Published in Antimicrob Agents Chemother on May 01, 2004
Challenges of antibacterial discovery. Clin Microbiol Rev (2011) 3.94
The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol (2008) 1.33
The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother (2011) 1.21
Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus. Biochemistry (2008) 1.13
Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor. Protein Sci (2008) 1.00
Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J Med Chem (2012) 0.90
New 2-thiopyridines as potential candidates for killing both actively growing and dormant Mycobacterium tuberculosis cells. Antimicrob Agents Chemother (2013) 0.90
AG205, a novel agent directed against FabK of Streptococcus pneumoniae. Antimicrob Agents Chemother (2006) 0.87
Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds. Antimicrob Agents Chemother (2005) 0.80
Crystallization and preliminary X-ray analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.80
Pharmacophore and molecular docking guided 3D-QSAR study of bacterial enoyl-ACP reductase (FabI) Inhibitors. Int J Mol Sci (2012) 0.78
Crystallization and preliminary X-ray crystallographic analysis of enoyl-ACP reductase III (FabL) from Bacillus subtilis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.75
In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui). Chin Med (2015) 0.75
Purification, crystallization and preliminary X-ray diffraction analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus mutans strain UA159. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
Rational questing for potential novel inhibitors of FabK from Streptococcus pneumoniae by combining FMO calculation, CoMFA 3D-QSAR modeling and virtual screening. J Mol Model (2010) 0.75
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J Biomol Screen (1999) 32.67
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature (2000) 7.30
Use of the Escherichia coli lac repressor and operator to control gene expression in Bacillus subtilis. Proc Natl Acad Sci U S A (1984) 6.00
Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J Bacteriol (1996) 5.58
Construction of single-copy integration vectors for Staphylococcus aureus. Gene (1991) 4.43
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob Agents Chemother (2001) 3.87
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. Biochemistry (1995) 3.04
Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res (2001) 2.60
Evaluation of a tetracycline-inducible promoter in Staphylococcus aureus in vitro and in vivo and its application in demonstrating the role of sigB in microcolony formation. Infect Immun (2001) 2.49
A triclosan-resistant bacterial enzyme. Nature (2000) 2.40
The enoyl-[acyl-carrier-protein] reductases FabI and FabL from Bacillus subtilis. J Biol Chem (2000) 2.33
Molecular basis of triclosan activity. Nature (1999) 2.18
Discovery of a novel and potent class of FabI-directed antibacterial agents. Antimicrob Agents Chemother (2002) 2.14
Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Appl Microbiol Biotechnol (2002) 1.96
Regulated expression of heterologous genes in Bacillus subtilis using the Tn10 encoded tet regulatory elements. Appl Microbiol Biotechnol (1990) 1.67
Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems. Antimicrob Agents Chemother (1999) 1.57
An array of target-specific screening strains for antibacterial discovery. Nat Biotechnol (2002) 1.56
Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). J Med Chem (2002) 1.44
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg Med Chem Lett (2001) 1.14
Modulations in lipid A and phospholipid biosynthesis pathways influence outer membrane protein assembly in Escherichia coli K-12. Mol Microbiol (1998) 1.08
Regulated ectopic expression and allelic-replacement mutagenesis as a method for gene essentiality testing in Staphylococcus aureus. Plasmid (2001) 1.07
Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents. Bioorg Med Chem Lett (2001) 0.97
Direct selection of cloned DNA in Bacillus subtilis based on sucrose-induced lethality. Appl Environ Microbiol (1996) 0.95
qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob Agents Chemother (2006) 5.50
Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol (2006) 4.22
H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science (2013) 3.33
Evaluating the impact of a single-day multidisciplinary clinic on the management of pancreatic cancer. Ann Surg Oncol (2008) 3.14
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell (2011) 2.61
Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae. Antimicrob Agents Chemother (2004) 2.56
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell (2012) 2.39
Pituitary homeobox 2 (PITX2) promotes thyroid carcinogenesis by activation of cyclin D2. Cell Cycle (2010) 2.29
ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther (2010) 2.18
A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell (2013) 2.14
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types. Proc Natl Acad Sci U S A (2008) 1.95
Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol (2009) 1.86
Novel broad-spectrum bis-(imidazolinylindole) derivatives with potent antibacterial activities against antibiotic-resistant strains. Antimicrob Agents Chemother (2009) 1.66
Increased Prevalence of Precursor Lesions in Familial Pancreatic Cancer Patients. Clin Cancer Res (2009) 1.65
Update on managing diaphragmatic rupture in blunt trauma: a review of 208 consecutive cases. Can J Surg (2009) 1.61
Imaging of renal lymphoma: patterns of disease with pathologic correlation. Radiographics (2006) 1.52
Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. J Biol Chem (2011) 1.45
Identifying the important HIV-1 recombination breakpoints. PLoS Comput Biol (2008) 1.42
trans-Diaqua-bis-(1H-imidazole-4-carboxyl-ato-κN,O)nickel(II). Acta Crystallogr Sect E Struct Rep Online (2011) 1.40
Intraventricular craniopharyngioma: morphological analysis and outcome evaluation of 17 cases. Acta Neurochir (Wien) (2011) 1.40
Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion. Antimicrob Agents Chemother (2010) 1.38
Di-μ-chlorido-bis-{[2-(8-quinol-yloxy)-acetato-κN,O,O]copper(II)}. Acta Crystallogr Sect E Struct Rep Online (2008) 1.35
High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synapse (2006) 1.30
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One (2012) 1.29
The mzQuantML data standard for mass spectrometry-based quantitative studies in proteomics. Mol Cell Proteomics (2013) 1.28
De novo derivation of proteomes from transcriptomes for transcript and protein identification. Nat Methods (2012) 1.26
A critical appraisal of techniques, software packages, and standards for quantitative proteomic analysis. OMICS (2012) 1.25
Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. J Med Chem (2011) 1.22
Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci U S A (2012) 1.21
Comparative in vitro activity profiles of novel bis-indole antibacterials against gram-positive and gram-negative clinical isolates. Antimicrob Agents Chemother (2010) 1.18
Golgi localization of Syne-1. Mol Biol Cell (2003) 1.17
Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure. Synapse (2008) 1.17
Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J Biol Chem (2005) 1.17
SOS regulation of qnrB expression. Antimicrob Agents Chemother (2008) 1.16
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen (2010) 1.14
Identification of a small-molecule entry inhibitor for filoviruses. J Virol (2011) 1.14
Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2010) 1.12
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun (2013) 1.08
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors. J Med Chem (2010) 1.08
Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR. Bioorg Med Chem (2010) 1.07
Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity. Br J Haematol (2013) 1.07
Anatomical study of the arachnoid envelope over the pineal region. Neurosurgery (2011) 1.06
Gene-environment interactions in Parkinson's disease and other forms of parkinsonism. Neurotoxicology (2010) 1.06
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity. J Med Chem (2011) 1.05
New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion. J Virol (2013) 1.04
HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: analysis of a Nairobi-Kenyan cohort. Med Microbiol Immunol (2013) 1.04
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis. Antimicrob Agents Chemother (2009) 1.03
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. J Med Chem (2004) 1.03
Sequence determinants of breakpoint location during HIV-1 intersubtype recombination. Nucleic Acids Res (2006) 1.02
Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold. Bioorg Med Chem Lett (2004) 1.02
A screen for regulators of survival of motor neuron protein levels. Nat Chem Biol (2011) 1.02
Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile. J Med Chem (2012) 1.01
A variant of estrogen receptor-alpha, ER-alpha36 is expressed in human gastric cancer and is highly correlated with lymph node metastasis. Oncol Rep (2010) 1.00
NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity. Mol Cancer Res (2009) 1.00
Genetic analysis of HIV-1 subtypes in Nairobi, Kenya. PLoS One (2008) 1.00
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem (2010) 0.99
XAV939, a tankyrase 1 inhibitior, promotes cell apoptosis in neuroblastoma cell lines by inhibiting Wnt/β-catenin signaling pathway. J Exp Clin Cancer Res (2013) 0.99
Autologous transplantation of adipose-derived mesenchymal stem cells ameliorates streptozotocin-induced diabetic nephropathy in rats by inhibiting oxidative stress, pro-inflammatory cytokines and the p38 MAPK signaling pathway. Int J Mol Med (2012) 0.98
Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1. Head Neck (2009) 0.98
Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol (2012) 0.98
Evidence of recombination between divergent hepatitis E viruses. J Virol (2005) 0.98
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett (2010) 0.96
A coaxial cable Fabry-Perot interferometer for sensing applications. Sensors (Basel) (2013) 0.95
Spectral estimation in unevenly sampled space of periodically expressed microarray time series data. BMC Bioinformatics (2007) 0.95
Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication. Molecules (2010) 0.95
Hypoxia inhibits the differentiation of mesenchymal stem cells into osteoblasts by activation of Notch signaling. Exp Mol Pathol (2012) 0.94
Effect on the expression of MMP-2, MT-MMP in laryngeal carcinoma Hep-2 cell line by antisense glucose transporter-1. Arch Med Res (2012) 0.93
Effect of antisense oligodeoxynucleotides glucose transporter-1 on enhancement of radiosensitivity of laryngeal carcinoma. Int J Med Sci (2013) 0.93
Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol (2012) 0.93
Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method. J Biomol Screen (2005) 0.93
Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine-evoked neurotoxicity. Ann N Y Acad Sci (2003) 0.92
Ketamine-induced neurotoxicity and changes in gene expression in the developing rat brain. Curr Neuropharmacol (2011) 0.92
The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis. J Biol Chem (2013) 0.91
Expression of glucose transporter-1 and -3 in the head and neck carcinoma--the correlation of the expression with the biological behaviors. ORL J Otorhinolaryngol Relat Spec (2008) 0.91
Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Mol Cell Biochem (2007) 0.90
A novel mode of protein kinase inhibition exploiting hydrophobic motifs of autoinhibited kinases: discovery of ATP-independent inhibitors of fibroblast growth factor receptor. J Biol Chem (2011) 0.89
Mutational analysis of quinolone resistance protein QnrB1. Antimicrob Agents Chemother (2013) 0.89
Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090. Bioorg Med Chem (2013) 0.89
The antiviral protein cyanovirin-N: the current state of its production and applications. Appl Microbiol Biotechnol (2010) 0.89
Dura-based cavernous hemangioma presenting as large intracerebral hematoma in a child: A rare clinico-pathological entity. J Pediatr Neurosci (2011) 0.88
Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities. J Med Chem (2012) 0.88
Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor. Bioorg Med Chem Lett (2013) 0.88
Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal Biochem (2008) 0.87
Biotemplated preparation of CdS nanoparticles/bacterial cellulose hybrid nanofibers for photocatalysis application. J Hazard Mater (2011) 0.87
Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases. Bioorg Med Chem (2009) 0.87
Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases. Protein Sci (2006) 0.87
Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorg Med Chem (2011) 0.87
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists. Bioorg Med Chem Lett (2005) 0.86
Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation. Antimicrob Agents Chemother (2009) 0.86
The impact of CpG island on defining transcriptional activation of the mouse L1 retrotransposable elements. PLoS One (2010) 0.86
Clinical significance of FDG single-photon emission computed tomography: Computed tomography in the diagnosis of head and neck cancers and study of its mechanism. Cancer Biother Radiopharm (2008) 0.86
Reliability of sonographic assessment of tendinopathy in tennis elbow. Skeletal Radiol (2011) 0.85
Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers. Future Oncol (2013) 0.85
Fine-needle aspiration biopsy of secondary neoplasms of the thyroid gland: a multi-institutional study of 62 cases. Cancer Cytopathol (2014) 0.85
Control of chronic inflammation with pathway selective estrogen receptor ligands. Curr Top Med Chem (2006) 0.85
A rare tumour in a rare location: desmoplastic fibroma in a toe. Foot Ankle Surg (2011) 0.85
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in gram-positive bacteria. Bioorg Med Chem Lett (2008) 0.85