Published in Br J Pharmacol on December 01, 2012
In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol (2014) 1.10
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci (2013) 0.96
Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice. J Pharmacol Exp Ther (2015) 0.83
The dual FAAH/MAGL inhibitor JZL195 has enhanced effects on endocannabinoid transmission and motor behavior in rats as compared to those of the MAGL inhibitor JZL184. Pharmacol Biochem Behav (2014) 0.81
Heterogeneous presynaptic distribution of monoacylglycerol lipase, a multipotent regulator of nociceptive circuits in the mouse spinal cord. Eur J Neurosci (2014) 0.80
Discriminative Stimulus Properties of the Endocannabinoid Catabolic Enzyme Inhibitor SA-57 in Mice. J Pharmacol Exp Ther (2016) 0.76
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling. Pharmacol Ther (2017) 0.75
Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity. J Lipid Res (2015) 0.75
2012 cannabinoid themed section. Br J Pharmacol (2012) 0.75
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76
Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol (2011) 10.40
Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci U S A (2002) 5.33
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32
An endocannabinoid mechanism for stress-induced analgesia. Nature (2005) 4.03
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (2011) 3.48
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron (2010) 3.28
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J Pharmacol Exp Ther (2009) 2.55
Cannabinoid receptors and pain. Prog Neurobiol (2001) 2.48
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chem Biol (2009) 2.48
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids. Proc Natl Acad Sci U S A (2005) 2.36
Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain. J Neurosci (2006) 2.02
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol (2010) 1.81
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther (2009) 1.74
The endocannabinoid system and pain. CNS Neurol Disord Drug Targets (2009) 1.59
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci (2004) 1.40
CB1 cannabinoid receptor-mediated modulation of food intake in mice. Br J Pharmacol (2005) 1.38
Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain (1999) 1.36
Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry. Anal Biochem (2006) 1.35
Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science (2009) 1.34
Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J Neurophysiol (2004) 1.33
Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain. Arthritis Rheum (2010) 1.27
Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake. Int J Obes (Lond) (2006) 1.16
Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. Br J Pharmacol (2004) 1.10
Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol (2011) 1.10
Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. Eur J Neurosci (2009) 1.09
Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms. Pharmacol Res (2010) 1.04
Spinal dorsal horn cell receptive field size is increased in adult rats following neonatal hindpaw skin injury. J Physiol (2003) 1.02
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology (2005) 1.02
Modulators of endocannabinoid enzymic hydrolysis and membrane transport. Handb Exp Pharmacol (2005) 1.00
Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. J Neurophysiol (2001) 0.93
Dynamic regulation of the endocannabinoid system: implications for analgesia. Mol Pain (2009) 0.93
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. Br J Pharmacol (2012) 0.93
The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat. Br J Pharmacol (1999) 0.92
Rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain after decapitation. Neurosci Lett (2001) 0.91
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochem Biophys Res Commun (2005) 0.88
Endocannabinoids: an appetite for fat. Proc Natl Acad Sci U S A (2011) 0.88
Neuronal and glial localization of the cannabinoid-1 receptor in the superficial spinal dorsal horn of the rodent spinal cord. Eur J Neurosci (2009) 0.87
Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays. Br J Pharmacol (2010) 0.82
Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol (2008) 13.18
Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J Cell Biol (1994) 5.14
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08
The impact of role models on medical students. J Gen Intern Med (1997) 3.99
Use of a HpaII-polymerase chain reaction assay to study DNA methylation in the Pgk-1 CpG island of mouse embryos at the time of X-chromosome inactivation. Mol Cell Biol (1990) 3.78
Women prefer hospital births. BMJ (1992) 2.88
Experiences in Hong Kong with the theory and practice of the albumin column method of sperm separation for sex selection. Hum Reprod (1998) 2.87
Energy efficient medium access protocol for wireless medical body area sensor networks. IEEE Trans Biomed Circuits Syst (2008) 2.75
A randomised prospective trial of intra-operative oesophageal Doppler-guided fluid administration in major gynaecological surgery. Anaesthesia (2013) 2.63
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Cell lineage-specific undermethylation of mouse repetitive DNA. Nature (1984) 2.43
Functional interchangeability of DNA replication genes in Salmonella typhimurium and Escherichia coli demonstrated by a general complementation procedure. Genetics (1984) 2.42
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26
Multiple shunt failures: an analysis of relevant factors. Childs Nerv Syst (1998) 2.25
Low-molecular-weight heparin for the treatment of acute ischemic stroke. N Engl J Med (1995) 2.17
A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma. J Clin Oncol (1988) 2.14
Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. Gastroenterology (1996) 2.13
Using a birth cohort to study ageing: representativeness and response rates in the National Survey of Health and Development. Eur J Ageing (2013) 2.12
Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice. Nat Genet (1995) 2.10
Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Gastroenterology (1999) 2.04
Arginine deiminase system and bacterial adaptation to acid environments. Appl Environ Microbiol (1987) 2.03
Two distinct endogenous type C viruses isolated from the asian rodent Mus cervicolor: conservation of virogene sequences in related rodent species. J Virol (1977) 1.98
Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer. J Virol (1989) 1.90
A comprehensive analysis of high school genetics standards: are states keeping pace with modern genetics? CBE Life Sci Educ (2011) 1.80
Minimal access approach to the management of large ovarian cysts. Surg Endosc (2006) 1.78
The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy. Pediatr Res (1992) 1.72
Tufts' four-year combined M.D.--M.P.H. Program: a training model for population-based medicine. Acad Med (1992) 1.70
Effects of ENU dosage on mouse strains. Mamm Genome (2000) 1.69
Methylation patterns of repetitive DNA sequences in germ cells of Mus musculus. Nucleic Acids Res (1984) 1.68
Meta-analysis of treatment termination rates among rheumatoid arthritis patients receiving disease-modifying anti-rheumatic drugs. Rheumatology (Oxford) (2000) 1.64
Immunosuppression and serious infections in children with acute lymphoblastic leukaemia: a comparison of three chemotherapy regimes. Br J Haematol (1980) 1.63
Assessment of the validity of the INR system for patients with liver impairment. Thromb Haemost (1994) 1.63
The association of obesity with infertility and related menstural abnormalities in women. Int J Obes (1979) 1.57
Guide to Receptors and Channels (GRAC), 2nd edition (2007 Revision). Br J Pharmacol (2007) 1.56
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia (2012) 1.55
Choreoathetosis after deep hypothermia without circulatory arrest. Ann Thorac Surg (1990) 1.51
Preoperative concurrent 5-fluorouracil infusion, mitomycin C and pelvic radiation therapy in tethered and fixed rectal carcinoma. Int J Radiat Oncol Biol Phys (1993) 1.51
Direct-to-consumer drug marketing: public service or disservice? Mt Sinai J Med (2001) 1.51
Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates. J Infect Dis (1994) 1.50
Genetic contamination of Dahl SS/Jr rats. Impact on studies of salt-sensitive hypertension. Hypertension (1994) 1.48
Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol (2003) 1.48
Use of transcranial Doppler ultrasound to predict outcome in patients with intracranial large-artery occlusive disease. Stroke (2000) 1.46
Outcome after temporary vascular occlusion for the management of renal trauma. J Urol (1994) 1.44
The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. Gen Pharmacol (1997) 1.44
Physician involvement in capital punishment. N Y State J Med (1991) 1.42
The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection. J Antimicrob Chemother (1997) 1.41
Optic nerve sheath decompression for glaucomatous optic neuropathy with normal intraocular pressure. Arch Ophthalmol (1993) 1.41
Animal experimentation for medical research. N Y State J Med (1989) 1.39
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br J Pharmacol (2007) 1.39
Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J Biol Chem (1998) 1.38
Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. Mol Cell Biol (1986) 1.37
Co-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres. J Neurocytol (1989) 1.37
Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene (1994) 1.36
Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm (Vienna) (1998) 1.35
Physiological properties of the lamina I spinoparabrachial neurons in the rat. J Neurophysiol (2000) 1.35
Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA (1978) 1.35
Characterization of a DNA probe for detection of Mycobacterium tuberculosis complex in clinical samples by polymerase chain reaction. J Clin Microbiol (1992) 1.34
Cognitive impairment and functional outcome after stroke associated with small vessel disease. J Neurol Neurosurg Psychiatry (2004) 1.33
Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism. Br J Pharmacol (2007) 1.32
Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J (2007) 1.32
Nucleotide sequence of a coleopteran-active toxin gene from a new isolate of Bacillus thuringiensis subsp. tolworthi. Nucleic Acids Res (1990) 1.27
Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet (2001) 1.26
Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein. Immunity (2001) 1.26
The mouse Mid1 gene: implications for the pathogenesis of Opitz syndrome and the evolution of the mammalian pseudoautosomal region. Hum Mol Genet (1998) 1.24
Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem (1996) 1.23
Genetic determination of the beta-galactosidase developmental program in mouse liver. Cell (1976) 1.23
An epizootic of cutaneous zygomycosis in cultured dwarf African clawed frogs (Hymenochirus curtipes) due to Basidiobolus ranarum. J Med Vet Mycol (1991) 1.22
Immunosuppressive and immunostimulatory factors produced by malignant cells in vitro. Int J Cancer (1974) 1.20
The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing. Blood (1998) 1.20
Disclosure and prevention of medical errors. Committee on Bioethical Issues of the Medical Society of the State of New York. Arch Intern Med (2000) 1.20
Parental imprinting studied by allele-specific primer extension after PCR: paternal X chromosome-linked genes are transcribed prior to preferential paternal X chromosome inactivation. Proc Natl Acad Sci U S A (1992) 1.19
In situ production of gamma interferon, interleukin-4, and tumor necrosis factor alpha mRNA in human lung tuberculous granulomas. Infect Immun (2000) 1.19
Disorganization of cultured vascular endothelial cell monolayers by fibrinogen fragment D. Science (1985) 1.19
A genetic nomenclature for human blood coagulation. Thromb Diath Haemorrh (1973) 1.18
Visual loss from idiopathic intracranial pachymeningitis. Neurology (1994) 1.17
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology (2003) 1.17
The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix. J Histochem Cytochem (2001) 1.16
Expression of nitric oxide synthase in ulcerative colitis. Eur J Clin Invest (1996) 1.15
Reverse transcriptase-PCR analysis of bacterial rRNA for detection and characterization of bacterial species in arthritis synovial tissue. Infect Immun (2000) 1.15
"Molecular rulers" for calibrating phenotypic effects of telomere imbalance. J Med Genet (2002) 1.14
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain. Br J Pharmacol (2008) 1.14
Cannabinoids and PPARalpha signalling. Biochem Soc Trans (2006) 1.13
Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia (2008) 1.12
The proteolytic substructure of light meromyosin. Localization of a region responsible for the low ionic strength insolubility of myosin. J Biol Chem (1983) 1.12
Finding of male-killing Spiroplasma infecting Drosophila melanogaster in Africa implies transatlantic migration of this endosymbiont. Heredity (Edinb) (2006) 1.11
'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol (2008) 1.09
Interaction of DNA polymerase III gamma and beta subunits in vivo in Salmonella typhimurium. Genetics (1986) 1.09
Induced migration of dental pulp stem cells for in vivo pulp regeneration. J Dent Res (2011) 1.09
Visual risk factors for driving difficulty among older drivers. Accid Anal Prev (2000) 1.08
Hereditary generalized juvenile polyposis associated with pulmonary arteriovenous malformation. Gastroenterology (1980) 1.08
Antitumor benzothiazoles. 7. Synthesis of 2-(4-acylaminophenyl)benzothiazoles and investigations into the role of acetylation in the antitumor activities of the parent amines. J Med Chem (1999) 1.07
Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science (1981) 1.06
Behavioral laterality in captive bonobos (Pan paniscus). J Comp Psychol (1993) 1.05
Mitochondria in organismal aging and degeneration. Biochim Biophys Acta (1999) 1.05