Published in PLoS One on August 20, 2012
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
COPASI--a COmplex PAthway SImulator. Bioinformatics (2006) 10.57
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
The Systems Biology Graphical Notation. Nat Biotechnol (2009) 8.53
Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science (2002) 7.92
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet (1999) 7.09
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Web-based kinetic modelling using JWS Online. Bioinformatics (2004) 4.03
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci U S A (2007) 3.90
Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci U S A (2006) 3.54
Stochastic modelling for quantitative description of heterogeneous biological systems. Nat Rev Genet (2009) 3.27
Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat Med (2004) 2.98
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol (2011) 2.64
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS One (2008) 2.33
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A (2003) 2.14
Transcription under the control of nuclear Arm/beta-catenin. Curr Biol (2006) 2.11
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Differential development of neuronal physiological responsiveness in two human neural stem cell lines. BMC Neurosci (2007) 1.88
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. J Cell Sci (2006) 1.78
A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways. Oncogene (2007) 1.76
The presence of FGF2 signaling determines whether beta-catenin exerts effects on proliferation or neuronal differentiation of neural stem cells. Dev Biol (2004) 1.59
When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol (2010) 1.57
Wnt signalling and the control of cellular metabolism. Biochem J (2010) 1.42
The making of Wnt: new insights into Wnt maturation, sorting and secretion. Development (2006) 1.39
Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells (2009) 1.32
Modeling and simulation of intracellular dynamics: choosing an appropriate framework. IEEE Trans Nanobioscience (2004) 1.25
Wnt signalling pathway parameters for mammalian cells. PLoS One (2012) 1.20
The role of dimerization in noise reduction of simple genetic networks. J Theor Biol (2003) 1.15
Computational processing and error reduction strategies for standardized quantitative data in biological networks. FEBS J (2005) 1.13
Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci (2009) 1.08
Wnt signaling and neural stem cells: caught in the Wnt web. Cell Tissue Res (2007) 1.07
Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells. J Theor Biol (2007) 1.01
Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis. FEBS Lett (2006) 1.01
Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity. Dev Biol (2007) 1.01
Protection of neurons derived from human neural progenitor cells by veratridine. Neuroreport (2009) 1.00
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry (2010) 0.98
Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behaviour. FEBS Lett (2007) 0.97
Cell therapy in Huntington disease. Neurosurg Focus (2008) 0.97
Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation. Cell Mol Biol Lett (2011) 0.97
Noise-reduction through interaction in gene expression and biochemical reaction processes. J Theor Biol (2004) 0.96
Sailing with the Wnt: charting the Wnt processing and secretion route. Exp Cell Res (2009) 0.95
Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem (2010) 0.94
Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex. Acta Neuropathol (1999) 0.94
A delay stochastic process with applications in molecular biology. J Math Biol (2008) 0.93
Cell cycle kinetics of expanding populations of neural stem and progenitor cells in vitro. Biotechnol Bioeng (2004) 0.91
Differentiation of human neural progenitor cells regulated by Wnt-3a. Biochem Biophys Res Commun (2010) 0.89
A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway. J Math Biol (2009) 0.89
Mathematical modelling of Wnt/β-catenin signalling. Biochem Soc Trans (2010) 0.86
Nucleo-cytoplasmic shuttling of APC can maximize β-catenin/TCF concentration. J Theor Biol (2011) 0.79
Expert opinion on temporary treatment recommendations for Fabry disease during the shortage of enzyme replacement therapy (ERT). Mol Genet Metab (2010) 2.13
RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy. Antimicrob Agents Chemother (2009) 1.60
Diagnostic difficulties in Krabbe disease: a report of two cases and review of literature. Folia Neuropathol (2012) 1.55
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy. Eur J Neurosci (2004) 1.43
Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients. Neurology (2013) 1.42
Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. Hum Mutat (2013) 1.17
Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the Stroke in Young Fabry Patients study. Stroke (2012) 1.14
Disorganization of the desmin cytoskeleton and mitochondrial dysfunction in plectin-related epidermolysis bullosa simplex with muscular dystrophy. J Neuropathol Exp Neurol (2002) 1.09
Long-term course and mutational spectrum of spatacsin-linked spastic paraplegia. Ann Neurol (2007) 1.08
Rule-based multi-level modeling of cell biological systems. BMC Syst Biol (2011) 1.06
Asparagine Synthetase Deficiency: New Inborn Errors of Metabolism. JIMD Rep (2015) 1.05
Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia. J Neurol (2013) 1.04
Gene mutations versus clinically relevant phenotypes: lyso-Gb3 defines Fabry disease. Circ Cardiovasc Genet (2014) 1.03
Investigating function and connectivity of morphometric findings--exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17). Neuroimage (2012) 1.01
Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells. Neurosci Lett (2010) 1.01
Functional characterisation of alpha-galactosidase a mutations as a basis for a new classification system in fabry disease. PLoS Genet (2013) 1.00
Protection of neurons derived from human neural progenitor cells by veratridine. Neuroreport (2009) 1.00
2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Proteomics (2006) 1.00
The microstructure of cornea verticillata in Fabry disease and amiodarone-induced keratopathy: a confocal laser-scanning microscopy study. Graefes Arch Clin Exp Ophthalmol (2008) 0.99
Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells. Biomed Eng Online (2010) 0.98
Design and validation of a metabolic disorder resequencing microarray (BRUM1). Hum Mutat (2010) 0.98
Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation. Cell Mol Biol Lett (2011) 0.97
NPC1: Complete genomic sequence, mutation analysis, and characterization of haplotypes. Hum Mutat (2002) 0.96
Newborn screening for lysosomal storage disorders in hungary. JIMD Rep (2012) 0.94
Orexinergic innervation of the extended amygdala and basal ganglia in the rat. Brain Struct Funct (2011) 0.94
Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem (2010) 0.94
Initial receptor-ligand interactions modulate gene expression and phagosomal properties during both early and late stages of phagocytosis. Eur J Cell Biol (2010) 0.93
Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. J Clin Invest (2014) 0.92
Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease. Neurosci Res (2008) 0.92
Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17. Cerebellum (2010) 0.91
Efferent projections of the anterior and posterodorsal regions of the medial nucleus of the amygdala in the mouse. Cells Tissues Organs (2009) 0.91
Residual galactosylsphingosine (psychosine) beta-galactosidase activities and associated GALC mutations in late and very late onset Krabbe disease. Clin Chim Acta (2002) 0.90
Multifocal white matter lesions associated with the D313Y mutation of the α-galactosidase A gene. PLoS One (2013) 0.90
Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression. Eur J Neurosci (2007) 0.90
2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells. Proteomics (2007) 0.89
Differentiation of human neural progenitor cells regulated by Wnt-3a. Biochem Biophys Res Commun (2010) 0.89
CAG repeats determine brain atrophy in spinocerebellar ataxia 17: a VBM study. PLoS One (2011) 0.89
Lyso-Gb3 Indicates that the Alpha-Galactosidase A Mutation D313Y is not Clinically Relevant for Fabry Disease. JIMD Rep (2012) 0.89
MRI in acute cerebral ischemia of the young: the Stroke in Young Fabry Patients (sifap1) Study. Neurology (2013) 0.89
Novel Mutations in FA2H-Associated Neurodegeneration: An Underrecognized Condition? J Child Neurol (2012) 0.88
A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3beta inhibitors. Org Biomol Chem (2010) 0.88
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome. Liver Int (2008) 0.88
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease. Hum Mol Genet (2005) 0.87
Wnt signal pathways and neural stem cell differentiation. Neurodegener Dis (2006) 0.87
Basilar artery diameter is a potential screening tool for Fabry disease in young stroke patients. Cerebrovasc Dis (2010) 0.86
Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells. Exp Cell Res (2004) 0.86
Persistent increase in cardiac troponin I in Fabry disease: a case report. BMC Cardiovasc Disord (2011) 0.86
Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks. Orphanet J Rare Dis (2013) 0.85
Mutation in FAM134B causing hereditary sensory neuropathy with spasticity in a Turkish family. Muscle Nerve (2014) 0.85
Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse. Metab Brain Dis (2011) 0.84
Leukodystrophies and other genetic metabolic leukoencephalopathies in children and adults. Brain Dev (2009) 0.84
Recommendations on reintroduction of agalsidase Beta for patients with fabry disease in europe, following a period of shortage. JIMD Rep (2012) 0.84
Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells. Biochem Pharmacol (2012) 0.84
Flexible experimentation in the modeling and simulation framework JAMES II--implications for computational systems biology. Brief Bioinform (2010) 0.84
Representation of individual gene expression in completely pooled mRNA samples. Biosci Biotechnol Biochem (2005) 0.83
Heterozygous S44L missense change of the spastin gene in amyotrophic lateral sclerosis. Amyotroph Lateral Scler (2008) 0.83
Juvenile parkinsonism associated with heterozygous frameshift ATP13A2 gene mutation. Eur J Paediatr Neurol (2011) 0.83
Kidney function and white matter disease in young stroke patients: analysis of the stroke in young fabry patients study population. Stroke (2012) 0.82
Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development. Neuroreport (2009) 0.82
Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells. BMC Cell Biol (2010) 0.81
Unraveling cellular phenotypes of novel TorsinA/TOR1A mutations. Hum Mutat (2014) 0.81
A novel SGCE gene mutation causing myoclonus dystonia in a family with an unusual phenotype. Acta Paediatr (2011) 0.81
Differential expression of the ADAMs in developing chicken retina. Dev Growth Differ (2011) 0.81
Expression of seven members of the ADAM family in developing chicken spinal cord. Dev Dyn (2010) 0.80
Cultivation of human neural progenitor cells in a 3-dimensional self-assembling peptide hydrogel. J Vis Exp (2012) 0.80
Trinucleotide repeat expansions in the junctophilin-3 gene are not found in Caucasian patients with a Huntington's disease-like phenotype. Ann Neurol (2002) 0.80
The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells. BMC Cancer (2014) 0.80
Fabry disease - underestimated in the differential diagnosis of multiple sclerosis? PLoS One (2013) 0.80
Regional expression of ADAM19 during chicken embryonic development. Dev Growth Differ (2011) 0.79
PET and MRI reveal early evidence of neurodegeneration in spinocerebellar ataxia type 17. J Nucl Med (2012) 0.79
Ciliary neurotrophic factor overexpression in neural progenitor cells (ST14A) increases proliferation, metabolic activity, and resistance to stress during differentiation. J Neurosci Res (2003) 0.79
Wnt-5a expression in the rat neuronal progenitor cell line ST14A. Exp Brain Res (2004) 0.79
Ih is maturing: implications for neuronal development. Neurodegener Dis (2006) 0.79
HES5 is a key mediator of Wnt-3a-induced neuronal differentiation. Stem Cells Dev (2014) 0.79
ADAM17 overexpression promotes angiogenesis by increasing blood vessel sprouting and pericyte number during brain microvessel development. Int J Dev Biol (2011) 0.79
Repeat expansion in spinocerebellar ataxia type 17 alleles of the TATA-box binding protein gene: an evolutionary approach. Eur J Hum Genet (2006) 0.79
Small molecules in stem cell research. Curr Pharm Biotechnol (2013) 0.79
X-linked Dystonia-Parkinsonism manifesting in a female patient due to atypical turner syndrome. Mov Disord (2013) 0.79
Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process. J Neuroimmunol (2004) 0.78
Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability. J Neurophysiol (2004) 0.78
Regional expression of the ADAMs in developing chicken cochlea. Dev Dyn (2010) 0.78
Differentiation of human neural progenitor cells in functionalized hydrogel matrices. Biores Open Access (2012) 0.78
Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages. J Neurosci Res (2005) 0.78
Proof-of-principle rapid noninvasive prenatal diagnosis of autosomal recessive founder mutations. J Clin Invest (2015) 0.78
Clinical, genetic, and brain sonographic features related to Parkinson's disease in Gaucher disease. J Neurol (2013) 0.78
Spontaneous calcium transients in human neural progenitor cells mediated by transient receptor potential channels. Stem Cells Dev (2013) 0.78
Efferent connections of the parabigeminal nucleus to the amygdala and the superior colliculus in the rat: a double-labeling fluorescent retrograde tracing study. Brain Res (2006) 0.78
Studying the role of lipid rafts on protein receptor bindings with cellular automata. IEEE/ACM Trans Comput Biol Bioinform (2013) 0.77
Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: a mouse model of Niemann-Pick type C1 disease. J Neurosci Res (2014) 0.77
Clinically relevant depressive symptoms in young stroke patients - results of the sifap1 study. Neuroepidemiology (2015) 0.77
Neuroproteomics in stem cell differentiation. Proteomics Clin Appl (2007) 0.77
Anatomical expression patterns of delta-protocadherins in developing chicken cochlea. J Anat (2012) 0.77
Lymphocyte subpopulations, oxidative burst and apoptosis in peripheral blood cells of patients with multiple sclerosis-effect of interferon-beta. Autoimmunity (2003) 0.77
Expression patterns of the ADAMs in early developing chicken cochlea. Dev Growth Differ (2013) 0.77
Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1. Cornea (2011) 0.77
Hereditary spastic paraplegia associated with axonal neuropathy: a novel mutation of SPG3A in a large family. J Clin Neuromuscul Dis (2011) 0.77
Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice. Glia (2014) 0.77
Discrete event, multi-level simulation of metabolite channeling. Biosystems (2004) 0.77