Published in Dev Neurobiol on November 01, 2012
Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer (2013) 2.17
Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech (2013) 0.84
Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. PLoS Genet (2013) 0.83
N-glycosylation requirements in neuromuscular synaptogenesis. Development (2013) 0.82
Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep (2015) 0.81
The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. PLoS One (2014) 0.77
Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep. PLoS Genet (2015) 0.76
A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi. BMC Biol (2015) 0.76
A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth. Rare Dis (2014) 0.75
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature (2007) 37.09
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science (1994) 10.45
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res (2008) 9.29
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development. Trends Neurosci (2001) 6.99
Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature (2008) 6.80
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature (2008) 5.32
Memory systems of the brain: a brief history and current perspective. Neurobiol Learn Mem (2004) 4.57
Making a better RNAi vector for Drosophila: use of intron spacers. Methods (2003) 4.42
Improved stability of Drosophila larval neuromuscular preparations in haemolymph-like physiological solutions. J Comp Physiol A (1994) 4.24
Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med (2007) 3.33
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J Cell Biol (2003) 3.26
Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron (1996) 3.05
Anaplastic lymphoma kinase: signalling in development and disease. Biochem J (2009) 3.05
The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron (2003) 2.86
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. Oncogene (1997) 2.80
The embryonic development of larval muscles in Drosophila. Development (1990) 2.67
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell (2011) 2.64
The Drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure. Neuron (1994) 2.41
Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae. J Neurosci (1989) 2.28
Differential ultrastructure of synaptic terminals on ventral longitudinal abdominal muscles in Drosophila larvae. J Neurobiol (1993) 2.23
Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development (1993) 2.15
Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron (1996) 2.05
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation. Nature (2004) 2.02
High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours. Biochem J (2008) 1.83
Target-selected mutant screen by TILLING in Drosophila. Genome Res (2005) 1.83
Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation. Cell (1999) 1.81
Ultrastructure of neuromuscular junctions in Drosophila: comparison of wild type and mutants with increased excitability. J Neurobiol (1993) 1.72
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers. Nature (2003) 1.69
Single-cell analysis of Drosophila larval neuromuscular synapses. Dev Biol (2001) 1.67
Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J Neurosci (2005) 1.63
HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell (2002) 1.61
Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion. Nature (2003) 1.59
The BMP ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control. Neuron (2007) 1.48
Preferential localization of glutamate receptors opposite sites of high presynaptic release. Curr Biol (2004) 1.46
Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. Cell (2007) 1.46
Octopamine immunoreactivity in the fruit fly Drosophila melanogaster. J Comp Neurol (1995) 1.42
Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila. BMC Biol (2005) 1.40
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology (2007) 1.39
Drosophila larval neuromuscular junction: molecular components and mechanisms underlying synaptic plasticity. Microsc Res Tech (2000) 1.37
Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans. J Neurosci (2011) 1.36
The Ras1-mitogen-activated protein kinase signal transduction pathway regulates synaptic plasticity through fasciclin II-mediated cell adhesion. J Neurosci (2002) 1.30
Synaptic targeting and localization of discs-large is a stepwise process controlled by different domains of the protein. Curr Biol (2000) 1.29
Genetic analysis of the mechanisms controlling target selection: target-derived Fasciclin II regulates the pattern of synapse formation. Neuron (1997) 1.27
Integrin-mediated regulation of synaptic morphology, transmission, and plasticity. J Neurosci (2000) 1.26
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster. EMBO Rep (2003) 1.24
Characterization of the expression of the ALK receptor tyrosine kinase in mice. Gene Expr Patterns (2006) 1.24
Unc-51 controls active zone density and protein composition by downregulating ERK signaling. J Neurosci (2009) 1.19
Segmentation and specification of the Drosophila mesoderm. Genes Dev (1996) 1.10
Emerging importance of ALK in neuroblastoma. Semin Cancer Biol (2011) 1.10
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol. PLoS One (2011) 1.10
latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron (1999) 1.09
Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo. Genes Cells (2001) 1.08
A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila. Development (1999) 1.07
Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. J Cell Sci (2004) 1.05
Assembly and maturation of the Drosophila larval neuromuscular junction. Int Rev Neurobiol (1999) 1.05
Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation. Cell (2001) 1.00
Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis. Pharmacol Biochem Behav (2011) 1.00
Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development (2002) 0.97
Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. Development (2010) 0.96
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling. Curr Biol (2008) 0.96
Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev (2008) 0.95
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning. PLoS Genet (2011) 0.92
The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK. J Exp Zool B Mol Dev Evol (2007) 0.91
ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction. Eur J Neurosci (2009) 0.91
Alk is a transcriptional target of LMO4 and ERα that promotes cocaine sensitization and reward. J Neurosci (2011) 0.90
Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster. J Neurosci (2003) 0.90
Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system. J Comp Neurol (2006) 0.89
A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila. Brain Res (2010) 0.87
The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Curr Biol (2004) 2.06
Living synaptic vesicle marker: synaptotagmin-GFP. Genesis (2002) 1.99
The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Curr Biol (2003) 1.91
Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron (2013) 1.83
CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat Neurosci (2008) 1.73
Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers. Nature (2003) 1.69
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell (2008) 1.69
The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr Biol (2004) 1.60
Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network. Bioessays (2002) 1.58
Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development (2008) 1.52
Organ allocation in adults with congenital heart disease listed for heart transplant: impact of ventricular assist devices. J Heart Lung Transplant (2013) 1.46
An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. J Neurosci (2005) 1.36
Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae. J Neurophysiol (2002) 1.33
Developmental regulation of glutamate receptor field size by nonvesicular glutamate release. Nat Neurosci (2002) 1.26
Ceramidase regulates synaptic vesicle exocytosis and trafficking. J Neurosci (2004) 1.24
Lipid regulation of the synaptic vesicle cycle. Nat Rev Neurosci (2005) 1.22
Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure. Development (2008) 1.21
Roles of ubiquitination at the synapse. Biochim Biophys Acta (2008) 1.19
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Front Synaptic Neurosci (2010) 1.18
Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol Cell Neurosci (2008) 1.15
Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation. Genes Dev (2007) 1.07
Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. J Neurobiol (2003) 1.05
Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. J Neurosci (2008) 1.04
Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nat Neurosci (2004) 1.04
Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. Dis Model Mech (2010) 1.02
Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. J Neurobiol (2004) 1.02
Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis. Mol Cell Proteomics (2005) 1.02
Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system. J Neurobiol (2003) 1.01
The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology. J Neurosci (2004) 1.00
Rolling blackout is required for synaptic vesicle exocytosis. J Neurosci (2006) 1.00
The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. J Cell Biol (2010) 1.00
A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS Genet (2012) 1.00
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Dev Biol (2004) 0.98
Harvesting and preparing Drosophila embryos for electrophysiological recording and other procedures. J Vis Exp (2009) 0.97
Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development (2002) 0.97
Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. J Neurosci (2008) 0.97
Fathoming fragile X in fruit flies. Trends Genet (2005) 0.96
The ubiquitin-proteasome system postsynaptically regulates glutamatergic synaptic function. Mol Cell Neurosci (2007) 0.96
Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. Development (2010) 0.96
In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Hum Mol Genet (2011) 0.96
Glycosylated synaptomatrix regulation of trans-synaptic signaling. Dev Neurobiol (2012) 0.95
Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. Neural Plast (2012) 0.94
Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission. Traffic (2002) 0.94
Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Dis Model Mech (2011) 0.94
Proteasome function is required to maintain muscle cellular architecture. Biol Cell (2007) 0.94
Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission. J Neurophysiol (2003) 0.93
Activity-dependent modulation of neural circuit synaptic connectivity. Front Mol Neurosci (2009) 0.93
Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. J Neurosci (2008) 0.93
miR-153 regulates SNAP-25, synaptic transmission, and neuronal development. PLoS One (2013) 0.92
The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. J Cell Sci (2010) 0.92
Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein. J Neurophysiol (2008) 0.90
Rolling blackout is required for bulk endocytosis in non-neuronal cells and neuronal synapses. J Cell Sci (2008) 0.89
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiol Dis (2010) 0.89
Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Front Neural Circuits (2009) 0.89
Disrupting the transmission of influenza a: face masks and ultraviolet light as control measures. Am J Public Health (2007) 0.87
Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments. Dev Dyn (2009) 0.86
Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Dis Model Mech (2013) 0.84
Drosophila modeling of heritable neurodevelopmental disorders. Curr Opin Neurobiol (2011) 0.84
Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Dev Biol (2011) 0.83
Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Dev Neurobiol (2012) 0.83
Anthrax vaccine and public health policy. Am J Public Health (2007) 0.83
Molecular and genetic analysis of the Drosophila model of fragile X syndrome. Results Probl Cell Differ (2012) 0.83
N-glycosylation requirements in neuromuscular synaptogenesis. Development (2013) 0.82
In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila. J Neurosci Methods (2007) 0.82
The cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function. J Cell Sci (2013) 0.81
Two peptide transmitters co-packaged in a single neurosecretory vesicle. Peptides (2008) 0.81
Remodeling of an identified motoneuron during metamorphosis: hormonal influences on the growth of dendrites and axon terminals. J Neurobiol (2005) 0.81
Electrophysiological recording in the Drosophila embryo. J Vis Exp (2009) 0.80
Techniques to dissect cellular and subcellular function in the Drosophila nervous system. Methods Cell Biol (2003) 0.80
Lessons from development: A role for asymmetric stem cell division in cancer. Stem Cell Res (2009) 0.79
Response: meaningless minis? Trends Neurosci (2002) 0.79
Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin. Traffic (2010) 0.77
Expression and function of scalloped during Drosophila development. Dev Dyn (2013) 0.77
Remodeling of an identified motoneuron during metamorphosis: central and peripheral actions of ecdysteroids during regression of dendrites and motor terminals. J Neurobiol (2002) 0.76
Affinity Density: a novel genomic approach to the identification of transcription factor regulatory targets. Bioinformatics (2009) 0.76