PubRank

Richard G Pestell

Author PubWeight™ 333.91‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Minireview: Cyclin D1: normal and abnormal functions. Endocrinology 2004 5.22
2 The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 2009 4.69
3 Gene expression phenotypic models that predict the activity of oncogenic pathways. Nat Genet 2003 3.78
4 Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010 3.15
5 An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009 3.15
6 A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. J Cell Biol 2008 3.02
7 Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010 3.00
8 Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis. Cell Cycle 2011 2.92
9 Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle 2011 2.91
10 Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle 2010 2.80
11 Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator. Cell Cycle 2011 2.68
12 Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A 2007 2.67
13 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 2005 2.59
14 Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation. Cell Cycle 2010 2.45
15 Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue. Cell Cycle 2011 2.39
16 Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest 2005 2.38
17 Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem 2004 2.37
18 Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors. Cell Cycle 2010 2.32
19 Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 2003 2.27
20 The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle 2010 2.26
21 Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer. Cancer Biol Ther 2009 2.25
22 Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol Cell Biol 2003 2.22
23 Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. J Cell Biol 2006 2.21
24 E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell 2002 2.20
25 Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5. Mol Cell Biol 2002 2.15
26 The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell Cycle 2010 2.10
27 The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts. Cell Cycle 2010 2.07
28 Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 2011 2.04
29 Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol 2011 2.03
30 Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 2005 2.01
31 Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment. Int J Biochem Cell Biol 2011 1.97
32 microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A 2010 1.97
33 Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function. Proc Natl Acad Sci U S A 2006 1.96
34 Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol 2006 1.95
35 Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 2002 1.95
36 Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle 2011 1.92
37 Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol 2006 1.91
38 Acetylation of androgen receptor enhances coactivator binding and promotes prostate cancer cell growth. Mol Cell Biol 2003 1.89
39 HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle 2010 1.89
40 p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci U S A 2009 1.89
41 Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling". Aging (Albany NY) 2010 1.88
42 An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle 2009 1.88
43 Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts. Am J Pathol 2009 1.87
44 IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 2003 1.86
45 Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther 2011 1.85
46 Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors. Cell Cycle 2011 1.82
47 DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth. Mol Cell Biol 2006 1.80
48 Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol 2004 1.80
49 Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment. Breast Cancer Res 2011 1.80
50 Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy. Cancer Biol Ther 2008 1.79
51 Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling. Cell Cycle 2010 1.74
52 Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell 2003 1.71
53 p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J Biol Chem 2003 1.70
54 Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. Cell 2009 1.68
55 Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicol Appl Pharmacol 2005 1.65
56 Cyclin D1 induction of cellular migration requires p27(KIP1). Cancer Res 2006 1.64
57 Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 2012 1.63
58 Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia. Am J Pathol 2002 1.62
59 ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest 2012 1.62
60 Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy. Cell Cycle 2009 1.61
61 The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 2005 1.60
62 Caveolin-1 promotes tumor progression in an autochthonous mouse model of prostate cancer: genetic ablation of Cav-1 delays advanced prostate tumor development in tramp mice. J Biol Chem 2005 1.59
63 The cell fate determination factor dachshund inhibits androgen receptor signaling and prostate cancer cellular growth. Cancer Res 2009 1.58
64 Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells. Am J Pathol 2006 1.55
65 Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells. Cancer Res 2010 1.55
66 BRCA1 gene in breast cancer. J Cell Physiol 2003 1.55
67 Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 2003 1.53
68 Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem 2004 1.53
69 Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer. Cancer Res 2006 1.52
70 Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc Natl Acad Sci U S A 2008 1.51
71 Androgen receptor acetylation governs trans activation and MEKK1-induced apoptosis without affecting in vitro sumoylation and trans-repression function. Mol Cell Biol 2002 1.48
72 Genetic ablation of caveolin-1 in mammary epithelial cells increases milk production and hyper-activates STAT5a signaling. Cancer Biol Ther 2006 1.48
73 Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther 2011 1.48
74 DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. J Biol Chem 2003 1.47
75 Energy transfer in "parasitic" cancer metabolism: mitochondria are the powerhouse and Achilles' heel of tumor cells. Cell Cycle 2011 1.46
76 Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol 2012 1.45
77 Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res 2010 1.45
78 The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion. Cancer Res 2010 1.44
79 BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha. Mol Endocrinol 2009 1.43
80 Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biol Ther 2011 1.43
81 Altered Rho GTPase signaling pathways in breast cancer cells. Breast Cancer Res Treat 2004 1.41
82 c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion. J Biol Chem 2010 1.40
83 Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin. EMBO J 2006 1.38
84 Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res 2005 1.37
85 CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 2012 1.37
86 Cyclin D1 functions in cell migration. Cell Cycle 2006 1.36
87 p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res 2002 1.36
88 Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer". Cell Cycle 2011 1.36
89 Cancer stem cells. Int J Biochem Cell Biol 2012 1.35
90 Acetylation of nuclear receptors in cellular growth and apoptosis. Biochem Pharmacol 2004 1.34
91 CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Res 2012 1.34
92 Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem 2005 1.33
93 Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells. Cell Cycle 2011 1.32
94 microRNA, cell cycle, and human breast cancer. Am J Pathol 2010 1.32
95 Cell fate determination factor Dachshund reprograms breast cancer stem cell function. J Biol Chem 2010 1.31
96 Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells. J Biol Chem 2002 1.30
97 Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol Biol Cell 2006 1.29
98 Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol Biol Cell 2002 1.29
99 CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 2012 1.29
100 Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production. Cell Cycle 2012 1.29
101 Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection. Cell Cycle 2011 1.29
102 The Dachshund gene in development and hormone-responsive tumorigenesis. Trends Endocrinol Metab 2009 1.28
103 In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol 2002 1.27
104 Breast cancer stem cells. Int J Biochem Cell Biol 2012 1.25
105 Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migration. J Biol Chem 2008 1.25
106 Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 2012 1.25
107 Accelerated aging in the tumor microenvironment: connecting aging, inflammation and cancer metabolism with personalized medicine. Cell Cycle 2011 1.24
108 Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene 2004 1.23
109 Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue. Cell Cycle 2012 1.23
110 Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders. Lab Invest 2009 1.22
111 Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism. Cell Cycle 2012 1.22
112 Caveolin-1-deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar Typhimurium infection. Infect Immun 2006 1.21
113 ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer. Cell Cycle 2008 1.21
114 Attenuation of Forkhead signaling by the retinal determination factor DACH1. Proc Natl Acad Sci U S A 2010 1.20
115 Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells. Carcinogenesis 2002 1.20
116 Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget 2012 1.20
117 Epigenetic regulation of nuclear steroid receptors. Biochem Pharmacol 2006 1.20
118 Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist 2013 1.20
119 Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene 2005 1.19
120 Spatially discrete, light-driven protein expression. Chem Biol 2002 1.18
121 Galectin-3 enhances cyclin D(1) promoter activity through SP1 and a cAMP-responsive element in human breast epithelial cells. Oncogene 2002 1.18
122 Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. J Biol Chem 2004 1.18
123 Altered expression of DACH1 and cyclin D1 in endometrial cancer. Cancer Biol Ther 2009 1.18
124 AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res 2003 1.18
125 MEK/ERK inhibitor U0126 affects in vitro and in vivo growth of embryonal rhabdomyosarcoma. Mol Cancer Ther 2009 1.17
126 Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res 2010 1.17
127 Dietary restriction: standing up for sirtuins. Science 2010 1.17
128 Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am J Pathol 2006 1.17
129 The role of breast cancer stem cells in metastasis and therapeutic implications. Am J Pathol 2011 1.16
130 Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation. Mol Cancer 2010 1.16
131 Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status. Am J Pathol 2006 1.16
132 Caveolin-1-deficient mice have an increased mammary stem cell population with upregulation of Wnt/beta-catenin signaling. Cell Cycle 2005 1.15
133 Loss of caveolin-1 causes the hyper-proliferation of intestinal crypt stem cells, with increased sensitivity to whole body gamma-radiation. Cell Cycle 2005 1.15
134 The cell fate determination factor DACH1 is expressed in estrogen receptor-alpha-positive breast cancer and represses estrogen receptor-alpha signaling. Cancer Res 2009 1.14
135 PPARgamma activation induces autophagy in breast cancer cells. Int J Biochem Cell Biol 2009 1.14
136 The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity. J Biol Chem 2004 1.14
137 ErbB2 induces Notch1 activity and function in breast cancer cells. Clin Transl Sci 2008 1.13
138 Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 2012 1.13
139 Notch1-induced transformation of RKE-1 cells requires up-regulation of cyclin D1. Cancer Res 2006 1.12
140 BRCA1 inhibition of telomerase activity in cultured cells. Mol Cell Biol 2003 1.12
141 Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation. Trends Endocrinol Metab 2007 1.11
142 Nuclear factor-kappaB enhances ErbB2-induced mammary tumorigenesis and neoangiogenesis in vivo. Am J Pathol 2009 1.11
143 EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res 2013 1.10
144 Caveolin-1 in breast cancer. Cancer Biol Ther 2004 1.09
145 Overview of cyclins D1 function in cancer and the CDK inhibitor landscape: past and present. Expert Opin Investig Drugs 2014 1.09
146 Trypanosoma cruzi infection activates extracellular signal-regulated kinase in cultured endothelial and smooth muscle cells. Infect Immun 2004 1.08
147 Examining the role of cyclin D1 in breast cancer. Future Oncol 2011 1.08
148 Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia. Proc Natl Acad Sci U S A 2003 1.08
149 Dachshund binds p53 to block the growth of lung adenocarcinoma cells. Cancer Res 2013 1.07
150 CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway. Cancer Res 2010 1.07
151 Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infect Immun 2003 1.07
152 Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor. Mol Cell Biol 2006 1.06
153 Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature. Am J Pathol 2009 1.06
154 Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth. Cancer Biol Ther 2011 1.05
155 SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. J Neurosci 2011 1.05
156 Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions. Am J Pathol 2009 1.05
157 MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals. Mol Cancer Ther 2011 1.05
158 The functional significance of nuclear receptor acetylation. Steroids 2007 1.04
159 Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties. Cancer Res 2002 1.04
160 Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. Mol Cancer Ther 2002 1.04
161 Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. Cancer Res 2002 1.03
162 Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer. Oncotarget 2013 1.03
163 Signal transduction mediated by cyclin D1: from mitogens to cell proliferation: a molecular target with therapeutic potential. Cancer Treat Res 2004 1.02
164 Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation. Clin Cancer Res 2007 1.00
165 Breast cancer cell proliferation is inhibited by BAD: regulation of cyclin D1. J Biol Chem 2007 1.00
166 Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation. Cancer Res 2013 1.00
167 Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res 2010 1.00
168 PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b. Cell Cycle 2011 0.99
169 Bone morphogenetic protein signaling regulates postnatal hair follicle differentiation and cycling. Am J Pathol 2004 0.98
170 Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB. Mol Biol Cell 2008 0.98
171 Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4. Cell Cycle 2013 0.97
172 Senescence and epigenetic dysregulation in cancer. Int J Biochem Cell Biol 2002 0.97
173 Gastrin-induced gastric adenocarcinoma growth is mediated through cyclin D1. Am J Physiol Gastrointest Liver Physiol 2003 0.96
174 Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose. Cancer Res 2005 0.95
175 Cyclin D1 determines estrogen signaling in the mammary gland in vivo. Mol Endocrinol 2013 0.95
176 Caloric restriction augments radiation efficacy in breast cancer. Cell Cycle 2013 0.95
177 Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells. J Natl Cancer Inst 2003 0.95
178 The CCL5/CCR5 axis promotes metastasis in basal breast cancer. Oncoimmunology 2013 0.94
179 Mechanisms for Helicobacter pylori CagA-induced cyclin D1 expression that affect cell cycle. Cell Microbiol 2006 0.94
180 Trypanosoma cruzi infection induces proliferation of vascular smooth muscle cells. Infect Immun 2006 0.94
181 Cyclin d1 induces chromosomal instability. Oncotarget 2012 0.94
182 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation. Mol Endocrinol 2005 0.94
183 Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis. Cancer Res 2009 0.93
184 Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide. Cell Cycle 2013 0.93
185 Amino acids regulate hepatocyte proliferation through modulation of cyclin D1 expression. J Biol Chem 2003 0.93
186 Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression. Cancer Biol Ther 2007 0.92
187 Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models. Endocrinology 2011 0.92
188 Bioinformatics analysis reveals transcriptome and microRNA signatures and drug repositioning targets for IBD and other autoimmune diseases. Inflamm Bowel Dis 2012 0.92
189 Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation. Am J Pathol 2009 0.91
190 The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res 2003 0.91
191 Cyclin D1 induction of Dicer governs microRNA processing and expression in breast cancer. Nat Commun 2013 0.91
192 Interferon-beta activates multiple signaling cascades in primary human microglia. J Neurochem 2002 0.91
193 Acetylation in nuclear receptor signaling and the role of sirtuins. Mol Endocrinol 2007 0.91
194 Recent advances in inducible expression in transgenic mice. Semin Cell Dev Biol 2002 0.91
195 Cyclins and cell cycle control in cancer and disease. Genes Cancer 2012 0.90
196 Reverse Warburg effect in a patient with aggressive B-cell lymphoma: is lactic acidosis a paraneoplastic syndrome? Semin Oncol 2013 0.90
197 Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers. Cancer Res 2006 0.90
198 Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle 2012 0.90
199 Acetylation and nuclear receptor action. J Steroid Biochem Mol Biol 2010 0.89
200 Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes. J Biol Chem 2004 0.89
201 Identification of a cyclin D1 network in prostate cancer that antagonizes epithelial-mesenchymal restraint. Cancer Res 2013 0.89
202 C-jun inhibits mammary apoptosis in vivo. Mol Biol Cell 2010 0.89
203 Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures. Cancer Res 2012 0.89
204 Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin Sci (Lond) 2002 0.88
205 Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition. Cell Cycle 2011 0.87
206 ErbB-2-induced mammary tumor growth: the role of cyclin D1 and p27Kip1. Biochem Pharmacol 2002 0.87
207 Imaging spontaneous MMTVneu transgenic murine mammary tumors: targeting metabolic activity versus genetic products. J Nucl Med 2009 0.87
208 p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Cancer Res 2006 0.87
209 Acetylation in hormone signaling and the cell cycle. Cytokine Growth Factor Rev 2002 0.87
210 The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster. Breast Cancer Res Treat 2014 0.87
211 The potential to target CCL5/CCR5 in breast cancer. Expert Opin Ther Targets 2014 0.86
212 Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J Mol Endocrinol 2005 0.86
213 Regulation of progesterone receptor signaling by BRCA1 in mammary cancer. Nucl Recept Signal 2006 0.86
214 Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J Biol Chem 2010 0.86
215 DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells. J Cell Biochem 2008 0.86
216 BRCA1 in hormone-responsive cancers. Trends Endocrinol Metab 2003 0.85
217 miRNAs regulate stem cell self-renewal and differentiation. Front Genet 2012 0.85
218 Activation of cyclin D1 by estradiol and spermine in MCF-7 breast cancer cells: a mechanism involving the p38 MAP kinase and phosphorylation of ATF-2. Oncol Res 2005 0.85
219 Epigenetics and the estrogen receptor. Ann N Y Acad Sci 2006 0.85
220 Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. Am J Physiol Heart Circ Physiol 2008 0.84
221 Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway. Mol Cancer Ther 2006 0.84
222 Small non-coding RNAs govern mammary gland tumorigenesis. J Mammary Gland Biol Neoplasia 2012 0.83
223 Inhibition of cyclin D1 gene transcription by Brg-1. Cell Cycle 2007 0.83
224 Mechanisms for progenitor cell-mediated repair for ischemic heart injury. Curr Stem Cell Res Ther 2012 0.83
225 Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration. Cancer Res 2012 0.83
226 5-Azacitidine restores and amplifies the bicalutamide response on preclinical models of androgen receptor expressing or deficient prostate tumors. Prostate 2010 0.83
227 Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res 2008 0.83
228 The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements. Cancer Res 2004 0.82
229 Compartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle 2013 0.82
230 Cell cycle regulatory proteins in the liver in murine Trypanosoma cruzi infection. Cell Cycle 2006 0.81
231 Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Expert Rev Anticancer Ther 2009 0.81
232 Disruption of c-Jun reduces cellular migration and invasion through inhibition of c-Src and hyperactivation of ROCK II kinase. Mol Biol Cell 2008 0.81
233 Stromal glycolysis and MCT4 are hallmarks of DCIS progression to invasive breast cancer. Cell Cycle 2013 0.80
234 Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta. Am J Respir Cell Mol Biol 2002 0.80
235 Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity. Sci Rep 2013 0.80
236 Regulation of host cell cyclin D1 by Trypanosoma cruzi in myoblasts. Cell Cycle 2007 0.80
237 MicroRNA-mediated cancer metastasis regulation via heterotypic signals in the microenvironment. Curr Pharm Biotechnol 2014 0.80
238 Caveolin-1 regulates the anti-atherogenic properties of macrophages. Cell Tissue Res 2014 0.79
239 Mayven induces c-Jun expression and cyclin D1 activation in breast cancer cells. Oncogene 2005 0.79
240 Role of BRCA1 in heat shock response. Oncogene 2003 0.79
241 Cancer metabolism: a therapeutic perspective. Nat Rev Clin Oncol 2017 0.79
242 Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation. Am J Pathol 2012 0.78
243 Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism. Cell Cycle 2008 0.78
244 Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation. Cell Cycle 2009 0.78
245 c-Jun is required for TGF-β-mediated cellular migration via nuclear Ca²⁺ signaling. Int J Biochem Cell Biol 2011 0.77
246 Histone acetylation/deacetylation as a regulator of cell cycle gene expression. Methods Mol Biol 2004 0.77
247 Analysis of nuclear receptor acetylation. Methods Mol Biol 2011 0.77
248 Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration. Mol Endocrinol 2014 0.76
249 Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR. Nucleic Acids Res 2007 0.75
250 Mammary gland selective excision of c-jun identifies its role in mRNA splicing. Cancer Res 2011 0.75
251 Cyclin D1 silencing suppresses tumorigenicity, impairs DNA double strand break repair and thus radiosensitizes androgen-independent prostate cancer cells to DNA damage. Oncotarget 2016 0.75
252 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-kappaB. Biochem Biophys Res Commun 2004 0.75
253 Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget 2015 0.75
254 Signal transduction inhibitors in cellular function. Methods Mol Biol 2004 0.75
255 A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines. Invest New Drugs 2005 0.75