Published in PLoS One on July 17, 2012
Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicol Sci (2013) 1.53
The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells. Cell Death Dis (2014) 0.95
The aryl hydrocarbon receptor: a novel target for immunomodulation in organ transplantation. Transplantation (2013) 0.86
Dioxin receptor regulates aldehyde dehydrogenase to block melanoma tumorigenesis and metastasis. Mol Cancer (2015) 0.84
Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One (2014) 0.83
Leflunomide suppresses growth in human medullary thyroid cancer cells. J Surg Res (2013) 0.78
Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells. Exp Biol Med (Maywood) (2014) 0.78
Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. Oncotarget (2016) 0.78
Leflunomide Induces Pulmonary and Hepatic CYP1A Enzymes via Aryl Hydrocarbon Receptor. Drug Metab Dispos (2015) 0.77
The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis (2015) 0.77
Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. Oncogene (2015) 0.77
Role of the Aryl Hydrocarbon Receptor in Colon Neoplasia. Cancers (Basel) (2015) 0.76
Inhibition of p70 S6 kinase (S6K1) activity by A77 1726 and its effect on cell proliferation and cell cycle progress. Neoplasia (2014) 0.76
Leflunomide induces NAD(P)H quinone dehydrogenase 1 enzyme via the aryl hydrocarbon receptor in neonatal mice. Biochem Biophys Res Commun (2017) 0.75
Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity. Acta Pharmacol Sin (2016) 0.75
The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy. Curr Opin Toxicol (2017) 0.75
The Complex Biology of the Aryl Hydrocarbon Receptor and Its Role in the Pituitary Gland. Horm Cancer (2017) 0.75
Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase. J Cancer (2017) 0.75
Is chronic AhR activation by rapidly metabolized ligands safe for the treatment of immune-mediated diseases? Curr Opin Toxicol (2017) 0.75
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research. Breast Cancer Res Treat (2006) 4.04
The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr (2008) 3.06
DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature (2011) 2.23
Early detection and treatment of skin cancer. Am Fam Physician (2000) 2.03
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers. J Clin Invest (2008) 1.95
Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem (2000) 1.77
Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol (1999) 1.72
p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev (1999) 1.68
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell (2008) 1.66
Aryl hydrocarbon receptor, cell cycle regulation, toxicity, and tumorigenesis. J Cell Biochem (2005) 1.59
Dynamic monitoring of cell adhesion and spreading on microelectronic sensor arrays. J Biomol Screen (2005) 1.52
The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry (1996) 1.48
Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol (2007) 1.43
The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer Res (2009) 1.37
The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol Cell Biol (1996) 1.34
Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol (1995) 1.33
Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. J Med Chem (2009) 1.28
Role of the aryl hydrocarbon receptor in cell cycle regulation. Chem Biol Interact (2002) 1.23
Complementation of Ah receptor deficiency in hepatoma cells: negative feedback regulation and cell cycle control by the Ah receptor. Exp Cell Res (1996) 1.22
Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). Int J Oncol (2002) 1.20
The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene (2005) 1.20
The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocr Relat Cancer (2009) 1.19
Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J Biol Chem (1995) 1.13
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. PLoS One (2012) 1.12
The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice. Carcinogenesis (2006) 1.12
The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One (2010) 1.07
Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opin Investig Drugs (1999) 1.04
The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochem Pharmacol (2008) 1.03
Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol (2009) 1.01
Molecular mechanisms of p21 and p27 induction by 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, involved in antiproliferation of human umbilical vascular endothelial cells. J Cell Physiol (2008) 0.99
The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning. J Invest Dermatol (2010) 0.97
The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell Melanoma Res (2010) 0.96
Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Mitochondrion (2002) 0.93
Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2. Cancer Res (2001) 0.92
2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells. Neurosci Lett (2004) 0.87
Analysis of the aryl hydrocarbon receptor (AhR) signal transduction pathway. Curr Protoc Toxicol (2002) 0.86
Inhibition of smooth muscle cell proliferation in vitro by leflunomide, a new immunosuppressant, is antagonized by uridine. Immunol Lett (1995) 0.78
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell (2004) 4.00
Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+ CD25+ cells with characteristics of regulatory T cells. J Immunol (2005) 2.21
Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev (2010) 1.81
Regenerative growth is impacted by TCDD: gene expression analysis reveals extracellular matrix modulation. Toxicol Sci (2006) 1.74
Recommendations for control of pathogens and infectious diseases in fish research facilities. Comp Biochem Physiol C Toxicol Pharmacol (2008) 1.66
Sulfidation of silver nanoparticles: natural antidote to their toxicity. Environ Sci Technol (2013) 1.64
In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon N Y (2007) 1.62
Evaluation of embryotoxicity using the zebrafish model. Methods Mol Biol (2011) 1.57
Development and maintenance of a specific pathogen-free (SPF) zebrafish research facility for Pseudoloma neurophilia. Dis Aquat Organ (2011) 1.53
Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. J Lab Autom (2012) 1.46
Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. Toxicol Appl Pharmacol (2008) 1.42
Multidimensional in vivo hazard assessment using zebrafish. Toxicol Sci (2013) 1.41
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol (2004) 1.40
Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol (2008) 1.38
Systematic evaluation of nanomaterial toxicity: utility of standardized materials and rapid assays. ACS Nano (2011) 1.37
Ethanol- and acetaldehyde-mediated developmental toxicity in zebrafish. Neurotoxicol Teratol (2004) 1.37
Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem (2007) 1.35
Dioxin and immune regulation: emerging role of aryl hydrocarbon receptor in the generation of regulatory T cells. Ann N Y Acad Sci (2010) 1.34
Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci (2002) 1.33
Modeling of the aryl hydrocarbon receptor (AhR) ligand binding domain and its utility in virtual ligand screening to predict new AhR ligands. J Med Chem (2009) 1.28
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res (2006) 1.24
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood (2007) 1.24
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell (2010) 1.22
Ethanol-dependent toxicity in zebrafish is partially attenuated by antioxidants. Neurotoxicol Teratol (2006) 1.21
Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish. Toxicology (2011) 1.18
Identification of zebrafish ARNT1 homologs: 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the developing zebrafish requires ARNT1. Mol Pharmacol (2005) 1.16
Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebrafish. Arch Toxicol (2010) 1.16
The zebrafish (Danio rerio) aryl hydrocarbon receptor type 1 is a novel vertebrate receptor. Mol Pharmacol (2002) 1.15
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. PLoS One (2012) 1.12
Persistent adult zebrafish behavioral deficits results from acute embryonic exposure to gold nanoparticles. Comp Biochem Physiol C Toxicol Pharmacol (2011) 1.11
Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. Drug Metab Dispos (2005) 1.11
Dithiocarbamates have a common toxic effect on zebrafish body axis formation. Toxicol Appl Pharmacol (2006) 1.08
Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. J Nutr Biochem (2011) 1.08
Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Mol Pharmacol (2007) 1.07
The anti-inflammatory drug leflunomide is an agonist of the aryl hydrocarbon receptor. PLoS One (2010) 1.07
Crosstalk between AHR and Wnt signaling through R-Spondin1 impairs tissue regeneration in zebrafish. FASEB J (2008) 1.07
Nicotinic receptors mediate changes in spinal motoneuron development and axonal pathfinding in embryonic zebrafish exposed to nicotine. J Neurosci (2002) 1.06
2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses tumor necrosis factor-alpha and anti-CD40-induced activation of NF-kappaB/Rel in dendritic cells: p50 homodimer activation is not affected. Mol Pharmacol (2002) 1.05
MicroRNAs control neurobehavioral development and function in zebrafish. FASEB J (2012) 1.04
Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics. J Biol Chem (2004) 1.04
Toxicity, uptake kinetics and behavior assessment in zebrafish embryos following exposure to perfluorooctanesulphonicacid (PFOS). Aquat Toxicol (2010) 1.04
Molecular signaling networks that choreograph epimorphic fin regeneration in zebrafish - a mini-review. Gerontology (2009) 1.03
Phosphoinositide binding to the substrate regulates susceptibility to proteolysis by calpain. J Biol Chem (2008) 1.03
Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol (2013) 1.02
Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration. J Biol Chem (2009) 1.02
Developmental toxicity of the dithiocarbamate pesticide sodium metam in zebrafish. Toxicol Sci (2004) 1.02
Aryl hydrocarbon receptor activation inhibits regenerative growth. Mol Pharmacol (2005) 1.00
Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo. Cancer Lett (2005) 1.00
TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway. Oncogene (2005) 1.00
Toxicity of chlorine to zebrafish embryos. Dis Aquat Organ (2014) 0.99
Aryl hydrocarbon receptor activation impairs extracellular matrix remodeling during zebra fish fin regeneration. Toxicol Sci (2006) 0.98
Influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antigen-presenting activity of dendritic cells. Toxicol Sci (2003) 0.98
Integrating zebrafish toxicology and nanoscience for safer product development. Green Chem (2013) 0.98
Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior. Toxicol Sci (2011) 0.97
Vitamin C deficiency activates the purine nucleotide cycle in zebrafish. J Biol Chem (2011) 0.97
Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). J Nutr (2011) 0.96
Gold nanoparticles disrupt zebrafish eye development and pigmentation. Toxicol Sci (2013) 0.96
AHR-dependent misregulation of Wnt signaling disrupts tissue regeneration. Biochem Pharmacol (2008) 0.96
Media ionic strength impacts embryonic responses to engineered nanoparticle exposure. Nanotoxicology (2011) 0.95
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. J Neurosci Res (2011) 0.94
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation of alloreactive CD8+ T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl hydrocarbon receptor in CD4+ T cells. J Immunotoxicol (2008) 0.94
Polycyclic aromatic hydrocarbons in water, sediment, soil, and plants of the Aojiang River waterway in Wenzhou, China. J Hazard Mater (2009) 0.94
Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol Sci (2010) 0.93
Contrasting the roles of costimulation and the natural adjuvant lipopolysaccharide during the induction of T cell immunity. J Immunol (2002) 0.93
Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol (2005) 0.93
2,3,7,8 Tetrachlorodibenzo-p-Dioxin (TCDD) Directly Enhances the Maturation and Apoptosis of Dendritic Cells In Vitro. J Immunotoxicol (2005) 0.93
Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology (2012) 0.91
An evolutionarily conserved mechanism of calcium-dependent neurotoxicity in a zebrafish model of fetal alcohol spectrum disorders. Alcohol Clin Exp Res (2014) 0.91
Exposure to sodium metam during zebrafish somitogenesis results in early transcriptional indicators of the ensuing neuronal and muscular dysfunction. Toxicol Sci (2008) 0.90
Bridging environmental mixtures and toxic effects. Environ Toxicol Chem (2012) 0.90
Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells. Cancer Res (2003) 0.90
2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits zebrafish caudal fin regeneration. Toxicol Sci (2003) 0.89
Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquat Toxicol (2004) 0.89
Zinc transporter expression in zebrafish (Danio rerio) during development. Comp Biochem Physiol C Toxicol Pharmacol (2011) 0.89
Quantification of fullerenes by LC/ESI-MS and its application to in vivo toxicity assays. Anal Chem (2007) 0.89
Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation. Front Immunol (2012) 0.88
Bioinformatics Resource Manager v2.3: an integrated software environment for systems biology with microRNA and cross-species analysis tools. BMC Bioinformatics (2012) 0.88
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor. J Biol Chem (2002) 0.88
Functional alterations in CD11b(+)Gr-1(+) cells in mice injected with allogeneic tumor cells and treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Int Immunopharmacol (2003) 0.88
Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere (2010) 0.88
Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response. J Immunotoxicol (2009) 0.88
Uncoupling nicotine mediated motoneuron axonal pathfinding errors and muscle degeneration in zebrafish. Toxicol Appl Pharmacol (2008) 0.87
Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol Appl Pharmacol (2013) 0.86
Early consequences of 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. Toxicol Sci (2004) 0.86
Non-coding RNAs--novel targets in neurotoxicity. Neurotoxicology (2012) 0.86
Endosulfan I and endosulfan sulfate disrupts zebrafish embryonic development. Aquat Toxicol (2009) 0.85
Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming behavior. Comp Biochem Physiol C Toxicol Pharmacol (2013) 0.84
Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenet Genomics (2005) 0.83
Chronic zebrafish PFOS exposure alters sex ratio and maternal related effects in F1 offspring. Environ Toxicol Chem (2011) 0.83
The α-tocopherol transfer protein is essential for vertebrate embryogenesis. PLoS One (2012) 0.83
A retrospective study of the prevalence and classification of intestinal neoplasia in zebrafish (Danio rerio). Zebrafish (2013) 0.81
Identification of a critical amino acid in the aryl hydrocarbon receptor. J Biol Chem (2002) 0.81
Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17β-estradiol in embryonic zebrafish. Reprod Toxicol (2013) 0.81
Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment. J Pharm Sci (2004) 0.80