| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.
|
Cell
|
2009
|
4.65
|
|
2
|
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
|
Cell Metab
|
2012
|
2.80
|
|
3
|
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
|
Nat Chem Biol
|
2012
|
1.46
|
|
4
|
Biochemical characterization of prostasin, a channel activating protease.
|
Biochem Biophys Res Commun
|
2004
|
1.30
|
|
5
|
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
|
J Org Chem
|
2002
|
1.26
|
|
6
|
Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.
|
Chem Biol
|
2004
|
1.24
|
|
7
|
Biochemical analysis of the 20 S proteasome of Trypanosoma brucei.
|
J Biol Chem
|
2003
|
1.04
|
|
8
|
A strategy to profile prime and non-prime proteolytic substrate specificity.
|
Bioorg Med Chem Lett
|
2005
|
0.91
|
|
9
|
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.
|
J Med Chem
|
2007
|
0.84
|
|
10
|
Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
|
J Med Chem
|
2006
|
0.81
|
|
11
|
Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening.
|
J Comb Chem
|
2005
|
0.77
|
|
12
|
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes.
|
Cell Metab
|
2017
|
0.75
|
|
13
|
Synthesis of C-11 modified mifepristone analog libraries.
|
Mol Divers
|
2007
|
0.75
|