Published in Proc Natl Acad Sci U S A on July 16, 2012
Substrate-bound structure of the E. coli multidrug resistance transporter MdfA. Cell Res (2015) 0.93
Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. Proc Natl Acad Sci U S A (2013) 0.91
Expanding the Limits of Thermoacidophily in the Archaeon Sulfolobus solfataricus by Adaptive Evolution. Appl Environ Microbiol (2015) 0.78
Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions. Sci Rep (2016) 0.75
Structural comparison of bacterial multidrug efflux pumps of the major facilitator superfamily. Trends Cell Mol Biol (2016) 0.75
Analysis of a complete library of putative drug transporter genes in Escherichia coli. J Bacteriol (2001) 4.69
Multiple molecular mechanisms for multidrug resistance transporters. Nature (2007) 3.96
Efflux-mediated drug resistance in bacteria: an update. Drugs (2009) 3.18
MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J Bacteriol (1997) 2.62
Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proc Natl Acad Sci U S A (1996) 2.45
Phylogeny of multidrug transporters. Semin Cell Dev Biol (2001) 2.31
A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. EMBO J (1999) 1.61
Bioenergetics of the staphylococcal multidrug export protein QacA. Identification of distinct binding sites for monovalent and divalent cations. J Biol Chem (1999) 1.57
Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis. Proc Natl Acad Sci U S A (2004) 1.46
Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study. Nat Rev Microbiol (2005) 1.36
Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim Biophys Acta (2008) 1.24
Evidence for chloramphenicol/H+ antiport in Cmr (MdfA) system of Escherichia coli and properties of the antiporter. J Biochem (1998) 1.22
Evidence for simultaneous binding of dissimilar substrates by the Escherichia coli multidrug transporter MdfA. Biochemistry (2001) 1.22
The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions. Proc Natl Acad Sci U S A (2003) 1.17
Determinants of substrate recognition by the Escherichia coli multidrug transporter MdfA identified on both sides of the membrane. J Biol Chem (2003) 1.15
Functional expression of mouse mdr1 in Escherichia coli. Proc Natl Acad Sci U S A (1993) 1.11
Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates. J Biol Chem (2004) 1.09
Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA. Biochemistry (2004) 1.08
Dissection of mechanistic principles of a secondary multidrug efflux protein. Mol Cell (2012) 1.07
EmrE, a multidrug transporter from Escherichia coli, transports monovalent and divalent substrates with the same stoichiometry. J Biol Chem (2004) 1.05
Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli. Proc Natl Acad Sci U S A (1996) 1.04
A flexible cation binding site in the multidrug major facilitator superfamily transporter LmrP is associated with variable proton coupling. FASEB J (2010) 1.02
3D model of the Escherichia coli multidrug transporter MdfA reveals an essential membrane-embedded positive charge. Biochemistry (2005) 1.00
MdfA from Escherichia coli, a model protein for studying secondary multidrug transport. J Mol Microbiol Biotechnol (2006) 0.95
The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain. J Biol Chem (2009) 0.94
An early event in the transport mechanism of LacY protein: interaction between helices V and I. J Biol Chem (2011) 0.89
A promiscuous conformational switch in the secondary multidrug transporter MdfA. J Biol Chem (2009) 0.80
Alkaline pH homeostasis in bacteria: new insights. Biochim Biophys Acta (2005) 2.64
Structural basis for intramembrane proteolysis by rhomboid serine proteases. Proc Natl Acad Sci U S A (2006) 1.90
Prophage excision activates Listeria competence genes that promote phagosomal escape and virulence. Cell (2012) 1.87
Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis. Proc Natl Acad Sci U S A (2004) 1.46
Divergence of nucleosome positioning between two closely related yeast species: genetic basis and functional consequences. Mol Syst Biol (2010) 1.44
Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study. Nat Rev Microbiol (2005) 1.36
Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim Biophys Acta (2008) 1.24
Widespread remodeling of mid-coding sequence nucleosomes by Isw1. Genome Biol (2010) 1.18
The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions. Proc Natl Acad Sci U S A (2003) 1.17
Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL. Eur J Biochem (2002) 1.17
Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix. J Biol Chem (2007) 1.17
Determinants of substrate recognition by the Escherichia coli multidrug transporter MdfA identified on both sides of the membrane. J Biol Chem (2003) 1.15
Integrative genomic analysis identifies isoleucine and CodY as regulators of Listeria monocytogenes virulence. PLoS Genet (2012) 1.14
Chromatin regulators as capacitors of interspecies variations in gene expression. Mol Syst Biol (2010) 1.14
Promiscuity in the geometry of electrostatic interactions between the Escherichia coli multidrug resistance transporter MdfA and cationic substrates. J Biol Chem (2004) 1.09
How intramembrane proteases bury hydrolytic reactions in the membrane. Nature (2009) 1.08
Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters. Mol Microbiol (2006) 1.08
Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA. Biochemistry (2004) 1.08
Dissection of mechanistic principles of a secondary multidrug efflux protein. Mol Cell (2012) 1.07
The core Escherichia coli signal recognition particle receptor contains only the N and G domains of FtsY. J Bacteriol (2004) 1.03
Rhomboid cleaves Star to regulate the levels of secreted Spitz. EMBO J (2007) 1.03
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli. J Cell Biol (2002) 1.02
Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae. Mol Biol Cell (2013) 1.01
3D model of the Escherichia coli multidrug transporter MdfA reveals an essential membrane-embedded positive charge. Biochemistry (2005) 1.00
Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis. Am J Hum Genet (2012) 0.99
Membrane targeting of ribosomes and their release require distinct and separable functions of FtsY. J Biol Chem (2007) 0.98
Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs. Proc Natl Acad Sci U S A (2009) 0.96
Expression of Na+,K+-ATPase in Pichia pastoris: analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling. J Biol Chem (2003) 0.95
MdfA from Escherichia coli, a model protein for studying secondary multidrug transport. J Mol Microbiol Biotechnol (2006) 0.95
Membrane topology of the multidrug transporter MdfA: complementary gene fusion studies reveal a nonessential C-terminal domain. J Bacteriol (2002) 0.94
The secondary multidrug/proton antiporter MdfA tolerates displacements of an essential negatively charged side chain. J Biol Chem (2009) 0.94
Listeria monocytogenes multidrug resistance transporters and cyclic di-AMP, which contribute to type I interferon induction, play a role in cell wall stress. J Bacteriol (2013) 0.91
Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo. J Biol Chem (2010) 0.89
No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA. J Bacteriol (2006) 0.87
Cleavage of a multispanning membrane protein by an intramembrane serine protease. Biochemistry (2009) 0.86
Membrane chaperone SecDF plays a role in the secretion of Listeria monocytogenes major virulence factors. J Bacteriol (2013) 0.86
Target-directed proteolysis at the ribosome. Proc Natl Acad Sci U S A (2005) 0.85
The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA. Mol Microbiol (2014) 0.85
Escherichia coli SRP, its protein subunit Ffh, and the Ffh M domain are able to selectively limit membrane protein expression when overexpressed. MBio (2010) 0.83
A promiscuous conformational switch in the secondary multidrug transporter MdfA. J Biol Chem (2009) 0.80
Benefits of acupuncture for diabetic gastroparesis: a comparative preliminary study. Acupunct Med (2013) 0.80
Membrane protein biogenesis in Ffh- or FtsY-depleted Escherichia coli. PLoS One (2010) 0.79
E. coli multidrug transporter MdfA is a monomer. Biochemistry (2007) 0.79
Tumor lysis syndrome and malignant melanoma. Med Oncol (2013) 0.78
TECPR2: a new autophagy link for neurodegeneration. Autophagy (2013) 0.77
Radical polymerization of the silene (Me3Si)2Si=CR2 by hydrogen transfer from a trimethylsilyl group. Angew Chem Int Ed Engl (2009) 0.75
Expression of Na,K-ATPase in P. pastoris: Fe2+-catalyzed cleavage of the recombinant enzyme. Ann N Y Acad Sci (2003) 0.75
The bioterrorism threat and dual-use biotechnological research: an Israeli perspective. Sci Eng Ethics (2008) 0.75