Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease.

PubWeight™: 2.42‹?› | Rank: Top 2%

🔗 View Article (PMC 522001)

Published in Proc Natl Acad Sci U S A on October 05, 2004

Authors

Wen Ning1, Chao-Jun Li, Naftali Kaminski, Carol A Feghali-Bostwick, Sean M Alber, Yuanpu P Di, Sherrie L Otterbein, Ruiping Song, Shizu Hayashi, Zhihong Zhou, David J Pinsky, Simon C Watkins, Joseph M Pilewski, Frank C Sciurba, David G Peters, James C Hogg, Augustine M K Choi

Author Affiliations

1: Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Articles citing this

The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest (2008) 3.90

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67

Essential role of MMP-12 in Fas-induced lung fibrosis. Am J Respir Cell Mol Biol (2007) 2.16

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted. Physiol Rev (2007) 2.14

CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2015) 1.99

Accelerated variant of idiopathic pulmonary fibrosis: clinical behavior and gene expression pattern. PLoS One (2007) 1.88

A dynamic bronchial airway gene expression signature of chronic obstructive pulmonary disease and lung function impairment. Am J Respir Crit Care Med (2013) 1.73

Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol (2007) 1.68

Comparison of normalization methods for CodeLink Bioarray data. BMC Bioinformatics (2005) 1.65

Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. PLoS Genet (2015) 1.52

Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol (2008) 1.51

Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med (2008) 1.50

Effect of active smoking on the human bronchial epithelium transcriptome. BMC Genomics (2007) 1.50

Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med (2007) 1.46

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression. Am J Physiol Lung Cell Mol Physiol (2009) 1.40

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med (2012) 1.38

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol (2011) 1.35

Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.35

Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma. Am J Pathol (2008) 1.30

Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs. Respir Res (2009) 1.29

Lung fibroblasts from patients with emphysema show markers of senescence in vitro. Respir Res (2006) 1.18

Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice. J Clin Invest (2011) 1.17

Pulmonary response to surface-coated nanotitanium dioxide particles includes induction of acute phase response genes, inflammatory cascades, and changes in microRNAs: a toxicogenomic study. Environ Mol Mutagen (2011) 1.16

Cytokine inhibition in the treatment of COPD. Int J Chron Obstruct Pulmon Dis (2014) 1.16

Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium. Am J Respir Crit Care Med (2010) 1.14

Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences. Int J Chron Obstruct Pulmon Dis (2011) 1.14

The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. Exp Cell Res (2007) 1.13

Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13

Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2013) 1.12

Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells. Am J Respir Cell Mol Biol (2006) 1.11

Quality control in microarray assessment of gene expression in human airway epithelium. BMC Genomics (2009) 1.10

Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis. J Biol Chem (2011) 1.07

CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. Am J Pathol (2008) 1.06

Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J (2011) 1.05

Translating the COPD transcriptome: insights into pathogenesis and tools for clinical management. Proc Am Thorac Soc (2008) 1.04

Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2012) 1.01

Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke. BMC Med Genomics (2009) 1.01

Transcriptomic studies of the airway field of injury associated with smoking-related lung disease. Proc Am Thorac Soc (2011) 0.99

The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. Am J Pathol (2009) 0.99

The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nat Commun (2015) 0.99

Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma (2011) 0.99

Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice. J Exp Med (2015) 0.98

Expression profiling identifies genes involved in emphysema severity. Respir Res (2009) 0.98

Identifying targets for COPD treatment through gene expression analyses. Int J Chron Obstruct Pulmon Dis (2008) 0.95

Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med (2016) 0.93

Role of the CX3CL1-CX3CR1 axis in chronic inflammatory lung diseases. Int J Clin Exp Med (2010) 0.93

What drives the peripheral lung-remodeling process in chronic obstructive pulmonary disease? Proc Am Thorac Soc (2009) 0.92

National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc (2008) 0.92

DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. Am J Respir Cell Mol Biol (2014) 0.91

Genetics and genomics of chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 0.91

RAGE and tobacco smoke: insights into modeling chronic obstructive pulmonary disease. Front Physiol (2012) 0.90

CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. PLoS One (2013) 0.90

The Epithelial Cell in Lung Health and Emphysema Pathogenesis. Curr Respir Med Rev (2006) 0.90

Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am J Respir Cell Mol Biol (2014) 0.89

Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol (2006) 0.89

Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling. Am J Pathol (2010) 0.89

Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation. J Biol Chem (2013) 0.88

Cytokine-induced tumor suppressors: a GRIM story. Cytokine (2010) 0.88

A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. Genome Med (2014) 0.87

In utero exposure to second-hand smoke aggravates adult responses to irritants: adult second-hand smoke. Am J Respir Cell Mol Biol (2012) 0.87

Role of elastases in the pathogenesis of chronic obstructive pulmonary disease: implications for treatment. Eur J Med Res (2010) 0.85

MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression. BMC Genomics (2014) 0.85

Cigarette smoke exposure inhibits extracellular MMP-2 (gelatinase A) activity in human lung fibroblasts. Respir Res (2007) 0.85

Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med (2016) 0.85

Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol (2014) 0.83

Integrative genomics of chronic obstructive pulmonary disease. Biochem Biophys Res Commun (2014) 0.82

Inhaled steroids modulate extracellular matrix composition in bronchial biopsies of COPD patients: a randomized, controlled trial. PLoS One (2013) 0.82

Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD. PLoS One (2011) 0.82

High bias gas flows increase lung injury in the ventilated preterm lamb. PLoS One (2012) 0.82

Delayed apoptosis by neutrophils from COPD patients is associated with altered Bak, Bcl-xl, and Mcl-1 mRNA expression. Diagn Pathol (2012) 0.80

Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: a case-control study. BMJ Open (2012) 0.80

Heterogeneity of lung mononuclear phagocytes in chronic obstructive pulmonary disease. J Innate Immun (2012) 0.79

Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease. Med J Islam Repub Iran (2014) 0.78

GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation. Am J Pathol (2011) 0.78

Genome-wide association and network analysis of lung function in the Framingham Heart Study. Genet Epidemiol (2014) 0.78

The mode of lymphoblastoid cell death in response to gas phase cigarette smoke is dose-dependent. Respir Res (2009) 0.78

Comprehensive Analysis of Transcriptome Sequencing Data in the Lung Tissues of COPD Subjects. Int J Genomics (2015) 0.78

Chronic respiratory symptoms in Croatian Adriatic island metapopulations. Croat Med J (2006) 0.78

Environmental-stress-induced Chromatin Regulation and its Heritability. J Carcinog Mutagen (2014) 0.78

Activation of Egr-1 in human lung epithelial cells exposed to silica through MAPKs signaling pathways. PLoS One (2013) 0.77

Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung. Ann Am Thorac Soc (2013) 0.77

Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study. Crit Care (2014) 0.77

Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease. Respir Res (2009) 0.77

Genes related to emphysema are enriched for ubiquitination pathways. BMC Pulm Med (2014) 0.77

Retracted Protein-protein interaction network analysis in chronic obstructive pulmonary disease. Lung (2013) 0.77

GRIM-19: A Double-edged Sword that Regulates Anti-Tumor and Innate Immune Responses. Transl Oncogenomics (2008) 0.76

Association of MicroRNA-196a2 Variant with Response to Short-Acting β2-Agonist in COPD: An Egyptian Pilot Study. PLoS One (2016) 0.76

S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin. Sci Rep (2016) 0.76

Impaired elastin deposition in Fstl1-/- lung allograft under the renal capsule. PLoS One (2013) 0.76

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget (2015) 0.75

SEGEL: A Web Server for Visualization of Smoking Effects on Human Lung Gene Expression. PLoS One (2015) 0.75

The role of small heat-shock protein αB-crystalline (HspB5) in COPD pathogenesis. Int J Chron Obstruct Pulmon Dis (2012) 0.75

Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep (2017) 0.75

Apical Secretion of FSTL1 in the Respiratory Epithelium for Normal Lung Development. PLoS One (2016) 0.75

Cigarette smoke extract induces placental growth factor release from human bronchial epithelial cells via ROS/MAPK (ERK-1/2)/Egr-1 axis. Int J Chron Obstruct Pulmon Dis (2016) 0.75

Exploring the interaction among EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population. Hum Genomics (2016) 0.75

Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD Severity. COPD (2016) 0.75

Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA. Immun Inflamm Dis (2017) 0.75

Next-Generation Sequencing: The Translational Medicine Approach from "Bench to Bedside to Population". Medicines (Basel) (2016) 0.75

Articles cited by this

Serial analysis of gene expression. Science (1995) 60.15

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med (2001) 27.83

FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. Bioinformatics (2004) 26.64

Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate. Nucleic Acids Res (2003) 9.30

The expression of three abundance classes of messenger RNA in mouse tissues. Cell (1976) 5.58

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron (2000) 4.29

Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction. J Mol Diagn (2000) 3.59

Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science (1996) 3.39

Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem (1994) 3.37

Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol (2001) 2.23

Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med (2001) 1.98

Generation of longer cDNA fragments from serial analysis of gene expression tags for gene identification. Proc Natl Acad Sci U S A (2000) 1.69

Arterial enlargement in response to high flow requires early expression of matrix metalloproteinases to degrade extracellular matrix. Exp Mol Pathol (2002) 1.62

Caspase-3 mediated neuronal death after traumatic brain injury in rats. J Neurochem (2000) 1.59

Practical approaches to analyzing results of microarray experiments. Am J Respir Cell Mol Biol (2002) 1.55

Molecular characteristics of non-small cell lung cancer. Proc Natl Acad Sci U S A (2001) 1.53

Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am J Respir Cell Mol Biol (2002) 1.52

Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J Biol Chem (1999) 1.41

Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1. Am J Physiol Cell Physiol (2002) 1.37

Epithelium-fibroblast interactions in response to airway inflammation. Immunol Cell Biol (2001) 1.19

The new role of SAGE in gene discovery. Trends Biotechnol (2003) 1.17

Tobacco smoke reduces viability in human lung fibroblasts: protective effect of glutathione S-transferase P1. Am J Physiol Lung Cell Mol Physiol (2001) 1.11

Expression of Egr-1 in late stage emphysema. Am J Pathol (2000) 1.11

Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. J Immunol (2001) 1.11

Genetic and environmental modulation of chronic obstructive pulmonary disease. Respir Physiol (2001) 1.10

TGF-beta1 stimulates HO-1 via the p38 mitogen-activated protein kinase in A549 pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol (2002) 1.09

Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis. Blood (2001) 1.09

Egr-1: is it always immediate and early? J Clin Invest (2000) 1.02

COPD in perspective. Chest (2002) 1.01

Mechanisms of COPD: conference summary. Chest (2000) 1.00

Genome-wide analysis of the endothelial transcriptome under short-term chronic hypoxia. Physiol Genomics (2004) 0.95

Serial analysis of gene expression to assess the endothelial cell response to an atherogenic stimulus. Gene (1999) 0.95

Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem (2002) 0.92

Retinoic acid attenuates cytokine-driven fibroblast degradation of extracellular matrix in three-dimensional culture. Am J Respir Cell Mol Biol (2001) 0.92

Analysis of host responses to microbial infection using gene expression profiling. Curr Opin Microbiol (2001) 0.92

Identification of genes that are induced after cadmium exposure by suppression subtractive hybridization. Toxicology (2003) 0.83

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med (2004) 17.08

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nat Med (2008) 9.05

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

Azithromycin for prevention of exacerbations of COPD. N Engl J Med (2011) 8.66

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8.33

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev (2006) 7.76

Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A (2003) 7.41

Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2007) 6.71

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. N Engl J Med (2010) 6.23

Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood (2011) 5.82

Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71

From signatures to models: understanding cancer using microarrays. Nat Genet (2005) 4.29

Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol (2002) 4.28

Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19

Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. N Engl J Med (2011) 4.16

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature (2003) 4.02

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A (2002) 4.00

Association of radiographic emphysema and airflow obstruction with lung cancer. Am J Respir Crit Care Med (2008) 3.94

Gene expression profiles distinguish idiopathic pulmonary fibrosis from hypersensitivity pneumonitis. Am J Respir Crit Care Med (2005) 3.72

Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood (2004) 3.68

Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med (2014) 3.51

Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol (2005) 3.47

Peripheral blood proteins predict mortality in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2012) 3.42

The lung tissue microbiome in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 3.36

Mechanisms of cell death in oxidative stress. Antioxid Redox Signal (2007) 3.33

Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008. Am J Respir Crit Care Med (2011) 3.33

Characterization of airway plugging in fatal asthma. Am J Med (2003) 3.23

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet (2013) 3.17

Up-regulation and profibrotic role of osteopontin in human idiopathic pulmonary fibrosis. PLoS Med (2005) 3.15

Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. J Biol Chem (2007) 3.09

Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway. J Biol Chem (2004) 3.06

Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02

The prediction of small airway dimensions using computed tomography. Am J Respir Crit Care Med (2004) 3.02

CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94

Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med (2012) 2.92

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med (2006) 2.92

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation. Thorax (2011) 2.84

MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med (2008) 2.79

Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med (2006) 2.77

Autophagy in human health and disease. N Engl J Med (2013) 2.73

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70

Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 2.68

Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol (2013) 2.60

Radiographic emphysema predicts low bone mineral density in a tobacco-exposed cohort. Am J Respir Crit Care Med (2010) 2.60

Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. Am J Respir Crit Care Med (2004) 2.60

Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome. Am J Med (2011) 2.59

Long-term follow-up of patients receiving lung-volume-reduction surgery versus medical therapy for severe emphysema by the National Emphysema Treatment Trial Research Group. Ann Thorac Surg (2006) 2.53

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J (2002) 2.53

Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain. Eur Heart J (2006) 2.47

Gene expression profiles of acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2009) 2.43

Idiopathic pulmonary fibrosis: aberrant recapitulation of developmental programs? PLoS Med (2008) 2.41

Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer. Am J Respir Crit Care Med (2007) 2.39

Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy (2008) 2.38

WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis. Am J Respir Cell Mol Biol (2009) 2.36

hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J (2006) 2.35

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33

Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet (2004) 2.32

First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. Cancer Discov (2012) 2.31

Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation data. PLoS One (2009) 2.29

Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem (2005) 2.28

An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23

A novel genomic signature with translational significance for human idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol (2015) 2.21

Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis. JAMA (2013) 2.20

Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic (2006) 2.20

A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis. Am J Pathol (2008) 2.17

Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med (2007) 2.17

Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest (2003) 2.16

Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol Cell Biochem (2002) 2.16

Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest (2005) 2.15

Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury. Nat Med (2003) 2.15

Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol (2003) 2.14

The relationship between pulmonary emphysema and kidney function in smokers. Chest (2012) 2.13

Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol (2002) 2.12

Automated lung segmentation in X-ray computed tomography: development and evaluation of a heuristic threshold-based scheme. Acad Radiol (2003) 2.10

MicroRNAs in idiopathic pulmonary fibrosis. Transl Res (2011) 2.10

Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet (2012) 2.09

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 2.06

Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization. Am J Respir Crit Care Med (2004) 2.05

Comparative analysis of algorithms for signal quantitation from oligonucleotide microarrays. Bioinformatics (2004) 2.04

Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology. Am J Respir Crit Care Med (2007) 2.04

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress. J Biol Chem (2003) 2.04

CO as a cellular signaling molecule. Annu Rev Pharmacol Toxicol (2006) 2.03

Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. Am J Physiol Heart Circ Physiol (2010) 2.03

Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood (2002) 2.02

Inhaled hydrogen sulfide protects against ventilator-induced lung injury. Anesthesiology (2010) 2.02

Quantification of lung microstructure with hyperpolarized 3He diffusion MRI. J Appl Physiol (1985) (2009) 2.01