A novel mutation in the transmembrane nonpore region of the KCNH2 gene causes severe clinical manifestations of long QT syndrome.

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Genetics of long-QT syndrome. J Hum Genet (2015) 0.95

Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects. Acta Pharmacol Sin (2014) 0.88

Proarrhythmic and Torsadogenic Effects of Potassium Channel Blockers in Patients. Card Electrophysiol Clin (2016) 0.82

Association of the hERG mutation with long‑QT syndrome type 2, syncope and epilepsy. Mol Med Rep (2016) 0.75

Mutation location matters in long QT syndrome type 2 (but behavior matters more). Heart Rhythm (2012) 0.75

Secondly ECG recordings in the emergency room revealed Garenoxacin-induced abnormal QT interval prolongation in a patient with multiple syncopal attacks. Heart Vessels (2015) 0.75

Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation (2005) 3.10

Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol (2004) 2.69

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β. J Clin Invest (2010) 2.64

CD38 is critical for social behaviour by regulating oxytocin secretion. Nature (2007) 2.44

Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation (2003) 2.28

Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART). J Am Coll Cardiol (2002) 2.26

Effect of intensive statin therapy on regression of coronary atherosclerosis in patients with acute coronary syndrome: a multicenter randomized trial evaluated by volumetric intravascular ultrasound using pitavastatin versus atorvastatin (JAPAN-ACS [Japan assessment of pitavastatin and atorvastatin in acute coronary syndrome] study). J Am Coll Cardiol (2009) 2.08

AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci (2003) 2.08

Long QT syndrome with compound mutations is associated with a more severe phenotype: a Japanese multicenter study. Heart Rhythm (2010) 2.00

Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens? Gastric Cancer (2012) 1.95

T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity. Clin Sci (Lond) (2003) 1.86

A calcium sensor in the sodium channel modulates cardiac excitability. Nature (2002) 1.83

Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest (2004) 1.80

Effect of rosuvastatin on coronary atheroma in stable coronary artery disease: multicenter coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS). Circ J (2009) 1.80

T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin Cardiol (2002) 1.72

Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow. Circ J (2011) 1.70

Oxidative mediated lipid peroxidation recapitulates proarrhythmic effects on cardiac sodium channels. Circ Res (2005) 1.70

Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve. Circulation (2003) 1.69

Development of the cardiac conduction system as delineated by minK-lacZ. J Cardiovasc Electrophysiol (2003) 1.65

MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance. Clin Cancer Res (2010) 1.64

Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm (2005) 1.63

Images in cardiovascular medicine. "Arteries within the artery" after Kawasaki disease: a lotus root appearance by intravascular ultrasound. Circulation (2002) 1.61

Trafficking-competent KCNQ1 variably influences the function of HERG long QT alleles. Heart Rhythm (2010) 1.61

The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development (2004) 1.59

Diabetes mellitus is a major negative determinant of coronary plaque regression during statin therapy in patients with acute coronary syndrome--serial intravascular ultrasound observations from the Japan Assessment of Pitavastatin and Atorvastatin in Acute Coronary Syndrome Trial (the JAPAN-ACS Trial). Circ J (2010) 1.58

Impact of severe earthquake on the occurrence of acute coronary syndrome and stroke in a rural area of Japan. Circ J (2009) 1.55

Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome. Diabetes Res Clin Pract (2007) 1.52

Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. Hum Mutat (2005) 1.51

Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet (2015) 1.51

An enhanced device for transluminal retrieval of vascular stents without surgical procedures: experimental studies. J Interv Cardiol (2010) 1.50

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet (2015) 1.50

Acute hyperglycemia is associated with adverse outcome after acute myocardial infarction in the coronary intervention era. Am Heart J (2005) 1.49

Cholesteryl ester transfer protein inhibitor (JTT-705) and the development of atherosclerosis in rabbits with severe hypercholesterolaemia. Clin Sci (Lond) (2002) 1.48

Impact of visceral adipose tissue and subcutaneous adipose tissue on insulin resistance in middle-aged Japanese. J Atheroscler Thromb (2012) 1.47

Impact of Elevated D-Dimer on Diagnosis of Acute Aortic Dissection With Isolated Neurological Symptoms in Ischemic Stroke. Circ J (2015) 1.46

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest (2005) 1.45

Reverse vessel remodeling but not coronary plaque regression could predict future cardiovascular events in ACS patients with intensive statin therapy--the extended JAPAN-ACS study. Circ J (2012) 1.45

Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study. Atherosclerosis (2011) 1.43

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum (2011) 1.42

Weekend onset of acute myocardial infarction does not have a negative impact on outcome in Japan. Circ J (2007) 1.42

Primary Sjögren's syndrome with chronic tubulointerstitial nephritis and lymphadenopathy mimicking IgG4-related disease. Mod Rheumatol (2013) 1.42

Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells. Biochem Biophys Res Commun (2008) 1.42

Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Gain-of-Function Mutations. Circ J (2015) 1.41

Clustering of metabolic syndrome components attenuates coronary plaque regression during intensive statin therapy in patients with acute coronary syndrome: the JAPAN-ACS subanalysis study. Circ J (2012) 1.40

Changes in cardiac tissue characterization in carriers with gene mutations associated with hypertrophic cardiomyopathy. Int J Cardiol (2005) 1.38

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation (2011) 1.38

Mutations in TSPAN12 cause autosomal-dominant familial exudative vitreoretinopathy. Am J Hum Genet (2010) 1.38

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 1.35

Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. Am J Cardiol (2005) 1.31

Comparison of waist circumference with body mass index for predicting abdominal adipose tissue. Diabetes Res Clin Pract (2008) 1.28

Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. J Biol Chem (2004) 1.27

Huge saccular aneurysm in a coronary-pulmonary fistula fed by the left and right coronary arteries. Circ J (2002) 1.24

Impacts of visceral adipose tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese. Obesity (Silver Spring) (2009) 1.23

Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin. J Biol Chem (2009) 1.22

Atrial fibrillation in KCNE1-null mice. Circ Res (2005) 1.21

Patternable solution-crystallized organic transistors with high charge carrier mobility. Adv Mater (2011) 1.21

A homozygosity-based search for mutations in patients with autosomal recessive retinitis pigmentosa, using microsatellite markers. Invest Ophthalmol Vis Sci (2004) 1.20

Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Atherosclerosis (2007) 1.19

Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. Am J Med Genet B Neuropsychiatr Genet (2008) 1.19

Reduction of serum ubiquinol-10 and ubiquinone-10 levels by atorvastatin in hypercholesterolemic patients. J Atheroscler Thromb (2005) 1.18

A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese. PLoS Genet (2012) 1.17

Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia. Am J Physiol Heart Circ Physiol (2010) 1.15

In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux. J Lipid Res (2003) 1.14

Apolipoprotein A-I deficiency results in markedly increased atherosclerosis in mice lacking the LDL receptor. Arterioscler Thromb Vasc Biol (2003) 1.12

Linear- and angular-shaped naphthodithiophenes: selective synthesis, properties, and application to organic field-effect transistors. J Am Chem Soc (2011) 1.11

Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol (2005) 1.10

Genes required for Drosophila nervous system development identified by RNA interference. Proc Natl Acad Sci U S A (2004) 1.10

Elevated plasma ghrelin level in underweight patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2004) 1.10