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Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods (2013) 8.12

Structure of the TRPV1 ion channel determined by electron cryo-microscopy. Nature (2013) 5.75

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles. Elife (2013) 4.42

Quantifying the local resolution of cryo-EM density maps. Nat Methods (2013) 4.36

TRPV1 structures in distinct conformations reveal activation mechanisms. Nature (2013) 3.62

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy. Ultramicroscopy (2013) 3.24

Beam-induced motion correction for sub-megadalton cryo-EM particles. Elife (2014) 2.66

Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 2.47

Measuring image resolution in optical nanoscopy. Nat Methods (2013) 2.42

Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol (2013) 1.90

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions. Acta Crystallogr D Biol Crystallogr (2015) 1.89

Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution. Cell (2014) 1.80

Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector. Elife (2014) 1.75

Drug sensing by the ribosome induces translational arrest via active site perturbation. Mol Cell (2014) 1.72

Semi-automated selection of cryo-EM particles in RELION-1.3. J Struct Biol (2014) 1.68

The complete structure of the large subunit of the mammalian mitochondrial ribosome. Nature (2014) 1.67

Structure of the large ribosomal subunit from human mitochondria. Science (2014) 1.64

Avoiding the pitfalls of single particle cryo-electron microscopy: Einstein from noise. Proc Natl Acad Sci U S A (2013) 1.64

Initiation of translation by cricket paralysis virus IRES requires its translocation in the ribosome. Cell (2014) 1.62

Structural dynamics of ribosome subunit association studied by mixing-spraying time-resolved cryogenic electron microscopy. Structure (2015) 1.61

Structural and functional insights into the mode of action of a universally conserved Obg GTPase. PLoS Biol (2014) 1.60

Structural mechanism of glutamate receptor activation and desensitization. Nature (2014) 1.58

Structural changes enable start codon recognition by the eukaryotic translation initiation complex. Cell (2014) 1.55

2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. Elife (2015) 1.52

Sampling the conformational space of the catalytic subunit of human γ-secretase. Elife (2015) 1.51

The Structural Basis of Actin Organization by Vinculin and Metavinculin. J Mol Biol (2015) 1.50

Cryo-EM enters a new era. Elife (2014) 1.48

Structure of a modular polyketide synthase. Nature (2014) 1.44

Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature (2015) 1.41

Molecular architecture of a eukaryotic translational initiation complex. Science (2013) 1.41

Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat Struct Mol Biol (2017) 1.40

Architecture and conformational switch mechanism of the ryanodine receptor. Nature (2014) 1.39

Mechanistic insights into the recycling machine of the SNARE complex. Nature (2015) 1.38

Structures of the Carbon-Phosphorus Lyase Complex Reveal the Binding Mode of the NBD-like PhnK. Structure (2015) 1.37

Protein secondary structure determination by constrained single-particle cryo-electron tomography. Structure (2012) 1.36

Molecular architecture and mechanism of the anaphase-promoting complex. Nature (2014) 1.36

Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature (2014) 1.34

The architecture of Tetrahymena telomerase holoenzyme. Nature (2013) 1.32

Mechanism of eIF6 release from the nascent 60S ribosomal subunit. Nat Struct Mol Biol (2015) 1.29

Cryo-EM structure of a novel calicivirus, Tulane virus. PLoS One (2013) 1.26

The architecture of the spliceosomal U4/U6.U5 tri-snRNP. Nature (2015) 1.24

In situ structural analysis of the Yersinia enterocolitica injectisome. Elife (2013) 1.24

Single particle cryo-electron microscopy and 3-D reconstruction of viruses. Methods Mol Biol (2014) 1.23

Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature (2015) 1.22

Cryo-EM structure of a 3D DNA-origami object. Proc Natl Acad Sci U S A (2012) 1.20

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature (2016) 1.19

Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature (2015) 1.19

An atomic model of brome mosaic virus using direct electron detection and real-space optimization. Nat Commun (2014) 1.18

Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity. Mol Cell (2015) 1.17

Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution. Nature (2016) 1.17

Visualizing GroEL/ES in the act of encapsulating a folding protein. Cell (2013) 1.16

Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env. Cell (2015) 1.16

Validation of cryo-EM structure of IP₃R1 channel. Structure (2013) 1.15

Controlling protein adsorption on graphene for cryo-EM using low-energy hydrogen plasmas. Nat Methods (2014) 1.15

Cryo-EM model validation using independent map reconstructions. Protein Sci (2013) 1.13

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature (2016) 1.12

De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy. Elife (2013) 1.11

A supramolecular assembly mediates lentiviral DNA integration. Science (2017) 1.10

Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling. Proc Natl Acad Sci U S A (2013) 1.10

Molecular mechanism of antibody-mediated activation of β-galactosidase. Structure (2014) 1.10

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Mol Cell (2015) 1.10

Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature (2014) 1.09

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA. Nat Struct Mol Biol (2014) 1.08

Cryo-EM structure of the spliceosome immediately after branching. Nature (2016) 1.07

Advances in Single-Particle Electron Cryomicroscopy Structure Determination applied to Sub-tomogram Averaging. Structure (2015) 1.07

EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy. Nat Methods (2015) 1.07

De novo protein structure determination from near-atomic-resolution cryo-EM maps. Nat Methods (2015) 1.05

Multifunctional RNA nanoparticles. Nano Lett (2014) 1.03

Assessing and maximizing data quality in macromolecular crystallography. Curr Opin Struct Biol (2015) 1.02

Pre-fusion structure of a human coronavirus spike protein. Nature (2016) 1.01

The architecture of the mammalian respirasome. Nature (2016) 1.01

EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics. Nat Struct Mol Biol (2014) 1.00

Structure and organization of heteromeric AMPA-type glutamate receptors. Science (2016) 1.00

Reprogramming an ATP-driven protein machine into a light-gated nanocage. Nat Nanotechnol (2013) 1.00

Reply to Subramaniam, van Heel, and Henderson: Validity of the cryo-electron microscopy structures of the HIV-1 envelope glycoprotein complex. Proc Natl Acad Sci U S A (2013) 0.99

The architecture of respiratory supercomplexes. Nature (2016) 0.99

Atomic structure of the entire mammalian mitochondrial complex I. Nature (2016) 0.99

Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell (2015) 0.99

Capsid expansion mechanism of bacteriophage T7 revealed by multistate atomic models derived from cryo-EM reconstructions. Proc Natl Acad Sci U S A (2014) 0.98

Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature (2016) 0.98

Seeing tobacco mosaic virus through direct electron detectors. J Struct Biol (2014) 0.97

Structure and gating of the nuclear pore complex. Nat Commun (2015) 0.96

Single particle tomography in EMAN2. J Struct Biol (2015) 0.96

2.9 Å Resolution Cryo-EM 3D Reconstruction of Close-Packed Virus Particles. Structure (2016) 0.95

Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling. Nat Commun (2015) 0.95

Model Building and Refinement of a Natively Glycosylated HIV-1 Env Protein by High-Resolution Cryoelectron Microscopy. Structure (2015) 0.94

Cross-validation in cryo-EM-based structural modeling. Proc Natl Acad Sci U S A (2013) 0.94

Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism. Structure (2013) 0.94

Single particle electron cryo-microscopy of a mammalian ion channel. Curr Opin Struct Biol (2014) 0.93

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike. Nat Commun (2015) 0.93

Bacterial tubulin TubZ-Bt transitions between a two-stranded intermediate and a four-stranded filament upon GTP hydrolysis. Proc Natl Acad Sci U S A (2014) 0.93

The dynamic conformational landscape of gamma-secretase Nadav. J Cell Sci (2015) 0.93

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability. Nat Commun (2016) 0.92

Structure of the Sec61 channel opened by a signal sequence. Science (2016) 0.92

Single-step antibody-based affinity cryo-electron microscopy for imaging and structural analysis of macromolecular assemblies. J Struct Biol (2014) 0.91

Structure of a human translation termination complex. Nucleic Acids Res (2015) 0.91

Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. J Biol Chem (2013) 0.91

Uncertainty in integrative structural modeling. Curr Opin Struct Biol (2014) 0.91

Mechanism of NMDA Receptor Inhibition and Activation. Cell (2016) 0.90

Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. J Mol Biol (2003) 12.04

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature (1997) 7.32

The correlation averaging of a regularly arranged bacterial cell envelope protein. J Microsc (1982) 6.38

Image processing for electron microscopy single-particle analysis using XMIPP. Nat Protoc (2008) 4.90

Outcome of the first electron microscopy validation task force meeting. Structure (2012) 4.35

A Bayesian view on cryo-EM structure determination. J Mol Biol (2011) 4.31

Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy. J Mol Biol (2011) 3.16

Noise bias in the refinement of structures derived from single particles. Ultramicroscopy (2004) 3.00

Ribosome structures to near-atomic resolution from thirty thousand cryo-EM particles. Elife (2013) 4.42

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy. Ultramicroscopy (2013) 3.24

Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy. J Mol Biol (2011) 3.16

Structure of ratcheted ribosomes with tRNAs in hybrid states. Proc Natl Acad Sci U S A (2008) 2.77

Hexameric ring structure of the full-length archaeal MCM protein complex. EMBO Rep (2003) 1.92

Insights into the molecular architecture of the 26S proteasome. Proc Natl Acad Sci U S A (2009) 1.81

Quasi-atomic model of bacteriophage t7 procapsid shell: insights into the structure and evolution of a basic fold. Structure (2007) 1.40

The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Proc Natl Acad Sci U S A (2009) 1.30

The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin. Nat Struct Mol Biol (2008) 1.29

Structure of active dimeric human telomerase. Nat Struct Mol Biol (2013) 1.23

Structure and uncoating of immature adenovirus. J Mol Biol (2009) 1.23

Cryo-EM structure of a 3D DNA-origami object. Proc Natl Acad Sci U S A (2012) 1.20

Data management challenges in three-dimensional EM. Nat Struct Mol Biol (2012) 1.19

Structure of hibernating ribosomes studied by cryoelectron tomography in vitro and in situ. J Cell Biol (2010) 1.19

An introduction to maximum-likelihood methods in cryo-EM. Methods Enzymol (2010) 1.18

Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA. Proc Natl Acad Sci U S A (2010) 1.08

Multiple distinct assemblies reveal conformational flexibility in the small heat shock protein Hsp26. Structure (2006) 1.06

A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation. Nat Struct Mol Biol (2004) 1.05

Conformational rearrangements of SV40 large T antigen during early replication events. J Mol Biol (2010) 1.05

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes Dev (2013) 1.01

Maximum likelihood based classification of electron tomographic data. J Struct Biol (2010) 1.00

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. DNA Repair (Amst) (2009) 0.98

SPI-EM: towards a tool for predicting CATH superfamilies in 3D-EM maps. J Mol Biol (2005) 0.97

tmRNA.SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes. J Struct Biol (2009) 0.92

Three-dimensional reconstruction of Heterocapsa circularisquama RNA virus by electron cryo-microscopy. J Gen Virol (2011) 0.85

Structure of hepatitis B surface antigen from subviral tubes determined by electron cryomicroscopy. J Mol Biol (2009) 0.83

Conformational changes of Escherichia coli sigma54-RNA-polymerase upon closed-promoter complex formation. J Mol Biol (2005) 0.78