Published in Annu Rev Physiol on January 01, 2010
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Mutational effects and the evolution of new protein functions. Nat Rev Genet (2010) 2.60
Molecular architecture of the mammalian circadian clock. Trends Cell Biol (2013) 2.26
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex. Science (2012) 2.20
Ligand-binding PAS domains in a genomic, cellular, and structural context. Annu Rev Microbiol (2011) 1.99
Development, differentiation, and diversity of innate lymphoid cells. Immunity (2014) 1.87
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation. Cell (2015) 1.83
Preferential duplication of intermodular hub genes: an evolutionary signature in eukaryotes genome networks. PLoS One (2013) 1.45
Aryl hydrocarbon receptor control of adaptive immunity. Pharmacol Rev (2013) 1.38
Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain. J Biol Chem (2010) 1.36
bHLH-PAS proteins in cancer. Nat Rev Cancer (2013) 1.23
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Structural integration in hypoxia-inducible factors. Nature (2015) 1.09
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Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol (2016) 1.03
Intracellular and intercellular processes determine robustness of the circadian clock. FEBS Lett (2011) 1.02
Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation (2010) 1.00
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver. Toxicol Sci (2010) 0.98
Regulation of alternative splicing by the circadian clock and food related cues. Genome Biol (2012) 0.97
Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated protein. Biophys J (2013) 0.94
Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel. PLoS One (2012) 0.94
Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. Proc Natl Acad Sci U S A (2013) 0.94
Structural properties of PAS domains from the KCNH potassium channels. PLoS One (2013) 0.94
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Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR. Nucleic Acids Res (2011) 0.92
MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells. J Immunol (2013) 0.90
Circadian rhythm and cartilage extracellular matrix genes in osseointegration: a genome-wide screening of implant failure by vitamin D deficiency. PLoS One (2011) 0.90
Circadian clock disruption in the mouse ovary in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett (2010) 0.88
Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain. Mol Cell Biol (2013) 0.88
Innate lymphoid cells in the defense against infections. Eur J Microbiol Immunol (Bp) (2013) 0.88
QSAR models of cytochrome P450 enzyme 1A2 inhibitors using CoMFA, CoMSIA and HQSAR. SAR QSAR Environ Res (2011) 0.85
Collective dynamics differentiates functional divergence in protein evolution. PLoS Comput Biol (2012) 0.85
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LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription. PLoS Genet (2014) 0.85
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Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function. PLoS One (2014) 0.84
Circadian clocks in fuel harvesting and energy homeostasis. Cold Spring Harb Symp Quant Biol (2011) 0.84
Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt(+) Innate Lymphoid Cells and Intraepithelial Lymphocytes. Front Immunol (2012) 0.84
Aryl hydrocarbon receptor nuclear translocator (ARNT) isoforms control lymphoid cancer cell proliferation through differentially regulating tumor suppressor p53 activity. Oncotarget (2016) 0.84
14-3-3θ is a binding partner of rat Eag1 potassium channels. PLoS One (2012) 0.83
Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene (2012) 0.83
Potential protective mechanisms of aryl hydrocarbon receptor (AHR) signaling in benign prostatic hyperplasia. Differentiation (2011) 0.82
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease. Front Immunol (2016) 0.82
The Legionella pneumophila kai operon is implicated in stress response and confers fitness in competitive environments. Environ Microbiol (2013) 0.82
Atomic force microscopy - looking at mechanosensors on the cell surface. J Cell Sci (2012) 0.80
Crystallization and preliminary crystallographic characterization of the PAS domains of EAG and ELK potassium channels. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.80
Influence of nutrient-derived metabolites on lymphocyte immunity. Nat Med (2015) 0.80
The aryl hydrocarbon receptor in innate T cell immunity. Semin Immunopathol (2013) 0.79
Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation. Nucleic Acids Res (2013) 0.79
Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force. Biophys J (2012) 0.79
Interplay between Dioxin-mediated signaling and circadian clock: a possible determinant in metabolic homeostasis. Int J Mol Sci (2014) 0.79
Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain. J Biol Chem (2016) 0.79
Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor. Semin Immunopathol (2013) 0.79
Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction. Environ Health Insights (2016) 0.79
New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection. Semin Immunopathol (2013) 0.78
Aryl hydrocarbon receptor activation by dioxin targets phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP-ribose) polymerase (TiPARP). J Biol Chem (2013) 0.78
Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics. BMC Genomics (2012) 0.78
Specific ligand binding domain residues confer low dioxin responsiveness to AHR1β of Xenopus laevis. Biochemistry (2013) 0.78
Tolerogenic dendritic cells. Semin Immunopathol (2016) 0.78
Discovery and biological characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]indole as an aryl hydrocarbon receptor activator generated by photoactivation of tryptophan by sunlight. Chem Biol Interact (2011) 0.77
A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep (2016) 0.77
Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways. Mol Cancer (2014) 0.77
Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Cell Metab (2016) 0.76
The Heme-Based Oxygen-Sensor Phosphodiesterase Ec DOS (DosP): Structure-Function Relationships. Biosensors (Basel) (2013) 0.76
A comparison of midline and tracheal gene regulation during Drosophila development. PLoS One (2014) 0.76
Crystal structures of the F and pSLT plasmid TraJ N-terminal regions reveal similar homodimeric PAS folds with functional interchangeability. Biochemistry (2014) 0.76
An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Environ Sci Technol (2015) 0.76
Sequence and functional characterization of hypoxia-inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus. Am J Physiol Regul Integr Comp Physiol (2016) 0.75
Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Sci Rep (2016) 0.75
Crystal structure of the PAS domain of the hEAG potassium channel. Acta Crystallogr F Struct Biol Commun (2016) 0.75
Regulation of melanopsins and Per1 by α -MSH and melatonin in photosensitive Xenopus laevis melanophores. Biomed Res Int (2014) 0.75
Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int (2016) 0.75
Mechanisms of transcription factor evolution in Metazoa. Nucleic Acids Res (2016) 0.75
The Influence of Human Interindividual Variability on the Low-Dose Region of Dose-Response Curve Induced by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Primary B Cells. Toxicol Sci (2016) 0.75
Intestinal inflammation and the diet: Is food friend or foe? World J Gastrointest Surg (2016) 0.75
NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife (2016) 0.75
Environmental Ligands of the Aryl Hydrocarbon Receptor and Their Effects in Models of Adult Liver Progenitor Cells. Stem Cells Int (2016) 0.75
Setting the PAS, the role of circadian PAS domain proteins during environmental adaptation in plants. Front Plant Sci (2015) 0.75
Structural characterization of mammalian bHLH-PAS transcription factors. Curr Opin Struct Biol (2016) 0.75
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity. Nucl Receptor Res (2016) 0.75
Mibefradil inhibition of the Cole-Moore shift and K(+)-conductance of the tumor-related Kv10.1 channel. Channels (Austin) (2017) 0.75
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. PLoS Biol (2004) 6.72
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A (2005) 6.26
Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM). Bioinformatics (2011) 6.20
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature (2010) 5.97
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron (2004) 5.71
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
Harmonics of circadian gene transcription in mammals. PLoS Genet (2009) 4.97
Circadian rhythms from flies to human. Nature (2002) 4.95
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science (2002) 4.24
Melanopsin is required for non-image-forming photic responses in blind mice. Science (2003) 4.22
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol (2010) 3.75
The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol (2007) 3.68
The Gene Wiki: community intelligence applied to human gene annotation. Nucleic Acids Res (2009) 3.51
JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms (2010) 3.42
Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci (2002) 3.34
A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell (2009) 3.27
Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness. Mol Cell (2003) 3.23
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch. Nat Immunol (2011) 2.99
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell (2003) 2.85
Extensive variation in chromatin states across humans. Science (2013) 2.83
Feedback repression is required for mammalian circadian clock function. Nat Genet (2006) 2.73
Network features of the mammalian circadian clock. PLoS Biol (2009) 2.59
Illumination of the melanopsin signaling pathway. Science (2005) 2.58
Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice. Science (2006) 2.41
The aryl hydrocarbon receptor: a perspective on potential roles in the immune system. Immunology (2009) 2.31
c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev Cell (2005) 2.30
Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis (2005) 2.30
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol (2005) 2.25
The imprinted gene Magel2 regulates normal circadian output. Nat Genet (2007) 2.18
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med (2012) 2.13
Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics (2007) 2.06
Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A (2004) 2.03
Applications of a rat multiple tissue gene expression data set. Genome Res (2004) 2.01
Small-molecule inhibitors of microrna miR-21 function. Angew Chem Int Ed Engl (2008) 2.00
The circadian clock interacts with metabolic physiology to influence reproductive fitness. Cell Metab (2011) 1.96
Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A (2005) 1.82
The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Mol Pharmacol (2007) 1.77
Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem (2003) 1.64
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation (2008) 1.62
Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Res (2005) 1.59
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. J Clin Invest (2013) 1.57
The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse. Mol Pharmacol (2004) 1.56
Patent ductus venosus and dioxin resistance in mice harboring a hypomorphic Arnt allele. J Biol Chem (2004) 1.56
WAVECLOCK: wavelet analysis of circadian oscillation. Bioinformatics (2008) 1.52
Large-scale profiling of Rab GTPase trafficking networks: the membrome. Mol Biol Cell (2005) 1.49
CircaDB: a database of mammalian circadian gene expression profiles. Nucleic Acids Res (2012) 1.47
EDGE: a centralized resource for the comparison, analysis, and distribution of toxicogenomic information. Mol Pharmacol (2005) 1.43
Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation (2005) 1.40
Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor. Toxicol Sci (2008) 1.38
A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc Natl Acad Sci U S A (2007) 1.34
Network dynamics to evaluate performance of an academic institution. Sci Transl Med (2010) 1.32
IVT-seq reveals extreme bias in RNA sequencing. Genome Biol (2014) 1.29
The transcription factor encyclopedia. Genome Biol (2012) 1.28
Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. J Biol Chem (2008) 1.27
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue. PLoS Genet (2012) 1.27
Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A (2004) 1.27
Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines. Mol Pharmacol (2005) 1.24
Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. J Neurosci (2003) 1.20
The aryl hydrocarbon receptor is activated by modified low-density lipoprotein. Proc Natl Acad Sci U S A (2007) 1.20
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs. J Biol Chem (2003) 1.19
It's all in the timing: many clocks, many outputs. J Biol Rhythms (2004) 1.17
The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A (2009) 1.15
Sequence variation and phylogenetic history of the mouse Ahr gene. Pharmacogenetics (2002) 1.11
Liver deformation in Ahr-null mice: evidence for aberrant hepatic perfusion in early development. Mol Pharmacol (2006) 1.09
The role of clock genes in pharmacology. Annu Rev Pharmacol Toxicol (2010) 1.08
Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res (2008) 1.06
Similarity queries for temporal toxicogenomic expression profiles. PLoS Comput Biol (2008) 1.06
Power-law-like distributions in biomedical publications and research funding. Genome Biol (2007) 1.06
Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. Bioinformatics (2013) 1.05
Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem (2007) 1.03
Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clock. Proc Natl Acad Sci U S A (2008) 1.02
The circadian clock gates the intestinal stem cell regenerative state. Cell Rep (2013) 1.02
EDGE(3): a web-based solution for management and analysis of Agilent two color microarray experiments. BMC Bioinformatics (2009) 1.01
D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan. Chem Res Toxicol (2009) 1.01
Circadian light input in plants, flies and mammals. Novartis Found Symp (2003) 0.99
Comparative analysis of human genome assemblies reveals genome-level differences. Genomics (2002) 0.99
miR-210 inhibits trophoblast invasion and is a serum biomarker for preeclampsia. Am J Pathol (2013) 0.98
Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol (2012) 0.98
Circadian clocks are seeing the systems biology light. Genome Biol (2005) 0.98
Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver. Toxicol Sci (2010) 0.98
Aspartate aminotransferase generates proagonists of the aryl hydrocarbon receptor. Mol Pharmacol (2003) 0.98
DNA arrays: applications and implications for circadian biology. J Biol Rhythms (2003) 0.97
A maternal Ahr null genotype sensitizes embryos to chemical teratogenesis. J Biol Chem (2004) 0.95
The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem (2010) 0.95
Wnt ligands signal in a cooperative manner to promote foregut organogenesis. Proc Natl Acad Sci U S A (2012) 0.94
Aryl hydrocarbon receptor response to indigoids in vitro and in vivo. Arch Biochem Biophys (2004) 0.94
A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse. Mol Pharmacol (2008) 0.94
RNA profiling in circadian biology. Methods Enzymol (2005) 0.94
Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem (2005) 0.93
Hepatic transcriptional networks induced by exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol (2007) 0.93
Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch. Curr Biol (2012) 0.93
The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev Cell (2011) 0.92