Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28213089)

Published in Pharmacol Ther on February 14, 2017

Authors

Gernot F Grabner1, Robert Zimmermann2, Rudolf Schicho3, Ulrike Taschler1

Author Affiliations

1: Institute of Molecular Biosciences, University of Graz, Graz, Austria.
2: Institute of Molecular Biosciences, University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria.
3: Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria; BioTechMed Graz, Graz, Austria. Electronic address: rudolf.schicho@medunigraz.at.

Articles citing this

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis. Biochim Biophys Acta (2017) 0.75

Articles cited by this

(truncated to the top 100)

Molecular characterization of a peripheral receptor for cannabinoids. Nature (1993) 13.45

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet (2005) 8.01

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A (2001) 7.15

Mechanisms for insulin resistance: common threads and missing links. Cell (2012) 6.85

Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet (2006) 6.50

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20

Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet (2007) 5.49

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 5.47

Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci U S A (2002) 5.33

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett (1994) 5.30

A second endogenous cannabinoid that modulates long-term potentiation. Nature (1997) 4.79

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem (1995) 4.53

The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol (2007) 4.22

An endocannabinoid mechanism for stress-induced analgesia. Nature (2005) 4.03

Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism. J Biol Chem (2006) 3.74

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol (2003) 3.60

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (2011) 3.48

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest (2008) 3.13

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci (2010) 3.11

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. JAMA (2008) 3.09

Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature (2005) 3.02

The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev (2005) 2.90

HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE ACTIVITIES IN ADIPOSE TISSUE. J Biol Chem (1964) 2.85

Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol (2005) 2.82

Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem (2003) 2.75

Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res (2009) 2.71

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68

Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes (2011) 2.67

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J Pharmacol Exp Ther (2009) 2.55

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chem Biol (2009) 2.48

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology (2007) 2.48

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest (2010) 2.32

cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem (1997) 2.30

The endocannabinoid system and the brain. Annu Rev Psychol (2012) 2.26

Protective effects of NSAIDs on the development of Alzheimer disease. Neurology (2008) 2.21

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand. FEBS Lett (1998) 2.16

Cannabinoid receptor signaling. Handb Exp Pharmacol (2005) 2.00

Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. Am J Hum Genet (2010) 1.95

Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury. FASEB J (2007) 1.93

Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. J Pharmacol Exp Ther (2006) 1.93

Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res (2007) 1.88

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review. Nutr J (2014) 1.82

Internalization and recycling of the CB1 cannabinoid receptor. J Neurochem (1999) 1.82

Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol (2010) 1.81

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol (2012) 1.79

Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol (2011) 1.74

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes. Chem Biol (2005) 1.74

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids. Pain (2009) 1.74

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc Natl Acad Sci U S A (2002) 1.74

Cannabinoid pharmacological properties common to other centrally acting drugs. Eur J Pharmacol (2003) 1.73

The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metab (2013) 1.67

Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med (1998) 1.66

Human neuropathy target esterase catalyzes hydrolysis of membrane lipids. J Biol Chem (2002) 1.62

Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. J Biol Chem (2008) 1.60

Interactions between synthetic vanilloids and the endogenous cannabinoid system. FEBS Lett (1998) 1.58

Brain regional distribution of endocannabinoids: implications for their biosynthesis and biological function. Biochem Biophys Res Commun (1999) 1.58

MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J Biol Chem (2003) 1.56

Cannabinoid tolerance and dependence: a review of studies in laboratory animals. Pharmacol Biochem Behav (2005) 1.49

Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene (2001) 1.49

Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses. Biol Psychiatry (2011) 1.49

Lipoprotein lipase: physiology, biochemistry, and molecular biology. Front Biosci (2001) 1.48

Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2. J Biol Chem (2003) 1.47

The pharmacologic and clinical effects of medical cannabis. Pharmacotherapy (2013) 1.46

Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Biochim Biophys Acta (1986) 1.45

2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab (2011) 1.44

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem (2011) 1.42

The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends Neurosci (1990) 1.42

Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue. J Biol Chem (1976) 1.37

Cannabinoid signaling in glial cells. Glia (2004) 1.35

Hormone-sensitive lipase--a multipurpose enzyme in lipid metabolism. Biochim Biophys Acta (1990) 1.34

Crystal structure of the human monoacylglycerol lipase, a key actor in endocannabinoid signaling. Chembiochem (2010) 1.34

CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance. Cell Metab (2010) 1.33

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav (2010) 1.33

Structural basis for human monoglyceride lipase inhibition. J Mol Biol (2009) 1.32

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. AAPS J (2009) 1.31

Endocannabinoid signal in the gut controls dietary fat intake. Proc Natl Acad Sci U S A (2011) 1.29

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism. Am J Physiol Endocrinol Metab (2008) 1.29

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. FASEB J (2011) 1.29

Rimonabant, a selective cannabinoid CB1 receptor antagonist, inhibits atherosclerosis in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.27

Endocannabinoid signals in the control of emotion. Curr Opin Pharmacol (2009) 1.26

Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell Rep (2012) 1.25

Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury. Neurosurgery (2005) 1.24

Involvement of the opioid system in the anxiolytic-like effects induced by Delta(9)-tetrahydrocannabinol. Psychopharmacology (Berl) (2002) 1.23

The fatty acid amide hydrolase (FAAH). Prostaglandins Leukot Essent Fatty Acids (2002) 1.22

A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease. Cell Rep (2012) 1.22

The endocannabinoid system and the treatment of mood and anxiety disorders. CNS Neurol Disord Drug Targets (2009) 1.22

The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. Int Rev Neurobiol (2009) 1.20

Physiology. COX-2 inhibitors and cardiovascular risk. Science (2012) 1.19

Brain lipid metabolism in the cPLA2 knockout mouse. J Lipid Res (2003) 1.18

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC. Proc Natl Acad Sci U S A (2013) 1.18

Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol. Biochem J (1999) 1.16

Demonstration of an intestinal monoglyceride lipase: an enzyme with a possible role in the intracellular completion of fat digestion. J Clin Invest (1963) 1.15

Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. J Pharmacol Exp Ther (2011) 1.14

Cannabinoid and opioid interactions: implications for opiate dependence and withdrawal. Neuroscience (2013) 1.14

Pancreatic triglyceride lipase and colipase: insights into dietary fat digestion. Gastroenterology (1994) 1.13

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging (Albany NY) (2009) 1.13

Catalytic properties of MGAT3, a putative triacylgycerol synthase. J Lipid Res (2006) 1.12