Published in J Biol Chem on July 25, 2006
Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol (2007) 2.24
The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res (2008) 2.21
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nat Struct Mol Biol (2010) 1.80
Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage. J Virol (2007) 1.44
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex. EMBO Rep (2009) 1.42
Crystal structure and carbohydrate analysis of Nipah virus attachment glycoprotein: a template for antiviral and vaccine design. J Virol (2008) 1.32
Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem (2008) 1.30
Structural plasticity of eph receptor A4 facilitates cross-class ephrin signaling. Structure (2009) 1.29
Structural characterization of the EphA4-Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J Biol Chem (2009) 1.19
A small molecule agonist of EphA2 receptor tyrosine kinase inhibits tumor cell migration in vitro and prostate cancer metastasis in vivo. PLoS One (2012) 1.15
Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding. J Cell Sci (2010) 1.11
Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions? Proteins (2010) 1.11
Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J (2009) 1.06
Three-dimensional structure of the EphB2 receptor in complex with an antagonistic peptide reveals a novel mode of inhibition. J Biol Chem (2007) 0.98
Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping. Nat Commun (2011) 0.94
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem J (2012) 0.93
Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochim Biophys Acta (2013) 0.93
Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations. BMC Biophys (2012) 0.93
Henipavirus receptor usage and tropism. Curr Top Microbiol Immunol (2012) 0.91
Cells under siege: viral glycoprotein interactions at the cell surface. J Struct Biol (2011) 0.91
Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.90
The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target. PLoS One (2013) 0.90
EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells Dev (2013) 0.85
Genomics of squamous cell lung cancer. Oncologist (2013) 0.85
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations. Br J Pharmacol (2014) 0.84
Targeting the Eph System with Peptides and Peptide Conjugates. Curr Drug Targets (2015) 0.84
A simple contact mapping algorithm for identifying potential peptide mimetics in protein-protein interaction partners. Proteins (2014) 0.82
PCalign: a method to quantify physicochemical similarity of protein-protein interfaces. BMC Bioinformatics (2015) 0.80
Unique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulations. PLoS One (2013) 0.79
EPH-EPHRIN in human gastrointestinal cancers. World J Gastrointest Oncol (2010) 0.79
Promiscuous and specific recognition among ephrins and Eph receptors. Biochim Biophys Acta (2014) 0.79
Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell (2015) 0.79
IFACEwat: the interfacial water-implemented re-ranking algorithm to improve the discrimination of near native structures for protein rigid docking. BMC Bioinformatics (2014) 0.78
Distinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5. PLoS One (2015) 0.76
Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes. Protein Sci (2015) 0.75
EphA4 has distinct functionality from EphA7 in the corticothalamic system during mouse brain development. J Comp Neurol (2015) 0.75
Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion. PLoS Pathog (2016) 0.75
Eph/ephrin signaling in the kidney and lower urinary tract. Pediatr Nephrol (2015) 0.75
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (2007) 20.32
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines. J Synchrotron Radiat (2002) 9.48
Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science (2003) 7.96
Deep-sea oil plume enriches indigenous oil-degrading bacteria. Science (2010) 6.73
Structure of an agonist-bound human A2A adenosine receptor. Science (2011) 6.21
A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (2008) 6.01
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86
Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18
A rare-cell detector for cancer. Proc Natl Acad Sci U S A (2004) 3.95
Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase. J Biol Chem (2004) 3.79
Crystal structure of a lipid G protein-coupled receptor. Science (2012) 3.78
Serial femtosecond crystallography of G protein-coupled receptors. Science (2013) 3.58
Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48
Acquired resistance to crizotinib from a mutation in CD74-ROS1. N Engl J Med (2013) 3.42
Structural basis for allosteric regulation of GPCRs by sodium ions. Science (2012) 3.40
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08
Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med (2012) 2.91
Structure of the human glucagon class B G-protein-coupled receptor. Nature (2013) 2.86
New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection. Acta Crystallogr D Biol Crystallogr (2008) 2.79
Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type. Arch Pathol Lab Med (2009) 2.73
Genetic evidence for three unique components in primary cell-wall cellulose synthase complexes in Arabidopsis. Proc Natl Acad Sci U S A (2007) 2.72
Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. J R Soc Interface (2009) 2.69
Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60
Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3. Structure (2005) 2.55
Comparison of dilute acid and ionic liquid pretreatment of switchgrass: Biomass recalcitrance, delignification and enzymatic saccharification. Bioresour Technol (2009) 2.32
High speed detection of circulating tumor cells. Biosens Bioelectron (2006) 2.29
Case study of the morphologic variation of circulating tumor cells. Hum Pathol (2006) 2.28
Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein. Structure (2003) 2.21
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol (2012) 2.21
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol (2003) 2.05
Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol (2012) 2.02
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure (2006) 1.97
Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome. Acta Crystallogr D Biol Crystallogr (2003) 1.92
Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86
mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure. Chembiochem (2004) 1.82
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science (2014) 1.81
Cytomorphology of circulating colorectal tumor cells:a small case series. J Oncol (2010) 1.66
Quantitative analysis of protein-RNA interactions by gel mobility shift. Methods Mol Biol (2008) 1.60
Deep-sea bacteria enriched by oil and dispersant from the Deepwater Horizon spill. Environ Microbiol (2012) 1.58
Plant cell walls throughout evolution: towards a molecular understanding of their design principles. J Exp Bot (2009) 1.57
Mechanistic studies of a flavin-dependent thymidylate synthase. Biochemistry (2004) 1.55
Optical quantification of cellular mass, volume, and density of circulating tumor cells identified in an ovarian cancer patient. Front Oncol (2012) 1.54
Three-dimensional crystallization of the Escherichia coli glycerol-3-phosphate transporter: a member of the major facilitator superfamily. Protein Sci (2003) 1.52
Enthalpy arrays. Proc Natl Acad Sci U S A (2004) 1.52
Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. Proteins (2006) 1.51
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function. Nat Rev Drug Discov (2012) 1.50
Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton. Phytomedicine (2009) 1.49
Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology. Phys Biol (2012) 1.45
Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization. Angew Chem Int Ed Engl (2006) 1.45
Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha. J Biol Chem (2005) 1.44
Molecular architecture of the chick vestibular hair bundle. Nat Neurosci (2013) 1.43
Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. J Mol Biol (2006) 1.42
Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol (2014) 1.42
In situ data collection and structure refinement from microcapillary protein crystallization. J Appl Crystallogr (2005) 1.42
High-pressure freezing, cellular tomography, and structural cell biology. Biotechniques (2006) 1.41
An unusual sugar conformation in the structure of an RNA/DNA decamer of the polypurine tract may affect recognition by RNase H. J Mol Biol (2003) 1.41
Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1. Proc Natl Acad Sci U S A (2007) 1.40
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A (2009) 1.39
Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling. Infect Immun (2007) 1.39
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. J Neurochem (2004) 1.38
High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Phys Biol (2012) 1.37
Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. Am J Hum Genet (2009) 1.37
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol (2007) 1.36
Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy. J Virol (2006) 1.34
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
The structure of a eukaryotic nicotinic acid phosphoribosyltransferase reveals structural heterogeneity among type II PRTases. Structure (2005) 1.33
Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium. J Cell Sci (2012) 1.32
In situ X-ray analysis of protein crystals in low-birefringent and X-ray transmissive plastic microchannels. Acta Crystallogr D Biol Crystallogr (2008) 1.32
The cooperative activities of CSLD2, CSLD3, and CSLD5 are required for normal Arabidopsis development. Mol Plant (2011) 1.30
Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 1.28
Natural acidophilic biofilm communities reflect distinct organismal and functional organization. ISME J (2008) 1.27
Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol (2008) 1.27
Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Plant Physiol (2012) 1.26
Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient. Front Oncol (2012) 1.26
Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs. J Virol (2006) 1.24
Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries. Chem Biol (2009) 1.24
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation. Protein Sci (2004) 1.23
Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase. Structure (2009) 1.23
Mutations in UDP-Glucose:sterol glucosyltransferase in Arabidopsis cause transparent testa phenotype and suberization defect in seeds. Plant Physiol (2009) 1.22
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh. J Mol Biol (2002) 1.21
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol (2005) 1.19
Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier. Proc Natl Acad Sci U S A (2012) 1.18
Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein. J Virol (2007) 1.18
Engineering secondary cell wall deposition in plants. Plant Biotechnol J (2012) 1.18
Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. Proteins (2004) 1.17
The effect of RNA secondary structures on RNA-ligand binding and the modifier RNA mechanism: a quantitative model. Gene (2005) 1.17