PubRank

Christopher A Bradfield

Author PubWeight™ 76.54‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 2010 5.97
2 An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010 3.75
3 The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 2007 3.68
4 AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol 2011 2.99
5 Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science 2006 2.41
6 The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology 2009 2.31
7 Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis 2005 2.30
8 Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol 2005 2.25
9 Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 2012 2.13
10 Mammalian Per-Arnt-Sim proteins in environmental adaptation. Annu Rev Physiol 2010 1.94
11 Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A 2005 1.82
12 The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Mol Pharmacol 2007 1.77
13 Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 2003 1.64
14 Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation 2008 1.62
15 The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse. Mol Pharmacol 2004 1.56
16 Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele. J Biol Chem 2004 1.56
17 EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information. Mol Pharmacol 2005 1.43
18 Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol Sci 2008 1.38
19 Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 2004 1.27
20 Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines. Mol Pharmacol 2005 1.24
21 The aryl hydrocarbon receptor is activated by modified low-density lipoprotein. Proc Natl Acad Sci U S A 2007 1.20
22 The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A 2009 1.15
23 Sequence variation and phylogenetic history of the mouse Ahr gene. Pharmacogenetics 2002 1.11
24 Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development. Mol Pharmacol 2006 1.09
25 Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res 2008 1.06
26 Similarity queries for temporal toxicogenomic expression profiles. PLoS Comput Biol 2008 1.06
27 Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem 2007 1.03
28 EDGE(3): a web-based solution for management and analysis of Agilent two color microarray experiments. BMC Bioinformatics 2009 1.01
29 D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Chem Res Toxicol 2009 1.01
30 Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor. Mol Pharmacol 2003 0.98
31 Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 2012 0.98
32 Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver. Toxicol Sci 2010 0.98
33 A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis. J Biol Chem 2004 0.95
34 The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 2010 0.95
35 Aryl hydrocarbon receptor response to indigoids in vitro and in vivo. Arch Biochem Biophys 2004 0.94
36 A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse. Mol Pharmacol 2008 0.94
37 Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 2005 0.93
38 Hepatic transcriptional networks induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol 2007 0.93
39 SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation. PLoS One 2012 0.89
40 Identification of the Ah-receptor structural determinants for ligand preferences. Toxicol Sci 2012 0.89
41 Application of genomics to toxicology research. Environ Health Perspect 2002 0.89
42 Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β. Toxicol Sci 2012 0.87
43 Conserved genomic structure of the Cyp1a1 and Cyp1a2 loci and their dioxin responsive elements cluster. Biochem Pharmacol 2008 0.87
44 Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid. Chem Res Toxicol 2009 0.87
45 Interaction networks in yeast define and enumerate the signaling steps of the vertebrate aryl hydrocarbon receptor. PLoS Biol 2004 0.87
46 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces premature activation of the KLF2 regulon during thymocyte development. J Biol Chem 2007 0.86
47 Immunology: T cells hang in the balance. Nature 2008 0.83
48 The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals. Toxicol Environ Chem 2012 0.81
49 Advances in toxicogenomics. Chem Res Toxicol 2005 0.80
50 The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene. PLoS One 2010 0.79
51 The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. Mol Pharmacol 2006 0.79
52 The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3. Mol Pharmacol 2005 0.79
53 Developing toxicologically predictive gene sets using cDNA microarrays and Bayesian classification. Methods Enzymol 2002 0.79
54 Clustered alignments of gene-expression time series data. Bioinformatics 2009 0.78
55 A time to divide: does the circadian clock control cell cycle? Dev Cell 2006 0.78
56 The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse. Ann Surg 2016 0.76