Published in J Biol Chem on September 04, 2012
TLR3 immunity to infection in mice and humans. Curr Opin Immunol (2013) 1.22
Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol (2016) 1.02
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH. J Virol (2014) 0.96
The multiple faces of proteinkinase R in antiviral defense. Virulence (2013) 0.91
Alphacoronavirus protein 7 modulates host innate immune response. J Virol (2013) 0.89
An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1). J Interferon Cytokine Res (2014) 0.86
Shared signatures between rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome uncovered through gene expression meta-analysis. Arthritis Res Ther (2014) 0.84
Induction of stress granules by interferon and down-regulation by the cellular RNA adenosine deaminase ADAR1. Virology (2014) 0.83
PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis. J Neuroimmunol (2014) 0.80
Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells. PLoS One (2013) 0.79
STAT2-dependent induction of RNA adenosine deaminase ADAR1 by type I interferon differs between mouse and human cells in the requirement for STAT1. Virology (2015) 0.79
Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses. J Virol (2014) 0.78
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction. PLoS Pathog (2016) 0.77
Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens. J Leukoc Biol (2014) 0.77
RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection. PLoS Pathog (2017) 0.76
AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18. Oncoimmunology (2016) 0.75
The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond. Front Immunol (2017) 0.75
Viral RNA at two stages of reovirus infection is required for the induction of necroptosis. J Virol (2017) 0.75
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA. EMBO J (2017) 0.75
Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions. J Virol (2016) 0.75
Dicer protein levels elevated by mild hyperthermia promote a pro-survival phenotype. Oncotarget (2017) 0.75
Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06
Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol (2009) 11.76
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol (2008) 8.85
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum. Proc Natl Acad Sci U S A (1967) 4.82
NF-kappaB and cancer-identifying targets and mechanisms. Curr Opin Genet Dev (2008) 4.61
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B. Proc Natl Acad Sci U S A (1994) 4.53
An atomic model of the interferon-beta enhanceosome. Cell (2007) 4.22
Interactions between double-stranded RNA regulators and the protein kinase DAI. Mol Cell Biol (1992) 4.16
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat Chem Biol (2010) 3.44
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell (2006) 3.23
Toll-like receptors and Type I interferons. J Biol Chem (2007) 3.07
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways. Nat Immunol (2007) 2.91
A20: central gatekeeper in inflammation and immunity. J Biol Chem (2008) 2.83
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol (2000) 2.71
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1995) 2.61
Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase. Virology (1992) 2.42
Mechanism of interferon action: phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase. Proc Natl Acad Sci U S A (1979) 2.39
Structure and function of the protein kinase R. Curr Top Microbiol Immunol (2007) 2.34
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe (2009) 2.33
Recognition of viral nucleic acids in innate immunity. Rev Med Virol (2010) 2.33
Translational control of the innate immune response through IRF-7. Nature (2008) 2.30
Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev (2008) 2.29
Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol (2007) 2.24
Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. Virology (1992) 1.81
Tyrosine 110 in the measles virus phosphoprotein is required to block STAT1 phosphorylation. Virology (2006) 1.80
Binding of the protein kinase PKR to RNAs with secondary structure defects: role of the tandem A-G mismatch and noncontiguous helixes. Biochemistry (1998) 1.76
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Proc Natl Acad Sci U S A (1995) 1.59
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe (2010) 1.56
Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity. J Exp Med (2008) 1.55
West Nile virus-induced interferon production is mediated by the double-stranded RNA-dependent protein kinase PKR. J Virol (2007) 1.54
Mechanism of interferon action. Activation of the human P1/eIF-2 alpha protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA. Virology (1989) 1.52
The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors. J Biol Chem (2008) 1.49
TRAF family proteins link PKR with NF-kappa B activation. Mol Cell Biol (2004) 1.40
Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cells. J Virol (2007) 1.37
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J Biol Chem (2008) 1.36
Attenuation of V- or C-defective measles viruses: infection control by the inflammatory and interferon responses of rhesus monkeys. J Virol (2008) 1.36
The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3. J Virol (2011) 1.30
Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR. J Biol Chem (2002) 1.28
Hepatitis C virus controls interferon production through PKR activation. PLoS One (2010) 1.21
Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus. J Virol (2008) 1.18
Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus. J Virol (2010) 1.18
RNA dimerization promotes PKR dimerization and activation. J Mol Biol (2009) 1.16
The N-terminus of PKR is responsible for the activation of the NF-kappaB signaling pathway by interacting with the IKK complex. Cell Signal (2006) 1.13
Molecular cloning of the complete genome of reovirus serotype 3. Virology (1984) 1.05
Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus. J Virol (2012) 1.02
Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins. J Biol Chem (2005) 0.97
RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis. Proc Natl Acad Sci U S A (2010) 1.94
Expression of interferon-inducible RNA adenosine deaminase ADAR1 during pathogen infection and mouse embryo development involves tissue-selective promoter utilization and alternative splicing. J Biol Chem (2005) 1.72
Interferon action and the double-stranded RNA-dependent enzymes ADAR1 adenosine deaminase and PKR protein kinase. Prog Nucleic Acid Res Mol Biol (2006) 1.62
RNA-specific adenosine deaminase ADAR1 suppresses measles virus-induced apoptosis and activation of protein kinase PKR. J Biol Chem (2009) 1.53
The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors. J Biol Chem (2008) 1.49
Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes. Biophys J (2003) 1.46
Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis. J Virol (2007) 1.45
New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery. J Gene Med (2005) 1.37
Protein kinase PKR plays a stimulus- and virus-dependent role in apoptotic death and virus multiplication in human cells. J Virol (2007) 1.37
Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry (2007) 1.36
Induction of protein kinase PKR-dependent activation of interferon regulatory factor 3 by vaccinia virus occurs through adapter IPS-1 signaling. J Biol Chem (2008) 1.36
Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level. Curr Med Chem (2004) 1.27
Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection. Cell Host Microbe (2012) 1.24
Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA. Top Curr Chem (2010) 1.20
Protein kinase PKR mediates the apoptosis induction and growth restriction phenotypes of C protein-deficient measles virus. J Virol (2008) 1.18
Mechanisms of protein kinase PKR-mediated amplification of beta interferon induction by C protein-deficient measles virus. J Virol (2010) 1.18
Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response. Curr Opin Immunol (2011) 1.15
Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon. Virology (2008) 1.12
Adenosine deaminases acting on RNA, RNA editing, and interferon action. J Interferon Cytokine Res (2010) 1.11
Stress granule formation induced by measles virus is protein kinase PKR dependent and impaired by RNA adenosine deaminase ADAR1. J Virol (2012) 1.07
Tissue selectivity of interferon-stimulated gene expression in mice infected with Dam(+) versus Dam(-) Salmonella enterica serovar Typhimurium strains. Infect Immun (2002) 1.04
RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment. Virology (2009) 1.03
Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus. J Virol (2012) 1.02
Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J Virol (2009) 1.02
Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications. Philos Trans A Math Phys Eng Sci (2006) 1.00
Activation of the RNA-dependent protein kinase PKR promoter in the absence of interferon is dependent upon Sp proteins. J Biol Chem (2005) 0.97
Adenosine deaminase ADAR1 increases gene expression at the translational level by decreasing protein kinase PKR-dependent eIF-2alpha phosphorylation. J Mol Biol (2009) 0.96
Activation of NF-kappaB-dependent gene expression by Salmonella flagellins FliC and FljB. Biochem Biophys Res Commun (2007) 0.94
Tipping the balance: antagonism of PKR kinase and ADAR1 deaminase functions by virus gene products. J Interferon Cytokine Res (2009) 0.92
Translational regulation of cyclin D1 by 15-deoxy-delta(12,14)-prostaglandin J(2). Cell Growth Differ (2002) 0.91
Innate interferon response in macrophage and epithelial cells infected with wild-type compared to DNA adenine methylase and flagellin mutant Salmonella enterica serovar Typhimurium. J Interferon Cytokine Res (2007) 0.91
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R. J Virol (2013) 0.89
The PKR kinase promoter binds both Sp1 and Sp3, but only Sp3 functions as part of the interferon-inducible complex with ISGF-3 proteins. Virology (2003) 0.88
Two-dimensional packing of short DNA with nonpairing overhangs in cationic liposome-DNA complexes: from Onsager nematics to columnar nematics with finite-length columns. J Am Chem Soc (2011) 0.88
An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1). J Interferon Cytokine Res (2014) 0.86
Knockdown by RNAi-proceed with caution. Nat Biotechnol (2004) 0.86
Comparison of tissue-selective proinflammatory gene induction in mice infected with wild-type, DNA adenine methylase-deficient, and flagellin-deficient Salmonella enterica. Infect Immun (2007) 0.83
DNA damage-binding proteins and heterogeneous nuclear ribonucleoprotein A1 function as constitutive KCS element components of the interferon-inducible RNA-dependent protein kinase promoter. J Biol Chem (2003) 0.83
The promoter-proximal KCS element of the PKR kinase gene enhances transcription irrespective of orientation and position relative to the ISRE element and is functionally distinct from the KCS-like element of the ADAR deaminase Promoter. J Interferon Cytokine Res (2002) 0.80
Host response to polyomavirus infection is modulated by RNA adenosine deaminase ADAR1 but not by ADAR2. J Virol (2011) 0.80
Interleukin-1 beta secretion is activated comparably by FliC and FljB flagellins but differentially by wild-type and DNA adenine methylase-deficient salmonella. J Interferon Cytokine Res (2008) 0.80
Regulation of the interferon-inducible PKR kinase gene: the KCS element is a constitutive promoter element that functions in concert with the interferon-stimulated response element. Virology (2002) 0.78
Functional analysis of the KCS-like element of the interferon-inducible RNA-specific adenosine deaminase ADAR1 promoter. Gene (2003) 0.78