Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat. Pain (2011) 0.98
A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Eur J Neurosci (2007) 0.97
Classification, treatment and outcomes of a patient with lumbar extension syndrome. Physiother Theory Pract (2006) 0.96
Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat. Eur J Neurosci (2001) 0.95
Prostaglandin effects after elimination of indirect hyperalgesic mechanisms in the skin of the rat. Brain Res (1989) 0.94
GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia. Pain (2011) 0.94
IB4-saporin attenuates acute and eliminates chronic muscle pain in the rat. Exp Neurol (2011) 0.93
Microglial GRK2: a novel regulator of transition from acute to chronic pain. Brain Behav Immun (2011) 0.90
The effects of phorbol ester on slowly conducting afferents of the cat's knee joint. Exp Brain Res (1993) 0.89
The influence of work-related exposures on the prognosis of neck/shoulder pain. Eur Spine J (2007) 0.87
Antisense oligonucleotides against receptor kinase GRK2 disrupt target selectivity of beta-adrenergic receptors in atrial myocytes. FEBS Lett (1999) 0.81
[Rheumatoid arthritis: current status of therapy]. Tunis Med (2007) 0.78
The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature (1997) 30.59
Coupled two-way clustering analysis of gene microarray data. Proc Natl Acad Sci U S A (2000) 5.55
The mechanism of placebo analgesia. Lancet (1978) 4.10
Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc Natl Acad Sci U S A (1996) 2.84
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron (1999) 2.82
Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst (1998) 2.67
Antinociceptive and motor effects of delta/mu and kappa/mu combinations of intrathecal opioid agonists. Pain (1992) 2.49
Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med (1996) 2.27
Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the epsilon isozyme of protein kinase C. J Neurosci (2000) 2.20
Formation of hybrid cell-cell channels. Proc Natl Acad Sci U S A (1989) 2.14
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin: a consensus statement. Society of Surgical Oncology. Ann Surg Oncol (2006) 2.13
Mechanical transduction by rat dorsal root ganglion neurons in vitro. Neurosci Lett (1999) 2.11
Cation fluxes and permeability changes accompanying bacteriophage infection of Escherichia coli. J Virol (1968) 1.97
Glutathione redox cycle protects cultured endothelial cells against lysis by extracellularly generated hydrogen peroxide. J Clin Invest (1984) 1.94
Functional isolation and characterization of human hematopoietic stem cells. Science (1995) 1.92
Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol (1999) 1.92
Characterization of six voltage-gated K+ currents in adult rat sensory neurons. J Neurophysiol (1996) 1.91
Recombinant human erythropoietin for patients with AIDS treated with zidovudine. N Engl J Med (1990) 1.89
Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci (1998) 1.88
A new role for cryptochrome in a Drosophila circadian oscillator. Nature (2001) 1.85
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci (1986) 1.84
Intraneuronal substance P contributes to the severity of experimental arthritis. Science (1984) 1.77
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci (1990) 1.77
Exacerbation of familial renal lymphangiomatosis during pregnancy. AJR Am J Roentgenol (1988) 1.75
A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat. Neurosci Lett (1998) 1.67
The narcotic antagonist naloxone enhances clinical pain. Nature (1978) 1.66
Role of interleukin-6 in chronic muscle hyperalgesic priming. Neuroscience (2008) 1.65
Mutational analysis of gap junction formation. Biophys J (1992) 1.63
Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain. Nature (1979) 1.63
Role of protein kinase A in the maintenance of inflammatory pain. J Neurosci (1999) 1.63
Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system. Neuroscience (1989) 1.62
Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience (1987) 1.62
Molecular analysis of mammalian timeless. Neuron (1998) 1.60
Effect of sympathetic activity on capsaicin-evoked pain, hyperalgesia, and vasodilatation. Neurology (1999) 1.59
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. Neuroscience (1991) 1.54
Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro. Neuroscience (1996) 1.53
Leukotriene B4 produces hyperalgesia that is dependent on polymorphonuclear leukocytes. Science (1984) 1.53
Nociceptor sensitization by extracellular signal-regulated kinases. J Neurosci (2001) 1.49
Oestrogen receptor B-region polymorphism and spontaneous abortion in women with breast cancer. Lancet (1990) 1.49
Genetic predisposition in breast cancer. Lancet (1994) 1.47
Therapy for inflammatory breast cancer: impact of doxorubicin-based therapy. Ann Surg Oncol (1995) 1.45
Pain-induced analgesia mediated by mesolimbic reward circuits. J Neurosci (1999) 1.44
Injectable medication for the treatment of multiple sclerosis: the influence of self-efficacy expectations and injection anxiety on adherence and ability to self-inject. Ann Behav Med (2001) 1.43
Transient attenuation of protein kinase Cepsilon can terminate a chronic hyperalgesic state in the rat. Neuroscience (2003) 1.42
Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J Rheumatol (1985) 1.42
Past pregnancy is associated with axillary node involvement in women with breast cancer. Cancer (1992) 1.42
Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma. J Clin Oncol (1991) 1.41
Lidocaine toxicity in primary afferent neurons from the rat. J Pharmacol Exp Ther (1998) 1.41
Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer. Radiother Oncol (2000) 1.39
Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol (1989) 1.38
A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells. J Clin Invest (1985) 1.38
Comparison of computed tomography and other imaging modalities in the evaluation of musculoskeletal tumors. Radiology (1979) 1.35
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways. Pain (2005) 1.34
Acridine binding by Escherichia coli: pH dependency and strain differences. J Bacteriol (1968) 1.34
The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain (1999) 1.33
Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture. Blood (1982) 1.32
Cell/cell channel formation involves disulfide exchange. Eur J Biochem (1991) 1.32
Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. Neuroscience (2010) 1.30
Nitric oxide signaling in pain and nociceptor sensitization in the rat. J Neurosci (1998) 1.28
Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. Neuroscience (2001) 1.28
Influence of the method of drug administration on analgesic response. Nature (1985) 1.27
A prospective observational study of chemotherapy-related nausea and vomiting in routine practice in a UK cancer centre. Support Care Cancer (2007) 1.27
Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J Neurophysiol (1989) 1.26
Key role for the epsilon isoform of protein kinase C in painful alcoholic neuropathy in the rat. J Neurosci (2000) 1.23
Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. J Comp Neurol (2000) 1.23
Neurophysiology of flight in wild-type and a mutant Drosophila. Proc Natl Acad Sci U S A (1973) 1.23
Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma. Prog Brain Res (1996) 1.23
Serotonin is a directly-acting hyperalgesic agent in the rat. Neuroscience (1992) 1.22
Autonomic components of the human pupillary light reflex. Invest Ophthalmol Vis Sci (1990) 1.22
Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc Natl Acad Sci U S A (1997) 1.22
The contribution of training to sensitivity in the nociceptive paw-withdrawal test. Brain Res (1989) 1.21
Gender difference in analgesic response to the kappa-opioid pentazocine. Neurosci Lett (1996) 1.21
Melanoma cell-cell interactions are mediated through heterophilic Mel-CAM/ligand adhesion. Cancer Res (1997) 1.20
Waiting times for treatment of rectal cancer in North West England. J R Soc Med (2004) 1.20
Hemodynamic and oxygen transport effects of a perfluorochemical blood substitute, fluosol-DA (20%). Crit Care Med (1980) 1.20
The contribution of neurogenic inflammation in experimental arthritis. J Immunol (1985) 1.19
Causalgia and reflex sympathetic dystrophy: does the sympathetic nervous system contribute to the generation of pain? Muscle Nerve (1999) 1.18
Role of a Ca(2+)-dependent slow afterhyperpolarization in prostaglandin E2-induced sensitization of cultured rat sensory neurons. Neurosci Lett (1996) 1.17
UV-inducible DNA repair in the cyanobacteria Anabaena spp. J Bacteriol (1987) 1.17
A Nursing Intervention Taxonomy for home health care. Nurs Health Care (1991) 1.16
Analgesic responses to morphine and placebo in individuals with postoperative pain. Pain (1981) 1.15
Multiple receptors involved in peripheral alpha 2, mu, and A1 antinociception, tolerance, and withdrawal. J Neurosci (1997) 1.15
Acquired cystic disease: replacing one kidney disease with another. Kidney Int (1985) 1.15
Diagnosis and management of lymphoceles after renal transplantation. Urology (1977) 1.15
Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature (1986) 1.14
Chocolate craving and liking. Appetite (1991) 1.14
Clinical response to regional intravenous guanethidine in patients with rheumatoid arthritis. J Rheumatol (1986) 1.13
Nociceptor subpopulations involved in hyperalgesic priming. Neuroscience (2009) 1.13
Association of transforming growth factor beta-1 single nucleotide polymorphisms with radiation-induced damage to normal tissues in breast cancer patients. Int J Radiat Biol (2003) 1.12
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat. Neuroscience (1995) 1.12
Direct cutaneous hyperalgesia induced by adenosine. Neuroscience (1990) 1.11
Microtubule disorientation and axonal swelling in unmyelinated sensory axons during vincristine-induced painful neuropathy in rat. J Comp Neurol (1998) 1.11
Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci (1988) 1.09
The foraging gene of Drosophila melanogaster: spatial-expression analysis and sucrose responsiveness. J Comp Neurol (2007) 1.09
Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens. Neuroscience (2001) 1.09
Protein kinase C inhibitors decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol (1994) 1.09
Stimulation of nuclease activity by thymine starvation. Biochem Biophys Res Commun (1972) 1.09
Role of pain in placebo analgesia. Proc Natl Acad Sci U S A (1979) 1.08