Published in Can Fam Physician on August 01, 2012
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The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada. CMAJ (2004) 21.24
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The genome of the African trypanosome Trypanosoma brucei. Science (2005) 11.48
Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00
Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med (2005) 10.58
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Less-tight versus tight control of hypertension in pregnancy. N Engl J Med (2015) 5.03
Literature Review of Florida Red Tide: Implications for Human Health Effects. Harmful Algae (2004) 5.00
Lopinavir-ritonavir versus nelfinavir for the initial treatment of HIV infection. N Engl J Med (2002) 4.89
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Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society. Gastroenterology (2006) 4.57
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Initial evaluation of the effects of aerosolized Florida red tide toxins (brevetoxins) in persons with asthma. Environ Health Perspect (2005) 3.38
The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature. J Neurosurg Pediatr (2014) 3.30
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Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial. JAMA (2013) 3.06
Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain. J Biol Chem (2002) 3.01
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Ultralow thermal conductivity in disordered, layered WSe2 crystals. Science (2006) 2.79
Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med (2009) 2.77
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An economic evaluation of activated protein C treatment for severe sepsis. N Engl J Med (2002) 2.69
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Tissue plasminogen activator in cardiac arrest with pulseless electrical activity. N Engl J Med (2002) 2.31
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The incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis following primary surgery. J Neurosurg Pediatr (2015) 2.20
Aggressive management of dengue shock syndrome may decrease mortality rate: a suggested protocol. Pediatr Crit Care Med (2005) 2.17
An epidemiologic survey of pediatric sepsis in regional hospitals in China. Pediatr Crit Care Med (2014) 2.16
The future of the regional training centres: planning for sustainability. Healthc Policy (2008) 2.14
Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery. Crit Care Med (2003) 2.13
A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med (2013) 2.11
Safety and efficiency of emergency department assessment of chest discomfort. CMAJ (2004) 2.09
Core competencies in the science and practice of knowledge translation: description of a Canadian strategic training initiative. Implement Sci (2011) 2.09
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Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years. Crit Care Med (2007) 2.04
Recommendations for sepsis management in resource-limited settings. Intensive Care Med (2012) 2.03
Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science (2005) 2.03
Low salivary cortisol levels and externalizing behavior problems in youth. Dev Psychopathol (2005) 2.01
An endowed chair in physician assistant studies. J Physician Assist Educ (2012) 2.00
Globalizing Physician Assistant Education. J Physician Assist Educ (2015) 1.99
Improved fecal DNA test for colorectal cancer screening. Clin Gastroenterol Hepatol (2006) 1.99
Global perspectives for prevention of infectious diseases associated with mass gatherings. Lancet Infect Dis (2012) 1.99
Canadian randomized trial of hemoglobin maintenance to prevent or delay left ventricular mass growth in patients with CKD. Am J Kidney Dis (2005) 1.92
Guidelines for colonoscopy surveillance after cancer resection: a consensus update by the American Cancer Society and the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology (2006) 1.89
Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis. Am J Hum Genet (2002) 1.88
Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet (2013) 1.87
Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum (2004) 1.87
Glycan receptor binding of the influenza A virus H7N9 hemagglutinin. Cell (2013) 1.84
Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis. Nat Genet (2013) 1.82
Root traits predict decomposition across a landscape-scale grazing experiment. New Phytol (2014) 1.80
Hot flashes and related outcomes in breast cancer survivors and matched comparison women. Oncol Nurs Forum (2002) 1.76
Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther (2004) 1.76
Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis. Pediatrics (2010) 1.73
Reoperation for intracranial hypertension in TWIST1-confirmed Saethre-Chotzen syndrome: a 15-year review. Plast Reconstr Surg (2009) 1.68
Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial. Clin Infect Dis (2003) 1.67
Benefits of off-pump bypass on neurologic and clinical morbidity: a prospective randomized trial. Ann Thorac Surg (2003) 1.67
Dengue and dengue hemorrhagic fever: management issues in an intensive care unit. J Pediatr (Rio J) (2007) 1.66
Compliance with post-operative adjuvant chemotherapy in non-small cell lung cancer. An analysis of National Cancer Institute of Canada and intergroup trial JBR.10 and a review of the literature. Lung Cancer (2005) 1.65
Gaps in the supply of physicians, advance practice nurses, and physician assistants. J Am Coll Surg (2011) 1.64
A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. Cancer Res (2009) 1.64
Care of the child with Ebola virus disease. Pediatr Crit Care Med (2015) 1.62
International multicenter investigation of LB20304, a new fluoronaphthyridone. Clin Microbiol Infect (1998) 1.60
Tolevamer, a novel nonantibiotic polymer, compared with vancomycin in the treatment of mild to moderately severe Clostridium difficile-associated diarrhea. Clin Infect Dis (2006) 1.59
Late neurologic and cognitive sequelae of inflicted traumatic brain injury in infancy. Pediatrics (2005) 1.59
Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department. Cochrane Database Syst Rev (2009) 1.58
A nurse-coordinated model of care versus usual care for stage 3/4 chronic kidney disease in the community: a randomized controlled trial. Clin J Am Soc Nephrol (2011) 1.58
Frontorhiny, a distinctive presentation of frontonasal dysplasia caused by recessive mutations in the ALX3 homeobox gene. Am J Hum Genet (2009) 1.57
Sexual dysfunction in women with ESRD requiring hemodialysis. Clin J Am Soc Nephrol (2012) 1.56
One-year follow-up of a therapeutic lifestyle intervention targeting cardiovascular disease risk. CMAJ (2007) 1.55
Structure, process, and outcome of all intensive care units within the province of British Columbia, Canada. J Intensive Care Med (2010) 1.55
Shiga Toxin-Producing Escherichia coli Infection, Antibiotics, and Risk of Developing Hemolytic Uremic Syndrome: A Meta-analysis. Clin Infect Dis (2016) 1.53
Clinical decision rules to improve the detection of adverse drug events in emergency department patients. Acad Emerg Med (2012) 1.52
Health service costs for patients on the waiting list. Can J Surg (2002) 1.52
Agreement in electrocardiogram interpretation in patients with septic shock. Crit Care Med (2011) 1.52
The relationship between organizational culture and family satisfaction in critical care. Crit Care Med (2012) 1.52
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome. J Pediatr Hematol Oncol (2010) 1.49
A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnesses. J Pediatr (2008) 1.48
Massive levothyroxine ingestion in a pediatric patient: case report and discussion. CJEM (2011) 1.48
Assessing the risk of laboratory-acquired meningococcal disease. J Clin Microbiol (2005) 1.47
Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care (2013) 1.46
Reliability of the knee examination in osteoarthritis: effect of standardization. Arthritis Rheum (2004) 1.46
Toward the inclusion of parents on pediatric critical care unit rounds. Pediatr Crit Care Med (2011) 1.46
An interdisciplinary approach to capacity building in applied research. Healthc Policy (2008) 1.45
Dealing with aggressive behavior within the health care team: a leadership challenge. J Crit Care (2006) 1.44
The development of an internet-based knowledge exchange platform for pediatric critical care clinicians worldwide*. Pediatr Crit Care Med (2014) 1.44
The impact of prolonged continuous wakefulness on resident clinical performance in the intensive care unit: a patient simulator study. Crit Care Med (2010) 1.43
Evaluation of a pediatric central venous oximetry catheter in critically ill children. Pediatr Crit Care Med (2010) 1.43