A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment.

PubWeight™: 0.93‹?›

🔗 View Article (PMC 3409104)

Published in J Gen Physiol on July 16, 2012

Authors

Saptarshi Mukherjee1, N Lowri Thomas, Alan J Williams

Author Affiliations

1: Institute of Molecular and Experimental Medicine, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, Wales, UK.

Articles cited by this

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. J Mol Biol (1965) 46.35

Cardiac excitation-contraction coupling. Nature (2002) 18.48

Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol (1983) 10.99

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25

Interaction at end-plate receptors between different choline derivatives. Proc R Soc Lond B Biol Sci (1957) 8.44

Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events. Biophys J (1996) 7.66

On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Philos Trans R Soc Lond B Biol Sci (1982) 7.45

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation (2001) 5.68

Ryanodine receptor calcium release channels. Physiol Rev (2002) 5.14

A general solution to the time interval omission problem applied to single channel analysis. Biophys J (1985) 5.04

Maximum likelihood estimation of aggregated Markov processes. Proc Biol Sci (1997) 4.96

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell (2003) 4.68

Allosteric mechanisms of signal transduction. Science (2005) 4.55

Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patients. Circulation (1995) 4.19

Burst kinetics of single calcium-activated potassium channels in cultured rat muscle. J Physiol (1983) 3.62

The voltage-gated potassium channels and their relatives. Nature (2002) 3.41

Mutations of the cardiac ryanodine receptor (RyR2) gene in familial polymorphic ventricular tachycardia. Circulation (2001) 3.34

Spontaneous openings of the acetylcholine receptor channel. Proc Natl Acad Sci U S A (1984) 3.34

Some precautions in using chelators to buffer metals in biological solutions. Cell Calcium (2004) 3.32

Structural mechanism of C-type inactivation in K(+) channels. Nature (2010) 3.30

RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci U S A (2004) 3.25

Enhanced basal activity of a cardiac Ca2+ release channel (ryanodine receptor) mutant associated with ventricular tachycardia and sudden death. Circ Res (2002) 2.64

Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum. J Physiol (1990) 2.47

Activation of NR1/NR2B NMDA receptors. Nat Neurosci (2003) 2.47

Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by luminal Ca2+. J Membr Biol (1994) 2.34

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Modulation of ryanodine receptor by luminal calcium and accessory proteins in health and cardiac disease. Cardiovasc Res (2007) 2.17

A mechanism for sudden infant death syndrome (SIDS): stress-induced leak via ryanodine receptors. Heart Rhythm (2007) 1.98

Macromolecular complexes regulating cardiac ryanodine receptor function. J Mol Cell Cardiol (2004) 1.93

Unliganded gating of acetylcholine receptor channels. Proc Natl Acad Sci U S A (2008) 1.80

Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants. J Gen Physiol (2000) 1.75

Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels. Nature (1997) 1.73

Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death. Cardiovasc Res (2004) 1.72

Ca2+ activation and Ca2+ inactivation of canine reconstituted cardiac sarcoplasmic reticulum Ca(2+)-release channels. J Physiol (1995) 1.71

The RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome: a comprehensive open reading frame mutational analysis. J Am Coll Cardiol (2009) 1.70

Molecular basis of Ca(2)+ activation of the mouse cardiac Ca(2)+ release channel (ryanodine receptor). J Gen Physiol (2001) 1.68

Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes. Proc Natl Acad Sci U S A (1999) 1.68

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ Res (2010) 1.61

Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit. J Neurosci (1997) 1.59

Postulated role of interdomain interaction within the ryanodine receptor in Ca(2+) channel regulation. J Biol Chem (2000) 1.59

Applying hidden Markov models to the analysis of single ion channel activity. Biophys J (2002) 1.55

Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites. Biophys J (2007) 1.54

Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance? Cardiovasc Res (2007) 1.42

A quantitative description of KcsA gating II: single-channel currents. J Gen Physiol (2007) 1.41

How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel? J Gen Physiol (1994) 1.37

Catecholaminergic polymorphic ventricular tachycardia. Prog Cardiovasc Dis (2008) 1.37

Molecular regulation of cardiac ryanodine receptor ion channel. Cell Calcium (2004) 1.34

Light at the end of the Ca(2+)-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels. Q Rev Biophys (2001) 1.30

On the structural basis of modal gating behavior in K(+) channels. Nat Struct Mol Biol (2010) 1.29

Gating reaction mechanisms for NMDA receptor channels. J Neurosci (2005) 1.28

Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels. Biophys J (2000) 1.27

Response of ryanodine receptor channels to Ca2+ steps produced by rapid solution exchange. Biophys J (1996) 1.26

Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage. Biophys J (1998) 1.25

Relationship between pore occupancy and gating in BK potassium channels. J Gen Physiol (2006) 1.24

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Mol Biol Cell (2004) 1.20

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A (2010) 1.20

Calcium-dependent gating of MthK, a prokaryotic potassium channel. J Gen Physiol (2006) 1.17

A model of the putative pore region of the cardiac ryanodine receptor channel. Biophys J (2004) 1.17

Model-based fitting of single-channel dwell-time distributions. Biophys J (2004) 1.13

The interaction of a neutral ryanoid with the ryanodine receptor channel provides insights into the mechanisms by which ryanoid binding is modulated by voltage. J Gen Physiol (2000) 1.11

Dysregulated sarcoplasmic reticulum calcium release: potential pharmacological target in cardiac disease. Pharmacol Ther (2008) 1.09

Catecholaminergic polymorphic ventricular tachycardia. Eur J Pediatr (2010) 1.08

Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyond. Curr Probl Cardiol (2009) 1.08

Calcium regulation of single ryanodine receptor channel gating analyzed using HMM/MCMC statistical methods. J Gen Physiol (2004) 1.06

Calcium activation of ryanodine receptor channels--reconciling RyR gating models with tetrameric channel structure. J Gen Physiol (2005) 1.06

Markovian models of low and high activity levels of cardiac ryanodine receptors. Biophys J (2001) 1.04

Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death. Biochem Biophys Res Commun (2005) 0.99

Kinetic diversity of Na+ channel bursts in frog skeletal muscle. J Gen Physiol (1989) 0.97

A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res (2011) 0.96

Modulation of Ca(2+)-gated cardiac muscle Ca(2+)-release channel (ryanodine receptor) by mono- and divalent ions. Am J Physiol (1998) 0.96

Allosteric modulation of ligand-gated ion channels. Biochem Pharmacol (2005) 0.96

Single channel analysis reveals different modes of Kv1.5 gating behavior regulated by changes of external pH. Biophys J (2005) 0.90

Loss of ryanodine receptor calcium-release channel expression associated with overactive urinary bladder smooth muscle contractions in a detrusor instability model. BJU Int (2005) 0.90

Ryanodine receptor as a new therapeutic target of heart failure and lethal arrhythmia. Circ J (2008) 0.90

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction. FEBS Lett (2010) 0.89

The structural biology of ryanodine receptors. Sci China Life Sci (2011) 0.89

The fifteen years of discoveries that shaped molecular electrophysiology: time for appraisal. Circ Res (2010) 0.88

Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP. J Membr Biol (2008) 0.88

Ryanodine receptor (RyR2) mutations in sudden cardiac death: studies in extended pedigrees and phenotypic characterization in vitro. Int J Cardiol (2009) 0.85

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochem Soc Trans (2007) 0.83

A two-gate model for the ryanodine receptor with allosteric modulation by caffeine and quercetin. Eur Biophys J (2008) 0.75

Articles by these authors

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs. Cell (2004) 16.15

Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis. Circ Res (2007) 1.83

Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current. Cardiovasc Res (2013) 1.57

Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies. J Mol Cell Cardiol (2006) 1.55

Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction. Circ Res (2005) 1.26

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Mol Biol Cell (2004) 1.20

A model of the putative pore region of the cardiac ryanodine receptor channel. Biophys J (2004) 1.17

Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials. Biophys J (2002) 1.12

Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction. J Biol Chem (2003) 1.06

CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. J Mol Biol (2009) 1.04

The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis. Cardiovasc Res (2002) 0.97

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. J Cell Sci (2012) 0.95

Ryanodine receptor interaction with the SNARE-associated protein snapin. J Cell Sci (2006) 0.93

Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2). Biophys J (2004) 0.89

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction. FEBS Lett (2010) 0.89

Myocardial calcium signalling and arrhythmia pathogenesis. Biochem Biophys Res Commun (2004) 0.89

Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor. Biophys J (2009) 0.87

The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides. J Gen Physiol (2012) 0.86

Pharmacological regulators of intracellular calcium release channels. Curr Pharm Des (2007) 0.85

N-terminus oligomerization regulates the function of cardiac ryanodine receptors. J Cell Sci (2013) 0.83

FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease. Biochem J (2009) 0.83

Excess noise in modified conductance states following the interaction of ryanoids with cardiac ryanodine receptor channels. FEBS Lett (2002) 0.83

Ryanodine-induced structural alterations in the RyR channel suggested by neomycin block. Biophys J (2002) 0.83

The interaction of an impermeant cation with the sheep cardiac RyR channel alters ryanoid association. Mol Pharmacol (2006) 0.83

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply. Cardiovasc Res (2013) 0.80

Functional characterization of the cardiac ryanodine receptor pore-forming region. PLoS One (2013) 0.80

Quantification of the effects of a ryanodine receptor channel mutation on interaction with a ryanoid. Mol Membr Biol (2007) 0.80

The ryanodine receptor pore: is there a consensus view? Curr Top Membr (2010) 0.80

The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance. Mol Pharmacol (2005) 0.79

An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channels. J Gen Physiol (2003) 0.79

Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors. Biochem Biophys Res Commun (2004) 0.79

Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochem Biophys Res Commun (2009) 0.78

Investigations of the contribution of a putative glycine hinge to ryanodine receptor channel gating. J Biol Chem (2013) 0.78

Voltage-sensitive equilibrium between two states within a ryanoid-modified conductance state of the ryanodine receptor channel. Biophys J (2005) 0.77

A novel and rapid approach to isolating functional ryanodine receptors. Biochem Biophys Res Commun (2002) 0.76

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Adv Exp Med Biol (2012) 0.75

Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death. Future Cardiol (2005) 0.75

Activation of the sheep cardiac Ca2+ release channel by simple heteroaromatics. Biochem Biophys Res Commun (2004) 0.75

Probing luminal negative charge in the type 3 ryanodine receptor. Biochem Biophys Res Commun (2005) 0.75