Published in J Bone Miner Res on December 01, 2012
Osteoclasts-Key Players in Skeletal Health and Disease. Microbiol Spectr (2016) 0.88
Vinculin regulates osteoclast function. J Biol Chem (2014) 0.81
Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms. J Bone Miner Res (2015) 0.80
Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol (2016) 0.76
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest (2000) 4.54
Paxillin: adapting to change. Physiol Rev (2004) 4.48
Paxillin and focal adhesion signalling. Nat Cell Biol (2000) 4.37
Paxillin comes of age. J Cell Sci (2008) 3.57
Osteoclastic bone resorption by a polarized vacuolar proton pump. Science (1989) 3.31
Paxillin: a focal adhesion-associated adaptor protein. Oncogene (2001) 3.03
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. J Cell Biol (2000) 2.13
Cytoskeletal coherence requires myosin-IIA contractility. J Cell Sci (2010) 2.13
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev (1997) 2.08
The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly. PLoS One (2007) 2.06
A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development (2004) 1.92
Paget disease of bone. J Clin Invest (2005) 1.92
Apatite-mediated actin dynamics in resorbing osteoclasts. Mol Biol Cell (2004) 1.91
High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype. J Cell Biochem (2003) 1.87
Podosomes in osteoclast-like cells: structural analysis and cooperative roles of paxillin, proline-rich tyrosine kinase 2 (Pyk2) and integrin alphaVbeta3. J Cell Sci (2001) 1.79
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med (2002) 1.71
GATA2 functions at multiple steps in hemangioblast development and differentiation. Development (2006) 1.69
A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J (2000) 1.67
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol Biol Cell (2007) 1.66
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin. J Cell Biol (2003) 1.65
Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation. Eur J Cell Biol (2008) 1.59
Paxillin phosphorylation controls invadopodia/podosomes spatiotemporal organization. Mol Biol Cell (2007) 1.39
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell (2008) 1.38
Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts. J Clin Invest (1997) 1.32
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol (2011) 1.32
Glycogen synthase kinase 3- and extracellular signal-regulated kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement. Mol Cell Biol (2006) 1.26
Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene (2002) 1.17
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol (2003) 1.15
Rac deletion in osteoclasts causes severe osteopetrosis. J Cell Sci (2011) 1.10
Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts. J Cell Sci (2002) 1.02
Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts. J Cell Sci (2010) 0.99
c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton. Mol Cell Biol (2012) 0.97
Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion. J Biol Chem (2009) 0.96
Surface-induced regulation of podosome organization and dynamics in cultured osteoclasts. Chembiochem (2009) 0.93
Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology (2000) 0.84
TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest (2004) 4.85
Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell (2009) 3.96
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64
IL-1 mediates TNF-induced osteoclastogenesis. J Clin Invest (2005) 3.56
Elastin fragments drive disease progression in a murine model of emphysema. J Clin Invest (2006) 3.11
Vascular extracellular matrix and arterial mechanics. Physiol Rev (2009) 3.05
Osteopetrosis. N Engl J Med (2004) 2.95
Autophagy proteins regulate the secretory component of osteoclastic bone resorption. Dev Cell (2011) 2.84
Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest (2003) 2.68
Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev (2006) 2.56
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell (2008) 2.46
The osteoclast: friend or foe? Annu Rev Pathol (2008) 2.45
Vav3 regulates osteoclast function and bone mass. Nat Med (2005) 2.30
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol (2007) 2.27
New insights into elastic fiber assembly. Birth Defects Res C Embryo Today (2007) 2.20
The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis. J Exp Med (2003) 2.20
c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. J Clin Invest (2003) 2.19
Depression, antidepressants, and bone health in older adults: a systematic review. J Am Geriatr Soc (2014) 2.08
The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol (2007) 2.07
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. Am J Physiol Heart Circ Physiol (2005) 2.06
Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest (2003) 2.05
NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem (2007) 1.99
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. Mol Cell Biol (2006) 1.97
Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nat Med (2003) 1.94
Glucocorticoids suppress bone formation via the osteoclast. J Clin Invest (2006) 1.92
A hierarchical order of factors in the generation of FLK1- and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development (2004) 1.92
Lysyl oxidase is required for vascular and diaphragmatic development in mice. J Biol Chem (2002) 1.90
High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype. J Cell Biochem (2003) 1.87
Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease. Circ Res (2007) 1.83
alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol Rev (2005) 1.81
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med (2002) 1.71
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest (2010) 1.71
GATA2 functions at multiple steps in hemangioblast development and differentiation. Development (2006) 1.69
The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. J Biol Chem (2005) 1.69
Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol (2012) 1.68
Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS Genet (2011) 1.68
Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol In Vitro (2009) 1.67
Highly restricted localization of RNA polymerase II within a locus control region of a tissue-specific chromatin domain. Mol Cell Biol (2003) 1.66
Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles. Environ Toxicol Pharmacol (2010) 1.65
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin. J Cell Biol (2003) 1.65
M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest (2005) 1.64
Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Genes Dev (2003) 1.62
Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene (2002) 1.62
Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. J Invest Dermatol (2004) 1.58
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis. J Lipid Res (2005) 1.58
Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development (2006) 1.56
Interleukin-4 reversibly inhibits osteoclastogenesis via inhibition of NF-kappa B and mitogen-activated protein kinase signaling. J Biol Chem (2001) 1.55
Vascular extracellular matrix and aortic development. Curr Top Dev Biol (2004) 1.53
DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell (2008) 1.52
Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circ Res (2009) 1.51
Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. Blood (2008) 1.51
Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo. J Immunol (2004) 1.50
Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression. Development (2002) 1.47
Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol (2006) 1.47
Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. J Biol Chem (2005) 1.46
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab (2008) 1.45
The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling. J Clin Invest (2004) 1.45
Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (2008) 1.40
Animal rights pressure on scientists. Science (2002) 1.39
A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. J Immunol (2003) 1.38
Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell (2008) 1.38
The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein. J Biol Chem (2001) 1.37
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A (2005) 1.37
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circ Res (2005) 1.37
Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway. Mol Cell (2010) 1.34
Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Hum Mol Genet (2006) 1.31
Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain. J Biol Chem (2003) 1.31
The stumbling block in lung repair of emphysema: elastic fiber assembly. Proc Am Thorac Soc (2006) 1.28
Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. J Biol Chem (2003) 1.27
Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology (2009) 1.27
Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Mol Genet Metab (2011) 1.27
Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Res (2008) 1.26
Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. J Biol Chem (2008) 1.26
Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene (2005) 1.25
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J Clin Invest (2005) 1.25
Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol (2008) 1.23
Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science (2013) 1.22
Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis. J Immunol (2003) 1.21
Elastin in large artery stiffness and hypertension. J Cardiovasc Transl Res (2012) 1.21
New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations. Hum Mutat (2011) 1.20
Evidence for the hemangioblast. Exp Hematol (2005) 1.20
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain. J Biol Chem (2004) 1.18
Discrete contributions of elastic fiber components to arterial development and mechanical compliance. Arterioscler Thromb Vasc Biol (2009) 1.18
Paxillin null embryonic stem cells are impaired in cell spreading and tyrosine phosphorylation of focal adhesion kinase. Oncogene (2002) 1.17
Critical role of beta3 integrin in experimental postmenopausal osteoporosis. J Bone Miner Res (2005) 1.17
Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice. Am J Physiol Heart Circ Physiol (2011) 1.16
Fibulin-2 is dispensable for mouse development and elastic fiber formation. Mol Cell Biol (2007) 1.16
Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema. Am J Physiol Lung Cell Mol Physiol (2006) 1.15
Both primitive and definitive blood cells are derived from Flk-1+ mesoderm. Blood (2008) 1.15
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2005) 1.14
ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood (2012) 1.14
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling. J Immunol (2010) 1.13
Bioavailability and toxicokinetics of citrate-coated silver nanoparticles in rats. Arch Pharm Res (2011) 1.12
Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arterioscler Thromb Vasc Biol (2011) 1.11
c-Fms tyrosine 559 is a major mediator of M-CSF-induced proliferation of primary macrophages. J Biol Chem (2007) 1.11
Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology (2009) 1.11
Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. Virology (2003) 1.11