Published in Front Oncol on July 18, 2012
Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications. Pharmacol Ther (2013) 1.15
Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell (2014) 1.09
Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications. Sensors (Basel) (2013) 1.07
Live-cell mass profiling: an emerging approach in quantitative biophysics. Nat Methods (2014) 1.01
Label-free high-throughput cell screening in flow. Biomed Opt Express (2013) 1.00
Cellular and molecular processes in ovarian cancer metastasis. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis. Am J Physiol Cell Physiol (2015) 0.97
Do circulating tumor cells play a role in coagulation and thrombosis? Front Oncol (2012) 0.92
Physical biology in cancer. 2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol (2013) 0.87
Targeting the tumour microenvironment in ovarian cancer. Eur J Cancer (2016) 0.86
Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy. J Biomed Opt (2013) 0.85
Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer. J Biomed Opt (2014) 0.85
Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network. Cell Mol Bioeng (2016) 0.84
Quantitative optical microscopy: measurement of cellular biophysical features with a standard optical microscope. J Vis Exp (2014) 0.84
Development of a method to quantify platelet adhesion and aggregation under static conditions. Cell Mol Bioeng (2014) 0.84
Physical biology in cancer. 1. Cellular physics of cancer metastasis. Am J Physiol Cell Physiol (2013) 0.81
The thrombotic potential of circulating tumor microemboli: computational modeling of circulating tumor cell-induced coagulation. Am J Physiol Cell Physiol (2014) 0.80
May CTC technologies promote better cancer management? EPMA J (2015) 0.79
Rolling in the deep: therapeutic targeting of circulating tumor cells. Front Oncol (2012) 0.79
Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells. Cell Mol Bioeng (2015) 0.78
Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear. Am J Physiol Cell Physiol (2013) 0.78
miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. Front Pharmacol (2016) 0.77
Circulating tumor cells from 4D model have less integrin beta 4 expression. J Surg Res (2014) 0.77
Circulating tumor cells as emerging tumor biomarkers in lung cancer. J Thorac Dis (2012) 0.77
Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohort. BMC Cancer (2016) 0.76
High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood. Micro Total Anal Syst (2015) 0.75
Hypertrophy changes 3D shape of hiPSC-cardiomyocytes: Implications for cellular maturation in regenerative medicine. Cell Mol Bioeng (2016) 0.75
Critical behavior of subcellular density organization during neutrophil activation and migration. Cell Mol Bioeng (2015) 0.75
High-Throughput Microfluidic Device for Rare Cell Isolation. Proc SPIE Int Soc Opt Eng (2015) 0.75
Evaluation of the metastatic potential of malignant cells by image processing of digital holographic microscopy data. FEBS Open Bio (2017) 0.75
Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med (2004) 27.92
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res (2004) 14.53
The biology of ovarian cancer: new opportunities for translation. Nat Rev Cancer (2009) 9.01
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol (2008) 8.72
Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data. Lancet Oncol (2009) 5.45
Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells. Am J Pathol (2000) 5.26
Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res (2006) 4.95
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum. Proc Natl Acad Sci U S A (2008) 4.10
In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. J Invest Dermatol (1999) 3.55
Assessing lead time of selected ovarian cancer biomarkers: a nested case-control study. J Natl Cancer Inst (2009) 3.48
Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med (2009) 2.73
Interference microscopy and mass determination. Nature (1952) 2.65
Optical measurement of cycle-dependent cell growth. Proc Natl Acad Sci U S A (2011) 2.41
Case study of the morphologic variation of circulating tumor cells. Hum Pathol (2006) 2.28
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol (2012) 2.21
Quantitative phase imaging of nanoscale cell structure and dynamics. Methods Cell Biol (2008) 1.97
Margination of leukocytes in blood flow through small tubes. Microvasc Res (1984) 1.73
Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood. Cytometry (2002) 1.70
Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol (2010) 1.66
Potential role of HE4 in multimodal screening for epithelial ovarian cancer. J Natl Cancer Inst (2011) 1.39
High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol (2012) 1.37
Using the Hilbert transform for 3D visualization of differential interference contrast microscope images. J Microsc (2000) 1.34
Circulating tumor cells predict progression free survival and overall survival in patients with relapsed/recurrent advanced ovarian cancer. Gynecol Oncol (2011) 1.18
Predictive value of symptoms for ovarian cancer: comparison of symptoms reported by questionnaire, interview, and general practitioner notes. J Natl Cancer Inst (2012) 1.07
Non-interferometric, non-iterative phase retrieval by Green's functions. J Opt Soc Am A Opt Image Sci Vis (2010) 1.06
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines. J Synchrotron Radiat (2002) 9.48
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (2008) 6.01
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
A rare-cell detector for cancer. Proc Natl Acad Sci U S A (2004) 3.95
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med (2012) 2.91
New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection. Acta Crystallogr D Biol Crystallogr (2008) 2.79
Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med (2009) 2.73
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface (2009) 2.69
Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure (2005) 2.55
High speed detection of circulating tumor cells. Biosens Bioelectron (2006) 2.29
Case study of the morphologic variation of circulating tumor cells. Hum Pathol (2006) 2.28
Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein. Structure (2003) 2.21
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol (2012) 2.21
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol (2003) 2.05
Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol (2012) 2.02
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J (2013) 2.01
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr (2003) 1.92
Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI. Blood (2008) 1.89
A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood (2010) 1.83
Factor XII inhibition reduces thrombus formation in a primate thrombosis model. Blood (2014) 1.81
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist. Arterioscler Thromb Vasc Biol (2007) 1.80
Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol (2010) 1.66
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol (2009) 1.64
Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry (2004) 1.55
Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation. Am J Physiol Cell Physiol (2013) 1.53
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition. Circ Cardiovasc Imaging (2012) 1.53
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins (2006) 1.51
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov (2012) 1.50
Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine (2009) 1.49
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A (2008) 1.45
Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol (2012) 1.45
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. J Mol Biol (2006) 1.42
In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42
Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem (2006) 1.40
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A (2009) 1.39
S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood (2011) 1.39
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem (2004) 1.38
High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol (2012) 1.37
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet (2009) 1.37
Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol (2006) 1.34
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr (2008) 1.32
Microfluidics and coagulation biology. Annu Rev Biomed Eng (2013) 1.30
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol (2008) 1.27
Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Front Oncol (2012) 1.26
Measurement of single cell refractive index, dry mass, volume, and density using a transillumination microscope. Phys Rev Lett (2012) 1.26
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol (2006) 1.24
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One (2010) 1.22
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol (2005) 1.19
Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. J Virol (2007) 1.18
Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins (2004) 1.17
Platelet shape change and spreading. Methods Mol Biol (2012) 1.13
Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism. Proc Natl Acad Sci U S A (2009) 1.13
Alcohol exposure during the developmental period induces beta-endorphin neuronal death and causes alteration in the opioid control of stress axis function. Endocrinology (2007) 1.12
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood (2007) 1.12
Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR. Proc Natl Acad Sci U S A (2012) 1.11
Improved absorption and bioactivity of active compounds from an anti-diabetic extract of Artemisia dracunculus L. Int J Pharm (2008) 1.09
Development of a Label-free Imaging Technique for the Quantification of Thrombus Formation. Cell Mol Bioeng (2012) 1.09
Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. Proteins (2004) 1.09
Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models. J Virol (2007) 1.08
Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch. J Virol (2007) 1.08
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus. J Virol (2007) 1.07
Efficient sorption of polyphenols to soybean flour enables natural fortification of foods. Food Chem (2012) 1.07
The leech product saratin is a potent inhibitor of platelet integrin alpha2beta1 and von Willebrand factor binding to collagen. FEBS J (2007) 1.06
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1. J Mol Biol (2008) 1.05
Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis. J Neuroimmunol (2010) 1.05
Cytometric comparisons between circulating tumor cells from prostate cancer patients and the prostate-tumor-derived LNCaP cell line. Phys Biol (2012) 1.05
Structural genomics of the severe acute respiratory syndrome coronavirus: nuclear magnetic resonance structure of the protein nsP7. J Virol (2005) 1.04
Cyclic adenosine monophosphate differentiated beta-endorphin neurons promote immune function and prevent prostate cancer growth. Proc Natl Acad Sci U S A (2008) 1.03