Published in J Neurosci on February 10, 2010
Interactions between the immune and nervous systems in pain. Nat Med (2010) 2.91
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther (2011) 2.13
Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling. Pain (2010) 1.17
GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol Sci (2012) 1.15
Targeting G protein coupled receptor-related pathways as emerging molecular therapies. Saudi Pharm J (2013) 1.06
Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. J Clin Invest (2013) 1.02
MicroRNA-124 as a novel treatment for persistent hyperalgesia. J Neuroinflammation (2012) 0.99
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain. Neuroscience (2012) 0.95
Neuroinflammation and comorbidity of pain and depression. Pharmacol Rev (2013) 0.93
Neuropathy-induced spinal GAP-43 expression is not a main player in the onset of mechanical pain hypersensitivity. J Neurotrauma (2011) 0.88
Monocytes/Macrophages control resolution of transient inflammatory pain. J Pain (2014) 0.87
Repeated Mu-Opioid Exposure Induces a Novel Form of the Hyperalgesic Priming Model for Transition to Chronic Pain. J Neurosci (2015) 0.85
Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun (2015) 0.84
G protein-coupled receptor kinase 2 moderates recruitment of THP-1 cells to the endothelium by limiting histamine-invoked Weibel-Palade body exocytosis. J Thromb Haemost (2014) 0.83
Focal Inflammation Causes Carbenoxolone-Sensitive Tactile Hypersensitivity in Mice. Open Pain J (2010) 0.83
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A (2016) 0.82
Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice. FASEB J (2012) 0.82
G protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting phosphatidylinositol 3-kinase and inhibiting p38 signaling. Mol Med (2012) 0.82
Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. J Biol Chem (2012) 0.80
G-protein-coupled receptor kinases in inflammation and disease. Genes Immun (2015) 0.80
Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage. Neurobiol Dis (2013) 0.77
Paroxetine alleviates rat limb post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia. Int J Clin Exp Med (2015) 0.77
IL4-10 Fusion Protein Is a Novel Drug to Treat Persistent Inflammatory Pain. J Neurosci (2016) 0.76
A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia. Biochem J (2014) 0.76
Spinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats. Brain Res (2013) 0.76
Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals. Mol Cell Biol (2017) 0.75
Downregulation of Spinal G Protein-Coupled Kinase 2 Abolished the Antiallodynic Effect of Electroacupuncture. Evid Based Complement Alternat Med (2015) 0.75
CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci (2016) 0.75
Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A. J Neuroinflammation (2016) 0.75
A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2. Cell Mol Neurobiol (2016) 0.75
Genomics of pain in osteoarthritis. Osteoarthritis Cartilage (2013) 0.75
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain (1988) 18.17
Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res (1999) 12.83
Intrathecal morphine in mice: a new technique. Eur J Pharmacol (1980) 5.99
Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci (2009) 5.53
The neuropathic pain triad: neurons, immune cells and glia. Nat Neurosci (2007) 5.38
A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature (1996) 4.63
Role of the immune system in chronic pain. Nat Rev Neurosci (2005) 4.10
MAP kinase and pain. Brain Res Rev (2008) 3.75
Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy. J Pharmacol Exp Ther (2003) 3.69
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci (2001) 3.55
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab (2006) 3.34
The role of neuroinflammation and neuroimmune activation in persistent pain. Pain (2001) 3.15
Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci (2001) 2.79
p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain (2007) 2.72
Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov (2003) 2.71
Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron (2007) 2.70
Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev (2006) 2.59
A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A (2005) 2.53
The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling. Biochim Biophys Acta (2006) 2.24
Current challenges in glia-pain biology. Neuron (2009) 2.11
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res (2006) 2.08
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A (1996) 2.06
Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain. Adv Exp Med Biol (2003) 1.84
A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Proc Natl Acad Sci U S A (2005) 1.82
Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain. J Leukoc Biol (2006) 1.75
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72
A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci (2006) 1.71
Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J Leukoc Biol (2008) 1.64
Mechanical and heat sensitization of cutaneous nociceptors after peripheral inflammation in the rat. J Neurophysiol (1999) 1.45
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus. J Biol Chem (1999) 1.42
Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci Lett (2005) 1.35
Decreased expression and activity of G-protein-coupled receptor kinases in peripheral blood mononuclear cells of patients with rheumatoid arthritis. FASEB J (1999) 1.33
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK. Curr Biol (2006) 1.25
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Immunol (2005) 1.24
Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Receptors Channels (1997) 1.20
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. J Leukoc Biol (2004) 1.16
Adjuvant arthritis induces down-regulation of G protein-coupled receptor kinases in the immune system. J Immunol (2001) 1.12
IL-1 beta signaling is required for mechanical allodynia induced by nerve injury and for the ensuing reduction in spinal cord neuronal GRK2. Brain Behav Immun (2007) 1.01
Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells. Circulation (2000) 0.98
A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Eur J Neurosci (2007) 0.97
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut (2007) 0.97
Low endogenous G-protein-coupled receptor kinase 2 sensitizes the immature brain to hypoxia-ischemia-induced gray and white matter damage. J Neurosci (2008) 0.95
Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors. Neurosci Lett (2007) 0.92
Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium. J Neurochem (2007) 0.91
Changes in the G-protein-coupled receptor desensitization machinery during relapsing-progressive experimental allergic encephalomyelitis. J Neuroimmunol (2003) 0.89
TRPV1 expression-dependent initiation and regulation of filopodia. J Neurochem (2007) 0.89
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
An SCN9A channelopathy causes congenital inability to experience pain. Nature (2006) 7.01
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn. Anesthesiology (2005) 4.42
A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med (2008) 3.98
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron (2006) 3.96
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science (2008) 3.46
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron (2010) 3.31
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci U S A (2004) 3.07
Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron (2005) 3.03
Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circ Res (2011) 2.99
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J Biol Chem (2010) 2.93
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat Med (2003) 2.83
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. J Clin Endocrinol Metab (2003) 2.72
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature (2007) 2.71
Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation (2009) 2.70
Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice. Circulation (2003) 2.70
Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res (2005) 2.67
The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. J Physiol (2003) 2.59
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest (2003) 2.56
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol (2004) 2.48
MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts. Circ Res (2009) 2.40
Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons. J Neurosci (2002) 2.40
Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system. Pain (2012) 2.34
Phenotyping hypertrophy: eschew obfuscation. Circ Res (2003) 2.32
MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res (2011) 2.32
Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature (2011) 2.31
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circ Res (2011) 2.27
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest (2007) 2.23
VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. Neuron (2010) 2.22
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res (2008) 2.22
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation. Circulation (2008) 2.21
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Mechanical ventilation alters the immune response in children without lung pathology. Intensive Care Med (2002) 2.11
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circ Res (2006) 2.08
Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat Med (2002) 2.05
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A (2006) 2.05
CatWalk-assisted gait analysis in the assessment of spinal cord injury. J Neurotrauma (2006) 1.98
Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am J Psychiatry (2010) 1.90
Adjuvant aspirin therapy reduces symptoms of schizophrenia spectrum disorders: results from a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry (2010) 1.90
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain (2011) 1.90
Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology (2010) 1.89
Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (2002) 1.88
Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8. Mol Pain (2005) 1.86
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A (2007) 1.86
Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev (2003) 1.84
Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci U S A (2012) 1.80
Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy. Circ Res (2012) 1.79
Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Physiology (Bethesda) (2007) 1.78
Repairing injured peripheral nerves: Bridging the gap. Prog Neurobiol (2010) 1.77
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure. Circulation (2006) 1.73
Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk. Circ Res (2012) 1.72
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nat Commun (2012) 1.72
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain (2005) 1.72
Beneficial effect of erythropoietin on sensorimotor function and white matter after hypoxia-ischemia in neonatal mice. Pediatr Res (2011) 1.67
GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol (2006) 1.66
RISC RNA sequencing for context-specific identification of in vivo microRNA targets. Circ Res (2010) 1.66
Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. J Clin Invest (2008) 1.65
Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circ Res (2005) 1.64
GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J Physiol (2003) 1.62
Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci (2013) 1.62
Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62
Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq. Circ Res (2010) 1.61
Additive protection of the ischemic heart ex vivo by combined treatment with delta-protein kinase C inhibitor and epsilon-protein kinase C activator. Circulation (2003) 1.60
Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circ Res (2003) 1.58
The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (2003) 1.54
Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.54
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. Neuron (2008) 1.52
The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J Neurotrauma (2005) 1.52
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation (2012) 1.52
Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation (2007) 1.51
Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circ Cardiovasc Genet (2010) 1.51
Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med (2004) 1.51
GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol (2007) 1.49
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia. Brain Behav Immun (2008) 1.49
Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice. J Neurosci (2002) 1.48
Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress. J Biol Chem (2005) 1.48
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest (2007) 1.48
Novel and nondetected human signaling protein polymorphisms. Physiol Genomics (2002) 1.44
Clinical and genetic modifiers of long-term survival in heart failure. J Am Coll Cardiol (2009) 1.42
Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One (2010) 1.41
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science (2011) 1.40