PubRank

Kai W Wucherpfennig

Author PubWeight™ 94.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med 2007 7.73
2 Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 2008 4.00
3 Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest 2003 3.40
4 Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol 2005 3.05
5 The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 2002 2.74
6 Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med 2007 2.64
7 Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2004 2.34
8 Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity 2007 2.23
9 The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell 2006 1.95
10 The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol 2006 1.83
11 Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. Blood 2002 1.82
12 Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol 2003 1.71
13 The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol 2005 1.64
14 Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest 2007 1.58
15 Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol 2007 1.54
16 The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A 2005 1.54
17 Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity 2012 1.50
18 Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol 2009 1.50
19 The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol 2010 1.44
20 Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol 2005 1.43
21 Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med 2012 1.38
22 HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol 2010 1.38
23 Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity 2005 1.36
24 A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med 2011 1.34
25 Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol 2004 1.30
26 Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A 2008 1.30
27 Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J 2004 1.28
28 Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol 2005 1.28
29 Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. J Immunol 2003 1.22
30 Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell 2012 1.21
31 Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol 2003 1.16
32 Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem 2007 1.16
33 Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. J Immunol 2002 1.14
34 Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA 2012 1.13
35 Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest 2010 1.13
36 MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One 2011 1.12
37 Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol 2006 1.10
38 An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines 2013 1.08
39 Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J Immunol 2005 1.08
40 Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest 2004 1.08
41 Suppression of autoimmune diabetes by soluble galectin-1. J Immunol 2009 1.06
42 A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol 2004 1.05
43 Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest 2014 1.04
44 Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J 2007 1.03
45 Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol 2008 1.03
46 Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. J Exp Med 2012 0.98
47 B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol 2008 0.98
48 A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem 2006 0.97
49 Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity 2005 0.97
50 The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Curr Opin Immunol 2011 0.95
51 The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood 2003 0.94
52 In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol 2009 0.93
53 Prevention of type 1 diabetes by gene therapy. J Clin Invest 2004 0.91
54 Response multilayered control of T cell receptor phosphorylation. Cell 2010 0.89
55 Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol 2013 0.89
56 Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip 2012 0.89
57 Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. AIDS 2012 0.88
58 Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol 2004 0.87
59 Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol 2004 0.85
60 Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nat Commun 2013 0.83
61 Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol 2004 0.83
62 Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. Eur J Immunol 2004 0.81
63 Immunomodulation for glioblastoma. Curr Opin Neurol 2017 0.81
64 Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Eng Des Sel 2011 0.80
65 Infectious triggers for inflammatory neurological diseases. Nat Med 2002 0.79
66 Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis 2007 0.78
67 Positively selecting peptides: their job does not end in the thymus. Nat Immunol 2009 0.76
68 Cracking the code of human T-cell immunity. Nat Biotechnol 2013 0.75
69 Erratum: The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nat Immunol 2017 0.75
70 Autoimmune diseases have been the focus of intense research efforts. Curr Opin Immunol 2011 0.75