The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 3399794)

Published in PLoS One on July 18, 2012

Authors

Chongjuan Wei1, Varun Kumar Bhattaram, John C Igwe, Elizabeth Fleming, Jennifer S Tirnauer

Author Affiliations

1: Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.

Articles cited by this

The selectivity of protein kinase inhibitors: a further update. Biochem J (2007) 15.73

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol (2003) 12.91

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J (2004) 10.82

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature (1998) 10.35

Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res (2002) 7.09

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol (2000) 6.01

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle. Mol Cell (2001) 5.57

Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology (2000) 5.40

Spindle orientation during asymmetric cell division. Nat Cell Biol (2009) 4.08

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell (2004) 3.87

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature (2003) 3.47

AMPK and cell proliferation--AMPK as a therapeutic target for atherosclerosis and cancer. J Physiol (2006) 3.11

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science (2001) 2.99

Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther (2010) 2.93

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development (2000) 2.84

Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity. J Cell Biol (1998) 2.60

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. Am J Pathol (1999) 2.59

PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells. Dev Cell (2007) 2.45

Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J Cell Biol (1994) 2.44

Retracted LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol (2007) 2.40

High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations. Am J Gastroenterol (2010) 2.32

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci U S A (2007) 2.20

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J Pathol (1999) 2.13

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science (2009) 2.13

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. EMBO J (2011) 2.08

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res (2002) 2.05

The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle (2009) 2.03

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am J Hum Genet (1998) 1.98

AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci U S A (2006) 1.98

The regulation of AMP-activated protein kinase by upstream kinases. Int J Obes (Lond) (2008) 1.98

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol (2008) 1.96

LGN regulates mitotic spindle orientation during epithelial morphogenesis. J Cell Biol (2010) 1.95

LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism. Physiol Rev (2009) 1.93

Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins. Curr Biol (2010) 1.86

Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol (2002) 1.84

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet (1999) 1.79

AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. Cell Mol Life Sci (2008) 1.77

LKB1 and AMPK in cell polarity and division. Trends Cell Biol (2008) 1.72

AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci U S A (2002) 1.67

The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta (2006) 1.67

VHL loss causes spindle misorientation and chromosome instability. Nat Cell Biol (2009) 1.65

Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res (2002) 1.60

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation. J Cell Biol (2010) 1.58

LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol (2004) 1.57

Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene (2004) 1.49

Cell division orientation in animals. Curr Biol (2011) 1.47

Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Mol Biol Cell (2009) 1.46

Mutations in the human LKB1/STK11 gene. Hum Mutat (2005) 1.45

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene (2003) 1.43

Mitotic spindle misorientation in cancer--out of alignment and into the fire. J Cell Sci (2011) 1.41

Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis. J Biol Chem (2011) 1.30

par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics (1992) 1.25

Molecular mechanisms of tumor suppression by LKB1. FEBS Lett (2010) 1.17

Spindle misorientation in tumors from APC(min/+) mice. Mol Carcinog (2009) 1.10

Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells. Cell Cycle (2009) 1.06

Role of LKB1-SAD/MARK pathway in neuronal polarization. Dev Neurobiol (2011) 1.06

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development (2007) 1.04

Asymmetric cell division: lessons from flies and worms. Curr Opin Genet Dev (1998) 1.03

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res (2005) 1.01

Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem (2007) 1.00

LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. BMC Cell Biol (2010) 0.98

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol (2009) 0.95

The LKB1 complex-AMPK pathway: the tree that hides the forest. Fam Cancer (2011) 0.95

LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation. PLoS One (2012) 0.91

RNA interference techniques to study epithelial cell adhesion and polarity. Methods Enzymol (2006) 0.87

Articles by these authors

High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation (2008) 3.46

Determining the position of the cell division plane. Nature (2003) 2.80

Surfing on microtubule ends. Trends Cell Biol (2003) 2.61

Identification of differentially expressed genes between osteoblasts and osteocytes. Bone (2009) 1.97

Mitotic spindle misorientation in cancer--out of alignment and into the fire. J Cell Sci (2011) 1.41

In-depth characterization of microRNA transcriptome in melanoma. PLoS One (2013) 1.38

Planar spindle orientation and asymmetric cytokinesis in the mouse small intestine. J Histochem Cytochem (2007) 1.37

Up-regulated Dicer expression in patients with cutaneous melanoma. PLoS One (2011) 1.18

Taxol-stabilized microtubules can position the cytokinetic furrow in mammalian cells. Mol Biol Cell (2005) 1.14

Spindle misorientation in tumors from APC(min/+) mice. Mol Carcinog (2009) 1.10

CK1 activates minus-end-directed transport of membrane organelles along microtubules. Mol Biol Cell (2011) 0.99

Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Lett (2006) 0.98

LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation. PLoS One (2012) 0.91

Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element. Mol Endocrinol (2004) 0.83

Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination. Biol Open (2012) 0.82

Bone matrix osteonectin limits prostate cancer cell growth and survival. Matrix Biol (2012) 0.82

Myocyte enhancer factor 2 (MEF2) tethering to muscle selective A-kinase anchoring protein (mAKAP) is necessary for myogenic differentiation. Cell Signal (2012) 0.81

Improved eukaryotic promoter-detection vector carrying two luciferase reporter genes. Biotechniques (2003) 0.80

Tumor suppressor interactions with microtubules: keeping cell polarity and cell division on track. Dis Model Mech (2010) 0.80

Sp1-dependent regulation of PPARα in bone metabolism. Int J Oral Maxillofac Implants (2014) 0.77

Stimulation of the CLIP-170--dependent capture of membrane organelles by microtubules through fine tuning of microtubule assembly dynamics. Mol Biol Cell (2011) 0.77

Adaptation and negotiation as an approach to care in paediatric diabetes specialist nursing practice: a critical review. J Clin Nurs (2002) 0.75

Effect of osmolality and selected ions on retraction of the distome body into the cercaria tail chamber of Proterometra macrostoma (Trematoda: Azygiidae). J Parasitol (2010) 0.75