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J Exp Med
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Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.
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Proc Natl Acad Sci U S A
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2004
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2.42
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3
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Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation.
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Am J Respir Crit Care Med
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2007
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2.17
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4
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Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition.
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Am J Pathol
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2005
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1.91
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5
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Unique characteristics of systemic sclerosis sine scleroderma-associated interstitial lung disease.
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2006
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Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis.
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Mol Cell Biol
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2009
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1.45
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7
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Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
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Am J Respir Cell Mol Biol
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2011
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1.44
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8
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Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension.
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Arthritis Rheum
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2011
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1.33
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9
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Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors.
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Arthritis Rheum
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2007
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1.33
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10
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Arthritis Rheum
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2007
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11
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Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis.
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Mol Cell Biol
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2010
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12
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Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration.
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Am J Pathol
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2006
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1.17
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13
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The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis.
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Arthritis Rheum
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2011
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1.13
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14
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Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis.
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Arthritis Rheum
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2006
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1.09
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15
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MAPK pathway mediates EGR-1-HSP70-dependent cigarette smoke-induced chemokine production.
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Am J Physiol Lung Cell Mol Physiol
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2007
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1.09
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16
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The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis.
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PLoS One
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2011
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1.02
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17
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Hepatocyte growth factor and other fibroblast secretions modulate the phenotype of human bronchial epithelial cells.
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Am J Physiol Lung Cell Mol Physiol
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2007
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1.02
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18
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The early growth response gene Egr2 (Alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses.
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Am J Pathol
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2011
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1.00
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19
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Anti-U11/U12 RNP antibodies in systemic sclerosis: a new serologic marker associated with pulmonary fibrosis.
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Arthritis Rheum
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2009
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0.99
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20
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The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms.
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Am J Pathol
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2009
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Human skin culture as an ex vivo model for assessing the fibrotic effects of insulin-like growth factor binding proteins.
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Open Rheumatol J
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2008
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Anti-th/to-positivity in a cohort of patients with idiopathic pulmonary fibrosis.
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J Rheumatol
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Localized expression of tenascin in systemic sclerosis-associated pulmonary fibrosis and its regulation by insulin-like growth factor binding protein 3.
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Arthritis Rheum
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A peptide derived from endostatin ameliorates organ fibrosis.
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Sci Transl Med
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Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
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Arthritis Rheum
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The pro-fibrotic factor IGFBP-5 induces lung fibroblast and mononuclear cell migration.
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Am J Respir Cell Mol Biol
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2009
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Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism.
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Hum Immunol
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Telomerase and telomere length in pulmonary fibrosis.
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Am J Respir Cell Mol Biol
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Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways.
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Am J Pathol
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2008
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A systems biology approach to genetic studies of complex diseases.
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FEBS Lett
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Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts.
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Am J Respir Cell Mol Biol
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Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles.
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Arthritis Rheum
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2005
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Transcriptional regulation of increased CCL2 expression in pulmonary fibrosis involves nuclear factor-κB and activator protein-1.
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Int J Biochem Cell Biol
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Decreased caveolin-1 levels contribute to fibrosis and deposition of extracellular IGFBP-5.
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J Cell Mol Med
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Role of insulin-like growth factor binding protein-3 in allergic airway remodeling.
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Am J Respir Crit Care Med
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HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors.
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PLoS One
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Pathogenesis of pulmonary fibrosis in systemic sclerosis: lessons from interstitial lung disease.
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Curr Rheumatol Rep
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Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD.
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Proc Am Thorac Soc
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Update on scleroderma-associated interstitial lung disease.
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Curr Opin Rheumatol
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Autoimmunity in idiopathic pulmonary fibrosis: are circulating autoantibodies pathogenic or epiphenomena?
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Am J Respir Crit Care Med
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Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis.
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PLoS One
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Estradiol promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
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Arthritis Res Ther
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2013
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Insulin-like growth factor binding proteins-3 and -5: central mediators of fibrosis and promising new therapeutic targets.
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Open Rheumatol J
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Interferon-gamma inducible protein-10 as a potential biomarker in localized scleroderma.
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Arthritis Res Ther
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Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts.
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PLoS One
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Editorial: molecular insights into systemic sclerosis-associated interstitial lung disease.
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Arthritis Rheumatol
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Role of endostatin in fibroproliferative disorders.-as a candidate for anti-fibrosis therapy-.
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Crit Rev Eukaryot Gene Expr
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IGF-I: mediator of fibrosis or carcinogenesis?
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Am J Physiol Lung Cell Mol Physiol
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Curr Opin Rheumatol
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