Published in Methods on July 27, 2012
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Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor. J Biol Chem (2013) 0.92
Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells. Proc Natl Acad Sci U S A (2013) 0.83
Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo. Oncotarget (2016) 0.82
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2). Biochem J (2015) 0.80
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation. Oncogene (2014) 0.78
The challenge of targeting notch in hematologic malignancies. Front Pediatr (2014) 0.78
Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. PLoS One (2015) 0.78
Generation of recombinant antibodies to rat GABAA receptor subunits by affinity selection on synthetic peptides. PLoS One (2014) 0.78
Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage. Neural Regen Res (2015) 0.78
Regionally-specified second trimester fetal neural stem cells reveals differential neurogenic programming. PLoS One (2014) 0.76
Polychlorinated biphenyls target Notch/Dll and VEGF R2 in the mouse placenta and human trophoblast cell lines for their anti-angiogenic effects. Sci Rep (2017) 0.75
Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors. PLoS One (2016) 0.75
Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers. Oncotarget (2017) 0.75
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
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High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells. Nucleic Acids Res (2002) 6.64
Mutations in NOTCH1 cause aortic valve disease. Nature (2005) 6.27
Transient expression of doublecortin during adult neurogenesis. J Comp Neurol (2003) 5.61
The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell (2009) 5.33
The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer (2003) 4.75
Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 4.56
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45
Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell (1991) 4.37
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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci (2004) 3.85
Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene. Development (1996) 3.84
Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci (2005) 3.67
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell (2006) 3.42
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Cell and molecular biology of Notch. J Endocrinol (2007) 2.45
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model. Blood (2009) 2.29
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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease. Arch Neurol (2008) 2.25
Application of phage display to high throughput antibody generation and characterization. Genome Biol (2007) 1.98
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem (2008) 1.83
Neural stem cell self-renewal. Crit Rev Oncol Hematol (2007) 1.76
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood (2008) 1.69
Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64
Inhibition of notch signaling in human embryonic stem cell-derived neural stem cells delays G1/S phase transition and accelerates neuronal differentiation in vitro and in vivo. Stem Cells (2010) 1.57
A genome annotation-driven approach to cloning the human ORFeome. Genome Biol (2004) 1.48
Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons. PLoS One (2012) 1.46
Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One (2010) 1.41
Notch controls proliferation and differentiation of stem cells in a dose-dependent manner. Eur J Neurosci (2006) 1.16
Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. Cancer Res (2010) 1.13
APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. PLoS One (2010) 1.11
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci (2010) 1.10
A simple vector system to improve performance and utilisation of recombinant antibodies. BMC Biotechnol (2006) 1.05
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. Proc Natl Acad Sci U S A (2002) 1.05
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display. Protein Eng Des Sel (2010) 1.02
Multiplexed expression and screening for recombinant protein production in mammalian cells. BMC Biotechnol (2006) 0.98
Mapping protein interactions by combining antibody affinity maturation and mass spectrometry. Anal Biochem (2011) 0.96
Notch as a molecular switch in neural stem cells. IUBMB Life (2010) 0.76
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases. Nucleic Acids Res (2013) 4.39
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol (2003) 2.47
Beyond natural antibodies: the power of in vitro display technologies. Nat Biotechnol (2011) 2.41
Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development (2003) 2.21
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
Application of phage display to high throughput antibody generation and characterization. Genome Biol (2007) 1.98
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17. Biochem J (2010) 1.93
Production of soluble mammalian proteins in Escherichia coli: identification of protein features that correlate with successful expression. BMC Biotechnol (2004) 1.83
Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol Cell Neurosci (2008) 1.62
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One (2009) 1.50
Treatment of a mouse model of spinal cord injury by transplantation of human induced pluripotent stem cell-derived long-term self-renewing neuroepithelial-like stem cells. Stem Cells (2012) 1.33
Cross-domain inhibition of TACE ectodomain. Proc Natl Acad Sci U S A (2011) 1.26
Expression profiling by high-throughput immunohistochemistry. J Immunol Methods (2004) 1.21
Impaired recognition of apoptotic neutrophils by the C1q/calreticulin and CD91 pathway in systemic lupus erythematosus. Arthritis Rheum (2006) 1.06
A simple vector system to improve performance and utilisation of recombinant antibodies. BMC Biotechnol (2006) 1.05
Accelerated screening of phage-display output with alkaline phosphatase fusions. Comb Chem High Throughput Screen (2004) 1.02
Multiplexed expression and screening for recombinant protein production in mammalian cells. BMC Biotechnol (2006) 0.98
Uptake and processing of Chlamydia trachomatis by human dendritic cells. Eur J Immunol (2002) 0.98
Mapping protein interactions by combining antibody affinity maturation and mass spectrometry. Anal Biochem (2011) 0.96
Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands. BMC Biol (2006) 0.89
Perfusion and diffusion MRI combined with ¹¹C-methionine PET in the preoperative evaluation of suspected adult low-grade gliomas. J Neurooncol (2013) 0.88
Recombinant antibodies and in vitro selection technologies. Methods Mol Biol (2012) 0.88
Hepatitis B virus core antigen: enhancement of its production in Escherichia coli, and interaction of the core particles with the viral surface antigen. Biol Chem (2003) 0.87
Mining mammalian genomes for folding competent proteins using Tat-dependent genetic selection in Escherichia coli. Protein Sci (2009) 0.87
Identification of soluble protein fragments by gene fragmentation and genetic selection. Nucleic Acids Res (2008) 0.86
Dendritic cells internalise and re-present conformationally intact soluble MHC class I alloantigen for generation of alloantibody. Eur J Immunol (2007) 0.85
Imaging-based chemical screens using normal and glioma-derived neural stem cells. Biochem Soc Trans (2010) 0.85
Non-immortalized human neural stem (NS) cells as a scalable platform for cellular assays. Neurochem Int (2011) 0.85
Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells. J Biomol Screen (2012) 0.83
Stem cells expanded from the human embryonic hindbrain stably retain regional specification and high neurogenic potency. J Neurosci (2013) 0.83
Selecting antagonistic antibodies that control differentiation through inducible expression in embryonic stem cells. Proc Natl Acad Sci U S A (2013) 0.83
Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies. Leuk Res (2009) 0.79
Resin tissue microarrays: a universal format for immunohistochemistry. J Histochem Cytochem (2005) 0.78
Microinjection of targeted embryonic stem cells and establishment of knockout mouse lines for Fmo genes. Methods Mol Biol (2006) 0.78
Control of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteria. Proc Natl Acad Sci U S A (2008) 0.78
Detection of weak receptor-ligand interactions using IgM and J-chain-based fusion proteins. Eur J Immunol (2012) 0.76
Expression screening in mammalian suspension cells. Methods Mol Biol (2014) 0.75
The long and winding road to antibody therapeutics. MAbs (2010) 0.75
Electroconvulsive therapy in the setting of implantable cardioverter-defibrillators. J ECT (2009) 0.75