Published in J Cell Biol on July 16, 2012
Spike-driven glutamate electrodiffusion triggers synaptic potentiation via a homer-dependent mGluR-NMDAR link. Neuron (2013) 1.51
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell (2013) 1.01
NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci (2013) 0.97
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neurosci Biobehav Rev (2014) 0.94
Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. Neuron (2015) 0.92
Metabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus bias. Br J Pharmacol (2015) 0.88
Optical control of an ion channel gate. Proc Natl Acad Sci U S A (2013) 0.87
Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors. EMBO Rep (2013) 0.83
Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci (2016) 0.80
Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell (2015) 0.80
Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Rep (2015) 0.78
Scaffold remodeling in space and time controls synaptic transmission. Bioarchitecture (2012) 0.76
Overstimulation of glutamate signals leads to hippocampal transcriptional plasticity in hamsters. Cell Mol Neurobiol (2014) 0.76
Targeting metabotropic glutamate receptors for novel treatments of schizophrenia. Mol Brain (2017) 0.75
Recycling endosomes supply AMPA receptors for LTP. Science (2004) 5.51
Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron (2001) 5.51
Homer: a protein that selectively binds metabotropic glutamate receptors. Nature (1997) 4.18
Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron (2001) 3.91
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron (1998) 3.59
Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET). Nat Methods (2006) 3.17
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci (2005) 2.96
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity. Brain Res Brain Res Rev (1999) 2.95
An architectural framework that may lie at the core of the postsynaptic density. Science (2006) 2.91
Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci (2000) 2.56
Real-time monitoring of ubiquitination in living cells by BRET. Nat Methods (2004) 2.23
Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. J Neurosci (2008) 2.22
Scaffolds: interaction platforms for cellular signalling circuits. Trends Cell Biol (2009) 2.15
The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. J Neurosci (2005) 1.97
Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol (2000) 1.97
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a. J Neurosci (2003) 1.77
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci (2000) 1.69
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron (2000) 1.68
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology (1997) 1.61
Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron (2010) 1.59
The use of resonance energy transfer in high-throughput screening: BRET versus FRET. Trends Pharmacol Sci (2002) 1.48
Homer as both a scaffold and transduction molecule. Sci STKE (2002) 1.44
Homers regulate drug-induced neuroplasticity: implications for addiction. Biochem Pharmacol (2007) 1.43
Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia. Genes Brain Behav (2005) 1.43
vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis. FEBS Lett (1997) 1.42
Homer proteins: implications for neuropsychiatric disorders. Curr Opin Neurobiol (2006) 1.38
Synaptic scaffolding protein Homer1a protects against chronic inflammatory pain. Nat Med (2006) 1.35
Molecular dynamics of postsynaptic receptors and scaffold proteins. Curr Opin Neurobiol (2008) 1.30
Phosphorylation-independent desensitization of GABA(B) receptor by GRK4. EMBO J (2003) 1.30
Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr Opin Neurobiol (1999) 1.20
Biomimetic divalent ligands for the acute disruption of synaptic AMPAR stabilization. Nat Chem Biol (2010) 1.18
NMDA receptor stimulation and brain-derived neurotrophic factor upregulate homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells. J Neurosci (2001) 1.17
Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons. J Neurosci (2008) 1.16
A simple method to transfer plasmid DNA into neuronal primary cultures: functional expression of the mGlu5 receptor in cerebellar granule cells. Neuropharmacology (1999) 1.16
Tetrameric hub structure of postsynaptic scaffolding protein homer. J Neurosci (2006) 1.13
Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long-Term Potentiation Through Protein Kinase C. Eur J Neurosci (1992) 1.11
Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors. J Biol Chem (2008) 1.11
Metabotropic glutamate receptors: intracellular signaling pathways. Curr Opin Pharmacol (2006) 1.10
Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. J Biol Chem (2003) 1.10
Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices. Br J Pharmacol (1993) 1.09
Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br J Pharmacol (2001) 1.09
Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer. Biophys J (2007) 1.08
Complex, multimodal behavioral profile of the Homer1 knockout mouse. Genes Brain Behav (2007) 1.02
Select overexpression of homer1a in dorsal hippocampus impairs spatial working memory. Front Neurosci (2007) 1.00
Group 5 metabotropic glutamate receptors: role in modulating cortical activity and relevance to cognition. Eur J Pharmacol (2010) 0.98
Potentiation of NMDA and AMPA responses by group I mGluR in spinal cord motoneurons. Neuropharmacology (1997) 0.98
Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis. Eur J Neurosci (2002) 0.95
Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. PLoS One (2010) 0.94
Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock. Eur J Neurosci (2005) 0.90
Peptide-enhanced cellular internalization of proteins in neuroscience. Brain Res Bull (2005) 0.85
Subcellular dynamic imaging of protein-protein interactions in live cells by bioluminescence resonance energy transfer. Methods Mol Biol (2010) 0.84
Shank expression is sufficient to induce functional dendritic spine synapses in aspiny neurons. J Neurosci (2005) 2.96
Extracellular interactions between GluR2 and N-cadherin in spine regulation. Neuron (2007) 2.45
Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29
Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene (2004) 2.09
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain (2007) 1.83
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem (2005) 1.81
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
GPCR interacting proteins (GIP). Pharmacol Ther (2004) 1.61
Plant insecticide L-canavanine repels Drosophila via the insect orphan GPCR DmX. PLoS Biol (2009) 1.60
Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res (2002) 1.53
The NOD2-RICK complex signals from the plasma membrane. J Biol Chem (2007) 1.50
A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor. J Biol Chem (2001) 1.49
Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity. J Neurosci (2007) 1.48
A single mutation in the 5-HT4 receptor (5-HT4-R D100(3.32)A) generates a Gs-coupled receptor activated exclusively by synthetic ligands (RASSL). J Biol Chem (2002) 1.42
CARD15/NOD2 is required for Peyer's patches homeostasis in mice. PLoS One (2007) 1.41
New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. J Cell Sci (2004) 1.40
Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons. Proc Natl Acad Sci U S A (2007) 1.40
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J Biol Chem (2009) 1.36
Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci (2005) 1.35
Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach. EMBO J (2002) 1.35
GPCR-jacking: from a new route in RTK signalling to a new concept in GPCR activation. Trends Pharmacol Sci (2007) 1.33
Shaggy, the homolog of glycogen synthase kinase 3, controls neuromuscular junction growth in Drosophila. J Neurosci (2004) 1.32
The 'magic tail' of G protein-coupled receptors: an anchorage for functional protein networks. FEBS Lett (2003) 1.32
Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol Pharmacol (2009) 1.29
GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies. Annu Rev Pharmacol Toxicol (2010) 1.27
Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response. J Neurosci (2004) 1.25
The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem (2004) 1.25
G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. J Biol Chem (2011) 1.21
Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways. J Neurosci (2011) 1.19
Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome. J Biol Chem (2003) 1.18
Epac mediates PACAP-dependent long-term depression in the hippocampus. J Physiol (2008) 1.17
Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol Cell Neurosci (2002) 1.15
Increased number of neural progenitors in human temporal lobe epilepsy. Neurobiol Dis (2005) 1.12
Direct interaction enables cross-talk between ionotropic and group I metabotropic glutamate receptors. J Biol Chem (2008) 1.11
Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice. J Neurosci (2004) 1.10
Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulation of cell surface expression and signal transduction. Mol Pharmacol (2007) 1.10
Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe (2012) 1.09
Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. Mol Biol Cell (2008) 1.08
Subcellular imaging of dynamic protein interactions by bioluminescence resonance energy transfer. Biophys J (2007) 1.08
Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens. Proc Natl Acad Sci U S A (2007) 1.06
NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB J (2007) 1.04
Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci (2010) 1.04
Identification and functional roles of metabotropic glutamate receptor-interacting proteins. Semin Cell Dev Biol (2004) 1.03
Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells. Eur J Neurosci (2002) 1.03
PICK1 uncoupling from mGluR7a causes absence-like seizures. Nat Neurosci (2008) 1.03
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells. J Biol Chem (2002) 1.01
Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. J Biol Chem (2002) 1.00
The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology. J Neurosci (2004) 1.00
Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability. Mol Biol Cell (2006) 1.00
Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. Cell Signal (2007) 1.00
A model for the functioning of family 3 GPCRs. Trends Pharmacol Sci (2002) 0.99
Muscle dystroglycan organizes the postsynapse and regulates presynaptic neurotransmitter release at the Drosophila neuromuscular junction. PLoS One (2008) 0.99
Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice. Eur J Neurosci (2002) 0.99
The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. EMBO J (2002) 0.98
The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells. Proteomics (2006) 0.97
Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One (2008) 0.97
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia. EMBO Mol Med (2012) 0.95
Enhanced detection of CNS cell secretome in plasma protein-depleted cerebrospinal fluid. J Proteome Res (2008) 0.95
Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. EMBO J (2009) 0.95
Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. PLoS One (2010) 0.94
Adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. Eur J Neurosci (2006) 0.94
Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus. Hippocampus (2012) 0.93
Uncoupling and endocytosis of 5-hydroxytryptamine 4 receptors. Distinct molecular events with different GRK2 requirements. J Biol Chem (2005) 0.92
MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. J Neurochem (2006) 0.91
Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol. J Neurosci (2008) 0.91
Alzheimer culprits: cellular crossroads and interplay. Cell Signal (2012) 0.91
A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J Biol Chem (2002) 0.90
PACAP type I receptor transactivation is essential for IGF-1 receptor signalling and antiapoptotic activity in neurons. EMBO J (2007) 0.90
β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice. Diabetologia (2013) 0.89
Calpain 3 is expressed in astrocytes of rat and Microcebus brain. J Chem Neuroanat (2003) 0.89
Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation. J Neurosci (2013) 0.89
Characterization and localization of cocaine- and amphetamine-regulated transcript (CART) binding sites. Peptides (2005) 0.89
Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects. J Biol Chem (2003) 0.89
Difference in mass analysis using labeled lysines (DIMAL-K): a new, efficient proteomic quantification method applied to the analysis of astrocytic secretomes. Mol Cell Proteomics (2005) 0.89
A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors. Biol Proced Online (2002) 0.89
5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling. Mol Biol Cell (2007) 0.89