N-acetylcysteine for sepsis and systemic inflammatory response in adults.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMID 22972094)

Published in Cochrane Database Syst Rev on September 12, 2012

Authors

Tamas Szakmany1, Balázs Hauser, Peter Radermacher

Author Affiliations

1: Department of Anaesthesia, Cwm Taf NHS Trust, Royal Glamorgan Hospital, Llantrisant, UK. szakmany@yahoo.co.uk.

Associated clinical trials:

A Trial of Vitamin B12 in Septic Shock (B12) | NCT03783091

Articles citing this

ROS function in redox signaling and oxidative stress. Curr Biol (2014) 3.35

Rethinking antioxidants in the intensive care unit. Am J Respir Crit Care Med (2013) 2.05

Protein kinase G oxidation is a major cause of injury during sepsis. Proc Natl Acad Sci U S A (2013) 0.87

Sepsis and septic shock. Nat Rev Dis Prim (2016) 0.85

Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med (2014) 0.79

N-acetylcysteine for the prevention of non-contrast media agent-induced kidney injury: from preclinical data to clinical evidence. Eur J Clin Pharmacol (2013) 0.77

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state. Sci Rep (2016) 0.76

Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia. Intensive Care Med Exp (2016) 0.75

Clinical management of acute liver failure: Results of an international multi-center survey. World J Gastroenterol (2016) 0.75

Gemfibrozil attenuates the inflammatory response and protects rats from abdominal sepsis. Exp Ther Med (2015) 0.75

N-acetylcysteine plus deferoxamine for patients with prolonged hypotension does not decrease acute kidney injury incidence: a double blind, randomized, placebo-controlled trial. Crit Care (2016) 0.75

Krüppel-like factor 5 mediates proinflammatory cytokine expression in lipopolysaccharide-induced acute lung injury through upregulation of nuclear factor-κB phosphorylation in vitro and in vivo. Mediators Inflamm (2014) 0.75

Personalizing Therapy in Idiopathic Pulmonary Fibrosis: A Glimpse of the Future? Am J Respir Crit Care Med (2015) 0.75

Pediatric Multiple Organ Dysfunction Syndrome: Promising Therapies. Pediatr Crit Care Med (2017) 0.75

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties. Front Immunol (2017) 0.75

Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis. Exp Ther Med (2017) 0.75

Articles by these authors

High versus low blood-pressure target in patients with septic shock. N Engl J Med (2014) 7.37

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity (2011) 2.87

Abandon the mouse research ship? Not just yet! Shock (2014) 2.60

Erythropoietin during porcine aortic balloon occlusion-induced ischemia/reperfusion injury. Crit Care Med (2008) 2.50

Systemic, pulmonary, and hepatosplanchnic effects of N-acetylcysteine during long-term porcine endotoxemia. Crit Care Med (2004) 2.14

Understanding the benefits and harms of oxygen therapy. Intensive Care Med (2015) 2.00

Effects of ventilation with 100% oxygen during early hyperdynamic porcine fecal peritonitis. Crit Care Med (2008) 1.85

Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated mice. Crit Care Med (2010) 1.70

Comparison of carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine aortic balloon occlusion-induced spinal cord ischemia/reperfusion injury. Intensive Care Med (2011) 1.60

Effects of intravenous sulfide during resuscitated porcine hemorrhagic shock*. Crit Care Med (2012) 1.58

Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock. Crit Care Med (2006) 1.54

Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. Crit Care Med (2005) 1.49

Effects of tempol, a free radical scavenger, on long-term hyperdynamic porcine bacteremia. Crit Care Med (2005) 1.48

Metaphyseal fracture healing in a sheep model of low turnover osteoporosis induced by hypothalamic-pituitary disconnection (HPD). J Orthop Res (2013) 1.42

Infrared ear thermometry in water-related accidents-not a good choice. J Emerg Med (2008) 1.41

Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: effects on hepatosplanchnic oxygen exchange and metabolism. Crit Care Med (2002) 1.40

Effects of Hyperoxia and Mild Therapeutic Hypothermia During Resuscitation From Porcine Hemorrhagic Shock. Crit Care Med (2016) 1.40

Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care. Crit Care (2009) 1.31

Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury. Shock (2008) 1.26

Renal haemodynamic, microcirculatory, metabolic and histopathological responses to peritonitis-induced septic shock in pigs. Crit Care (2008) 1.20

Glucose metabolism and catecholamines. Crit Care Med (2007) 1.19

Physiological and clinical aspects of apnea diving. Clin Chest Med (2005) 1.19

Target blood pressure in sepsis: between a rock and a hard place. Crit Care (2013) 1.13

Endotoxin elimination in sepsis: physiology and therapeutic application. Langenbecks Arch Surg (2010) 1.12

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects. Br J Pharmacol (2014) 1.10

Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats. Crit Care (2010) 1.08

Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth Analg (2005) 1.08

Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. Crit Care Med (2005) 1.05

Effect of increased cardiac output on hepatic and intestinal microcirculatory blood flow, oxygenation, and metabolism in hyperdynamic murine septic shock. Crit Care Med (2005) 1.01

Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial. Crit Care (2009) 0.98

Plasma disappearance of indocyanine green: a marker for excretory liver function? Intensive Care Med (2005) 0.98

Metabolic alterations in sepsis and vasoactive drug-related metabolic effects. Curr Opin Crit Care (2003) 0.96

Multivariate determination of 13CO2/12CO2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors. Anal Bioanal Chem (2013) 0.96

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock. Intensive Care Med Exp (2013) 0.96

Inflammatory effects of hypothermia and inhaled H2S during resuscitated, hyperdynamic murine septic shock. Shock (2011) 0.95

Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock (2004) 0.94

Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia/reperfusion injury. Shock (2011) 0.93

Does vasopressor therapy have an indication in hemorrhagic shock? Ann Intensive Care (2013) 0.93

Cardiopulmonary, histologic, and inflammatory effects of intravenous Na2S after blunt chest trauma-induced lung contusion in mice. J Trauma (2011) 0.93

Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs. Intensive Care Med (2005) 0.93

Carbamylated erythropoietin-FC fusion protein and recombinant human erythropoietin during porcine kidney ischemia/reperfusion injury. Intensive Care Med (2013) 0.92

Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor. Dis Model Mech (2013) 0.92

The parp-1 inhibitor ino-1001 facilitates hemodynamic stabilization without affecting DNA repair in porcine thoracic aortic cross-clamping-induced ischemia/reperfusion. Shock (2006) 0.91

Temperature and cell-type dependency of sulfide effects on mitochondrial respiration. Shock (2012) 0.91

Catecholamines and vasopressin during critical illness. Crit Care Clin (2006) 0.91

Influence of an orally effective SOD on hyperbaric oxygen-related cell damage. Free Radic Res (2004) 0.91

Extravascular lung water volume measurement by a novel lithium-thermal indicator dilution method: comparison of three techniques to post-mortem gravimetry. Intensive Care Med (2008) 0.90

Applying gases for microcirculatory and cellular oxygenation in sepsis: effects of nitric oxide, carbon monoxide, and hydrogen sulfide. Curr Opin Anaesthesiol (2009) 0.89

Hyperoxia may be beneficial. Crit Care Med (2010) 0.89

Endogenous H2S in hemorrhagic shock: innocent bystander or central player? Crit Care (2012) 0.89

Hemodynamic, metabolic, and organ function effects of pure oxygen ventilation during established fecal peritonitis-induced septic shock. Crit Care Med (2009) 0.88

Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Intensive Care Med (2002) 0.88

Effect of prone position on hepato-splanchnic hemodynamics in acute lung injury. Intensive Care Med (2002) 0.88

Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock. Crit Care (2003) 0.88

Role of alveolar macrophages in the inflammatory response after trauma. Shock (2014) 0.88

Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia. Shock (2007) 0.86

High versus low blood-pressure target in septic shock. N Engl J Med (2014) 0.86

Metabolic effects of norepinephrine and dobutamine in healthy volunteers. Shock (2002) 0.86

Total haemoglobin mass and spleen contraction: a study on competitive apnea divers, non-diving athletes and untrained control subjects. Eur J Appl Physiol (2007) 0.86

Genotoxicity of hyperbaric oxygen. Mutat Res (2002) 0.85

Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies. Intensive Care Med (2005) 0.85

Pathophysiology of tissue acidosis in septic shock: blocked microcirculation or impaired cellular respiration? Crit Care Med (2008) 0.84

Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury. Intensive Care Med (2006) 0.84

Nitric oxide, leukocytes and microvascular permeability: causality or bystanders? Crit Care (2008) 0.83

Acute kidney injury in sepsis: is renal blood flow more than just an innocent bystander? Intensive Care Med (2007) 0.83

Nitric oxide, bacteria, and host defense in sepsis: who needs what? Shock (2004) 0.83

Effects of pretreatment hypothermia during resuscitated porcine hemorrhagic shock. Crit Care Med (2013) 0.82

The effect of iNOS deletion on hepatic gluconeogenesis in hyperdynamic murine septic shock. Intensive Care Med (2007) 0.82

Year in review in Intensive Care Medicine, 2006. II. Infections and sepsis, haemodynamics, elderly, invasive and noninvasive mechanical ventilation, weaning, ARDS. Intensive Care Med (2007) 0.82

Selepressin in Septic Shock: A Step Toward Decatecholaminization? Crit Care Med (2016) 0.81

Vasopressin in vasodilatory shock: is the heart in danger? Crit Care (2008) 0.81

The selective poly(ADP)ribose-polymerase 1 inhibitor INO1001 reduces spinal cord injury during porcine aortic cross-clamping-induced ischemia/reperfusion injury. Intensive Care Med (2007) 0.81

The effect of superoxide dismutase overexpression on hepatic gluconeogenesis and whole-body glucose oxidation during resuscitated normotensive murine septic shock. Shock (2008) 0.81

Inotropes and vasopressors: more than haemodynamics! Br J Pharmacol (2012) 0.81

Levosimendan in septic shock: another piece in the puzzle, but many pieces are still lacking. Intensive Care Med (2007) 0.81

Lactate in shock: a high-octane fuel for the heart? Intensive Care Med (2007) 0.81

Effect of SOD-1 over-expression on myocardial function during resuscitated murine septic shock. Intensive Care Med (2008) 0.80

The world according to poly(ADP-ribose) polymerase (PARP)--update 2006. Intensive Care Med (2006) 0.80

Acute liver injury and biomarkers: a biological lesson from indocyanine green. Shock (2009) 0.80

Measuring end products of nitric oxide in vivo. Methods Enzymol (2002) 0.80

Effects of a cantaloupe melon extract/wheat gliadin biopolymer during aortic cross-clamping. Intensive Care Med (2007) 0.80

Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis. Intensive Care Med (2004) 0.80

Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma. Shock (2015) 0.80

Inhaled hydrogen sulfide induces suspended animation, but does not alter the inflammatory response after blunt chest trauma. Shock (2012) 0.80

Drug-Induced "Suspended Animation": Can a Dream Become True? Crit Care Med (2015) 0.80

Interaction of hyperbaric oxygen, nitric oxide, and heme oxygenase on DNA strand breaks in vivo. Mutat Res (2005) 0.79

Hyperoxia during septic shock--Dr. Jekyll or Mr. Hyde? Shock (2012) 0.79

Catecholamines and vasopressin during critical illness. Endocrinol Metab Clin North Am (2006) 0.79