Published in Development on July 01, 1996
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86
Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol (2001) 2.56
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol (1997) 2.48
Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. J Clin Invest (2005) 2.38
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res (2008) 2.19
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev (1997) 2.17
Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn (2004) 2.12
Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. Mol Cell Biol (1997) 2.12
Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood (2007) 2.01
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev (2002) 1.97
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A (2005) 1.90
RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol (1997) 1.89
Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol Biol Cell (1998) 1.87
Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood (2010) 1.84
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol (2006) 1.80
Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol (2005) 1.79
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J (2004) 1.78
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Neoplastic transformation by Notch requires nuclear localization. Mol Cell Biol (2000) 1.64
Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol (2001) 1.61
Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60
Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol (2003) 1.57
Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation. J Virol (1997) 1.56
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Coordinating tissue interactions: Notch signaling in cardiac development and disease. Dev Cell (2012) 1.55
Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol (2000) 1.54
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Proc Natl Acad Sci U S A (2001) 1.54
Inhibition of granulocytic differentiation by mNotch1. Proc Natl Acad Sci U S A (1996) 1.54
Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol (2002) 1.52
Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol (2002) 1.51
The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis (2013) 1.50
Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res (2010) 1.49
Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines. Mol Cell Biol (1998) 1.48
Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47
p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol (2002) 1.38
VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38
SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood (2005) 1.37
Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol (2007) 1.36
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA. J Virol (2004) 1.32
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal. Nat Cell Biol (2009) 1.29
Notch signalling via RBP-J promotes myeloid differentiation. EMBO J (2000) 1.28
Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol (2005) 1.27
Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J Exp Med (2000) 1.26
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One (2012) 1.23
Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis. Cold Spring Harb Perspect Med (2012) 1.21
Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells. Br J Cancer (2005) 1.19
Notch signaling respecifies the hemangioblast to a cardiac fate. Nat Biotechnol (2008) 1.19
Inhibition of Notch signaling by a γ-secretase inhibitor attenuates hepatic fibrosis in rats. PLoS One (2012) 1.16
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science (2012) 1.15
The notch pathway intermediate HES-1 silences CD4 gene expression. Mol Cell Biol (1998) 1.14
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc Natl Acad Sci U S A (2007) 1.11
Antiangiogenic therapy for cancer: an update. Pharmacotherapy (2012) 1.10
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. EMBO J (2002) 1.10
Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells. Microvasc Res (2008) 1.08
Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats. Am J Pathol (2010) 1.07
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
A functional analysis of Notch mutations in Drosophila. Genetics (1997) 1.07
Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One (2009) 1.04
Notch signaling in glioblastoma: a developmental drug target? BMC Med (2010) 1.04
Common integration sites for MMTV in viral induced mouse mammary tumors. J Mammary Gland Biol Neoplasia (2008) 1.02
Notch signaling during vascular development. Proc Natl Acad Sci U S A (2001) 0.99
Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-β signaling to drive malignant progression. Cancer Res (2014) 0.99
An Epstein-Barr virus protein interacts with Notch. J Virol (2001) 0.99
Notch signaling in cardiac development and disease. Pediatr Cardiol (2009) 0.98
Activation of Notch signaling pathway in HIV-associated nephropathy. AIDS (2010) 0.97
Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells. Methods (2012) 0.97
Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology (2010) 0.97
Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res (2008) 0.97
Impact of notch signaling on inflammatory responses in cardiovascular disorders. Int J Mol Sci (2013) 0.96
Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation. Am J Med Genet C Semin Med Genet (2013) 0.96
Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activity. J Biol Chem (2011) 0.95
Notching on Cancer's Door: Notch Signaling in Brain Tumors. Front Oncol (2015) 0.95
Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93
Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2. Ann Rheum Dis (2012) 0.92
Calcium binding to tandem repeats of EGF-like modules. Expression and characterization of the EGF-like modules of human Notch-1 implicated in receptor-ligand interactions. Protein Sci (1997) 0.91
Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol (2009) 0.90
Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. PLoS One (2012) 0.90
The emerging roles of Notch signaling in leukemia and stem cells. Biomark Res (2013) 0.90
The nuclear receptor E75A has a novel pair-rule-like function in patterning the milkweed bug, Oncopeltus fasciatus. Dev Biol (2009) 0.90
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2014) 0.88
Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. Biol Reprod (2013) 0.87
Intracisternal type A particle-mediated activation of the Notch4/int3 gene in a mouse mammary tumor: generation of truncated Notch4/int3 mRNAs by retroviral splicing events. J Virol (1999) 0.87
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats. Biochem Biophys Res Commun (2010) 0.86
Expression of HES and HEY genes in infantile hemangiomas. Vasc Cell (2011) 0.86
Notch1 is pan-endothelial at the onset of flow and regulated by flow. PLoS One (2015) 0.85
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics (2006) 0.85
Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol (2011) 0.85
Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature (2001) 7.43
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet (1997) 4.46
Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86
Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci (2001) 3.85
Superconductivity at 43 K in SmFeAsO1-xFx. Nature (2008) 3.80
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev (2001) 3.67
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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol (2001) 2.56
Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56
Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol (2001) 2.52
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Visualization and functional characterization of the developing murine cardiac conduction system. Development (2001) 1.97
Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr (2000) 1.97
Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene (2008) 1.95
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