PubRank

Robert P Mecham

Author PubWeight™ 108.71‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 2004 4.85
2 Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest 2006 3.11
3 Vascular extracellular matrix and arterial mechanics. Physiol Rev 2009 3.05
4 Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 2003 2.68
5 New insights into elastic fiber assembly. Birth Defects Res C Embryo Today 2007 2.20
6 Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol 2005 2.06
7 Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest 2003 2.05
8 Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med 2003 1.94
9 Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem 2002 1.90
10 Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease. Circ Res 2007 1.83
11 The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem 2005 1.69
12 Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol 2004 1.58
13 Vascular extracellular matrix and aortic development. Curr Top Dev Biol 2004 1.53
14 Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res 2009 1.51
15 Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol 2006 1.47
16 Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. J Biol Chem 2005 1.46
17 Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab 2008 1.45
18 A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. J Immunol 2003 1.38
19 The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein. J Biol Chem 2001 1.37
20 Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A 2005 1.37
21 Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res 2005 1.37
22 Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Hum Mol Genet 2006 1.31
23 The stumbling block in lung repair of emphysema: elastic fiber assembly. Proc Am Thorac Soc 2006 1.28
24 Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. J Biol Chem 2003 1.27
25 Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab 2011 1.27
26 Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Res 2008 1.26
27 Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. J Biol Chem 2008 1.26
28 Elastin in large artery stiffness and hypertension. J Cardiovasc Transl Res 2012 1.21
29 New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations. Hum Mutat 2011 1.20
30 Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem 2004 1.18
31 Discrete contributions of elastic fiber components to arterial development and mechanical compliance. Arterioscler Thromb Vasc Biol 2009 1.18
32 Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice. Am J Physiol Heart Circ Physiol 2011 1.16
33 Fibulin-2 is dispensable for mouse development and elastic fiber formation. Mol Cell Biol 2007 1.16
34 Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema. Am J Physiol Lung Cell Mol Physiol 2006 1.15
35 A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2005 1.14
36 Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arterioscler Thromb Vasc Biol 2011 1.11
37 Microfibril-associated MAGP-2 stimulates elastic fiber assembly. J Biol Chem 2006 1.10
38 Elastic fiber macro-assembly is a hierarchical, cell motion-mediated process. J Cell Physiol 2006 1.09
39 Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. J Biol Chem 2008 1.08
40 Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment. Biochem J 2003 1.07
41 Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circ Res 2007 1.06
42 The importance of elastin to aortic development in mice. Am J Physiol Heart Circ Physiol 2010 1.05
43 Development, composition, and structural arrangements of the ciliary zonule of the mouse. Invest Ophthalmol Vis Sci 2013 1.04
44 Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture. Am J Physiol Heart Circ Physiol 2007 1.04
45 Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure. J Appl Physiol (1985) 2008 1.04
46 Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. Circ Res 2010 1.02
47 Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry 2008 1.01
48 Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. J Biol Chem 2003 1.00
49 Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts. J Cell Sci 2010 0.99
50 Mechanisms of emphysema in autosomal dominant cutis laxa. Matrix Biol 2010 0.99
51 Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arterioscler Thromb Vasc Biol 2011 0.96
52 Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis. Dev Dyn 2008 0.96
53 Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells. Matrix Biol 2004 0.95
54 Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice. J Cell Biochem 2012 0.94
55 Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 2003 0.94
56 Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling. J Biol Chem 2010 0.94
57 Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood 2008 0.93
58 Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. J Biol Chem 2004 0.93
59 Ocular phenotype of Fbn2-null mice. Invest Ophthalmol Vis Sci 2013 0.93
60 Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. J Biol Chem 2002 0.92
61 A fiber-based constitutive model predicts changes in amount and organization of matrix proteins with development and disease in the mouse aorta. Biomech Model Mechanobiol 2012 0.91
62 Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle. J Am Heart Assoc 2013 0.91
63 Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. J Biol Chem 2010 0.90
64 Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation. J Biol Chem 2011 0.89
65 Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. J Physiol 2015 0.89
66 Domains 16 and 17 of tropoelastin in elastic fibre formation. Biochem J 2007 0.89
67 Processing of type II procollagen amino propeptide by matrix metalloproteinases. J Biol Chem 2001 0.88
68 Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J Biol Chem 2013 0.87
69 Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. Am J Respir Cell Mol Biol 2015 0.87
70 Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome. Invest Ophthalmol Vis Sci 2013 0.85
71 Characterization of an in vitro model of calcification in retinal pigmented epithelial cells. J Atheroscler Thromb 2003 0.85
72 Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle? Mol Genet Genomics 2008 0.85
73 Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration. Am J Respir Cell Mol Biol 2007 0.83
74 Tropoelastin inhibits vascular calcification via 67-kDa elastin binding protein in cultured bovine aortic smooth muscle cells. J Atheroscler Thromb 2004 0.82
75 Ultrastructural properties of ciliary zonule microfibrils. J Struct Biol 2002 0.82
76 Paxillin contracts the osteoclast cytoskeleton. J Bone Miner Res 2012 0.81
77 Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa. J Biol Chem 2012 0.81
78 The intracellular form of human MAGP1 elicits a complex and specific transcriptional response. Int J Biochem Cell Biol 2007 0.80
79 Expression of elastic components in healthy and varicose veins. World J Surg 2003 0.79
80 Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding. J Biol Chem 2011 0.79
81 Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. J Appl Physiol (1985) 2006 0.79
82 The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix. Macromol Biosci 2010 0.79
83 Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing. Clin Exp Pharmacol Physiol 2009 0.79
84 Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency. Am J Physiol Heart Circ Physiol 2014 0.79
85 B-Myb represses elastin gene expression in aortic smooth muscle cells. J Biol Chem 2004 0.79
86 Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin. Matrix Biol 2008 0.78
87 Characterization of erectile function in elastin haploinsufficicent mice. J Sex Med 2011 0.78
88 Zap70 inhibits Syk-mediated osteoclast function. J Cell Biochem 2013 0.78
89 Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells. Biochim Biophys Acta 2005 0.77
90 Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner. J Biol Chem 2013 0.75
91 Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry 2006 0.75
92 Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells. J Atheroscler Thromb 2002 0.75
93 Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study. J Voice 2010 0.75