EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 22828828)

Published in Virchows Arch on July 25, 2012

Authors

Shioto Suzuki1, Yoh Dobashi, Hiroshi Minato, Ryosuke Tajiri, Tomokazu Yoshizaki, Akishi Ooi

Author Affiliations

1: Department of Molecular and Cellular Pathology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan. shiosuzuki-path@umin.net

Articles cited by this

The measurement of observer agreement for categorical data. Biometrics (1977) 216.56

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med (2004) 71.08

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med (2004) 30.26

American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol (2006) 25.12

Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol (2005) 7.43

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol (2006) 3.01

Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol (2008) 2.85

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications. Cancer Res (2007) 2.67

Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy. Cancer (2007) 2.38

The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer (1993) 2.23

The HER-2/neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy. Oncologist (1998) 2.02

Amplification and overexpression of HER-2/neu in carcinomas of the salivary gland: correlation with poor prognosis. Cancer Res (1994) 1.41

HER-2/neu in breast cancer: interobserver variability and performance of immunohistochemistry with 4 antibodies compared with fluorescent in situ hybridization. Mod Pathol (2001) 1.41

Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay. Diagn Pathol (2006) 1.37

Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients. Am J Surg Pathol (2007) 1.32

Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas. Histopathology (2008) 1.29

Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance. Clin Cancer Res (2010) 1.26

HER2 expression in salivary gland carcinomas: dependence on histological subtype. Clin Cancer Res (2004) 1.25

HER2 testing in the UK: further update to recommendations. J Clin Pathol (2008) 1.22

Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol (2009) 1.19

The role of the epidermal growth factor receptor in breast cancer. J Mammary Gland Biol Neoplasia (2006) 1.12

Mammalian target of rapamycin: a central node of complex signaling cascades. Int J Clin Exp Pathol (2011) 1.11

Immunohistochemical study of epidermal growth factor receptor in adenoid cystic carcinoma of salivary gland origin. Head Neck (2002) 1.09

A phase II pharmacodynamic study of erlotinib in patients with advanced non-small cell lung cancer previously treated with platinum-based chemotherapy. Clin Cancer Res (2008) 1.08

Parotid carcinoma: expression of kit protein and epidermal growth factor receptor. J Oral Pathol Med (2006) 0.92

Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib. Head Neck (2009) 0.92

Epidermal growth factor receptor kinase domain mutations are rare in salivary gland carcinomas. Br J Cancer (2009) 0.91

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas. Hum Pathol (2010) 0.90

First-time-in-man and pharmacokinetic study of weekly oral perifosine in patients with solid tumours. Eur J Cancer (2010) 0.87

MDM2, P53, P21WAF1 and pAKT protein levels in genesis and behaviour of adenoid cystic carcinoma. Cancer Epidemiol (2009) 0.80

Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas. Mod Pathol (2006) 0.80

Cetuximab in the management of locoregionally advanced head and neck cancer: expanding the treatment options? Eur J Cancer (2010) 0.76

Gene amplification of ERBB2 and EGFR in adenocarcinoma in situ and intramucosal adenocarcinoma of Barrett's esophagus. Pathol Int (2010) 0.75

Articles by these authors

EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology (2008) 5.53

Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor). Am J Surg Pathol (2005) 3.30

Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology (2006) 2.83

IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung. Hum Pathol (2005) 2.31

Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem (2003) 2.08

Achlorhydria, parietal cell hyperplasia, and multiple gastric carcinoids: a new disorder. Am J Surg Pathol (2005) 2.03

EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. Int J Cancer (2006) 1.97

Biliary cystic tumors with bile duct communication: a cystic variant of intraductal papillary neoplasm of the bile duct. Mod Pathol (2006) 1.86

IgG4-Related Chronic Sclerosing Dacryoadenitis. Arch Ophthalmol (2007) 1.82

Status of c-erbB-2 in gastric adenocarcinoma: a comparative study of immunohistochemistry, fluorescence in situ hybridization and enzyme-linked immuno-sorbent assay. Int J Cancer (2002) 1.80

Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res (2007) 1.69

Bronchioloalveolar carcinoma of the lung 3 centimeters or less in diameter: a prognostic assessment. Ann Thorac Surg (2004) 1.64

Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study. Mod Pathol (2004) 1.59

Gene amplification of ESR1 in breast cancers--fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dependent probe amplification study. J Pathol (2012) 1.55

Amplification and overexpression of c-erbB-2, epidermal growth factor receptor, and c-met in biliary tract cancers. J Pathol (2005) 1.52

Comparative immunohistochemical analysis of IMP3, GLUT1, EMA, CD146, and desmin for distinguishing malignant mesothelioma from reactive mesothelial cells. Am J Clin Pathol (2014) 1.45

Pathologic and biological assessment of lung tumors showing ground-glass opacity. Ann Thorac Surg (2006) 1.42

Invasive micropapillary salivary duct carcinoma: a distinct histologic variant with biologic significance. Am J Surg Pathol (2004) 1.40

Inhibition of GSK-3 beta activity attenuates proliferation of human colon cancer cells in rodents. Cancer Sci (2007) 1.40

Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. Int J Rheumatol (2012) 1.39

Malignant myoepithelioma arising from recurrent pleomorphic adenoma of minor salivary gland. Auris Nasus Larynx (2002) 1.39

Nonspecific interstitial pneumonia with abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune disease. Intern Med (2008) 1.35

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 1.35

Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha. Mol Cell Biol (2004) 1.33

Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp Gerontol (2009) 1.32

A case of primary small cell carcinoma of the breast. Breast Cancer (2007) 1.32

EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells. Cancer Res (2006) 1.31

Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. Mod Pathol (2003) 1.30

Distribution of CD4+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer. J Surg Res (2005) 1.27

The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma. Lab Invest (2008) 1.26

Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma. J Hepatol (2008) 1.25

Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas. An immunohistochemical and fluorescence in situ hybridization study. Cancer (2005) 1.24

Expression of epidermal growth factor receptor in gastric carcinomas. Clin Gastroenterol Hepatol (2003) 1.20

Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors. Clin Cancer Res (2012) 1.19

Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongue. Auris Nasus Larynx (2008) 1.17

Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines. J Virol (2011) 1.11

Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement. Pathol Int (2010) 1.10

Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer. BMC Cancer (2010) 1.09

Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens. Am J Surg Pathol (2006) 1.08

Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study. Hum Pathol (2006) 1.05

Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas and their morphological mimics. Int J Clin Exp Pathol (2013) 1.05

Trastuzumab-mediated antibody-dependent cellular cytotoxicity against esophageal squamous cell carcinoma. Clin Cancer Res (2005) 1.05

A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings. Auris Nasus Larynx (2008) 1.02

Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement? Acta Otolaryngol (2009) 1.02

Clinicopathological study of surgically treated cases of tracheobronchial adenoid cystic carcinoma. Gen Thorac Cardiovasc Surg (2010) 1.01

Identification of novel candidate tumour marker genes for intrahepatic cholangiocarcinoma. J Hepatol (2008) 1.00

Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer (2005) 1.00

MUC1 induced by Epstein-Barr virus latent membrane protein 1 causes dissociation of the cell-matrix interaction and cellular invasiveness via STAT signaling. J Virol (2006) 0.99

Warthin's tumor associated with IgG4-related disease. Auris Nasus Larynx (2012) 0.99

Epstein-barr virus latent membrane protein 1 induces and causes release of fibroblast growth factor-2. Cancer Res (2002) 0.98

Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma. Acta Otolaryngol (2008) 0.98

Adamantinoma of the proximal femur: a case report. J Orthop Sci (2004) 0.96

Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer. Cancer Lett (2003) 0.96

The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas. Cancer (2011) 0.96

Seprase, a membrane-type serine protease, has different expression patterns in intestinal- and diffuse-type gastric cancer. Oncology (2003) 0.96

Overlap of idiopathic portal hypertension and scleroderma: report of two autopsy cases and a review of literature. J Gastroenterol Hepatol (2002) 0.95

Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line. Laryngoscope (2004) 0.94

Dedifferentiation in low-grade mucoepidermoid carcinoma of the parotid gland. Hum Pathol (2003) 0.94

B-cell neurolymphomatosis confined to the peripheral nervous system. J Neurol Sci (2007) 0.94

LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer. BMC Cancer (2012) 0.93

EGFR-dependent and independent activation of Akt/mTOR cascade in bone and soft tissue tumors. Mod Pathol (2009) 0.93

Involvement of epidermal growth factor receptor and downstream molecules in bone and soft tissue tumors. Hum Pathol (2007) 0.93

Ciliated hepatic cyst without smooth muscle layer: a variant of ciliated hepatic foregut cyst? Pathol Int (2006) 0.93

Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas. Cancer (2009) 0.92

Prevalence of human papillomavirus in oropharyngeal cancer: a multicenter study in Japan. Oncology (2014) 0.92

Advanced lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection under cardiopulmonary bypass. Ann Thorac Cardiovasc Surg (2010) 0.91

High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers. Cancer Sci (2009) 0.91

Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma. Int J Cancer (2004) 0.91

A case of metastatic breast cancer with outgrowth of HER2-negative cells after eradication of HER2-positive cells by humanized anti-HER2 monoclonal antibody (trastuzumab) combined with docetaxel. Hum Pathol (2004) 0.91

Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy. Intern Med (2008) 0.91

A 90-year-old woman with trachea-invading thyroid cancer requiring four-ring resection of cervical trachea because of airway stenosis. Ann Thorac Cardiovasc Surg (2007) 0.90

Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers. Am J Clin Pathol (2013) 0.90

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas. Hum Pathol (2010) 0.90

Cushing's syndrome and big IGF-II associated hypoglycaemia in a patient with adrenocortical carcinoma. BMJ Case Rep (2010) 0.90

Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma in Sjögren's syndrome showing only the LIP pattern radiologically. Intern Med (2012) 0.90

MR findings of nine cases of palatal tumor. Magn Reson Med Sci (2005) 0.89

Cleavage of amyloid-beta precursor protein (APP) by membrane-type matrix metalloproteinases. J Biochem (2006) 0.89

A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer. Auris Nasus Larynx (2008) 0.89

Upregulation of special AT-rich-binding protein 1 by Epstein-Barr virus latent membrane protein 1 in human nasopharyngeal cells and nasopharyngeal cancer. J Gen Virol (2012) 0.89

Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma. Cancer Sci (2013) 0.89

Expression patterns of seprase, a membrane serine protease, in cervical carcinoma and cervical intraepithelial neoplasm. Anticancer Res (2003) 0.89

α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression. Hum Pathol (2012) 0.89

Prognostic value of cell motility activation factors in patients with tongue squamous cell carcinoma. Hum Pathol (2006) 0.89

Autoimmune pancreatitis with multifocal mass lesions. Radiat Med (2006) 0.88

Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model. Clin Exp Metastasis (2002) 0.88

Gene amplification of Myc and its coamplification with ERBB2 and EGFR in gallbladder adenocarcinoma. Anticancer Res (2009) 0.88

Aberration of epidermal growth factor receptor expression in bone and soft-tissue tumors: protein overexpression, gene amplification and activation of downstream molecules. Mod Pathol (2004) 0.87

Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma. Oral Oncol (2012) 0.87

Clonal spread of beta-lactamase-producing amoxicillin-clavulanate-resistant (BLPACR) strains of non-typeable Haemophilus influenzae among young children attending a day care in Japan. Int J Pediatr Otorhinolaryngol (2010) 0.87

'Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer'. Cancer Lett (2005) 0.87

Podoplanin is a useful diagnostic marker for epithelioid hemangioendothelioma of the liver. Mod Pathol (2007) 0.87

Respiratory epithelial adenomatoid hamartoma of the maxillary sinus. J Laryngol Otol (2002) 0.87