A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation.

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Published in J Cereb Blood Flow Metab on September 12, 2012

Authors

William C Kreisl1, Kimberly J Jenko, Christina S Hines, Chul Hyoung Lyoo, Winston Corona, Cheryl L Morse, Sami S Zoghbi, Thomas Hyde, Joel E Kleinman, Victor W Pike, Francis J McMahon, Robert B Innis, Biomarkers Consortium PET Radioligand Project Team

Author Affiliations

1: Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892-1026, USA. kreislw@mail.nih.gov

Associated clinical trials:

A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS) | NCT02714036

Novel PET Radioligands as Inflammatory Biomarkers in Rheumatoid Arthritis and Myositis | NCT03912428

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