Published in Kidney Int on August 29, 2012
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Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice. PLoS One (2014) 0.77
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The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats. Kidney Int (2007) 1.53
Oral active vitamin D is associated with improved survival in hemodialysis patients. Kidney Int (2008) 1.46
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The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr (2001) 1.40
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Ultrastructural analysis of vascular calcifications in uremia. J Am Soc Nephrol (2010) 1.21
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Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am J Pathol (2011) 1.14
Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease. Circulation (2009) 1.12
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Determination of the elastin content of tissues by measuring desmosine and isodesmosine. Anal Biochem (1977) 1.06
Efficacy of 19-Nor-1,25-(OH)2D2 in the prevention and treatment of hyperparathyroid bone disease in experimental uremia. Kidney Int (2003) 1.05
Daily variability in mineral metabolites in CKD and effects of dietary calcium and calcitriol. Clin J Am Soc Nephrol (2012) 1.02
The role of FGF-23 in CKD-MBD and cardiovascular disease: friend or foe? Nephrol Dial Transplant (2010) 1.02
25-hydroxyvitamin D concentration is inversely associated with serum MMP-9 in a cross-sectional study of African American ESRD patients. BMC Nephrol (2011) 0.96
Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification. J Pharmacol Exp Ther (2006) 0.90
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Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human vascular smooth muscle cells. Am J Physiol Renal Physiol (2007) 0.87
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Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem (2006) 6.50
Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol (2010) 4.59
The parathyroid is a target organ for FGF23 in rats. J Clin Invest (2007) 4.47
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem (2007) 4.42
BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A (2007) 4.00
Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res (2006) 3.97
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Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol (2005) 3.01
Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J (2010) 2.91
The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int (2004) 2.89
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol (2010) 2.67
Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res (2011) 2.56
Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective. Kidney Int (2010) 2.50
Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem (2011) 2.46
Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int (2010) 2.35
Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int (2004) 2.25
Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci U S A (2009) 2.23
Smooth muscle cell plasticity: fact or fiction? Circ Res (2012) 2.18
Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arterioscler Thromb Vasc Biol (2005) 2.18
Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction. Radiology (2010) 2.08
Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol (2007) 2.02
The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. Am J Pathol (2004) 1.88
Osteopontin inhibits mineral deposition and promotes regression of ectopic calcification. Am J Pathol (2002) 1.88
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol (2006) 1.86
Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation (2010) 1.83
BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells. Atherosclerosis (2008) 1.80
Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. Kidney Int (2002) 1.78
Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism. Annu Rev Physiol (2013) 1.78
Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int (2009) 1.77
Effect of high protein diet on stone-forming propensity and bone loss in rats. Kidney Int (2003) 1.76
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Metabolic syndrome and the risk of calcium stones. Nephrol Dial Transplant (2012) 1.71
Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res (2002) 1.69
Albumin regulates the Na+/H+ exchanger 3 in OKP cells. J Am Soc Nephrol (2003) 1.67
Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med (2002) 1.67
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int (2013) 1.66
Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis. J Am Soc Nephrol (2006) 1.66
Klotho: a novel regulator of calcium and phosphorus homeostasis. Pflugers Arch (2011) 1.63
The role of osteopontin in inflammatory processes. J Cell Commun Signal (2009) 1.57
Comparison of insulin action on glucose versus potassium uptake in humans. Clin J Am Soc Nephrol (2011) 1.57
Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol (2005) 1.54
Hypercalciuria associated with high dietary protein intake is not due to acid load. J Clin Endocrinol Metab (2011) 1.54
Circadian variation in urine pH and uric acid nephrolithiasis risk. Nephrol Dial Transplant (2007) 1.51
Etiological role of estrogen status in renal stone formation. J Urol (2002) 1.48
Effects of cyclosporine in osteopontin null mice. Kidney Int (2002) 1.47
Regulation of cardiovascular calcification. Cardiovasc Pathol (2004) 1.46
Long-term combined treatment with thiazide and potassium citrate in nephrolithiasis does not lead to hypokalemia or hypochloremic metabolic alkalosis. Kidney Int (2003) 1.46
Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett (2009) 1.45
Defining hypercalciuria in nephrolithiasis. Kidney Int (2011) 1.44
Metabolic basis for low urine pH in type 2 diabetes. Clin J Am Soc Nephrol (2010) 1.41
Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes. Am J Physiol Renal Physiol (2013) 1.40
Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis. Am J Physiol Renal Physiol (2005) 1.31
Runx2/Cbfa1, but not loss of myocardin, is required for smooth muscle cell lineage reprogramming toward osteochondrogenesis. J Cell Biochem (2010) 1.29
Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy. Nephrol Dial Transplant (2010) 1.29
Vascular calcification: an update on mechanisms and challenges in treatment. Calcif Tissue Int (2013) 1.29
Smooth muscle cells deficient in osteopontin have enhanced susceptibility to calcification in vitro. Cardiovasc Res (2005) 1.28
Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. J Clin Invest (2011) 1.27
Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion. Am J Physiol Renal Physiol (2008) 1.27
The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection. Kidney Int (2013) 1.27
Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis (2012) 1.26
Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell (2005) 1.24
Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods. Proc Natl Acad Sci U S A (2004) 1.23
The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY) (2010) 1.21
Luminal Na(+)/H (+) exchange in the proximal tubule. Pflugers Arch (2008) 1.21
Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence. Am J Physiol Renal Physiol (2002) 1.20
Novel insights into the pathogenesis of uric acid nephrolithiasis. Curr Opin Nephrol Hypertens (2004) 1.20
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev (2005) 1.19
Biochemical and stone-risk profiles with topiramate treatment. Am J Kidney Dis (2006) 1.19
Mechanisms of vascular calcification. Adv Chronic Kidney Dis (2007) 1.18
Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Mol Cell Proteomics (2008) 1.18
Rapid Communication: relative effect of urinary calcium and oxalate on saturation of calcium oxalate. Kidney Int (2004) 1.18
Direct effects of phosphate on vascular cell function. Adv Chronic Kidney Dis (2011) 1.17
Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials (2007) 1.17
Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis. Am J Physiol Renal Physiol (2012) 1.16
Sources of cells that contribute to atherosclerotic intimal calcification: an in vivo genetic fate mapping study. Cardiovasc Res (2012) 1.16
Immunohistologic labeling of murine endothelium. Cardiovasc Pathol (2003) 1.15
Role of Klotho in aging, phosphate metabolism, and CKD. Am J Kidney Dis (2011) 1.15
Microporous nanofibrous fibrin-based scaffolds for bone tissue engineering. Biomaterials (2008) 1.14
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am J Pathol (2011) 1.14
Secreted klotho and chronic kidney disease. Adv Exp Med Biol (2012) 1.13
Role of c-SRC and ERK in acid-induced activation of NHE3. Kidney Int (2002) 1.13
A fibrinogen-based precision microporous scaffold for tissue engineering. Biomaterials (2007) 1.12
Nephrolithiasis in children. Pediatr Nephrol (2005) 1.12