Published in Int J Mol Sci on March 20, 2012
Development and validation of a genetic algorithm for flexible docking. J Mol Biol (1997) 14.36
Epidemiology of drug resistance: implications for a post-antimicrobial era. Science (1992) 7.59
Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins. J Am Chem Soc (1988) 6.41
Triclosan targets lipid synthesis. Nature (1998) 4.70
The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem (2005) 3.69
Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity. J Med Chem (1994) 3.60
LigandScout: 3-D pharmacophores derived from protein-bound ligands and their use as virtual screening filters. J Chem Inf Model (2005) 3.48
Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery. Annu Rev Microbiol (2001) 3.35
Enoyl-acyl carrier protein reductase (fabI) plays a determinant role in completing cycles of fatty acid elongation in Escherichia coli. J Biol Chem (1995) 2.80
Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis. J Biol Chem (1998) 2.75
Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res (2001) 2.60
Molecular basis of triclosan activity. Nature (1999) 2.18
Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway. Acc Chem Res (2008) 2.07
A mechanism of drug action revealed by structural studies of enoyl reductase. Science (1996) 2.03
Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J Biol Chem (2000) 1.93
Evaluation of docking performance: comparative data on docking algorithms. J Med Chem (2004) 1.79
The worldwide prevalence of methicillin-resistant Staphylococcus aureus. Int J Antimicrob Agents (1995) 1.68
Structural basis and mechanism of enoyl reductase inhibition by triclosan. J Mol Biol (1999) 1.67
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem (2003) 1.56
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J Med Chem (2002) 1.44
The enoyl-[acyl-carrier-protein] reductase (FabI) of Escherichia coli, which catalyzes a key regulatory step in fatty acid biosynthesis, accepts NADH and NADPH as cofactors and is inhibited by palmitoyl-CoA. Eur J Biochem (1996) 1.42
Efficient overlay of small organic molecules using 3D pharmacophores. J Comput Aided Mol Des (2006) 1.40
The millennium bugs--the need for and development of new antibacterials. Int J Antimicrob Agents (2000) 1.37
A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase. J Mol Biol (2001) 1.21
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett (2001) 1.14
Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase. Antimicrob Agents Chemother (2004) 1.13
4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI. Bioorg Med Chem (2006) 1.09
Identification of inhibitors of bacterial enoyl-acyl carrier protein reductase. Curr Drug Targets Infect Disord (2005) 1.05
QSAR and CoMFA: a perspective on the practical application to drug discovery. Drug Des Discov (2000) 1.03
Trends in antimicrobial resistance of Streptococcus pneumoniae in Japan. Antimicrob Agents Chemother (1995) 0.99
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett (2001) 0.97
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI). Bioorg Med Chem Lett (2009) 0.85
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI. Bioorg Med Chem Lett (2009) 0.83
Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature (2008) 4.52
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A (2008) 4.07
Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity. J Biol Chem (2005) 2.29
Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19
Comparative study on ChIP-seq data: normalization and binding pattern characterization. Bioinformatics (2009) 2.02
Rb is critical in a mammalian tissue stem cell population. Genes Dev (2007) 1.92
Dramatic increase of Cesarean deliveries in the midst of health reforms in rural China. Soc Sci Med (2010) 1.91
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res (2010) 1.88
JNK3 perpetuates metabolic stress induced by Aβ peptides. Neuron (2012) 1.80
Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly. Nature (2012) 1.75
Virtual mouse placenta: tissue layer segmentation. Conf Proc IEEE Eng Med Biol Soc (2005) 1.63
A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Biol Ther (2008) 1.62
Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes (2007) 1.61
The dose-response decrease in heart rate variability: any association with the metabolites of polycyclic aromatic hydrocarbons in coke oven workers? PLoS One (2012) 1.55
Reconstruction of cellular biological structures from optical microscopy data. IEEE Trans Vis Comput Graph (2008) 1.52
BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res (2010) 1.51
ErbB4-neuregulin signaling modulates synapse development and dendritic arborization through distinct mechanisms. J Biol Chem (2008) 1.46
Does prenatal maternal stress impair cognitive development and alter temperament characteristics in toddlers with healthy birth outcomes? Dev Med Child Neurol (2014) 1.45
A graphene-pure-sulfur sandwich structure for ultrafast, long-life lithium-sulfur batteries. Adv Mater (2013) 1.40
Clonal production and organization of inhibitory interneurons in the neocortex. Science (2011) 1.39
An ets2-driven transcriptional program in tumor-associated macrophages promotes tumor metastasis. Cancer Res (2010) 1.39
Tensor classification of N-point correlation function features for histology tissue segmentation. Med Image Anal (2008) 1.38
Canonical and atypical E2Fs regulate the mammalian endocycle. Nat Cell Biol (2012) 1.37
Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists. Proc Natl Acad Sci U S A (2010) 1.36
Potent and orally active small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem (2009) 1.34
Atypical E2F repressors and activators coordinate placental development. Dev Cell (2012) 1.33
Feature-based registration of histopathology images with different stains: an application for computerized follicular lymphoma prognosis. Comput Methods Programs Biomed (2009) 1.32
Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. J Biol Chem (2010) 1.28
Disparities in analgesia and opioid prescribing practices for patients with musculoskeletal pain in the emergency department. J Emerg Nurs (2006) 1.26
Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. J Neurosci (2010) 1.25
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Mol Cancer Ther (2008) 1.22
Space-time latent component modeling of geo-referenced health data. Stat Med (2010) 1.21
Asymmetric synthesis of primary amines via the spiroborate-catalyzed borane reduction of oxime ethers. Org Lett (2007) 1.20
Weighted frequent gene co-expression network mining to identify genes involved in genome stability. PLoS Comput Biol (2012) 1.19
Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China. J Clin Endocrinol Metab (2011) 1.19
Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res (2011) 1.19
Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains. J Biol Chem (2009) 1.16
Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet (2011) 1.14
Using gene co-expression network analysis to predict biomarkers for chronic lymphocytic leukemia. BMC Bioinformatics (2010) 1.12
Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma. Neuro Oncol (2009) 1.10
An efficient organocatalytic method for constructing biaryls through aromatic C-H activation. Nat Chem (2010) 1.10
New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC. Inflamm Bowel Dis (2009) 1.09
Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells. Toxicology (2009) 1.09
Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. Mol Cancer Ther (2008) 1.08
Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem (2010) 1.08
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem (2013) 1.08
Autonomic dysreflexia causes chronic immune suppression after spinal cord injury. J Neurosci (2013) 1.07
Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor. Biochemistry (2004) 1.07
RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation. PLoS One (2010) 1.07
Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res (2007) 1.06
Studies on the toxicity of gambogic acid in rats. J Ethnopharmacol (2008) 1.05
Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. J Cancer Res Clin Oncol (2009) 1.05
Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. J Hepatol (2011) 1.04
KIAA0101 interacts with BRCA1 and regulates centrosome number. Mol Cancer Res (2011) 1.04
MMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples. Bioinformatics (2013) 1.04
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. J Med Chem (2007) 1.04
Enhancing the activity of a protein by stereospecific unfolding: conformational life cycle of insulin and its evolutionary origins. J Biol Chem (2009) 1.02
Determinants of variation in analgesic and opioid prescribing practice in an emergency department. J Opioid Manag (2007) 1.01
TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Blood (2009) 1.01
A personalized microRNA microarray normalization method using a logistic regression model. Bioinformatics (2009) 1.01
Robust 3D reconstruction and identification of dendritic spines from optical microscopy imaging. Med Image Anal (2008) 1.01
Characterization of a wheat HSP70 gene and its expression in response to stripe rust infection and abiotic stresses. Mol Biol Rep (2010) 1.01
Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Mol Biol Cell (2008) 1.01
Toxicological studies of gambogic acid and its potential targets in experimental animals. Basic Clin Pharmacol Toxicol (2006) 1.00
Dual-mode imaging of cutaneous tissue oxygenation and vascular function. J Vis Exp (2010) 1.00
Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia. Chin J Cancer (2013) 1.00
Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells. Chin J Cancer (2012) 0.99
Oncogenic role of kinesin proteins and targeting kinesin therapy. Cancer Sci (2013) 0.99
Low postnatal care rates in two rural counties in Anhui Province, China: perceptions of key stakeholders. Midwifery (2010) 0.99
Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PLoS One (2011) 0.98
Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes. Nucleic Acids Res (2012) 0.98
Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases. Biochim Biophys Acta (2013) 0.97
Using Frequent Co-expression Network to Identify Gene Clusters for Breast Cancer Prognosis. Proc Int Joint Conf Bioinforma Syst Biol Intell Comput (2009) 0.97
Multi-dimensional discovery of biomarker and phenotype complexes. BMC Bioinformatics (2010) 0.97
Physical activity might not be the protective factor for health risk behaviours and psychopathological symptoms in adolescents. J Paediatr Child Health (2007) 0.96
Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol. Invest Ophthalmol Vis Sci (2012) 0.96
Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J Biol Chem (2008) 0.95
k-Neighborhood decentralization: a comprehensive solution to index the UMLS for large scale knowledge discovery. J Biomed Inform (2011) 0.95
Cyclin-dependent kinase 7/9 inhibitor SNS-032 abrogates FIP1-like-1 platelet-derived growth factor receptor α and bcr-abl oncogene addiction in malignant hematologic cells. Clin Cancer Res (2012) 0.94
Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Eur J Pharmacol (2008) 0.94
Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling. Cell Signal (2013) 0.94
Gambogic acid inhibits tumor cell adhesion by suppressing integrin β1 and membrane lipid rafts-associated integrin signaling pathway. Biochem Pharmacol (2011) 0.93
Cohort Profile: the China-Anhui Birth Cohort Study. Int J Epidemiol (2012) 0.93
Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. Biochem Biophys Res Commun (2012) 0.93
Predicting glioblastoma prognosis networks using weighted gene co-expression network analysis on TCGA data. BMC Bioinformatics (2012) 0.93
Effectively processing medical term queries on the UMLS Metathesaurus by layered dynamic programming. BMC Med Genomics (2014) 0.93
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. Int J Cancer (2010) 0.93
Wogonoside inhibits lipopolysaccharide-induced angiogenesis in vitro and in vivo via toll-like receptor 4 signal transduction. Toxicology (2009) 0.92
Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology (2013) 0.92
Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators Inflamm (2013) 0.92
DNA-templated synthesis in three dimensions: Introducing a micellar scaffold for organic reactions. Angew Chem Int Ed Engl (2006) 0.92
From sequencer to supercomputer: an automatic pipeline for managing and processing next generation sequencing data. AMIA Jt Summits Transl Sci Proc (2012) 0.92
Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity. Biochemistry (2004) 0.92
Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues. Biochemistry (2004) 0.92
Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse. J Physiol (2013) 0.92
Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Toxicology (2011) 0.91
Competitive or noncompetitive, that's the question: research toward histone deacetylase inhibitors. Mol Cancer Ther (2008) 0.91
An indicator of cancer: downregulation of monoamine oxidase-A in multiple organs and species. BMC Genomics (2008) 0.91
Copper-catalyzed desymmetric intramolecular Ullmann C-N coupling: an enantioselective preparation of indolines. J Am Chem Soc (2012) 0.91
Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. Cell Signal (2012) 0.91